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MP containing quinolisidine alkaloids

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Medicinal plant and Medicinal plant materials that contain quinolisidine and isoquinoline alkaloids. MP containing quinolisidine alkaloids. Herba Thermopsidis Semina Thermopsidis Thermopsis lanceolata- False lupine, bush pea Fabaceae. - PowerPoint PPT Presentation
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Medicinal plant and Medicinal plant and Medicinal plant materials Medicinal plant materials that contain quinolisidine that contain quinolisidine and isoquinoline alkaloids and isoquinoline alkaloids
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Page 1: MP containing quinolisidine alkaloids

Medicinal plant and Medicinal plant and Medicinal plant materials Medicinal plant materials that contain quinolisidine that contain quinolisidine and isoquinoline alkaloidsand isoquinoline alkaloids

Page 2: MP containing quinolisidine alkaloids

MP containing MP containing quinolisidine alkaloidsquinolisidine alkaloids

Page 3: MP containing quinolisidine alkaloids

Herba Thermopsidis Herba Thermopsidis Semina ThermopsidisSemina ThermopsidisThermopsis lanceolata- False Thermopsis lanceolata- False lupine, bush pealupine, bush peaFabaceaeFabaceae Constituents. Constituents. Herb contains up Herb contains up

to 2.5% of alkaloids, chiefly to 2.5% of alkaloids, chiefly thermopsine, its isomer anagirine; thermopsine, its isomer anagirine; homothermopsine, cytysine, homothermopsine, cytysine, methylcytysine, pachicarpine, etc.methylcytysine, pachicarpine, etc.

Seeds must contain not less than Seeds must contain not less than 2.5% of cytysine.2.5% of cytysine.

Uses.Uses. This drug has expectorant This drug has expectorant properties and properties and dry extract, tablets dry extract, tablets against cough, dry mixture against cough, dry mixture against cough against cough andand infusion infusion are are produced from this plant. In low produced from this plant. In low dosses medicines from thermopsis dosses medicines from thermopsis lanceolata excite respiratory lanceolata excite respiratory center, in high dosses can cause center, in high dosses can cause vomiting and paralyze the centres vomiting and paralyze the centres of brain and medulla oblongata.of brain and medulla oblongata.

Page 4: MP containing quinolisidine alkaloids

Herba Thermopsidis Herba Thermopsidis alternifloraealternifloraeThermopsis alterniflora- Thermopsis alterniflora- FabaceaeFabaceae Constituents. Constituents. The The

main constituent is main constituent is cytysine.cytysine.

Uses. Uses. CytytonCytyton excites excites respiratory centre and respiratory centre and used to treat shock used to treat shock conditions, conditions, intoxication and intoxication and asphyxia. Tablets asphyxia. Tablets tabextabex are used to help are used to help quit smoking. quit smoking.

Page 5: MP containing quinolisidine alkaloids
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Herba Sophorae pachycarpaeHerba Sophorae pachycarpaeSophora pachycarpa- Sophora pachycarpa- FabaceaeFabaceae

Constituents. Constituents. Herb Herb and seeds contain and seeds contain quinolisidine alkaloids quinolisidine alkaloids (2-3%), the main is (2-3%), the main is pakhycarpine (not pakhycarpine (not less than 0.5%).less than 0.5%).

Uses. Uses. Pakhycarpine Pakhycarpine hydroiodinehydroiodine is used to is used to stimulate delivery.stimulate delivery.

Page 7: MP containing quinolisidine alkaloids

Cormi SecurinegaeCormi SecurinegaeSecurinega suffruticosaSecurinega suffruticosaEuphorbiaceaeEuphorbiaceae

Constituents. Constituents. The main The main alkaloid is securenin (up to alkaloid is securenin (up to 0.3% in leaves). Except 0.3% in leaves). Except securenin 7 other alkaloids securenin 7 other alkaloids are found in this plant: are found in this plant: suphruticodine, suphruticodine, alosecurinin, securinol A, B, alosecurinin, securinol A, B, C, dihydrosuphruticonin.C, dihydrosuphruticonin.

Uses. Uses. Secureninum nitrateSecureninum nitrate is used as tonic medicine is used as tonic medicine to treat palsy, to treat palsy, neurasthenia, sexual neurasthenia, sexual disorders.disorders.

Page 8: MP containing quinolisidine alkaloids

MP and MPM containing MP and MPM containing isoquinoline alkaloidsisoquinoline alkaloids

Page 9: MP containing quinolisidine alkaloids

Capitata papaveris, OpiumCapitata papaveris, OpiumPapaver somniferum- Papaver somniferum- Opium poppyOpium poppyPapaveraceaePapaveraceae

Constituents. Constituents. Poppy capsules Poppy capsules contain, when ripe, 0.18-0.28% of contain, when ripe, 0.18-0.28% of morphine. Poppy seeds contain only morphine. Poppy seeds contain only very small quantities of narcotine, very small quantities of narcotine, papaverine and thebaine in addition papaverine and thebaine in addition to morphine and codeine. to morphine and codeine.

Uses. Uses. OmnoponOmnopon and and morphinmorphine are e are strong painkillers, which are used to strong painkillers, which are used to reduce pain. reduce pain. Codeine, codterpine, Codeine, codterpine, tablets against coughtablets against cough are used for are used for cough soothing. cough soothing. PapaverinePapaverine has has spasmolitic action on blood vessels spasmolitic action on blood vessels and thus can be used to treat and thus can be used to treat hypertension, angina and migraine. hypertension, angina and migraine. Papaverine is part of Papaverine is part of paphyllinpaphyllin (papaverine + plathyphylline), (papaverine + plathyphylline), papasol papasol (papaverine + dibazole), (papaverine + dibazole), khelliverinekhelliverine (papaverine + khellin), (papaverine + khellin), khellatrinekhellatrine (papaverine + khelline + (papaverine + khelline + atropine), atropine), bepasalbepasal, , niquoverine, niquoverine, palufin, theoverinepalufin, theoverine, etc., etc.

Page 10: MP containing quinolisidine alkaloids
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Herba Glaucii flaviHerba Glaucii flaviGlaucium flavum- Glaucium flavum- Yellow horn poppyYellow horn poppyPapaveraceaePapaveraceae

Constituents. Constituents. Plant contains up to 4% Plant contains up to 4% of alkaloids, the most valuable is glaucin of alkaloids, the most valuable is glaucin and it content is almost near 50% of all and it content is almost near 50% of all alkaloids, sometimes it reaches 2% of the alkaloids, sometimes it reaches 2% of the mass of all aerial part of the plant. Other mass of all aerial part of the plant. Other alkaloids are extracted from Glaucium alkaloids are extracted from Glaucium flavum: coridine, isocoridine, isoboldine flavum: coridine, isocoridine, isoboldine etc.etc.

Uses. Uses. GlaucinGlaucin has cough soothing action, has cough soothing action, which is stronger and longer of that of which is stronger and longer of that of codeine and does not have narcotic codeine and does not have narcotic effect. Medicines effect. Medicines glaucinum glaucinum hydrochloridumhydrochloridum, , glauventglauvent and and broncholytinbroncholytin reduce cough and are used reduce cough and are used in treatment of bronchitis, pneumonias in treatment of bronchitis, pneumonias and different diseases of bronchial tubes and different diseases of bronchial tubes and lungs.and lungs.

Page 12: MP containing quinolisidine alkaloids
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Herba MacleayaeHerba MacleayaeMacleaya cordata- Plume poppyMacleaya cordata- Plume poppyPapaveraceaePapaveraceae

Constituents. Constituents. The plant The plant contains isoquinoline contains isoquinoline alkaloids (0.7-1.5%): alkaloids (0.7-1.5%): alocryptopine, sanguinarine, alocryptopine, sanguinarine, khelleritrine, protopine, khelleritrine, protopine, berberine.berberine.

Uses. Uses. SanguiritrineSanguiritrine has has antimicrobial action against antimicrobial action against gram-positive bacteria, has gram-positive bacteria, has antitrichomonadal activity. antitrichomonadal activity. Also is used to treat cerebral Also is used to treat cerebral palsy in children, miopathia palsy in children, miopathia and paresis.and paresis.

Page 14: MP containing quinolisidine alkaloids

Herba ChelidoniiHerba ChelidoniiChelidonium majus- Greater celandineChelidonium majus- Greater celandinePapaveraceaePapaveraceae

Constituents. Constituents. Greater Greater celandine contains up to 4% of celandine contains up to 4% of alkaloids including α- and β-alkaloids including α- and β-allocryptopine, berberine, allocryptopine, berberine, chelerythrine, chelidonine, chelerythrine, chelidonine, chelirubine, choline, coptisine, chelirubine, choline, coptisine, hydroxychelidonine, and hydroxychelidonine, and others.others.

Uses. Uses. The drug has many The drug has many traditional uses based on its traditional uses based on its reputed anodyne, reputed anodyne, antispasmodic, caustic, antispasmodic, caustic, diaphoretic, diuretic, diaphoretic, diuretic, hydragogue, narcotic and hydragogue, narcotic and purgative properties. It also has purgative properties. It also has fungistatic and bacteriostatic fungistatic and bacteriostatic actin on TB agents. Juice from actin on TB agents. Juice from fresh herb or roots can be used fresh herb or roots can be used to treat throat warts. to treat throat warts.

Page 15: MP containing quinolisidine alkaloids

Folia BerberidisFolia BerberidisRadices BerberidisRadices BerberidisBerberis vulgaris- BarberryBerberis vulgaris- BarberryBerberidaceaeBerberidaceae

Constituents. Constituents. The main alkaloid The main alkaloid is berberin (up to 1.5% in roots). is berberin (up to 1.5% in roots). Plant also contains palmatin, Plant also contains palmatin, columbamine, yatroricine, columbamine, yatroricine, oxicantine and khelidonic acid, oxicantine and khelidonic acid, polysaccharides, carotinoids, polysaccharides, carotinoids, antocyanes, ascorbic acid etc.antocyanes, ascorbic acid etc.

Uses. Uses. Berberinum bisulphateBerberinum bisulphate (from roots) has holagogue (from roots) has holagogue action and used to treat chronic action and used to treat chronic hepatitis and cholelithiasis. hepatitis and cholelithiasis. Tincture from leaves has tonic Tincture from leaves has tonic action on womb muscles after action on womb muscles after delivery. delivery.

Page 16: MP containing quinolisidine alkaloids

Tubera cum radicibus Stephaniae glabraeTubera cum radicibus Stephaniae glabraeStephania glabraStephania glabraMenispermaceaeMenispermaceae

Constituents. Constituents. TheThe mainmain alkaloids are gindarine alkaloids are gindarine (up to 30% of all (up to 30% of all alkaloids) and stepharine.alkaloids) and stepharine.

Uses. Uses. Gindarinum Gindarinum hydrochloridehydrochloride is is tranquiliser and is used to tranquiliser and is used to treat CNS diseases, has treat CNS diseases, has sedative, light hypnotic sedative, light hypnotic effect and hypotensive effect and hypotensive action.action.

Page 17: MP containing quinolisidine alkaloids

Folia Ungerniae victorisFolia Ungerniae victorisUngernia victorisUngernia victorisAmaryllidaceaeAmaryllidaceae

Constituents. Constituents. Leaves contain Leaves contain alkaloids of galantamine and alkaloids of galantamine and likorine type. The main are likorine type. The main are galantamine, galantine, galantamine, galantine, likorine (0.05-0.1%).likorine (0.05-0.1%).

Uses. Uses. Galantaminum Galantaminum hydrobromidehydrobromide is used to treat is used to treat miasthenia, radiculitis, miasthenia, radiculitis, cerebral palsy. cerebral palsy. Likorinum Likorinum hydrochloridehydrochloride has broncholitic has broncholitic action and is used as action and is used as expectorant.expectorant.


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