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1
What is NCCTG?What is NCCTG?What is NCCTG?What is NCCTG?
North Central Cancer Treatment GroupNorth Central Cancer Treatment Group
Jan C. Buckner, MDJan C. Buckner, MD
Group ChairGroup Chair
June 17, 2003June 17, 2003
North Central Cancer Treatment GroupNorth Central Cancer Treatment Group
Jan C. Buckner, MDJan C. Buckner, MD
Group ChairGroup Chair
June 17, 2003June 17, 2003
2
PurposePurposePurposePurpose
• To improve duration and quality of life To improve duration and quality of life by performing high quality clinical by performing high quality clinical trials in the community settingtrials in the community setting
• To improve understanding of cancer To improve understanding of cancer biology and biological consequences biology and biological consequences of treatmentof treatment
• To improve methodology for To improve methodology for conducting clinical trialsconducting clinical trials
• To improve duration and quality of life To improve duration and quality of life by performing high quality clinical by performing high quality clinical trials in the community settingtrials in the community setting
• To improve understanding of cancer To improve understanding of cancer biology and biological consequences biology and biological consequences of treatmentof treatment
• To improve methodology for To improve methodology for conducting clinical trialsconducting clinical trials
3
NCCTG DistinctivesNCCTG DistinctivesNCCTG DistinctivesNCCTG Distinctives
• Community-basedCommunity-based
• Single Research BaseSingle Research Base
• Intertwined with MCCC and Mayo Intertwined with MCCC and Mayo FoundationFoundation
• Community-basedCommunity-based
• Single Research BaseSingle Research Base
• Intertwined with MCCC and Mayo Intertwined with MCCC and Mayo FoundationFoundation
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OrganizationOrganizationOrganizationOrganization
• MembersMembers• GovernanceGovernance
• MayoMayo• Administrative InfrastructureAdministrative Infrastructure• Scientific ExpertiseScientific Expertise
• MembersMembers• GovernanceGovernance
• MayoMayo• Administrative InfrastructureAdministrative Infrastructure• Scientific ExpertiseScientific Expertise
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FundingFundingFundingFunding
• NCINCI
• MayoMayo
• ContractsContracts
• MembersMembers
• PhilanthropyPhilanthropy
• NCINCI
• MayoMayo
• ContractsContracts
• MembersMembers
• PhilanthropyPhilanthropy
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Criteria for MembershipCriteria for MembershipCriteria for MembershipCriteria for Membership
• AccrualAccrual
• Data quality and timelinessData quality and timeliness
• AccrualAccrual
• Data quality and timelinessData quality and timeliness
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Categories of MembershipCategories of MembershipCategories of MembershipCategories of Membership
• CCOPCCOP
• ConsortiumConsortium
• AffiliateAffiliate
• CCOPCCOP
• ConsortiumConsortium
• AffiliateAffiliate
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ParticipantsParticipantsParticipantsParticipants
• 1247 physicians1247 physicians
• 424 sites424 sites
• 1247 physicians1247 physicians
• 424 sites424 sites
June 16, 2003
CP1041821-2
AKAK
WAWA
ORORIDID
MTMT
SaskatchewanSaskatchewan
WYWY
UTUTNVNV
CACA
AZAZ NMNM
COCO
NENE
SDSD
NDNDMNMN
MOMOKSKS
FLFL
NCNC
MIMI
KYKY
OHOH
WVWV VAVA
PAPA
NYNY
MDMDDEDE
NJNJCTCT
RIRI
MAMA
MEME
NHNHVTVT
IAIAILIL
WIWI
OntarioOntario
DCDC
HIHI
MexicoMexico
GAGA
TXTX LALA
ARARALAL
TNTN
MSMS
OKOK SCSC
ININ
CP1041821-1
AKAK
WAWA
ORORIDID
MTMT
SaskatchewanSaskatchewan
WYWY
UTUTNVNV
CACA
AZAZ NMNM
COCO
NENE
SDSD
NDNDMNMN
MOMOKSKS
FLFL
NCNC
MIMI
KYKY
OHOH
WVWV VAVA
PAPA
NYNY
MDMDDEDE
NJNJCTCT
RIRI
MAMA
MEME
NHNHVTVT
IAIA
1717
2222
55
77
22
33 ILIL
WIWI
OntarioOntario
DCDC99
2828
2929
55 1919
6161
3311
37373030
11
11
2
HIHI
MexicoMexico
11
GAGA88
TXTX LALA
ARARALAL
TNTN
MSMS
OKOK
2277
1010
11
1010
SCSC11
ININ1
11
What are our research What are our research components?components?
What are our research What are our research components?components?
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Funded ProgramsFunded ProgramsFunded ProgramsFunded Programs
• BrainBrain
• BreastBreast
• GIGI
• LungLung
• Cancer ControlCancer Control
• BrainBrain
• BreastBreast
• GIGI
• LungLung
• Cancer ControlCancer Control
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Working GroupsWorking GroupsWorking GroupsWorking Groups
• MelanomaMelanoma
• ProstateProstate
• HematologyHematology
• MelanomaMelanoma
• ProstateProstate
• HematologyHematology
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Discipline-Oriented Discipline-Oriented CommitteesCommittees
Discipline-Oriented Discipline-Oriented CommitteesCommittees
• Novel TherapeuticsNovel Therapeutics
• Quality of LifeQuality of Life
• Gender and Ethnic DiversityGender and Ethnic Diversity
• Patient AdvocacyPatient Advocacy
• Novel TherapeuticsNovel Therapeutics
• Quality of LifeQuality of Life
• Gender and Ethnic DiversityGender and Ethnic Diversity
• Patient AdvocacyPatient Advocacy
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Modality CommitteesModality CommitteesModality CommitteesModality Committees
• Medical OncologyMedical Oncology
• PathologyPathology• Biospecimen RepositoryBiospecimen Repository
• Radiation OncologyRadiation Oncology
• SurgerySurgery
• Medical OncologyMedical Oncology
• PathologyPathology• Biospecimen RepositoryBiospecimen Repository
• Radiation OncologyRadiation Oncology
• SurgerySurgery
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Core Support ServicesCore Support ServicesCore Support ServicesCore Support Services
• BiostatisticsBiostatistics
• InformaticsInformatics
• Data ManagementData Management
• AuditAudit
• Operations OfficeOperations Office
• CommunicationsCommunications
• Data Monitoring CommitteeData Monitoring Committee
• BiostatisticsBiostatistics
• InformaticsInformatics
• Data ManagementData Management
• AuditAudit
• Operations OfficeOperations Office
• CommunicationsCommunications
• Data Monitoring CommitteeData Monitoring Committee
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Who are our Mayo Clinic Who are our Mayo Clinic investigators?investigators?
Who are our Mayo Clinic Who are our Mayo Clinic investigators?investigators?
18
Mayo Clinic MD’s and PhD’s Mayo Clinic MD’s and PhD’s Participating in NCCTGParticipating in NCCTG
Mayo Clinic MD’s and PhD’s Mayo Clinic MD’s and PhD’s Participating in NCCTGParticipating in NCCTG
247
27 31
305
0
50
100
150
200
250
300
350
Rochester Jacksonville Scottsdale TOTAL
247
27 31
305
0
50
100
150
200
250
300
350
Rochester Jacksonville Scottsdale TOTAL
June 16, 2003
19
Departments/DivisionsDepartments/DivisionsRepresentedRepresented
Departments/DivisionsDepartments/DivisionsRepresentedRepresented
40
8 8
0
5
10
15
20
25
30
35
40
Rochester Jacksonville Scottsdale
40
8 8
0
5
10
15
20
25
30
35
40
Rochester Jacksonville Scottsdale
July, 2001
20
Departments/Divisions/ProgramsDepartments/Divisions/ProgramsA-MA-M
Departments/Divisions/ProgramsDepartments/Divisions/ProgramsA-MA-M
• Anesthesiology
• Area Medicine
• Biochemistry and Molecular Biology
• Cardiovascular Diseases
• Clinical Epidemiology
• Dermatology
• Endocrinology
• Gastroenterology and Hepatology
• Anesthesiology
• Area Medicine
• Biochemistry and Molecular Biology
• Cardiovascular Diseases
• Clinical Epidemiology
• Dermatology
• Endocrinology
• Gastroenterology and Hepatology
• General Internal Medicine
• Hematology
• Health Sciences Research
• Laboratory Medicine and Pathology
• Medical Genetics
• Molecular Genetics
• Molecular Medicine Program
• General Internal Medicine
• Hematology
• Health Sciences Research
• Laboratory Medicine and Pathology
• Medical Genetics
• Molecular Genetics
• Molecular Medicine Program
July, 2001
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Departments/Divisions/ProgramsDepartments/Divisions/ProgramsN-ZN-Z
Departments/Divisions/ProgramsDepartments/Divisions/ProgramsN-ZN-Z
• Neurologic Surgery
• Neurology
• Nicotine Dependence Center
• Nuclear Medicine
• Obstetrics and Gynecology
• Oncology
• Physical Medicine and Rehabilitation
• Neurologic Surgery
• Neurology
• Nicotine Dependence Center
• Nuclear Medicine
• Obstetrics and Gynecology
• Oncology
• Physical Medicine and Rehabilitation
• Psychiatry and Psychology
• Pulmonary and Critical Care Medicine
• Radiation Oncology
• Radiology
• Surgery
• Transplant Center
• Urology
• Neurology
• Radiation Oncology
• Surgery
• Transplantation
• Psychiatry and Psychology
• Pulmonary and Critical Care Medicine
• Radiation Oncology
• Radiology
• Surgery
• Transplant Center
• Urology
• Neurology
• Radiation Oncology
• Surgery
• Transplantation
July, 2001
22
What is our productivity?What is our productivity?What is our productivity?What is our productivity?
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Protocol ActivityProtocol ActivityCancer Treatment and ControlCancer Treatment and Control
Protocol ActivityProtocol ActivityCancer Treatment and ControlCancer Treatment and Control
• HistoricalHistorical• 384 over 25 years384 over 25 years
• Currently activeCurrently active• 50 open50 open• 235 closed with follow up taking 235 closed with follow up taking
placeplace
• Currently in developmentCurrently in development• 3737
• HistoricalHistorical• 384 over 25 years384 over 25 years
• Currently activeCurrently active• 50 open50 open• 235 closed with follow up taking 235 closed with follow up taking
placeplace
• Currently in developmentCurrently in development• 3737
June 13, 2003
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Patient AccrualPatient AccrualCancer Treatment and ControlCancer Treatment and Control
(58,537 over 25 years)(58,537 over 25 years)
Patient AccrualPatient AccrualCancer Treatment and ControlCancer Treatment and Control
(58,537 over 25 years)(58,537 over 25 years)
3,010
4,684 4,870
0500
1,0001,5002,0002,5003,0003,5004,0004,5005,000
2000 2001 2002
3,010
4,684 4,870
0500
1,0001,5002,0002,5003,0003,5004,0004,5005,000
2000 2001 2002
June 13, 2003
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Tissue SpecimensTissue Specimens(10,334 over 25 years)(10,334 over 25 years)
Tissue SpecimensTissue Specimens(10,334 over 25 years)(10,334 over 25 years)
755 775
938
0100200300400500600700800900
1,000
2000 2001 2002
755 775
938
0100200300400500600700800900
1,000
2000 2001 2002
June 13, 2003
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NCCTG PublicationsNCCTG Publications2000-2002 Journals2000-2002 Journals
NCCTG PublicationsNCCTG Publications2000-2002 Journals2000-2002 Journals
• Am J Clin Oncol
• Br J Haematol
• Cancer
• Cancer Invest
• Clinical Cancer Research
• Current Oncology Reports
• Int J Gynaecol Obstet
• Int J Radiat Oncol Biol Phys
• Invest New Drugs
• J Clin Oncol
• J Neurooncol
• J Neurosurg
• Am J Clin Oncol
• Br J Haematol
• Cancer
• Cancer Invest
• Clinical Cancer Research
• Current Oncology Reports
• Int J Gynaecol Obstet
• Int J Radiat Oncol Biol Phys
• Invest New Drugs
• J Clin Oncol
• J Neurooncol
• J Neurosurg
• J Natl Cancer Inst
• JAMA
• Lancet
• Leukemia
• Lung Cancer
• Meta-Analysis
• N Engl J Med
• Oncology
• Oncol Nurs Forum
• Semin Oncol
• Stat Med
• Support Care Cancer
• J Natl Cancer Inst
• JAMA
• Lancet
• Leukemia
• Lung Cancer
• Meta-Analysis
• N Engl J Med
• Oncology
• Oncol Nurs Forum
• Semin Oncol
• Stat Med
• Support Care Cancer
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What are the education What are the education components?components?
What are the education What are the education components?components?
28
Target AudiencesTarget AudiencesTarget AudiencesTarget Audiences
• PhysiciansPhysicians
• NursesNurses
• CRA’sCRA’s
• Patient AdvocatesPatient Advocates
• PhysiciansPhysicians
• NursesNurses
• CRA’sCRA’s
• Patient AdvocatesPatient Advocates
29
Educational SymposiaEducational SymposiaTopicsTopics
Educational SymposiaEducational SymposiaTopicsTopics
• New Directions in Oncologic ImagingNew Directions in Oncologic Imaging
• Colorectal Cancer: Revising Colorectal Cancer: Revising Standards/Evolving TreatmentsStandards/Evolving Treatments
• Breast Cancer Management: Current Status Breast Cancer Management: Current Status and Future Research Directionsand Future Research Directions
• Molecular Markers: Current Oncologic Molecular Markers: Current Oncologic ApplicationApplication
• Melanoma in the 21st CenturyMelanoma in the 21st Century
• AJCC Staging of Breast/Colon CancerAJCC Staging of Breast/Colon Cancer
• New Directions in Oncologic ImagingNew Directions in Oncologic Imaging
• Colorectal Cancer: Revising Colorectal Cancer: Revising Standards/Evolving TreatmentsStandards/Evolving Treatments
• Breast Cancer Management: Current Status Breast Cancer Management: Current Status and Future Research Directionsand Future Research Directions
• Molecular Markers: Current Oncologic Molecular Markers: Current Oncologic ApplicationApplication
• Melanoma in the 21st CenturyMelanoma in the 21st Century
• AJCC Staging of Breast/Colon CancerAJCC Staging of Breast/Colon Cancer
June, 2003
30
Education Symposia Education Symposia Visiting LecturersVisiting Lecturers
Education Symposia Education Symposia Visiting LecturersVisiting Lecturers
• NR DunnickNR Dunnick University of MichiganUniversity of Michigan
• RJ MayerRJ Mayer Dana FarberDana Farber
• NJ MeropolNJ Meropol Fox ChaseFox Chase
• AP VenookAP Venook University of CaliforniaUniversity of California
• GN Hortobagyi GN Hortobagyi MD AndersonMD Anderson
• HL McLeodHL McLeod Washington UniversityWashington University
• CM BalchCM Balch ASCOASCO
• H FreemanH Freeman NCI; Harlem HospitalNCI; Harlem Hospital
• NR DunnickNR Dunnick University of MichiganUniversity of Michigan
• RJ MayerRJ Mayer Dana FarberDana Farber
• NJ MeropolNJ Meropol Fox ChaseFox Chase
• AP VenookAP Venook University of CaliforniaUniversity of California
• GN Hortobagyi GN Hortobagyi MD AndersonMD Anderson
• HL McLeodHL McLeod Washington UniversityWashington University
• CM BalchCM Balch ASCOASCO
• H FreemanH Freeman NCI; Harlem HospitalNCI; Harlem Hospital
31
Nurses and CRAsNurses and CRAsNurses and CRAsNurses and CRAs
• Semi-annual symposiaSemi-annual symposia• Specific Disease FocusSpecific Disease Focus• CAMCAM• Special PopulationsSpecial Populations
• CRA Training WorkshopsCRA Training Workshops• Skills FairSkills Fair• SOCRA certificationSOCRA certification• Double enrollmentDouble enrollment
• Semi-annual symposiaSemi-annual symposia• Specific Disease FocusSpecific Disease Focus• CAMCAM• Special PopulationsSpecial Populations
• CRA Training WorkshopsCRA Training Workshops• Skills FairSkills Fair• SOCRA certificationSOCRA certification• Double enrollmentDouble enrollment
32
Patient AdvocatesPatient AdvocatesPatient AdvocatesPatient Advocates
• Coalition modulesCoalition modules• Clinical trial components and conductClinical trial components and conduct
• Semi-annual meetingsSemi-annual meetings• Dinner speakers/guestsDinner speakers/guests• Committee businessCommittee business• Research committee participationResearch committee participation
• Spring Symposium 2003Spring Symposium 2003
• Coalition modulesCoalition modules• Clinical trial components and conductClinical trial components and conduct
• Semi-annual meetingsSemi-annual meetings• Dinner speakers/guestsDinner speakers/guests• Committee businessCommittee business• Research committee participationResearch committee participation
• Spring Symposium 2003Spring Symposium 2003
33
VisionVisionVisionVision
• GrowthGrowth
• Financial securityFinancial security
• CollaborationCollaboration
• GrowthGrowth
• Financial securityFinancial security
• CollaborationCollaboration
34
GrowthGrowthGrowthGrowth
• AccrualAccrual
• Scientific ProgramsScientific Programs• BreadthBreadth• DepthDepth• New ProgramsNew Programs
• MelanomaMelanoma
• MembershipMembership
• AccrualAccrual
• Scientific ProgramsScientific Programs• BreadthBreadth• DepthDepth• New ProgramsNew Programs
• MelanomaMelanoma
• MembershipMembership
35
Financial SecurityFinancial SecurityFinancial SecurityFinancial Security
• Prudent managementPrudent management
• Ancillary grants/contractsAncillary grants/contracts
• Industry partnershipIndustry partnership
• Prudent managementPrudent management
• Ancillary grants/contractsAncillary grants/contracts
• Industry partnershipIndustry partnership
36
CollaborationCollaborationCollaborationCollaboration
• Mayo Clinic Cancer CenterMayo Clinic Cancer Center
• Cooperative Groups/CoalitionCooperative Groups/Coalition
• Academic institutionsAcademic institutions
• IndustryIndustry
• Mayo Clinic Cancer CenterMayo Clinic Cancer Center
• Cooperative Groups/CoalitionCooperative Groups/Coalition
• Academic institutionsAcademic institutions
• IndustryIndustry
37
PurposePurposePurposePurpose