The Curriculum Vitae of
Mr Lyndon da Cruz
MBBS, MA (Oxon), FRCOphth. (Lond.), PhD, FRACO (Aust.)
Consultant Ophthalmic Surgeon
Specializing in Medical and Surgical Retina
Moorfields Eye Hospital, NHS foundation Trust (Specialty Interests: AMD, Diabetes, Macular and diabetic Surgery)
Honorary Consultant: Great Ormond Street Hospital for Children
Honorary Reader
Institute of Ophthalmology
University College, London
1st January 2011
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THE CURRICULUM VITAE OF MR LYNDON DA CRUZ
PERSONAL DETAILS Registration: Full (unlimited) G.M.C. registration (Reg. No. 3629578) Full registration Medical Board of Western Australia
(Reg. No. 8236)
HIC specialist register as a Specialist Ophthalmologist in Australia from the 22nd October 1999
STA (Specialist Training Authority) United Kingdom Specialist
Register as a specialist Ophthalmologist (Reg. No. 3629578) Nationality: Australian Citizen United Kingdom Permanent Resident EDUCATION 1977-1981 Churchlands Senior High School, Perth, Western Australia
Music Scholarship - Music scholar 1977 – 1981. Fitzpatrick Prize: Dux of School (1981) –
Music A Physics A Chemistry A Maths algebra trigonometry A English A Maths applied and calculus A English Literature A 1981 State Government General Exhibition
Ranked 2nd highest score of 12 000 A level candidates for the year 1981
1982-1987 University of Western Australia (UWA)
Medical School (MBBS).
Reynolds Scholar, St George's College, UWA (Medicine) 1982
State Health Department Prize in Research 1986
Prize paper published, Australian Medical Journal 1988
Smith-Coffey Medical Prize, U.W.A. 1987
1989-1990 University of Western Australia
Faculty of Philosophy (B.A. Philosophy) - First year - A+ distinction (subsequently accepted to read Philosophy at Christ Church, Oxford)
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1990-1992 University of Oxford
Christ Church BA (Hons) Physiology and Philosophy. 2:1 (Finals at 2 years)
Christ Church Travel Bursary 1991. To attend Symposium on Kant’s ‘Groundwork to the metaphysics of Morals’ – Charles University, Prague
1995-1999 University of Western Australia PhD
Thesis: Adenovirus Gene Transfer to Retinal Pigment Epithelium
QUALIFICATIONS
1987 MBBS University of Western Australia.
1992 BA (Hons) University of Oxford
1994 FRCOphth. London, England
1999 FRACO Australia
1999 PhD University of Western Australia
2001 MA University of Oxford
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POST DOCTORAL FELLOWSHIPS 2000 Howard Florey Fellowship - The Royal Society (London)
Post-doctoral fellowship to bring outstanding biomedical scientists from
Australia to England funded from Lord Florey’s bequest to the Royal Society
1999 Neil Hamilton Fairley Fellowship – NHMRC, Australia
This is the premier, national, medical post-doctoral research fellowship from
the National Health Medical Research Council of Australia (NHMRC)
(declined)
1999 Menzies Scholar - Menzies foundation / NHMRC, Australia
Single, national, prize scholarship awarded by the NHMRC to the top post-
doctoral fellowship candidate in the Biological Sciences or Medicine for the
whole of Australia
PRIZES 2001 Royal Society of Medicine, Ophthalmology: Prize Presentation
‘Physiological rescue in rds mice using virus gene transfer’
2001 Royal Society of Medicine, Ophthalmology: Research Prize – overall ‘FMM and SLO Autofluorescence in Bullseye Macular Dystrophy’
1999 Hadlee Travelling Fellowship - Medical School UWA
Research of phenotype-genotype in retinal diseases with Prof. Alan Bird 1997 ARVO / Pharmacia Travel Scholarship, Fort Lauderdale, USA Prize Paper: ‘The role of cellular orientation in gene transfer to the RPE’ 1997 Novartis (Sandoz) Young Scientific Investigator Award
Prize Paper: ‘Adenovirus mediated gene transfer to the RPE’ 1996 International Society for Eye Research (ISER) Travel Fellowship
Prize paper: ‘Hyaluronic acid receptors in ocular tissues and their role in adenoviral gene transfer’
1996 Royal Australian College of Ophthalmologists / Pharmacia Prize
Best scientific paper at the 26th National RACO meeting 1995 Promega Open Essay Prize
Prize essay: ‘Gene Therapy and the Eye’
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RESEARCH GRANTS AND FUNDING 2011 – 2013 £2 200 000 Pfizer Phase II: Stem cell transplant in AMD
2010 –2012 £2 400 000 CIRM(California Institute of Regenerative
Medicine) MRC collaborative grant. Imaging in
stem cell transplantation
2008 – 2011 £ 2 100 000 Pfizer Phase I: Stem cell transplant in AMD
2008 –2010 £ 1 300 000 Lincy Foundation Grant – Retinal Stem Cell
transplantation. P Coffey (PI), L da Cruz (PI)
2007 – 2011 £ 250 000 Second Sight - Argus II Artificial Retina
L da Cruz (PI)
2007-2010 £ 3 800 000 The London Project Embryonic Stem cells for Retinal
Transplant P Coffey, L da Cruz, R Andrews
2006 - 2009 £ 1 950 000 Stem Cell Ventures, (ceased 2007)
Immortalised cells for RPE transplantation
P Coffey (PI), L da Cruz (PI), J Greenwood
2006 - 2008 £ 440 000 Moorfields Special Trustees grant
Avastin vs Normal care in wet AMD. A Tufail (PI),
L da Cruz, J Dowler, C Egan, Z Gregor, P Hykin
2005 - 2006 £ 138 000 Moorfields Special Trustees ‘Developing Gene
therapy. L da Cruz (PI), R Ali (PI)
2004- 2007 £ 950 000 Gene therapy; Department of Health R Ali (PI),
S Battachaya, L da Cruz, A Moore, A Thrasher
2004 -2007 £ 140 482 Frances and Renee Hock Fellowship
RPE transplantation L da Cruz (PI)
2003 - 2005 £ 55 000 Moorfields Special Trustees grant for Retinal
Translocation L da Cruz (PI)
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PUBLICATIONS
53 Sandinha MT, Crawley L, Thaung C, Da Cruz L. Familial exudative
vitreoretinopathy with an anterior segment vasoproliferative mass. Graefes Arch
Clin Exp Ophthalmol. 2011 Apr 1. [Epub ahead of print]
52 Chen FK, Patel PJ, Xing W, Crossland MD, Bunce C, Rubin GS, Da Cruz L.
Intrasession Repeatability of Fixation Stability Assessment with the Nidek MP-1.
Optom Vis Sci. 2011 Mar 31. [Epub ahead of print].
51 Patel PJ, Chen FK, Da Cruz L, Rubin GS, Tufail A. Contrast sensitivity
outcomes in the ABC trial. A randomized trial of bevacizumab for neovascular
age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011 Feb 10. [Epub
ahead of print].
50 Patel PJ, Chen FK, Da Cruz L, Rubin GS, Tufail A. Test-retest variability of
reading performance metrics using MNREAD in patients with age-related macular
degeneration. Invest Ophthalmol Vis Sci. 2011 Mar 18. [Epub ahead of print]
49 Rahman W, Chen FK, Yeoh J, Patel P, Tufail A, da Cruz L. Repeatability of
manual subfoveal choroidal thickness measurements in healthy subjects using the
technique of enhanced depth imaging optical coherence tomography. Invest
Ophthalmol Vis Sci. 2010 Nov 18.
48 Chen FK, Patel PJ, Webster AR, Coffey PJ, Tufail A, da Cruz L. Nidek MP1 Is
Able To Detect Subtle Decline In Function In Inherited And Age-Related Atrophic
Macular Disease With Stable Visual Acuity. Retina. 2010 Oct 1.
47 Ahuja AK, Dorn JD, Caspi A, McMahon MJ, Dagnelie G, da cruz L, Stanga P,
Humayun MS, Greenberg RJ; Argus II Study Group. Blind subjects implanted with the
Argus II retinal prosthesis are able to improve performance in a spatial-motor
task. Br J Ophthalmol. 2010 Sep 29.
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46. Patel PJ, Chen FK, Ikeji F, Richardson M, da Cruz L, Tufail A. Intrasession
repeatability of optical coherence tomography measures in active neovascular age-related
macular degeneration. Acta Ophthalmol. 2009 Nov 7. [Epub ahead of print]
45: Yeoh J, Rahman W, Chen F, Hooper C, Patel P, Tufail A, Webster AR, Moore AT,
da Cruz L. Choroidal imaging in inherited retinal disease using the technique of
enhanced depth imaging optical coherence tomography. Graefes Arch Clin Exp
Ophthalmol. 2010 Jul 17.
44: Tufail A, Patel PJ, Egan C, Hykin P, da Cruz L, Gregor Z, Dowler J, Majid MA,
Bailey C, Mohamed Q, Johnston R, Bunce C, Xing W; ABC Trial Investigators.
Bevacizumab for neovascular age related macular degeneration (ABC Trial):
multicentre randomised double masked study. BMJ. 2010 Jun 9;340:c2459.
43. Chen FK, Patel PJ, Uppal GS, Tufail A, Coffey PJ, da Cruz L. Long-term
outcomes following full macular translocation surgery in neovascular age-related
macular degeneration. Br J Ophthalmol. 2010 May 21.
42. Rotsos T, Sagoo MS, Dacruz L, Andrews R, Dowler J. Intravitreal anti-VEGF
treatment in eyes with combined choroidal neovascularisation and vitreomacular
traction syndrome. Br J Ophthalmol. 2010 Jun 16. [Epub ahead of print] PubMed
PMID: 20558421.
41. Chen FK, Patel PJ, Coffey PJ, Tufail A, da Cruz L. Increased fundus autofluorescence
in neovascular age-related macular degeneration is associated with outer segment
shortening in macular translocation model. Invest Ophthalmol Vis Sci. 2010 Mar 10.
40. Carr AJ, Vugler AA, Hikita ST, Lawrence JM, Gias C, Chen LL, Buchholz DE, Ahmado
A, Semo M, Smart MJ, Hasan S, da Cruz L, Johnson LV, Clegg DO, Coffey PJ. Protective
effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal
dystrophic rat. PLoS One. 2009 Dec 3;4(12):e8152
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39. Patel PJ, Browning AC, Chen FK, da Cruz L, Tufail A. Interobserver agreement for
the detection of optical coherence tomography features of neovascular age-related
macular degeneration. Invest Ophthalmol Vis Sci. 2009 Jun 24.
38. Chen FK, Uppal GS, MacLaren RE, Coffey P, Rubin G, Tufail A, Aylward GW, da Cruz
L Long-term visual and microperimetry outcomes following autologous retinal pigment
epithelium choroid graft for neovascular age-related macular degeneration. Clin
Experiment Ophthalmol. 2009 Apr;37(3):275-85.
37. Humayun MS, Dorn JD, Ahuja AK, Caspi A, Filley E, Dagnelie G, Salzmann J,
Santos A, Duncan J, daCruz L, Mohand-Said S, Eliott D, McMahon MJ, Greenberg RJ.
Preliminary 6 month results from the Argus II epiretinal prosthesis feasibility
study. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:4566-8.
36. Chen FK, Patel PJ, Xing W, Bunce C, Egan C, Tufail A, Coffey PJ, Rubin G, da Cruz
L. Test-retest variability of microperimetry using the Nidek MP1 in patients with macular
disease. Invest Ophthalmol Vis Sci. 2009 Mar 25.
35. Wickham LJ, Chen FK, Lewis GP, Uppal GS, Neveu MM, Wright GA, Robson AG,
Webster A, Grierson I, Hiscott P, Coffey PJ, Holder G, Fisher SK, da Cruz L.
Clinicopathological case series of four patients with inherited macular disease.
Invest Ophthalmol Vis Sci. 2009 Mar 11.
34. Carr AJ, Vugler A, Lawrence J, Chen LL, Ahmado A, Chen FK, Semo M, Gias C,
da Cruz L, Moore HD, Walsh J, Coffey PJ. Molecular characterization and functional
analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel
human retinal assay. Mol Vis. 2009;15:283-95.
33. Rahman W, Georgalas I, da Cruz L. Macular hole formation after vitrectomy for
retinal detachment. Acta Ophthalmol. 2010 Jun;88(4):e147-8
32. Wickham L, Lewis GP, Charteris DG, Fisher SK, da Cruz L. Histological analysis of
retinas sampled during translocation surgery: a comparison with normal and
transplantation retinas. Br J Ophthalmol. 2008 Dec 17.
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31. Patel PJ, Bunce C, Tufail A, ABC Trial Investigators (da Cruz L co-investigator). A
randomised, double-masked phase III/IV study of the efficacy and safety of Avastin(R)
(Bevacizumab) intravitreal injections compared to standard therapy in subjects with
choroidal neovascularisation secondary to age-related macular degeneration: clinical trial
design. Trials. 2008 Oct 14;9(1):56
30. Chen F, Patel PJ, Uppal GS, Rubin GS, Coffey PJ, Aylward GW, da Cruz L. A
comparison of macular translocation with patch graft in neovascular age-related macular
degeneration Invest Ophthalmol Vis Sci. 2008 Dec 5.
29 da Cruz L. New developments in age-related macular degeneration (AMD) Community
Eye Health. 2008 Sep;21(67):50.
28 Aylward B, da Cruz L, Ezra E, Sullivan P, MacLaren RE, Charteris D, Gregor Z,
Bainbridge J, Minihan M. Stickler syndrome. Ophthalmology. 2008 Sep;115(9):1636-7
27: Vugler A, Carr A, Lawrence J, Chen LL, Burrell K, Wright A, Lundh P, Semo M,
Ahmado A, Gias C, da Cruz L, Moore H, Andrews P, Walsh J, Coffey P. Elucidating the
phenomenon of HESC-derived RPE: Anatomy of cell genesis, expansion and retinal
transplantation. Exp Neurol. 2008 Sep 27.
26: Patel PJ, Chen FK, da Cruz L, Tufail A. Segmentation Error in Stratus Optical
Coherence Tomography for Neovascular Age-related Macular Degeneration.
Invest Ophthalmol Vis Sci. 2008 Aug 1.
25: Patel PJ, Chen FK, Ikeji F, Xing W, Bunce C, da Cruz L, Tufail A. Repeatability of
stratus optical coherence tomography measures in neovascular age-related macular
degeneration. Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1084-8.
24: Chen FK, Uppal GS, Rubin GS, Webster AR, Coffey PJ, da Cruz L. Evidence of retinal
function using microperimetry following autologous retinal pigment epithelium-choroid graft
in macular dystrophy. Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3143-50. Epub Mar 3.
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23 da Cruz L. The Future of Retinal Pigment Epithelial transplantation. Ophthalmology
International. 2007 June; 46-51.
22: da Cruz L, Chen FK, Ahmado A, Greenwood J, Coffey P. RPE transplantation and its
role in retinal disease. Prog Retin Eye Res. 2007 Nov;26(6):598-635. Epub 2007 Jul 25.
21: Vugler A, Lawrence J, Walsh J, Carr A, Gias C, Semo M, Ahmado A, da Cruz L,
Andrews P, Coffey P. Embryonic stem cells and retinal repair. Mech Dev. 2007 Nov-
Dec;124(11-12):807-29. Epub 2007 Aug 15. Review.
20: Uppal G, Milliken A, Lee J, Acheson J, Hykin P, Tufail A, da Cruz L. New algorithm for
assessing patient suitability for macular translocation surgery. Clin Experiment Ophthalmol.
2007 Jul;35(5):448-57.
19: Abeysiri P, Bunce C, da Cruz L. Outcomes of surgery for retinal detachment in
patients with Stickler syndrome: a comparison of two sequential 20-year cohorts.
Graefes Arch Clin Exp Ophthalmol. 2007 Nov;245(11):1633-8. Epub 2007 Jun 20.
18: Tay E, Bainbridge J, da Cruz L. Subretinal abscess after scleral buckling surgery: a
rare risk of retinal surgery. Can J Ophthalmol. 2007 Feb;42(1):141-2.
17: MacLaren RE, Uppal GS, Balaggan KS, Tufail A, Munro PM, Milliken AB, Ali RR,
Rubin GS, Aylward GW, da Cruz L. Autologous transplantation of the retinal pigment
epithelium and choroid in the treatment of neovascular age-related macular degeneration.
Ophthalmology. 2007 Mar;114(3):561-70.
16: Vote BJ, Tranos P, Bunce C, Charteris DG, da Cruz L. Long-term outcome of
combined pars plana vitrectomy and scleral fixated sutured posterior chamber intraocular
lens implantation. Am J Ophthalmol. 2006 Feb;141(2):308-312.
15: El-Amir AN, Sagoo MS, da Cruz L. Age-related macular degeneration.
Br J Hosp Med (Lond). 2005 Dec;66(12):677-81.
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14: O'Sullivan EP, da Cruz L. Acute glaucoma in the unoperated eye after macular hole
surgery. Eye. 2005 Jun;19(6):702-3.
13: Schlichtenbrede FC, da Cruz L, Stephens C, Smith AJ, Georgiadis A, Thrasher
AJ, Bainbridge JW, Seeliger MW, Ali RR. Long-term evaluation of retinal function in
Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy. J Gene Med.
2003 Sep;5(9):757-64.
12: Wong D, Charteris DG, da Cruz L. Age related macular degeneration: macular
relocation surgery was not taken into account. BMJ. 2003 Jun 28;326(7404):1459;
11: da Cruz L, Dadour IR, McAllister IL, Jackson A, Isaacs T. Seasonal variation in
trachoma and bush flies in north-western Australian Aboriginal communities. Clin
Experiment Ophthalmol. 2002 Apr;30(2):80-3.
10: da Cruz L, McAllister IL. An Australian family with macular dystrophy linked to
autosomal recessive alopecia universalis. Br J Ophthalmol. 2001 Feb;85(2):239.
9: Shen WY, Garrett KL, da Cruz L, Constable IJ, Rakoczy PE. Dynamics of
phosphorothioate oligonucleotides in normal and laser photocoagulated retina. Br J
Ophthalmol. 1999 Jul;83(7):852-61.
8: da Cruz L, Robertson T, Hall MO, Constable IJ, Rakoczy PE. Cell polarity, phagocytosis
and viral gene transfer in cultured human retinal pigment epithelial cells. Curr Eye Res.
1998 Jun;17(6):668-72.
7: da Cruz L, Rakoczy P, Constable I. Ocular gene therapy: the basic science and current
state of research. Aust N Z J Ophthalmol. 1997 May;25(2):97-104. Review.
6: da Cruz L, Constable IJ, Barry CJ. Spontaneous resolution of a full-thickness macular
hole with good visual acuity. Arch Ophthalmol. 1997 Jan;115(1):130-1.
5: da Cruz L, Rakoczy P, Perricaudet M, Constable IJ. Dynamics of gene transfer to
retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1996 Nov;37(12):2447-54.
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4: da Cruz L, Rakoczy PE, Constable IJ. Expression of transgenes in human and rat
retinal pigment epithelium in vitro using an adenoviral vector. Aust N Z J Ophthalmol. 1996
May;24(2 Suppl):78-81.
3. Constable I, Rakoczy PE, da Cruz L. Hyaluronan and gene transfer to the retinal
pigment epithelium of the eye. Prospects for the treatment of subretinal neovascularization
in ARMD. In: Hyaluronan in drug delivery, 4th international workshop 1996. The Royal
Society of Medicine Press Ltd. London
2: da Cruz L, James B, Gray R, Elston J. Multiple vortex vein varices masquerading as
choroidal secondaries. Br J Ophthalmol. 1994 Oct;78(10):800-1.
1: Cullingford R, da Cruz L, Webb S, Shean R, Jamrozik K. Legibility of health warnings
on billboards that advertise cigarettes. Med J Aust. 1988 Apr 4;148(7):336-8.
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INVITED LECTURES
2009
30th September 2009 The Clinical Potential of RPE Cells in Retinal Repair European Vision and Eye Research Conference, Slovenia
18th September RPE cell transplantation for retinal disease Bristol Syposium
13th June 2009 The Argus II retinal prosthesis SOE meeting Amsterdam
27th May – 31st May Advances in Artificial Retina Pan Hellenic Ophthalmological
Meeting, Crete 23rd May 2009 Surgery for Macular Disease, Belgrade, Serbia 18th and 19th May Retinal Detachment following cataract surgery
The Artificial Retina. Royal College Meeting Birmingham,
11th March 2009 - Stem Cell Retinal Transplantation. Spring Symposium
The Royal College of Surgeons and Physicians of Glasgow
6th February 2009. The Bionic Eye: Progress in Artificial Retina
All India Ophthalmological Meeting, Jaipur, India.
2008
23rd May 2008 Translocation in the Anti-VEGF era
European Society of Retinal Specialists, Vienna, Austria
16th May 2008 Embryonic Stem-Cell derived RPE cells for Transplantation
Croatian – OphthalmologicalSchool, Dubrovnik, Croatia
11th April 2008 Is there still a role for surgery in SRNVM in the anti-VEGF era?
Challenges in Uveitis, Ancona, Italy
13th Jan. 2008 Pigment Epithelial Transplantation 2nd Greek Vitreo-retinal
Society Meeting, Athens, Greece
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23rd January 2008 RPE Transplantation in AMD
The William McKenzie Memorial Symposium – Glasgow, Scotland
2007
7th July 2007 Type II SRNVM – Diagnosis and Therapy
London Uveitis Meeting
14th July 2007 Translocation for AMD : post Avastin
Croatian – OphthalmologicalSchool, Dubrovnik, Croatia
31st May 2007 RPE Transplantation and Translocation for Macular diseases
31st May 2007n Recent Advances in the Treatment of Inherited Retinal diseases
8th Jordanian Ophthalmology Meeting, Amman, Jordan
14th January 2007 1st Greek Vitreo-retinal Society Meeting
Athens, Greece
2006
Key note Lecture
15th August 2006 Surgery for PDR and Macular Edema
Pan Pacific Opthalmological Meeting, Hong Kong, China
Invited Lecture
13th August 2006 Transplantation Translocation and other strategies for ARMD
Pan Pacific Ophthalmological Meeting, Hong Kong, China
17th June 2006 Surgery in Uveitis
International Uveitis Society meeting, Monte Carlo, Monaco
8th April 2006 Macular Translocation Surgery
Croatian – Ophthalmological School, Dubrovnik, Croatia
2005
5th July 2005 Surgery for AMD current and Future Approaches
The Oxford Congress
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19th May 2005 Surgical Stategies in AMD
Pan Hellenic Opthalmic Socirty Meeting, Mykonos, Greece
March 2005 Surgery for ARMD and Diabetes
Danish Ophthalmic College Meeting, Kolding, Denmark
Invited Lecture Courses 2003-2008
2003 – 2008 Surgery for Age related Macular Degeneration
Vitreo-Macular Tractions Syndromes
Moorfields Macular Course,Moorfields Eye hospital, London, UK 2003 – 2008 New Innovations in Retinal Surgery for Macular Diseases
VR in a Day, St Thomas and Moorfields Eye Hospital, London, UK PUBLISHED ABSTRACTS 1. Schlichtenbrede F, da Cruz L, Stephens C, Bainbridge JWB, Salt T, Ali RR.
Improvement of neuronal visual responses in the superior colliculus of rds mice following gene therapy. The Association for Research in Vision and Ophthalmology (ARVO) annual meeting. May 6th to 10th 2002, Fort Lauderdale, Florida. Invest. Ophthalmol. Vis. Sci. 38(4):1192
2. da Cruz L, Leung V, Kurz-Levin M, Fitzke F, Bird AC. Fine Matrix Mapping and
Scanning Laser Autofluorescence Demonstrating the Structural-functional Relationship of the Macula in Bullseye Macular Dystrophy. Abstracts Presented at XXVth International Coingress of Ophthalmology , Sydney April 2002.
3. da Cruz L, Stephens C, de Alwis M, Bainbridge J, Ali RR. Physiological rescue in
rds mice using virus gene transfer. Abstracts XXVth International Coingress of Ophthalmology , Sydney April 2002.
4. da Cruz L. Growth Factors in Diabetes, Diabetic retinopathy symposium: Abstracts
From the European Society of Ophthalmology Meeting SOE Meeting, Istanbul,Turkey, 3rd – 7th June, 2001.
5. da Cruz L, Stephens C, de Alwis M, Bainbridge J, Ali RR. Physiological rescue in
rds mice using virus gene transfer. Abstracts Presented at theRoyal Society of Medicine Ophthalmology Section.
6. da Cruz L, Stephens C, de Alwis M, Bainbridge J, Ali RR. ERG demonstrating functional rescue in rds mice following adeno-associated virus gene transfer. Abstracts Presented at the Joint European Research Meeting in Ophthalmology and Vision, EVER meeting, Alicante, 10-13 October 2001.
7. da Cruz L, Rakoczy PE, Constable IJ. The role of cellular orientation in gene
transfer to the RPE. The Association for Research in Vision and Ophthalmology
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(ARVO) annual meeting. May 11th to 16th 1997, Fort Lauderdale, Florida. Invest. Ophthalmol. Vis. Sci. 38(4):1192
8. da Cruz L, Rakoczy PE, Constable IJ. Hyaluronic acid receptors in ocular tissues
and their role in adenoviral gene transfer. XII ISER scientific meeting, Yokahama, Japan. Exp. Eye Res. 1996, 63(Supp. 1):S.120
9. da Cruz L, Rakoczy PE, Constable IJ. Adenovirus mediated gene transfer to the
Retinal Pigment Epithelium Abstracts from the Novartis Young Investigators Day, Sir Charles Gairdner Hospital, Perth, June 1997 .
10. da Cruz L, Rakoczy PE, Constable IJ. (1997) Gene transfer to retinal cells using a
viral vector. Abstracts to Surg. Registrars Scientific Papers Day, St John of God Hospital, Perth, 12th July, 1997.
11. da Cruz L, Rakoczy PE, Constable IJ. Ocular gene therapy - Aspects of targeting
the retinal pigment epithelium. Proceedings of 28th annual scientific congress of the Royal Australian College of Ophthalmologists, 4th - 8th November, 1996, Perth Australia.
12. da Cruz L, Rakoczy PE, Constable IJ. Gene transfer to the Retinal Pigment
Epithelium. Abstracts Presented at the National Ophthalmic and Visual Science Meeting, Australian National University, Canberra, 30th November to 1st December, 1996.
13. da Cruz L, Rakoczy PE, Constable IJ. Gene transfer to Human Retinal Pigment
Epithelial Cells In-Vitro using an Adenoviral Vector. Abstracts Presented at the National Ophthalmic and Visual Science Meeting, Deakin University, Geelong, Australia, December 2nd and 3rd 1995.
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THESES
1. Honours thesis
da Cruz L. (1992) Expression of the proto-oncogenes C-fos and C-jun in the rat
brain in two pathological situations (B.A. honours dissertation).
2. PhD thesis
da Cruz L. (1999) The Dynamics of Adenovirus Gene Transfer to the Retinal
Pigment Epithelium.
CHAPTERS IN BOOKS Ryan retina 4th Edition Chapter 155; Surgery in the Treatment of Cystoid Macular edema Eyetext.net Internet textbook of Ophthalmology. Monographs 1. Diabetic retinopathy: Non Proliferative Diabetic Retinopathy. L da Cruz, A. Hamilton 2. Vascular Disease: Central Retinal Vein Occlussion. PG Hykin, L da Cruz 3. Inherited Chorioretinal Diseases: Progress in Gene Therapy. L da Cruz RESEARCH REFERENCING/ Editing 1997 – 1999 Reviewer of articles for Clinical and Experimental Ophthalmology 2000 – 2005 Reviewer articles for Eye 2000 –2005 Reviewer of Grants: Ophthalmic research Institute of Australia (ORIA) 2000 – 2005 Editor Medical retinal section E-textbook Eyetext.net
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OPHTHALMOLOGY TRAINING 23 Aug. 2002 – Mar 2003 Moorfields Eye Hospital, VR Fellow Mr G.W. Ayleward July 2001 – Aug. 2002 Moorfields Eye Hospital, Surgical Retinal Fellow
Mr D.G. Charteris, Mr P.M. Sullivan, Mr Z. Gregor
Mar. 2000 – July 2001 Moorfields Eye Hospital, Medical Retina Fellow Prof. A.C. Bird, Mr P. Hykin, Mr A.M.P. Hamilton Jan. 1999 - Feb. 2000 Royal Perth Hospital, Perth
S/Registrar Vitreo-Retinal Fellow, Dr I.L.McAllister July 1998 – Jan. 1999 Princess Margaret Hospital for Children, Perth Registrar in Ophthalmology – Mr G. Lam Jan. 1998 - July 1998 Royal Perth Hospital, Perth Registrar in Ophthalmology – Mr I.L. Mc Allister July 1997- Jan. 1998 Fremantle Hospital, Perth Registrar in Ophthalomology – Dr D. Barnes Jan. 1997- July 1997 Sir Charles Gairdner Hospital, Perth Registrar in Ophthalmology – Dr G. Barrett Feb. 1995 – Jan. 1997 Lions Eye Institute, Perth Research registrar in Ophthalmology Prof. I. J. Constable Sept. 1994 - Feb. 1995 Prince Charles Eye Unit, King Edward VII Hospital, Windsor 3rd Year SHO Head of department Mr J.J. Kanski Aug. 1993 - Aug. 1994 Oxford Eye Hospital, Radcliffe Infirmary, Oxford 2nd Year SHO Head of department Prof. A.J. Bron Aug. 1992 - Aug. 1993 Princess Margaret Hospital, Swindon, Wiltshire 1st Year SHO Head of department Mr J. Ramsay POST-GRADUATE OPHTHALMIC EXAMINATIONS
Royal College of Ophthalmologists, London 1992 Part I FRCOphth. (October) 1993 Part II FRCOphth. Optics module (June)
1994 Part III Final fellowship FRCOphth. (September)
Royal Australian College of Ophthalmologists 1996 Part I RACO Examination (August) 1998 Part II RACO Examination (August)
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SURGICAL VISITS 2002 Prof. C. Eckardt – Frankfurt-Hoecst, Germany
Macular Rotation Surgery: assisted at macular rotation surgery, discussions about the surgery and technical aspects of procedure
2002 Assoc. Prof C. Toth – Eye Centre, Duke University, North Corolina, USA
Macular Rotation Surgery: watched multiple surgery cases, long discussions about the surgery and technical aspects of procedure as well as associated research potential. Supervised wet lab surgery
Dr Michael Cooney – Duke Eye Centre, Duke University Age related Macular disease unit. Integrated ARMD units and attended clinics with integration of the medical, research and surgery options
2002 Mr Mark Benson – Birmingham Eye Centre
Macular Rotation Surgery: Assist macular rotation case and discussion about macular rotation surgery within the NHS setting
COMMUNITY EYE TRIPS 1997 West Kimberly (Broome, Derby, Fitzroy Crossing) – Regional Eye
Camps Screening for diabetic retinopathy, glaucoma and trachoma, carrying out cataract surgery and general ophthalmic clinics
1998 Gascoine (Carnarvon, Onslow, Exmouth) – Regional Eye Camps
Screening for diabetic retinopathy, glaucoma and trachoma, carrying out cataract surgery and general ophthalmic clinics
POSTGRADUATE COURSES ATTENDED 1993 Ophthalmic microsurgical course, Stoke-Mandeville Hospital
1993 Optics/Refraction course, Moorfields Eye Hospital
Optics/Refraction course, Queens Medical Centre, Notts
1994 Final Fellowship Course, Moorfields Eye Hospital
1994 Clinical Fellowship Course, King Edward VII Hospital, Windsor
1998 Ophthalmology final fellowship course, Melbourne
Ophthalmology final fellowship course, Sydney Eye Hospital
2001 Macular Course, Moorfields Eye Hospital, London
2001 Cambridge Symposium, ARMD Cambridge, United Kingdom
2001 International Symposium of Diabetic Retinopathy, Naples, Italy
2001 European Association for Diabetic Eye Complications (EASDEC), Paris
2001 Macular rotation course Frankfurt
2002 Advanced microsurgical course Antwerp
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IT AND MANAGEMENT 1991-1992 President Graduate Common Room Christ Church Oxford. Managed academic and social requirements for 170 graduates including
budget 2002 E - patient Fellow – Involved in teaching and development of the Electronic
patient record at MEH. I was also involved in the ‘roll-out’, initial trouble- shooting and development of the DTC E-patient system
CLINICAL AUDIT
2001 - 2002 Personal audit of my first 200 primary Retinal Detachments for outcome
2001 Participated in MEH audit of macular on retinal detachment (MORD)
2002 Participated in MEH audit of primary retinal detachment success rate
2002 Participation in current MEH/VR audit on: Macula state at presentation in RD
FORMAL TEACHING APPOINTMENTS University of Western Australia
1995 University Tutor in Head and Neck Anatomy, Complete academic year
1996 University Tutor in Neuroanatomy, Complete academic year UWA
1996 University Tutor in Head and Neck Anatomy, Complete academic year UWA
1999 University lecturer in Gene Therapy, Complete academic year Visual Science degree, Centre for Ophthalmology and Visual Science, UWA
Teaching positions in London
2000 – 2002 Tutor for Diabetic Retinopathy and Glaucoma Course, Institute of Optometry
2002 E-Patient Fellow – teaching electronic patient to doctors and nurses TEACHING LECTURES 2000 Ophthalmology lectures – Optometry course, City University, London
2001 Moorfields part III fellowship course, Moorfields Eye Hospital, London
2001 Ophthalmology lectures – Optometry course City University, London
1999 – 2002 Fellow in Vitreo-retinal Surgery – Teaching and supervising
Phakoemulsification surgery and vitreo-retinal surgery to registrars
2000-2002 Lectures for the SpR teaching programme in Medical and Surgical Retina
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EXTRA CURRICULAR ACTIVITIES
MUSIC 1979-81 Principal Trombonist, Combined Schools Orchestra 1982 Principal Trombonist, University of W.A. Orchestra 1982 Principal Trombonist, West. Australian Youth Orchestra SPORT AUSTRALIAN RULES FOOTBALL 1982-84 University of Western Australia Football Team 1990-91 University of Oxford Australian Football Team Oxford Vs Cambridge Varsity Match 1990, 1991 FENCING 1988-90 University of Western Australia Fencing Club 1990-92 Oxford University Fencing Club: Represented Oxford in the European Universities tournament, Amsterdam. Oxford Assassins Vs Cambridge WHITE WATER KAYAKING 1990, 1991 Successful completion of the Avon Descent- 135 kilometre international
white water kayak race ROWING 1985-87 University of Western Australia Boat Club 1990-91 Christ Church, Oxford Boat Club, Blades in 'Torpids' 1991 and 'Eights' 1991 POSITIONS HELD IN CLUBS/SOCIETIES 1984, 1986 Western Australian Medical Student Society (WAMSS) 1986 WAMSS Representative to University Education Council
1986 Australian National Kidney Foundation Committee 1991- 92 President of Graduate Common Room, Christ Church, Oxford
