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NATO
Science for Peace and Security (SPS) Programme
Workshop on CBRN Defence – 22-24 October 2013 – Brussels
Emerging Security Challenges Division
NATO
Brussels, Belgium, 22.10.2013
Antibacterial coatings based on sonochemically
designed surface metal nanofoams, 2011, CLG
984267
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Antibacterial coatings based on sonochemically designed surface metal
nanofoams, 2011, CLG 984267
• General overview: Advances for a new generation of active metal surfaces with
feedback properties.
• Objectives: Technologies for fabrication of surface metal nanofoams for active
chemicals storage by “green” ultrasound irradiation with combination with self-
assembly complexation between biocide and polyelectrolyte in open/close states
and formation of surface nanoreservoirs capable of long-term storage and
controllable release of the entrapped antimicrobial agents which provide a basis for
novel CNBR decontamination coatings.
• Expected outcomes comprehensible to the non-expert: fabrication of
surface encapsulation systems capable of long-term storage and controllable
release of the entrapped antimicrobial agents which provide a basis for novel CNBR
decontamination coatings.
Project Description
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What did we want to achieve ?
Rational interface design
inorganic / polymeric / biological
→ antifouling systems, new medical therapies for human transplants, stem-cell research
Understanding and controlling of sonochemical reaction at solid surfaces
→ boost fundamental research, control of nucleation
Nanoengineered Cavitation Interfaces
Bio-active Surface
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What is special in sonochemistry?
High Energy
Fast
Localised
Sonoparameters → easy way to various structures
Red/Ox vis-à-vis reaction in liquid
Additive in liquid → single-step hybrids
“Hot spot” theory
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Focused ultrasonic treatment
* Lower left inset shows multibubble sonoluminecence
** Right inset shows ultrasonic unit for sonochemical modification, where 1) piezoceramic transducer; 2) booster; 3)
irradiating horn; 4) gas inlet; 5) thermoelement; 6) thermostated sonocell.
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Surface capsules could be formed at higher intensity of sonication
Cavitation assisted porous surfaces
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Surface capsules on metal surface
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Design of intelligent surfaces
TEM ultramicrocut of sonomodified metal
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Types of capsules
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Surface pore loading
“Surface” drug delivery: stimuli-responsive, controlled, extended, multi-drug, with biosensing
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Encapsulation forces
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Controllable release behavior
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Specific example of the system
Doxorubicin chemisorption via sonication
IR spectra
D.V. Andreeva, D.V. Sviridov, A. Masic. H. Möhwald, E.V. Skorb, SMALL 8 (2012) 820
Fast creation of reactive groups on both inorganic and organic sides
Release profile
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Specific example of the system
D.V. Andreeva, D.V. Sviridov, A. Masic. H. Möhwald, E.V. Skorb, SMALL 8 (2012) 820
Release profile
before biocide release
after biocide release
LIVE/DEAD BacLight bacteria visualisation: inactivated – red; living – green
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J. Gensel, T. Borke, N. Pazos- Perez, A. Fery, D.V. Andreeva, E. Betthausen, A. H. E. Müller, H. Möhwald,
E.V. Skorb, Adv. Mater. 24 (2012) 985
Immobilization of pH-responsive triblock terpolymer micelles
L. lactic bacteria produce lactic acid, pH ↓, micelle’s corona size ↑ and push off the cells
Spatial and temporal resolved cell attraction
Advances of self-regulated system
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Project Outcome
Antibacterial coatings based on sonochemically designed surface metal
nanofoams, 2011, CLG 984267
• Results (direct scientific and educational successes):
Novel ultrasound-assisted method of modification of metal surface and
formation of metal nanofoams with high stability, high surface area and high
adhesive properties;
Novel encapsulation systems with controllable release of biocide and other
active compounds;
5 publications in high ranking scientific journals in the field of materials science
and nanotechnology, e.g. Adv. Mater., Nanoscale, Small, J. Mater. Chem.,
Photochem. Photobiol. Sci.
• Impact :
sustainable technology for novel CRBN decontamination coatings;
potential application in protective coatings, drug delivery, implants protection,
tissue engineering, lab-on-chip, sensors and biosensors.
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Antibacterial coatings based on sonochemically designed surface metal
nanofoams, 2011, CLG 984267
• What research in CBRN Defence requires urgent and substantial
attention? A novel nanoengineered systems for manipulation with cells in
the bioanalytic lab-on-chip systems.
• What should be the focus of the SPS Programme in CBRN
Defence? Use advances of novel nanoengineered materials, systems
fundamental understanding and technological adaptation.
• Ideas for potential SPS activities in the CBRN field (according to
your expertise) Hybrid materials for encapsulation systems, stimuli-
responsive surfaces, CBRN decontamination coatings.
Way Forward – SPS CBRN
