Date post: | 30-Dec-2015 |
Category: |
Documents |
Upload: | gregory-farmer |
View: | 219 times |
Download: | 0 times |
Myocardial Ischemia, Injury & Infarction
Chapter 15
Robert J. Huszar, MD
Instructor
Patricia L. Thomas, MBA, RCIS
Outline
• Coronary Artery Circulation
• Coronary Artery Disease
• Acute Coronary Syndromes
• Acute Myocardial Syndrome
Coronary Artery Disease/Risk Factors
• Family History• Gender• Race• Age• Cigarette Smoking• Diabetes Mellitus• Hypertension• Elevated Cholesterol• Obesity• Lack of Exercise• Stress• Cocaine Use
Pathophysiology of CAD
• Phase 1: Appearance of an atheromatous Plaques
• Phase 2: Formation of thrombus on the surface of the plaque after erosion or rupture– Erosion: endothelial covering of the plaque is torn
away– Rupture: fibrous cap is weakened/surge of blood
pressure/vasospasm
• Phase 3: Resolution or Occlusion
Myocardial Ischemia, Injury & Infarction
Results from the failure of local CA to supply sufficient oxygenated blood to the myocardial tissue.– Occlusion or obstruction:atherosclerotic CA with
blood clots– CA Spasm caused by constriction of smooth muscle
in the wall of the CA.– Other reasons such as arrhythmia, PE, Hypotension
or shock– Increased Myocardial workload– Decreased level of oxygen in blood delivered to the
myocardium