Karim El-Sayed El-Abassiry

Nanotechnology is the science that deals with the processes that occur at molecular level and of nanolength scale size.

Pharmaceutical nanotechnology embraces applications of nanoscience to pharmacy as nanomaterials, and as devices like drug delivery, diagnostic, imaging and biosensor.

Introduction

Apoptosis

Genetics of cancer

Insertion Mutation

Shape of the protein

Growing olderTobaccoSunlight

radiationCertain chemicals and other substances

Some viruses and bacteriaCertain hormones

Family history of cancerAlcohol

Radiation

Cancer treatment

Nanomedicine

Diagnosis

Quantum dots

nanoparticles with quantum confinement properties

Diagnosis

Sensor test chips

thousands of nanowires

Nanowires

Nanowire sensor composition

Diagnosis

Carbon Nano Tubes

Used to make DNA biosensors

Carbon Nano Tubes

Diagnosis

Nanoscale Cantilevers

coated with molecules capable of binding to specific molecules that only cancer cells secrete

Nanoparticles as Drug DeliveryMany types of nanoparticles are under various

stages of development as drug delivery systems, including liposomes and other lipid-

based carriers (such as lipid emulsions and lipid-drug complexes), polymer-drug conjugates, polymer microspheres, micelles, and various

ligand-targeted products

Liposomes and Other Lipid-based

Nanoparticles

targeted to the internalizing antigen CD44 on B16F10 melanoma cells showed enhanced intracellular drug uptake from the targeted liposomes when compared with the free form of DOX. The enhanced uptake was correlated with enhanced cell killing efficacy. A liposomal formulation of cisplatin that lacked efficacy demonstrated encouraging therapeutic results when delivered in an immunoliposome targeted to an internalizing antigen. Recently, promising results were reported from a Phase I clinical study that evaluated the effect of MCC-465, a PEGylated liposomal formulation containing DOX targeted with an F(ab')2 fragment of a human mAb named GAH, in patients with metastatic stomach cancer

study of a liposome formulation of doxorubicin

(DOX)