Monthly Healthcare Review February 2016 · 2016-09-25 · Monthly Healthcare Review February 2016...

Monthly Healthcare Review

February 2016

Company NameLast Financing

DateHQ Location Description

Last

Financing

Size

(Millions)

Lead Manager

Shield Therapeutics

(STX)

26-Feb-16 Wollerau,

Switzerland

Developer of an oral product for iron deficiency anemia which will replace intravenous iron

therapy for critically ill patients with inflammatory bowel disease.

46.55 Liberum Capital Ltd

Proteostasis

Therapeutics (PTI)

11-Feb-16 Cambridge, MA Developer of small molecule therapeutics to control the body’s protein homeostasis. The

company develops therapeutics that regulate protein homeostasis to improve outcomes for

patients with neurodegenerative and orphan diseases.

50.00 Leerink Partners,

RBC Capital

Markets

AveXis (AVXS) 11-Feb-16 Bannockburn,

IL

Developer of treatments for rare and life-threatening neurological genetic diseases. The

company is developing scAAV9.CB.SMN, an on-going Phase 1 clinical trial for the

treatment of spinal muscular atrophy (SMA) Type 1, an autosomal-recessive genetic

disorder characterized by lower motor neuron loss and progressive muscle weakness.

95.00 Goldman, Sachs &

Co., Jefferies

B.R.A.I.N. (BNN) 09-Feb-16 Zwingenberg,

Germany

Developer of white biotechnology. The company discovers BioActives, natural compounds

and proprietary enzymes for chemical, pharmaceuticals, food and cosmetics industries.

Their key technology creates micro-organisms for the conversion of carbon containing

industrial waste that flows into secondary raw materials.

34.97 ODDO Seydler

Apellis 08-Feb-16 Crestwood, KY Developer of novel therapeutics and drug delivery technologies. The company develops

peptide drugs focused on the immunology space such as asthma and chronic obstructive

pulmonary disease.

86.25 Barclays Capital,

Citigroup Global

Markets, Leerink

Partners

Editas Medicine

(EDIT)

03-Feb-16 Cambridge, MA Developer of drugs to treat disorders caused by a singular genetic defect. The company is

developing genome editing technology into a novel class of human therapeutics designed to

enable precise and corrective molecular modification to treat the underlying cause of a

broad range of diseases at the genetic level.

94.40 J.P. Morgan

Securities, Morgan

Stanley & Co.

BeiGene (BGNE) 03-Feb-16 Beijing, China Developer of oncology drugs. The company performs clinical-stage oncology research and

development focused on discovering, developing and commercializing targeted and immune-

oncology therapeutics to help serve the unmet needs in cancers that are prevalent in China

and the Asia-Pacific region.

158.40 Cowen and

Company,

Goldman, Sachs &

Co, Morgan Stanley

The following table includes the medical devices, biotechnology, pharmaceuticals, and healthcare IPO pricings, filings and withdrawals announced over the previous month.

IPOs

Compiled by: Morgan Reape

Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 1


February 2016

Company Name

Last

Financing

Date

HQ Location Round Description

Last

Financing

Size

(Millions)

Lead Investor(s)

Retina Implant 29-Feb-16 Reutlingen,

Germany

Angel Developer of subretinal implants for partially sighted and blind patients.

The company is developing the first fully functioning electronic retinal

implant to restore useful vision to the blind.

28.86 Max Reindl, other

undisclosed

Medlanes 29-Feb-16 Berlin, Germany Early Stage VC Provider of online medical advice and care services. The company

combines machine-learning technology with doctor knowledge to offer

patients a first contact point to healthcare spanning a large number of

medical conditions.

Undisclosed AXA Strategic

Ventures

MedCPU 29-Feb-16 New York, NY Later Stage VC Provider of real-time clinical care software. The company's application

captures the clinical picture from clinicians' free-text notes, dictations and

structured documentation entered into electronic medical records and

analyzes that data against a growing library of content for generating real-

time precise prompts for care consideration.

35.00 UPMC Health

System

Applied Pathways 29-Feb-16 Schaumburg, IL Later Stage VC Developer of an enterprise knowledge-management platform. The

company develops Web-based software tools designed to enable clinicians,

Web developers and business managers to develop, maintain and deploy

rules-based applications, training materials to custom portal and translated

practice processes into flow charts.

6.00 Health Enterprise

Partners

4D Healthware 29-Feb-16 Chicago, IL Seed Round Developer of an online platform that helps patients to take care of their

health through mobile devices. The company provides a platform that

combines relevant information from each patient’s health history plus real

time data gathered from devices such as activity trackers, mobile apps,

wireless scales and wearable biometric sensors such that the data can be

utilized to provide a recommended care plan for each patient.

0.61 Undisclosed

Third Pole 26-Feb-16 San Francisco, CA Angel Developer of a medical inhalation device offering nitric oxide needed for

babies with respiratory failure.

2.68 Undisclosed

Targeted Diagnostics &

Therapeutics

26-Feb-16 West Chester, PA Angel Owner and operator of a biotechnology company developing molecular-

based technologies. The company's technology is used for the targeted

detection, diagnosis and treatment of gastrointestinal cancers and

infectious diseases.

0.76 Undisclosed

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced

over the previous month.




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Expansion Technologies 26-Feb-16 Cambridge, MA Angel Developer of novel therapeutic methods using nano scale-precise optical

microscopy.

2.00 Undisclosed

CHD Bioscience 26-Feb-16 Fort Collins, CO Angel Developer of topical therapeutic products. The company develops anti-

microbial technology to prevent the spread of dermal and orthopedic

bacterial infections.

1.74 Undisclosed

Celcuity 26-Feb-16 Minneapolis, MN Angel Developer of a biotech-based analysis platform for the pharmaceutical

sector. The company is the developer of cell-based assays to assess the

functionality of disease-related signaling pathways within a patient's cells to

determine whether a drug therapy is having the intended effect.

5.50 Undisclosed

Vivify Health 25-Feb-16 Plano, TX Later Stage VC Provider of a healthcare-management platform. The company delivers

direct-to-consumer care, including customized care plans, coaching,

educational video content and interactive video conferencing for patients

and their healthcare providers.

17.00 UPMC Health

System

VitalWare 25-Feb-16 Yakima, WA Early Stage VC Provider of a business intelligence platform for healthcare providers by

integrating key processes including documentation, coding, billing and

auditing.

Undisclosed F-Prime Capital

Pertners

Versago Vascular

Access

25-Feb-16 West Bridgewater,

MA

Seed Round Operator of a vascular access technology company. The company develops

a patented technology that displaces multiple traditional access applications

in apheresis and chemotherapy.

1.65 Primo Medical

Group

Synaptive 25-Feb-16 Toronto, Canada Early Stage VC Provider of neurosurgical technological products and services. The

company provides advanced tools and information for neurosurgeons,

radiologists, surgeons and hospitals to focus on patient outcomes.

0.91 Undisclosed

Specialists On Call 25-Feb-16 Reston, VA PE Growth/

Expansion

Provider of specialty physician consultations to acute-care hospitals via

telemedicine. The company offers specialty physician services and provides

on-call coverage to suburban and urban acute-care hospitals via

videoconferencing to improve patient care and increase the financial and

clinical strength of community hospitals.

64.77 Greenwoods Capital

Partners




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Chromis Therapeutics 25-Feb-16 San Diego, CA Seed Round Developer of anti-viral pharmaceuticals. The company engages in the

discovery and development of antiviral drugs for chronic hepatitis B viral

infections using proprietary drug-design platform.

3.00 Torrey Pines

Investment

Avraham

Pharmaceuticals

25-Feb-16 Yavneh, Israel Later Stage VC Developer of products for the treatment and prevention of

neurodegenerative disorders. The company's product, Ladostigil, provides

a drug candidate for treatment of Alzheimer’s disease in patients diagnosed

with mild cognitive impairment.

4.00 Pomtifax, Clal

Biotechnology

Industries, Yissum

Research

Development

Company

Rani Therapeutics 24-Feb-16 San Jose, CA Later Stage VC Developer of an oral drug delivery technology. The company provides an

oral biotherapeutics technology for the delivery of peptides, proteins and

therapeutic antibodies, which to date can only be delivered through

injections.

37.00 AstraZeneca, Virtus

Inspire Ventures,

Ping An Ventures

PolyPid 24-Feb-16 Petach Tikva, Israel Later Stage VC Developer of proprietary drug-delivery technology. The company develops

pharmaceutically active ingredients utilizing its nano-based drug-delivery

platform for sustained release.

22.00 Shavit Capital,

Aurum Ventures

Visikol 23-Feb-16 New Brunswick, NJ Early Stage VC Developer of a biological clearing agent. The company offers a chemical

formula called Visikol that penetrates tissues, renders them transparent and

allows 3-dimensional imaging of both plant and animal specimens without

causing any structural damage.

0.50 Foundation Venture

Capital Group

Myra 23-Feb-16 Bangalore, India Early Stage VC Provider of online pharmacy delivery services. The company provides an

online mobile application to deliver medicine to the doorstep in 30 minutes

with a flat 15% discount.

Undisclosed Matrix Partners,

Pranay Chulet,

Prashant Malik

Augustine Temperature

Management

23-Feb-16 Eden Prairie, MN Later Stage VC Developer of normothermia technologies. The company manufactures

conductive fabric patient warming systems for surgical patients.

7.80 Undisclosed

Vanquish Oncology 22-Feb-16 Champaign, IL Early Stage VC Developer of a drug on molecular defects in specific cancer cells. The

company targets to create personalized oncology therapeutics for unmet or

underserved cancer markets.

1.05 Undisclosed




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Svelte Medical Systems 22-Feb-16 New Providence,

NJ

Later Stage VC Developer of balloon expandable stents. The company designs and

develops non-thrombogenic and non-inflammatory drug eluting stents for

the treatment of atherosclerosis.

44.40 CNF Investments

SigTuple 22-Feb-16 Bangalore, India Seed Round Developer of data driven intelligence for automated analysis of medical

images and data to aid diagnosis. The company provides a data driven,

machine learned, cloud based technology for detection of anomalies and

trends in medical data using deep learning.

Undisclosed Sachin Bansal, Binny

Bansal, Accei

Partners

PSKW 22-Feb-16 Bedminster, NJ PE Growth/

Expansion

Provider of patient prescription medication assistance and payment

reimbursement services. The company provides pharmaceutical and

biopharma loyalty relationship marketing services, co-pay eligibility

verification services, digital relationship tools and co-pay assistance

programs. It also offers co-pay incentive cards, vouchers, coupons,

messages, reminders and discount offers.

68.25 Undisclosed

Prima-Temp 22-Feb-16 Boulder, CO Early Stage VC Developer of a healthcare device that provides continuous core

temperature measurements. The company develops wireless monitoring

technology that can detect subtle changes in core body temperature and

communicate the data directly to a smartphone. It has applications for

fertility monitoring, early disease detection, sleep disorder, heat exhaustion,

chemotherapy, obesity and weight loss.

1.64 Green Park & Golf

Ventures

Precision Ocular 22-Feb-16 London, United

Kingdom

Early Stage VC Developer of a drug-based treatment for retinal diseases. The company

provides a treatment for retinal diseases, including age-related macular

degeneration, diabetic macular edema, retinal vein occlusion, uveitis and

cystoid macular edema.

19.34 Imperial

Innovations Group

KeyNatura 22-Feb-16 Kopavogur, Iceland Early Stage VC Provider of astaxanthin, an antioxidant from sea creatures. 2.40 Eyrir Invest




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



IMPACT Therapeutics 22-Feb-16 NanJing, China Later Stage VC Provider of drug discovery services. The company is engaged in the

discovery, development and commercialization of therapeutics to treat

cancer and other life-threatening diseases.

10.00 China Orient

Summit Capital,

Sungent

BioVenture,

HAIBANG

Ventures,

Guangzhou

YUEXIU Industrial

Investment Fund,

Lilly Asia Ventures

CenterX 22-Feb-16 Madison, WI Angel Provider of e-prescribing and medication adherence tracking software. The

company offers a cloud-based electronic prescribing directory for

prescribers, pharmacists and payers to electronically handle patient

prescriptions.

3.33 Undisclosed

CardioDx 22-Feb-16 Redwood City, CA Later Stage VC Developer of clinically validated genomic tests to aid in assessing and

tailoring care of individuals with cardiovascular disease. The company

offers cardiovascular genomics diagnostic services for heart diseases

including coronary artery disease, cardiac arrhythmia and heart failure.

12.37 Undisclosed

SeqLL 19-Feb-16 Woburn, MA Angel Provider of molecule sequencing technology. The company provides true

single molecule sequencing of RNA or DNA which offers researchers

RNA sequencing data capturing the depth and breadth of findings.

1.00 Undisclosed

RadiFit Athletics 19-Feb-16 Miramar, FL Accelerator/

Incubator

Manufacturer of orthopedic products, accessories and medical devices.

The company develops custom knee sleeves with real time technology that

monitors athletic movements and is designed to reduce injuries and tears.

0.02 PowerMoves

NOLA

NurseGrid 19-Feb-16 Portland, OR Early Stage VC Developer of a mobile application for nurse scheduling in hospitals. The

company offers a suite of scheduling and staffing software that allows

nurses to communicate and share schedules with their colleagues in real-

time.

1.16 Undisclosed




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



NICO 19-Feb-16 Indianapolis, IN Later Stage VC Developer of surgical devices. The company develops technology and

products for the field of corridor surgery, including cranial, ENT, spinal,

and otolaryngology.

15.07 River Cities Capital

Funds, Rose-

Hulman Institute of

Technology

Fractyl 19-Feb-16 Waltham, MA Early Stage VC Developer of medical devices for the treatment of chronic diseases,

particularly focusing on improving the health of people with Type 2

diabetes.

47.17 Mithril Capital

Management

eFFECTOR

Therapeutics

19-Feb-16 San Diego, CA Early Stage VC Developer of protein-synthesis drugs. The company is pioneering a new

class of small-molecule drugs that act by selectively regulating translation

(or protein synthesis). The company is developing translation regulators to

restore homeostasis to the protein-synthesis landscape, offering treatment

for a variety of serious conditions, including cancer.

56.00 Altitude Life Science

Ventures

BrainCheck 19-Feb-16 Houston, TX Angel Developer of a device that helps in measurement of brain function

designed to aid in the diagnosis of traumatic brain injury.

2.25 Undisclosed

Yumanity Therapeutics 18-Feb-16 Cambridge, MA Early Stage VC Developer of drugs for neurodegenerative diseases caused by protein

misfolding. The company is engaged in the research and development of

therapies for patients with Alzheimer’s disease, Parkinson’s disease and

amyotrophic lateral sclerosis.

51.01 Fidelity

Management &

Research

Unchained Labs 18-Feb-16 Pleasanton, CA Early Stage VC Developer of life science biologics tools. The company offers protein

stability platform and products for biologics that helps researchers to

measure multiple protein stability parameters.

25.00 Novo Ventures,

Canaan Partners.

TPG Biotech

Reset Therapeutics 18-Feb-16 South San

Francisco, CA

Later Stage VC Developer of therapeutics for the circadian system. The company engages

in research and development of an engine for identifying components of

the circadian system that can be targeted to treat metabolic and related

disorders, such as diabetes, obesity and cardiovascular disease.

29.73 Undisclosed

Osteonovus 18-Feb-16 Toledo, CA Angel Developer of a bone regeneration biomaterial. The company develops a

synthetic bone graft to fill bone gaps and voids in the skeletal system

during orthopedic surgery.

1.25 Undisclosed




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Opternative 18-Feb-16 Chicago, IL Early Stage VC Provider of online eye-examination services. The company provides a Web

portal that enables users to receive an eye exam, and to receive

prescriptions for glasses or contact lenses within minutes.

6.00 Jump Capital

Micreos 18-Feb-16 Wageningen,

Netherlands

Later Stage VC Developer of phage-based anti-bacterial products. The company develops

products based on phage technology as a replacement for antibiotics in

health care, veterinary medicine, the food processing industry and

agriculture.

13.32 Undisclosed

Health Catalyst 18-Feb-16 Salt Lake City, UT Later Stage VC Provider of healthcare data warehousing, analytics and outcomes

improvement services. The company's platform helps healthcare

organizations of all sizes improve clinical, financial, and operational

outcomes needed to improve population health and accountable care.

70.00 Norwest Venture

Partners, UPMC

Avrobio 18-Feb-16 Cambridge, MA Seed Round Developer of step-change cell and gene therapies targeting cancer and rare

disease. The company’s approach is to genetically modify a patient’s own

cells by adding a functional copy of the faulty gene, and modified cells are

then infused back into the patient via a one-time procedure to deliver long-

lasting, continuous elevation of endogenous enzyme.

1.50 Atlas Ventures

Vitagene 17-Feb-16 San Francisco, CA Seed Round Developer of a platform for physicians. The company's platform is used by

doctors to create tailored supplement regimen for their patients. Its

monthly supplements are personalized to the patient's specific needs and

nutritional gaps.

5.50 Spectrum 28

Vicarious Surgical 17-Feb-16 Cambridge, MA Early Stage VC Developer of a software for use in surgical procedures. The company

develops a virtual reality software integrated with surgical robotics for use

in minimally invasive surgical procedures.

2.39 Rothenberg

Ventures, other

undisclosed

Synlogic 17-Feb-16 Cambridge, MA Early Stage VC Provider and developer of therapeutic microbes and novel engineered

bacteria for therapeutic use in the treatment of disease.

40.00 OrbiMed Advisors

Saphetor 17-Feb-16 Lausanne,

Switzerland

Seed Round Owner and operator of a biotechnology and precision medicine company.

The company develops a Next Generation Sequencing technology that

enables the research and analysis of genomes, genes and exomes.

1.21 Undisclosed




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Pliant Therapeutics 17-Feb-16 Redwood City, CA Early Stage VC Developer of new therapies to treat fibrotic disorders. The company has

developed a product engine that has the potential to address the needs of

many patients by targeting fibrosis in a variety of organs and conditions.

45.00 Third Rock

Ventures

Piktorex 17-Feb-16 Warszawa, Poland Early Stage VC Developer of medical pictograms. The company offers medical stickers in

the form of pictograms that informs patients about correct medication

dosages.

Undisclosed Black Pearls

Cro Analytics 17-Feb-16 New Hope, PA Early Stage VC Provider of clinical research performance data collection, reporting,

consulting, benchmarking and predictive clinical trial analytics for the

biopharma industry.

2.50 Ben Franklin

Technology Partners

Corvidia 17-Feb-16 Waltham, MA Early Stage VC Developer of precision cardiovascular therapies. The company's pipeline

programs identify patients with unique sensitivity to specific biologic

pathways, potentially allowing for the rapid development of therapies

targeting those pathways.

26.00 Sofinnova Partners,

Apple Tree Partners

3D Vision Systems 17-Feb-16 Ann Arbor, MI Angel Manufacturer of medical equipment and supplies. 0.10 Undisclosed

Thermedical 16-Feb-16 Waltham, MA Angel Developer of a thermal ablation system to treat cancer and cardiac

arrhythmias. The company develops an ablation therapy system for the

treatment of liver cancer patients and patients with ventricular tachycardia,

an abnormal rapid heart rhythm.

3.50 Undisclosed

Seven Bridges 16-Feb-16 Cambridge, MA Later Stage VC Provider of a biomedical data analysis platform to help genomic research

institutions analyze, store and act on genomics and other biological

intelligence.

45.00 Kryssen Capital

ScarX 16-Feb-16 Toronto, Canada Early Stage VC Developer of a treatment for fibrosis. The company provides a

prescription cream to treat and prevent post-surgical scarring.

2.00 Accel-Rx Health

Sciences

Accelerator, BDC

Capital, MaRS

Innovation




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



OrPro Therapeutics 16-Feb-16 San Diego, CA Angel Developer of Theradux, a modified recombinant thioredoxin for the

treatment of cystic fibrosis. The company provides a class of inhaled non-

systemic drugs based on the thioredoxin active site for the treatment of

patients with cystic fibrosis and other obstructive respiratory diseases.

2.34 Jlabs

Onko Solutions 16-Feb-16 Austin, TX Early Stage VC Developer of a portable medical device for detection of cervical cancer

that does not require laboratory analysis or a tissue sample.

1.60 Angel Ventures

Mexico, Promotora

Social Mexico,

Ambar Venture

Capital

Medsphere Systems 16-Feb-16 Carlsbad, CA Later Stage VC Provider of an open-source electronic health-record system. The company

provides an electronic health-record system designed to encourage

clinician adoption, facilitate workflow automation and foster

interoperability.

0.16 Undisclosed

KindHeart 16-Feb-16 Chapel Hill, NC Angel Owner and operator of a medical-simulation company. The company

provides surgical simulators which are used in the study of surgical

procedures and robotic surgery.

0.25 Undisclosed

Constant Therapy 16-Feb-16 Lexington, MA Early Stage VC Provider of iPad tools for continuous and personalized therapy to people

with cognitive, language, communication and learning disorders. The

company provides products designed for use by patients of traumatic brain

injury, stroke, aphasia and learning disabled clients in addition to speech

and language pathologists or occupational therapists.

1.97 Undisclosed

Cala Health 16-Feb-16 Burlingame, CA Early Stage VC Developer of novel therapies based on neuroscience discoveries. The

company is designing a new wearable medical device for patients who

suffer hand and wrist tremors.

18.00 Johnson & Johnson

Development

Corporation, Lux

Capital, Lightstone

Ventures




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Akarna Therapeutics 16-Feb-16 Encinitas, CA Early Stage VC Developer of molecule therapeutics. The company develops small

molecule therapeutics for the treatment of non-alcoholic steatohepatitis.

14.32 Forbion Capital

Partners

Theraworx 15-Feb-16 Asheville, NC Later Stage VC Provider of therapeutic skin care products. The company manufactures

products that include specialty care packs for peri-care prior to foley

catheter insertion and on-going foley maintenance.

6.86 Undisclosed

Magnesium

Development Company

15-Feb-16 Missoula, MT Angel Operator of a medical device development company. The company

develops sports medical devices using metal alloy technology combining

the strength and handling properties of metal with complete absorption for

application in sports medicine orthopedics.

1.00 Undisclosed

Summit Medventures

Holdings

12-Feb-16 Austin, TX Angel Developer of an orthopedic implant technology. The company provides

cortical screws for surgical purposes in the areas of trauma, spine, and total

joints.

1.74 Undisclosed

PhysIQ 12-Feb-16 Naperville, IL Later Stage VC Developer of personalized predictive analytics. The company offers a

remote patient monitoring system with predictive analytics technology that

differentiates abnormal physiological behavior from normal physiological

variation.

3.61 Undisclosed

ColonaryConcepts 12-Feb-16 Newton, MA Angel Provider of a technology platform that promotes gastrointestinal health. 8.20 Undisclosed

Behold.ai 12-Feb-16 New York, NY Accelerator/

Incubator

Provider of diagnostic imaging software. The company provides healthcare

practitioners with a platform that identifies visual differences between

images of healthy tissue and those with nodules, lesions and other

abnormalities.

0.09 gener8tor

Allergy Amulet 12-Feb-16 Boston, MA Accelerator/

Incubator

Developer of an allergen detection device that enables simple and mobile

measurements to help individuals avoid inadvertently ingesting target

allergens.

0.02 gener8tor

MilliDrop 11-Feb-16 Paris, France Seed Round Developer of in vitro diagnostics machines and instruments for academic

and medical research. The company designs and develops cell culture

machines based on millifluidics technology for bacteriological research and

diagnosis purpose.

1.11 Seventure Partners




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Bamboo Therapeutics 11-Feb-16 Chapel Hill, NC Early Stage VC Developer of gene therapies for treating monogenic disorders. The

company specializes in developing therapeutic reagents to treat diseases

related to central nervous system and neuromuscular diseases.

49.47 CureDuchenne

Rio Grande

Neurosciences

10-Feb-16 San Francisco, CA Angel Developer of therapeutic devices for traumatic brain injuries. The

company engages in the development of electrotherapeutics for

neurological applications and treatment of neurodegenerative diseases.

4.53 Undisclosed

MiRTLE Medical 10-Feb-16 North Andover,

MA

Angel Operator of a biotechnology company. The company offers monitoring

devices for patients undergoing an MRI scan.

0.03 Undisclosed

Lantern 10-Feb-16 San Francisco, CA Early Stage VC Provider of an online mental health wellness services. The company

provides personalized online programs coached by experienced

professionals to strengthen the mental health.

17.00 UPMC

Hemovent 10-Feb-16 Aachen, Germany Early Stage VC Developer of the ECMO (Extra Corporeal Membrane Oxygenation) unit

that supports or replaces heart and lung function in the event of cardiac

and respiratory failure.

6.00 MIG Verwaltungs

Halo Neuroscience 10-Feb-16 San Francisco, CA Early Stage VC Developer of neurotechnologies to help unlock human potential. The

company is the developer of a device that uses pulses of energy to

stimulate brain neurons, potentially leading to effects such as accelerated

learning or improved body movement control. The company's product is

designed for use by professional athletes and stroke rehabilitation.

9.00 Lux Capital

BiOptix Diagnostics 10-Feb-16 Boulder, CO Later Stage VC Developer of a biomolecule detection system. The company provides E-

SPR (Enhanced Surface Plasmon Resonance) technology platform for the

detection of molecular interactions.

1.66 Undisclosed

ARMO BioSciences 10-Feb-16 Redwood City, CA Later Stage VC Developer of immunotherapeutics. The company is a clinical-stage

enterprise developing immunotherapies focused on multiple, difficult-to-

treat oncology indications.

50.00 Kleiner Perkins

Caufield & Byers,

OrbiMed, DAG

Ventures




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Andas 10-Feb-16 Minneapolis, MN Angel Developer of a breathalyzer technology. The company provides a

technology that communicates an accurate level of intoxication via breath

analysis through smart phones.

0.65 Undisclosed

Vigilant Biosciences 9-Feb-16 Fort Lauderdale, FL Angel Developer of a medical technology for detection of cancer. The company

offers a technology to detect oral cancers at an early stage and improve

overall survival rates.

3.24 Undisclosed

SwervePay 9-Feb-16 Lake Villa, IL Early Stage VC Provider of cloud based information technology services. The company

offers a mobile payment platform, electronic invoicing, payment plans,

customer integration software and virtual point of sale services.

10.00 Garland Capital

Group

HealthBeacon 9-Feb-16 Dublin, Ireland Seed Round Provider of a treatment compliance monitoring tool. The company offers a

device that monitors medical adherence of patients who use self-injectable

medications at home. It also offers a medical waste bin to dispose the

needles.

1.30 Enterprise Ireland

Genotek 9-Feb-16 Moscow, Russia Angel Provider of services related to genome sequencing and DNA testing. The

company delivers genetic and DNA tests which prevents inherited

diseases, and helps to plan pregnancy in women and also provides a

platform to check the results of the DNA tests online.

2.00 Alexander Voloshin,

Maxim Basov

First Stop Health 9-Feb-16 Chicago, IL Seed Round Provider of an online health care concierge service. The company offers

24/7 services to consult with primary care physicians and board-certified

specialists. Members can talk to a doctor to obtain medical information,

medical advice, diagnosis and prescriptions from common conditions.

2.10 Tim Shumacher,

other undisclosed

Eximis Surgical 9-Feb-16 Louisville, CO Angel Developer and supplier of medical and surgical devices to hospitals and

clinics for using them in invasive surgical procedures.

1.00 Undisclosed

Endoshape 9-Feb-16 Idaho Springs, CO Later Stage VC Developer of polymer-based vascular embolization products. The

company provides embolization products for the treatment of serious

clinical conditions. The company's function is to commercialize novel

medical devices based on its proprietary polymer technology, with a focus

on the coil embolization and occlusion market.

7.10 Undisclosed




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Biodesix 9-Feb-16 Boulder, CO Later Stage VC Developer of multivariate protein diagnostics based on a mass

spectrometry-based discovery platform. The company provides VeriStrat, a

pretreatment serum testing tool that helps oncologists select between

erlotinib and single-agent chemotherapy for advanced lung cancer patients.

17.76 Undisclosed

Amplyx

Pharmaceuticals

9-Feb-16 San Diego, CA Later Stage VC Developer of oral and injectable anti-infective drugs, including protease

inhibitors and antibiotics.

49.20 RiverVest Venture

Partners

Via Surgical 8-Feb-16 Amirim, Israel Angel Developer of a mesh fixation device needed for a hernia repair procedure.

The company develops a suture like mesh fixation device that enables

durable and easy fixation of soft tissue prosthetics (including hernia mesh

products) for a variety of procedures. The company's product,

SutureLAPTM, reduces the risk of hernia recurrence.

6.00 Bensile

Veristride 8-Feb-16 Salt Lake City, UT Angel Provider of a movement analytics system. The company offers an

integrated shoe insole analysis system that gives users their own

information about their movement abilities, including real-time

information and feedback.

1.00 Undisclosed

Velano Vascular 8-Feb-16 San Francisco, CA Early Stage VC Developer of blood drawing devices for hospitals. The company develops

a needle free device that reduces pain and discomfort for patients while

drawing blood.

3.50 First Round Capital,

White Owl Capital,

Kapor Capital

Revitope Oncology 8-Feb-16 San Francisco, CA Angel Developer of a cancer immunotherapy. The company develops a

technology which redirects existing viral immune response to target the

tumor cell and treat cancer.

8.50 Undisclosed

Golo 8-Feb-16 Bear, DE Angel Developer of weight-loss management medicines and tablets. 2.45 Undisclosed

Genomind 8-Feb-16 King of Prussia, PA Later Stage VC Developer of neuropsychiatric disease biomarker tests. The company

offers the Genecept Assay, a genetic test designed to help clinicians

optimize treatment decisions for their patients with mental illness.

15.75 Capital Alignment

Partners




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Fios Genomics 8-Feb-16 Edinburgh, United

Kingdom

Later Stage VC Provider of bioinformatics data analysis services. The company specializes

in the analysis of datasets and recognising patterns and trends associated

with a trait, disease or drug response. It caters to pharma, contract research

organizations and academia for drug discovery & development and applied

research across all species.

0.79 Scottish Enterprise,

TRI Cap,

Archangels Informal

Investment

Blackford Analysis 8-Feb-16 Edinburgh, United

Kingdom

Later Stage VC Developer of software to accelerate routine radiology. The company

provides a software suite based on algorithms and multi-core processing

technologies to allow quick registration of current and previous volumes of

tomographic scans, such as CT, MRI and PET.

0.93 Scottish Enterprise,

Archangels Informal

Investment

BiologicsMD 8-Feb-16 Fayetteville, AR Angel Operator of a therapeutic development company. The company is focused

on developing highly-targeted therapies for the treatment of severe bone

disorders and hair loss related diseases and conditions.

0.40 Undisclosed

Regentis Biomaterials 5-Feb-16 Or-Akiva, Israel Later Stage VC Operator of a tissue repair company. The company focuses on developing

and commercializing an innovative hydrogel platform for the repair of

damaged tissue.

15.00 Haisco

Pharmaceutical

Group

Quantum Imaging 5-Feb-16 Coventry, United

Kingdom

Early Stage VC Provider of medical imaging devices. The company specializes in detection

of acute coronary syndromes and ischemia in patients with chest pain.

6.59 IP Group

PermeAbility 5-Feb-16 Portugal Seed Round Developer of medical devices to analyze intestinal permeability and

detection of early disease states, in particular metabolic diseases such as

diabetes and obesity.

0.11 Caixa Capital

Néosanté 5-Feb-16 Salon-de-Provence,

France

Angel Provider of rental and trading services of medical equipment. 1.44 Undisclosed

Nano Precision Medical 5-Feb-16 Emeryville, CA Angel Developer of medical drugs using nano portal technology. The company

develops titanium capsules that provide therapeutic molecules by using a

proprietary titania nanoporous membrane technology called

NanoPortalTM.

0.71 Undisclosed

Linguaflex 5-Feb-16 Weston, FL Later Stage VC Developer of therapies for obstructive sleep apnea. The company offers an

implanted device, Linguaflex LTR, which manipulates the upper airway to

treat sleeping problems.

3.60 Undisclosed




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



IlluminOss 5-Feb-16 East Providence, RI Later Stage VC Developer of minimally invasive orthopedic systems for the stabilization

and treatment of bone fractures. The company's products include a

photodynamic bone stabilization system for low load bearing bones, such

as fractures of the hands, wrists, clavicle, arms and ankle.

5.00 Undisclosed

Affinivax 5-Feb-16 Cambridge, MA Angel Owner and operator of a company developing vaccines based on the

Multiple Antigen Presenting System that provide protection against

infectious diseases.

2.50 Bill & Melinda

Gates Foundation,

other undisclosed

WiSilica 4-Feb-16 Aliso Viejo, CA Early Stage VC Provider of an Internet of Things (IoT) platform that enables devices to

connect by using Bluetooth Low Energy and helps to connect objects,

locations and people to create smart environments that have predictive

intelligence. It also helps customers to connect energy, public

infrastructure and healthcare systems with intelligent devices managed by

mobile applications and the Cloud.

3.35 FirstFloor Capital

Tribogenics 4-Feb-16 Los Angeles, CA Later Stage VC Provider of portable X-ray technology. The company is developing low-

cost, miniature X-ray devices with applications for the mining, industrial,

military and medical imaging markets.

10.00 Nikon

Perosphere 4-Feb-16 Danbury, CT Early Stage VC Operator of a pharmaceutical company focused on developing rescue

medications. The company engages in identifying and developing chemical

entities and other therapeutics that can be used as rescue drugs. It also

offers a reversal agent for new oral anticoagulants.

6.21 Undisclosed

Joylux 4-Feb-16 Seattle, WA Angel Developer of medical devices and therapeutic systems. The company

specializes in developing a medical instrument called VSCULPT for

rejuvenation of the vaginal tissue and pelvic floor toning.

2.02 Undisclosed

DiACardio 4-Feb-16 Omer, Israel Accelerator/

Incubator

Provider of decision support tools for cardiologists. The company offers

products for echocardiography and helps in evaluating heart failure signs.

Undisclosed Microsoft Ventures




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Pear Therapeutics 3-Feb-16 Boston, MA Early Stage VC Developer of digital health interventions to enhance clinical outcomes. The

company provides mobile health application for clinicians and cost-

effective services for payors. It also develops digital therapies to address

severe conditions including addiction, schizophrenia, pain, post-traumatic

stress disorder, anxiety, depression and sleep.

20.00 5AM Ventures,

Arboretum

Ventures, Jazz

Venture Partners

LAM Therapeutics 3-Feb-16 Guilford, CT Angel Developer of drugs for the treatment of Lymphangioleiomyomatosis

(LAM), a rare lung disease found primarily in women. The company aims

to develop drugs with the potential to produce long-lasting responses to

treatment, thus improving length and quality of life for LAM patients.

40.00 Undisclosed

JustRight Surgical 3-Feb-16 Boulder, CO Angel Developer of surgical instruments that allow access to confined and often

delicate structures.

11.20 Undisclosed

Galera 3-Feb-16 Malvern, PA Later Stage VC Developer of treatments for cancer patients. The company focuses on

development of drugs that can prevent the debilitating effects of radiation

in the treatment of cancer.

42.00 Novo

Epinex Diagnostics 3-Feb-16 Tustin, CA Angel Developer of a test for monthly diabetes monitoring. The company

provides a platform for rapid tests uses existing technologies to create

quantitative diagnostic tests for the point-of-care and over-the-counter

markets.

0.10 Undisclosed

ENYO Pharma 3-Feb-16 Lyon, France Early Stage VC Developer of a drug discovery platform for the treatment of chronic viral

infections. The company develops molecules modulating host functions

for the treatment of acute and chronic viral infections and identifies new

intracellular therapeutic targets and molecules acting against these targets.

24.42 Sofinnova Partners

Elemental Machines 3-Feb-16 Cambridge, MA Seed Round Provider of a suite of intelligent technology products to help scientists

accelerate time to discovery by improving experimental reproducibility.

The company offers Elemental Insights, an intuitive web-based software

application that provides real-time visualizations and dashboards to

pinpoint factors affecting outcomes.

2.50 FF Angel, Project 11

Ventures, 2M

Companies




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Cellics Therapeutics 3-Feb-16 San Diego, CA Angel Developer of red blood cell technology for the treatment of rare diseases.

The company develops nanosponge technology for the treatment of animal

venoms and rare diseases that are caused by virulent factors attacking red

blood cells.

3.00 Undisclosed

BioDirection 3-Feb-16 Oro Valley, AZ Later Stage VC Developer of a portable, point-of-care brain injury screening and

monitoring device. The company uses nanotechnology that can identify

specific molecules in the blood and determine how the body is reacting to

injury and disease to separate minor head injuries from mild traumatic

head injury.

4.00 Provident

Healthcare Capital,

other undisclosed

ArborMetrix 3-Feb-16 Ann Arbor, MI Early Stage VC Provider of clinical performance analytics tools for hospital and specialty-

based care. The company's solutions combine insights and statistics to

measure clinical performance and efficiency.

1.98 Undisclosed

Spero Therapeutics 2-Feb-16 Cambridge, MA Early Stage VC Operator of a biopharmaceutical company developing novel therapies for

the treatment of bacterial infections. The company's pipeline of anti-

infective agents is focused exclusively on gram-negative bacterial

infections. The company's MvfR inhibitor program works differently from

existing antibiotics by targeting a pathway involved in two critical bacterial

processes: virulence and persistence.

30.00 Atlas Venture, SR

One, MRL Ventures

Mission Therapeutics 2-Feb-16 Cambridge, United

Kingdom

Later Stage VC Provider of pharmaceutical research and drug discovery services. The

company provides new molecular understandings of human cell biology

into drugs that will improve the management of life-threatening diseases,

particularly cancer.

85.94 Imperial

Innovations

Businesses,

Woodford Patient

Capital

Intelerad Medical

Systems

2-Feb-16 Montreal, Canada PE Growth/

Expansion

Provider of medical imaging business services. The company specializes in

medical imaging, distributed radiology services, distributed architecture and

workflow orchestration, radiology, workflow modules and training services.

Undisclosed Novacap

Investments

Reven Pharmaceuticals 1-Feb-16 Sarasota, FL Early Stage VC Provider of vascular diseases treatment services. The company develops

medical products for the treatment of vascular diseases such as critical limb

ischemia, peripheral arterial disease, coronary artery disease and endothelial

dysfunction.

100.00 Undisclosed




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Omedix 1-Feb-16 Scottsdale, AZ Later Stage VC Provider of a patient-engagement platform for medical practices designed

to streamline check-in and create efficiencies within the engagement

process. Services include self-service portals, appointment reminders by

text, e-mail or phone, website creation with mobile capacity and paper-free

check-in.

0.93 Undisclosed

Neolight 1-Feb-16 Scottsdale, AZ Seed Round Developer of a phototherapy technology. The company offers a medical

technology that develops photo-therapy beds to cure jaundice in pre-term

and full term babies.

0.60 Undisclosed

Lightbeam Health

Solutions

1-Feb-16 Irving, TX Early Stage VC Provider of population health management tools and services in the areas

of enterprise data warehouse, physician engagement, analytics, care

management, searchlight-risk stratification and patient engagement for

Accountable Care Organizations, payers, large provider groups, health

systems and other healthcare organizations. It also offers cloud based

hosting, data backup and disaster recovery services.

Undisclosed HBM Healthcare

Investments

Intelligent

Fingerprinting

1-Feb-16 Cambridge, United

Kingdom

Later Stage VC Developer of drug screening technologies. The company offers a

fingerprint-based drug screening device that that detects drug use through

fingerprint sweat analysis.

3.58 Undisclosed

General Automation

Lab Technologies

1-Feb-16 San Francisco, CA Angel Provider of microbiology cultivation and screening systems. The company

is involved in the discovery, development and commercialization of

microbial products.

2.59 Undisclosed

Gaia Herbs 1-Feb-16 Brevard, NC PE Growth/

Expansion

Producer of organic herbal products. The company provides different

types of medicinal herbal products that include liquid herbal, syrups,

tablets and capsules for different health issues.

20.86 Undisclosed

EchoPixel 1-Feb-16 Mountain View, CA Early Stage VC Manufacturer and developer of medical imaging devices. The company's

technology enables 3-D medical imaging for procedures like CT scans,

colonoscopies, ultrasound tests and other image-based examinations.

1.75 Undisclosed

Cricket Health 1-Feb-16 San Francisco, CA Seed Round Owner and operator of a healthcare technology company. The company

offers software and services for home dialysis accessible to patients.

2.63 First Round Capital




February 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Cirdan Ultra 1-Feb-16 Lisburn, United

Kingdom

Later Stage VC Developer of healthcare imaging technology and related software. The

company is engaged in the design, manufacture and supply of software and

imaging technologies designed to accelerate and enhance diagnosis. The

company uses its expertise in high-performance camera and image-

processing technology to develop new imaging modalities using X-ray, near-

infrared and visible light wavelengths.

4.15 Kernel Capital

Batu Biologics 1-Feb-16 San Diego, CA Angel Operator of a immunotherapeutic company. The company is focused on

developing the “ValloVax” platform, an allogeneic and universal donor

cellular vaccine designed to stimulate a targeted immune response against

the blood vessels of the tumor for an array of cancers.

0.45 Undisclosed

Atlas5D 1-Feb-16 Cambridge, CA Early Stage VC Provider of a sensor based health and movement tracking device that

allows caretakers to keep track of and engage with patients by alerting

them about any change in their movements or vital health parameters.

3.00 GreyBird Ventures




February 2016

Acquirer Target HQ Location Date DescriptionTransaction

Value (Millions)

Dentsply International Sirona Dental

Systems

Long Island City,

NY

29-Feb-16 Manufacturer of high-quality dental equipment. The company provides products

in each of its four product segments: dental CAD/CAM systems; imaging systems;

treatment centers; and instruments.

5560.00

Hikma Pharmaceuticals Roxane

Laboratories

Columbus, OH 29-Feb-16 Provider of pharmaceutical products. The company manufactures oral solids

(tablets, capsules), oral liquids (solutions, syrups), topical solutions and nasal

sprays.

2117.00

Onxeo DNA Therapeutics Évry, France 29-Feb-16 Developer of medicines for cancer treatment. The company focuses on the

development of drugs for sensitizing resistant cancer and other conventional

cancer therapies.

1.89

EviCore QPID Boston, MA 26-Feb-16 Provider of a health intelligence platform. The company's platform offers an

electronic health record search engine, a scalable library of HIPAA-compliant

search queries and a programming system for application and query development.

Undisclosed

Vance Street Capital,

Lexington Partners, NB

Private Equity Partners,

RCP Advisors, Madison

Capital Funding

A&E Medical Farmingdale, NJ 25-Feb-16 Manufacturer of a range of electrosurgical and neurosurgical medical devices

including double wire high strength sternum closure system and a wide variety of

MYO/Wire temporary cardiac pacing wires and extension leads, MYO/Wire II

stainless steel sutures, MYO/Punch surgical punches and patient cables.

Undisclosed

Natureplex Medline Industries

(Enema Category)

Mundelein, IL 24-Feb-16 Supplier of enema kits, enema bags and tubes. Undisclosed

SeQuent Scientific Indo Phyto

Chemicals

New Delhi, India 24-Feb-16 Manufacturer of steroid and hormone drugs mainly for the female health segment. 1.00

SpectraScience Oncoscope Durham, NC 23-Feb-16 Developer of clinical optical imaging applications which provides images and

information on tissue microstructure for the purpose of epithelial tissues in the

oral cavity, esophagous, stomach, colon, lung, cervix and bladder.

Undisclosed

Recipharm Mitim Brescia, Italy 23-Feb-16 Operator of a pharmaceutical contract manufacturing company. The company's

product portfolio includes beta lactams in dry sterile powder for injectable

solutions, tablets, oral suspensions and injectable sterile solutions.

75.48

Mergers and AcquisitionsThe following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous

month.




February 2016


Value (Millions)


month.

Medsphere Systems MBS/Net Cleveland, OH 23-Feb-16 Developer of document management software and and an implementer of

electronic health records. The company provides medical billing and revenue cycle

management consulting services. It also provides clients with insight into all

aspects of practice management, including ever-evolving regulations and policies.

Undisclosed

The Goldman Sachs

Group

HRA Pharma Paris, France 19-Feb-16 Designer of products, devices and supporting services in niche areas of the health

industry. The company offers reproductive health products, Bemedrex for asthma,

Deprenyl for Parkinson's disease and information and associated services for

healthcare providers and other users.

Undisclosed

Cipla Exelan

Pharmaceuticals

Lawrenceville, GA 19-Feb-16 Provider of pharmaceutical products. The company focuses on the sales and

marketing of different pharmaceutical products for the government and

institutional market.

50.00

OvaGene Oncology Etta Healthcare Edina, MN 19-Feb-16 Manufacturer and developer of healthcare devices. The company offers portable

blood test, panel based test, biomarkers and other related products.

Undisclosed

Cipla InvaGen

Pharmaceuticals

Hauppauge, NY 18-Feb-16 Manufacturer of prescription medicines. The company engages in development,

manufacturing, marketing and distribution of generic prescription medicines with

focus on wide range of therapeutic areas including, cardiovascular, anti-infective,

CNS, anti-inflammatory, anti-diabetic and anti-depressants.

500.00

Thermo Fisher

Scientific

Inel France 12-Feb-16 Provider of real-time X-ray diffraction systems. The company offers XRD

instruments, from simple benchtop instruments for routine applications to

sophisticated platforms for analysis of nano-materials, pharmaceuticals, coatings

and other advanced materials.

Undisclosed

Sogo Medical GM Medical

Company

Fukuoka, Japan 12-Feb-16 Supplier of medical instruments. The company is engaged in the supply,

installation and maintenance of medical equipment.

Undisclosed

NuVasive Ellipse

Technologies

Aliso Viejo, CA 11-Feb-16 Developer of devices for treatment of gastroesophageal reflux disease, morbid

obesity and abnormal curvature of spine. The company is focused on developing

its implantable remote control technology platforms to include treatments for a

broad spectrum of spinal and orthopedic deformity applications, orthopedic

trauma and fracture management.

410.00




February 2016


Value (Millions)


month.

Astellas Pharma Ocata Therapeutics Marlborough, MA 10-Feb-16 Provider of cellular therapies and regenerative medicine. The company provides

stem cell-based technologies and other proprietary methods in the field of

regenerative medicine to bring patient-specific therapies.

359.60

Constellation

Healthcare

Technologies

MDRX Medical

Billing

Akron, OH 10-Feb-16 Provider of outsourced hospital practice management, private practice

management and consulting services (including outsourced billing, collections,

operations and financial management) to both independent and health system-

based physician groups.

30.00

Tikehau IM, Sėbastein

Aguettant

Delpharm Boulogne, France 10-Feb-16 Manufacturer of pharmaceutical products. The company engages in

pharmaceutical processing and pharmaceutical contract outsourcing. It offers

tablets, pills, film coated tablets, granulates, pouches, capsules and veterinary

products.

Undisclosed

Almirall Thermi Irving, TX 9-Feb-16 Manufacturer of temperature-controlled, radiofrequency devices for use in

medical procedures. The company develops thermistor-controlled radio frequency

technologies for applications in the aesthetic medical marketplace.

80.00

Moseda CareKit Health Toronto, Canada 9-Feb-16 Provider of an online care-coordination platform. The company offers a platform

and mobile application designed to connect patients, families and care teams to

help ensure quality care in the home.

0.07

Almirall Poli Group Milan, Italy 8-Feb-16 Operator of a diversified portfolio of proprietary drugs focused primarily on

dermatology, gynecological and respiratory products.

444.01

Caerus Corp OrthoCor Medical Arden Hills, MN 8-Feb-16 Developer of noninvasive and mobile medical devices for knee pain relief. The

company develops drug-free, noninvasive and mobile medical device which uses

pulsed electromagnetic field technology for knee pain relief.

Undisclosed

Prestige Brands DenTek Oral Care Maryville, TN 8-Feb-16 Manufacturer of dental care and oral health products. The company primarily

manufactures floss picks, nightguards and dental picks.

225.00

Schülke & Mayr Vic Pharma

Industria E

Comercio

Taquaritinga, Brazil 5-Feb-16 Manufacturer of pharmaceutical products. The company is engaged in the

production and distribution of hygiene and sanitizing products and medicines.

Undisclosed

Pozen Tribute

Pharmaceuticals

Milton, Canada 5-Feb-16 Developer of pharmaceutical and healthcare products. The company is involved

in the development and marketing of polysaccharide-based therapeutic products

used in the treatment of osteoarthritis and certain types of cystitis.

146.00




February 2016


Value (Millions)


month.

Flamel Technologies FSC Pediatrics Charlotte, NC 5-Feb-16 Provider of pharmaceutical products and medical devices that have been

approved for children.

20.25

Pharmaron Quotient

Bioresearch

United Kingdom 4-Feb-16 Operator of a contract research organization in the life sciences sector. The

company focuses on integrating radiochemistry and metabolism. It provides

services related to radiochemistry, drug metabolism and E-fate, which it tailors to

pharmaceutical, biotechnology, agrochemical and chemical sponsors worldwide,

using technologies underpinned by scientific, chemical and biological expertise.

Undisclosed

ViaCyte Janssen

(BetaLogics)

Horsham, PA 4-Feb-16 Developer of transformational stem cell therapy to treat diabetes and to eliminate

a need for exogenous insulin.

Undisclosed

ResMed Inova Labs Austin, TX 4-Feb-16 Manufacturer of medical devices. The company develops and commercializes

innovative products like LifeChoice Activox and Activox DUO2 oxygen

concentrators for patients with respiratory illness.

Undisclosed

IMS Health Dimensions

Healthcare

Dubai, United Arab

Emirates

4-Feb-16 Provider of healthcare informatics and consulting services. The company provides

pharmacy benefit management, online e-claim, health information management,

drug information, patient records and e-prescribing services.

Undisclosed

Halma CenTrak Newtown, PA 4-Feb-16 Developer of real-time locating systems for healthcare facilities to provide

immediate tracking and management of medical equipment, staff and patients.

140.00

Endologix TriVascular Santa Rosa, CA 3-Feb-16 Developer of endovascular aortic repair stent graft systems. The company

provides product for treatment of abdominal aortic aneurysms and also provides

thoracic stent graft systems for the treatment of the thoracic aorta.

211.00

TE Connectivity Creganna Tactx

Medical

Galway, Ireland 3-Feb-16 Manufacturer of medical devices. The company manufactures invasive delivery

and access devices. It offers full spectrum of services to design, develop and

deliver finished medical devices.

895.00

IMS Health AlphaImpactRx San Mateo, CA 3-Feb-16 Provider of primary research and analysis for biopharmaceutical and consumer

health companies. The company uses consulting expertise, innovative technology,

proprietary physician panels and syndicated data assets to provide market research

to help its global healthcare clients make informed business decisions to develop

and market their products.

Undisclosed




February 2016


Value (Millions)


month.

Cordlife Group StemLife Malaysia Kuala Lumpur,

Malaysia

2-Feb-16 Provider of stem cell banking services, stem cell therapy and consultation services.

It also offers collecting, testing, processing and cyro-preservation of umbilical

cord blood stem cells, harvesting, testing, processing and cyro-preservation of

peripheral blood stem cells and stem cell therapy services.

15.15

Cofactor Genomics Narus

Biotechnologies

Palo Alto, CA 2-Feb-16 Provider of bio-marker development services. The company operates as a early-

stage molecular diagnostics company focused on providing cures for neurological

diseases.

Undisclosed

Abbott Laboratories Kalila Medical Campbell, CA 2-Feb-16 Developer of cardiac catheter technologies. The company provides a platform of

specialized delivery and access catheters that can be leveraged across multiple

endovascular applications, including atrial fibrillation ablation, mitral valve repair,

ASD/PFO closure, left atrial appendage closure, transseptal puncture, and LV

lead placement.

Undisclosed

Shenzhen Yaohaikang

Investment

Development Company

Jiangsu Neptunus

Bio-Pharmaceutical

Company

China 2-Feb-16 Provider of research and development services of bio pharmaceutical products. 8.82

MedCap Inpac Pharma Lund, Sweden 2-Feb-16 Manufacturer of pharmaceuticals and probiotics. The company provides contract-

manufacturing services for packaging pharmaceuticals, probiotics and medical

devices.

1.36

Stevanato Group SVM Automatik Silkeborg, Denmark 1-Feb-16 Manufacturer of packaging products and assembled equipment. The company

specializes in assembly systems and packaging machines for serialization for the

pharmaceutical industry

9.44

Sun Pharmaceutical

(Solus and Solus

Care operating)

Gurgaon, India 1-Feb-16 Manufacturer and distributor of pharmaceutical products. The company provides

a wide range of pharmaceutical products such as drugs, medical supplies and

equipment.

25.10

Strides Arcolab SG Safety Pyeongtaek, South

Korea

1-Feb-16 Manufacturer of protective equipment. 13.14

Medgenome Labs Lifecode Foster City, CA 1-Feb-16 Provider of interpretive software for the human genome. The company provides

whole exome DNA sequencing infrastructures for the clinical market.

Undisclosed




February 2016


Value (Millions)


month.

Medtronic Bellco Mirandola, Italy 1-Feb-16 Manufacturer of renal care medical devices. The company manufactures and

distributes dialyzers, fluids, machines and hematic lines for the treatment of renal

pathologies. It focuses on developing equipment for haemodialysis used in kidney

disease and also produces products for extra-corporeal blood filtration.

Undisclosed

Balchem Albion Minerals Clearfield, UT 1-Feb-16 Manufacturer of nutritional and mineral products like mineral amino acid chelates,

specialized mineral salts and mineral complexes for animals, plants and humans.

111.50



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