PATENT PENDING

INTESTINAL AND IMMUNITY PRIMER

IMPROVING POST-WEANING PERFORMANCE Weaning is a stressful time in a pig’s life that often contributes to intestinal and immune dysfunctions. Piglets experience biological stress from a number of physiological, environmental, and social challenges that slow the development of a healthy intestinal environment and immune function. This “fall back” effect represents a major source of production losses in swine operations.

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• Separation from the sow

• Transition to dry food

• Increased exposure to pathogens

• Change in physical environment

• Co-mingling

• Social hierarchy

Stressors slow the development of a healthy intestinal environment and immune function:

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PASSIVE IMMUNITY

WEEKS OF AGE

ACTIVE IMMUNITY

EARLY WEANING

4-5 Kg

Live Weight

CONVENTIONAL WEANING

5-10 Kg

Live Weight

1 2 3 4 5 6 7 8

LEV

EL O

F IM

MU

NIT

Y

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RAPID IMMUNE FUNCTION IS CRITICAL TO PIGLET PERFORMANCEA newborn pig acquires passive immunity by absorbing the antibodies that are present in colostrum. Antibody levels decline to very low levels by the time the piglet reaches about three weeks of age. A pig’s own immune system only begins to develop at about three weeks of age and is not able to defend against pathogens until as much as five weeks of age. This makes the piglet very susceptible to disease and reduced performance during the post-weaning period.

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WEANING NEGATIVELY AFFECTS INTESTINAL ENVIRONMENTA healthy intestinal environment does more that just aid in the digestion and absorption of nutrients. The mucus and epithelial cells that line the small intestine form the piglet’s first line of defense to protect it from harmful bacterial and fungal toxins, bacteria, or feed-associated antigens. The intestinal lumen is home to the largest population of immune cells in the piglets growing body. When the intestinal barrier is disrupted by changes the piglet undergoes at weaning, these substances are absorbed and result in diarrhea, mal-absorption, and reduced growth and production.

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An increase in crypt depth is also associated with weaning and reduces the replenishment of healthy epithelial cells

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BIOLOGICAL STRESS WEAKENS THE INTESTINAL ENVIRONMENTThe villus height and surface area are typically reduced by 50% five days post-weaning and may take as much as fifteen days to fully recover. An increase in crypt depth is also associated with weaning and reduces the replenishment of healthy epithelial cells that provide a barrier function against disease. These changes to the intestinal environment contribute to post-weaning diarrhea and reduced performance by decreasing the piglet’s digestive and absorptive capacity.

Nutrient absorption is typically reduced by

approximately 50%

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NEOPRIME POSITIVELY MODIFIES THE INTESTINAL ENVIRONMENTNeoPrime “primes” the development of the piglet’s intestinal environment to improve performance. Its unique formula reduces the level of pathogenic bacteria and toxins from the intestines, energizes and strengthens the cells that form the intestinal barrier, and stimulates the the innate and adaptive immune system to help it get ready to defend against pathogens.

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ProtectsAgainst

Biotoxins

EnergizesIntestinal

Cells

StimulatesImmune System

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