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MP08 P Endokrinopatije 22.01.2011

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8/13/2019 MP08 P Endokrinopatije 22.01.2011

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Smanjeno luenje hormonaSmanjeno luenje hormona ACTHACTHACTHACTHACTHACTHACTHACTH

SEKUNDARNSEKUNDARNAA HIPOFUNKCIJHIPOFUNKCIJAAnadbubrene ljezde koja je slinanadbubrene ljezde koja je slinaprimarnoj (Addisonprimarnoj (Addison--ovoj bolesti).ovoj bolesti).

luenje aldosterona normalno, budui daluenje aldosterona normalno, budui daono nije zavisno od luenja ACTH.ono nije zavisno od luenja ACTH.

Smanjeno luenje hormonaSmanjeno luenje hormona TSHTSHTSHTSHTSHTSHTSHTSH

dovodi do SEKUNDARNE HIPOTIREOZEdovodi do SEKUNDARNE HIPOTIREOZEkoja se kliniki teko razlikuje od primarne.koja se kliniki teko razlikuje od primarne.Nedostatak TSH u deijem uzrastu dovodiNedostatak TSH u deijem uzrastu dovodi

mentalnom razvojumentalnom razvoju

u odraslih do razvoja MIKSEDEMA.u odraslih do razvoja MIKSEDEMA.

Smanjeno luenje hormona PRLSmanjeno luenje hormona PRL

ima samo jedno kliniko obelejeima samo jedno kliniko obeleje --nepostojanje laktacije nakon porodjaja.nepostojanje laktacije nakon porodjaja.

Klasian primer je postpartalna nekrozaKlasian primer je postpartalna nekroza

(SHEEHAN(SHEEHAN--OV SINDROM).OV SINDROM).

POVEPOVEANO LUANO LUENJE HORMONAENJE HORMONA

Najei uzroci luenja hormona suNajei uzroci luenja hormona sufunkcionalnifunkcionalni tumori hipofizetumori hipofize (mikro(mikro-- iimakroadenomi) koji lue hormone.makroadenomi) koji lue hormone.

hormon, najeehormon, najee PRL, STH ili ACTH,PRL, STH ili ACTH,

oo vrlo retko TSH, LH i FSH.vrlo retko TSH, LH i FSH.
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