Neoplasia Introduction

ByDR.HALA BADAWILECTURER OF PATHOLOGY

Neoplasia Introduction NeoplasiaCharacteristics

BENIGNMALIGNANTGross picture Spherical or ovoid in shape Mostly capsulated No haemorrhage or necrosis Not capsulated Areas of necrosis and haemorhage In solid organs: fixed irregular mass with ill defined bordersIn body surfaces: Polypoid (fungating), infiltrating or ulcerative

3NeoplasiaCharacteristics

BENIGNMALIGNANTMicroscopic pictureCytological Features Cytological atypia (anaplasia) Change in cellular morphologyCellular polymorphism, nuclear hyperchromatism, mitoses & tumour giant cells Change in cellular pattern (Loss of polarity)Cells like the original cell Microscopic Features (ANAPLASIA) PleomorphismHyperchromatic nucleiMultiple large nucleoliHigh N/C ratioHigh mitotic rateAbnormal mitosis Tumor giant cells

Neoplasia