Motifs of Protein StructureMotifs of Protein Structure

Adapted from “Introduction to Protein Structure” by Branden & Tooze

Adapted from “Introduction to Protein Structure” by Branden & Tooze

-helix is a dipole moment.

Adapted from “Introduction to Protein Structure” by Branden & Tooze

Adapted from “Introduction to Protein Structure” by Branden & Tooze

1

3

2

Adapted from “Introduction to Protein Structure” by Branden & Tooze

antiparallel -sheet

Adapted from “Introduction to Protein Structure” by Branden & Tooze

Adapted from “Introduction to Protein Structure” by Branden & Tooze

parallel -sheet

Adapted from “Introduction to Protein Structure” by Branden & Tooze

134 25

1 3 2 4 5

Adapted from “Introduction to Protein Structure” by Branden & Tooze

Loop regions are at the surface of protein molecules

Adapted from “Introduction to Protein Structure” by Branden & Tooze

myoglobin

Adapted from “Introduction to Protein Structure” by Branden & Tooze

myoglobin triosephosphate isomerase

Adapted from “Introduction to Protein Structure” by Branden & Tooze

Topology diagram

aspartatetranscarbamoylase

flavodoxin:redox protein

plastocyanin:electron carrier

Adapted from “Introduction to Protein Structure” by Branden & Tooze

helix-turn-helix motif

Adapted from “Introduction to Protein Structure” by Branden & Tooze

Calcium-binding motif

Troponin-C: a muscle proteinAdapted from “Introduction to Protein Structure” by Branden & Tooze

Calcium-binding motif

Adapted from “Introduction to Protein Structure” by Branden & Tooze

Conformational change of calmodulConformational change of calmodulin upon peptide bindingin upon peptide binding

-hairpin motif

bovine trypsin inhibitor snake venom erabutoxinAdapted from “Introduction to Protein Structure” by Branden & Tooze

staphylococcus nuclease

Greek key motif

Adapted from “Introduction to Protein Structure” by Branden & Tooze

-hairpin motif

Greek key motif

?

Adapted from “Introduction to Protein Structure” by Branden & Tooze

motif

right hand left handAdapted from “Introduction to Protein Structure” by Branden & Tooze

Large polypeptide chains fold into several domains

Adapted from “Introduction to Protein Structure” by Branden & Tooze

domains are built from structural motifs

triosephosphate isomeraseAdapted from “Introduction to Protein Structure” by Branden & Tooze

protein structure

domain

motif

secondary structure

primary structure

P53

DNA-binding domain

sheet-turn-helix

-helix & -sheet & turn

linear chain

simple motifs combine to form complex motifs

Adapted from “Introduction to Protein Structure” by Branden & Tooze