“Multiscale” data integration into a structure/function model of H/ACA guide RNAs in Archaea

keywords: structural & RNA biology, phylogeny, transcriptomics, bioinformatics

Fabrice Leclerc IGM - Orsay

fabrice.leclerc@igmors.u-psud.fr

Outline

✤ H/ACA guide RNAs: structure(s) & “old/new” function(s) (Eukaryotes)

✤ Archaea: H/ACA (Euryarchaea + Crenarchaea) & H/ACA-like (Crenarchaea): variations on the same theme ?

✤ Alternative function(s) in Archaea ?