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Nepal 2011 Immunization and Vaccine Development South-East Asia Region World Health Organization• SEARO/FHR/IVD • 29 August 2012 N epal is a landlocked country bordering with India in the east, west and south, and with China in the north. Topographically, Nepal is divided into three distinct ecological zones: the mountain (Himal), the hill and the plain (Terai). Nepal is divided into five administrative regions and 75 districts. Districts are further divided into village development committees and municipalities. Nepal is the home of 27 millions people and annual population growth rate is 2.1 (2000-2010). Nineteen percent population lives in urban areas. The average household size has decreased from 5.4 in 2001 to 4.7 in 2011. The expanded programme on immunization (EPI) in Nepal was launched in 1979 with two vaccines (BCG and DTP) in three districts. Immunization was made available to all 75 districts by 1989. Source: Comprehensive multi-year plan 2007-2011; WHO, world health statistics 2012 and Nepal demographic health survey 2011. Table 1: Basic information 1 2011 Division/Province/State/Region 5 District 75 Municipality 58 Village development committee 3,915 Ward 36,041 Population density (per sq. km) 181 Population living in urban areas 19% Population using improved drinking-water sources 89% Population using improved sanitation 31% Total expenditure on health as % of GDP 5.5 Literacy rate among adults aged >15 years 59% Births attended by skilled health personnel 36% Vaccine Age of administration BCG At birth DTP-Hib-HepB 6 weeks, 10 weeks, 14 weeks OPV 6 weeks, 10 weeks, 14 weeks Measles 9 months JE 12-23 months (high-risk districts) TT During pregnancy Vitamin A 6-59 months EPI history n Launched in 1979 and made available to all 75 districts by 1989. n HepB started in 2002 (in phase manner) n DTP-HepB started in 2005. n AD syringes introduced in 2005. n JE introduced in 2007. n DTP-Hib-HepB introduced in 2009. n Plan to introduce MR in 2012/2013. Source: cMYP 2007-2011 and 2011-2016 Immunization system highlights n There is a comprehensive multi-year plan (cMYP) for immunization covering 2011- 2016. n 26 (35%) priority districts had updated micro-plans that include activity to improve immunization coverage. n A standing technical advisory group on immunization is available. It has formal written terms of reference. n Cold chain equipment inventory was updated in 2010. n Out of 75 districts, 57 (76%) had >80% coverage for DTP-Hib-HepB3, 31 (41%) had >90% coverage for MCV1 and 22 (29%) had >80% coverage for TT2+ in pregnant women in 2011. n One (1%) district reported more than 10% drop-out rate for DTP1 to DTP3. n Nepal demographic health survey was conducted in 2011. No coverage survey is planned for the next 24 months. n Vaccine wastage rates 2011: BCG=79%, DTP-Hib-HepB=9%, OPV=23%, MCV=64% and TT=33%. n A national policy for health care waste management including waste from immunization activities is available. n A national system to monitor adverse events following immunization (AEFI) is available. Six AEFI were reported and four events were categorized as “serious” in 2011. n 20% of all spending on vaccine was government financed. n 22% of all spending on routine immunizations was government financed. n Routine vaccines: BCG, OPV, Measles, TT and JE are procured from government funds, and Pentavalent (DTP-Hib-HepB) is co-financed by the government. n A follow-up on the 2010 VPD surveillance review recommendations was completed in May 2011. n For intensification of routine immunization in 2012, Nepal has a plan to reach high- risk areas, migrant/un-reached population and low performing areas. n There is a draft “Immunization Act – 2012”. Total population 27,976,661 Live births 689,020 Children <1 year 655,777 Children <5 years 3,338,608 Children <15 years 11,125,854 Pregnant women 765,578 Women of child bearing age (15-49 years) 5,541,862 Crude birth rate (per 1000 population) 24.1 Neonates protected at birth against NT 81% Neonatal mortality rate 28 (per 1000 LB) Infant mortality rate 41 (per 1000 LB) Under-five mortality rate 50 (per 1000 LB) Maternal mortality ratio 170 (per 100000 LB) 1 SEAR annual EPI reporting form, 2011 and WHO, world health statistics, 2012 Table 2: Immunization schedule, 2011 Disclaimer: The boundaries and names shown and the designations used on all the maps do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Source: WHO/UNICEF joint reporting form (JRF) 2011
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Page 1: Nepal 2011 - South-East Asia Regional Office expanded programme on immunization (EPI) in Nepal was launched in 1979 ... 2011 0 94 1,733 193 95 (49%) 2,359 1,175 39,023 129 ... epi@ntc.net.np,

Nepal 2011

Immunization andVaccine Development

South-East Asia Region

World Health Organization• SEARO/FHR/IVD • 29 August 2012

Nepal is a landlocked country bordering with India in the east, west and south, and with China in the north. Topographically, Nepal is divided into three distinct ecological zones: the mountain (Himal), the hill and the plain (Terai). Nepal is

divided into five administrative regions and 75 districts. Districts are further divided into village development committees and municipalities. Nepal is the home of 27 millions people and annual population growth rate is 2.1 (2000-2010). Nineteen percent population lives in urban areas. The average household size has decreased from 5.4 in 2001 to 4.7 in 2011. The expanded programme on immunization (EPI) in Nepal was launched in 1979 with two vaccines (BCG and DTP) in three districts. Immunization was made available to all 75 districts by 1989.

Source: Comprehensive multi-year plan 2007-2011; WHO, world health statistics 2012 and Nepal demographic health survey 2011.

Table 1: Basic information1 2011Division/Province/State/Region 5

District 75

Municipality 58

Village development committee 3,915

Ward 36,041

Population density (per sq. km) 181

Population living in urban areas 19%

Population using improved drinking-water sources

89%

Population using improved sanitation 31%

Total expenditure on health as % of GDP 5.5

Literacy rate among adults aged >15 years 59%

Births attended by skilled health personnel 36%

Vaccine Age of administration

BCG At birth

DTP-Hib-HepB 6 weeks, 10 weeks, 14 weeks

OPV 6 weeks, 10 weeks, 14 weeks

Measles 9 months

JE 12-23 months (high-risk districts)

TT During pregnancy

Vitamin A 6-59 months

EPI historyn Launched in 1979 and made available

to all 75 districts by 1989.n HepB started in 2002 (in phase manner)n DTP-HepB started in 2005.n AD syringes introduced in 2005.n JE introduced in 2007.n DTP-Hib-HepB introduced in 2009.n Plan to introduce MR in 2012/2013.

Source: cMYP 2007-2011 and 2011-2016

Immunization system highlights

n There is a comprehensive multi-year plan (cMYP) for immunization covering 2011-2016.

n 26 (35%) priority districts had updated micro-plans that include activity to improve immunization coverage.

n A standing technical advisory group on immunization is available. It has formal written terms of reference.

n Cold chain equipment inventory was updated in 2010.

n Out of 75 districts, 57 (76%) had >80% coverage for DTP-Hib-HepB3, 31 (41%) had >90% coverage for MCV1 and 22 (29%) had >80% coverage for TT2+ in pregnant women in 2011.

n One (1%) district reported more than 10% drop-out rate for DTP1 to DTP3.

n Nepal demographic health survey was conducted in 2011. No coverage survey is planned for the next 24 months.

n Vaccine wastage rates 2011: BCG=79%, DTP-Hib-HepB=9%, OPV=23%, MCV=64% and TT=33%.

n A national policy for health care waste management including waste from immunization activities is available.

n A national system to monitor adverse events following immunization (AEFI) is available. Six AEFI were reported and four events were categorized as “serious” in 2011.

n 20% of all spending on vaccine was government financed.

n 22% of all spending on routine immunizations was government financed.

n Routine vaccines: BCG, OPV, Measles, TT and JE are procured from government funds, and Pentavalent (DTP-Hib-HepB) is co-financed by the government.

n A follow-up on the 2010 VPD surveillance review recommendations was completed in May 2011.

n For intensification of routine immunization in 2012, Nepal has a plan to reach high-risk areas, migrant/un-reached population and low performing areas.

n There is a draft “Immunization Act – 2012”.

Total population 27,976,661

Live births 689,020

Children <1 year 655,777

Children <5 years 3,338,608

Children <15 years 11,125,854

Pregnant women 765,578

Women of child bearing age (15-49 years)

5,541,862

Crude birth rate (per 1000 population)

24.1

Neonates protected at birth against NT

81%

Neonatal mortality rate 28 (per 1000 LB)

Infant mortality rate 41 (per 1000 LB)

Under-five mortality rate 50 (per 1000 LB)

Maternal mortality ratio 170 (per 100000 LB)

1 SEAR annual EPI reporting form, 2011 and WHO, world health statistics, 2012

Table 2: Immunization schedule, 2011

Disclaimer: The boundaries and names shown and the designations used on all the maps do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.

Source: WHO/UNICEF joint reporting form (JRF) 2011

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E P I F a c t S h E E t

World Health Organization• SEARO/FHR/IVD • 29 August 2012

Source: WHO/UNICEF estimates, 2012

Figure 2: DTP3 coverage1, diphtheria and pertussis cases2, 1980-2011

Figure 3: DTP-Hib-HepB3 coverage by district, 2011

Figure 5: MCV1 coverage by district, 2011

602112166

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1980 1985 1990 1995 2000 2005 2006 2007 2008 2009 2010 2011

Year

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Diphtheria cases Pertussis cases DTP3 coverage

1 WHO/UNICEF estimates, 20122 WHO vaccine-preventable diseases: monitoring system 2012 global summary

1 WHO/UNICEF estimates, 20122 WHO vaccine-preventable diseases: monitoring system 2012 global summary

Source: SEAR annual EPI reporting form, 2011 (administrative data)

Source: SEAR annual EPI reporting form, 2011 (administrative data)

0

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1980 1985 1990 1995 2000 2005 2006 2007 2008 2009 2010 2011

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Measles cases MCV1 coverage

93974810 5023

<70% 70% - 79% 80% - 89% > 90%

<70% 70% - 79% 80% - 89% > 90%

Figure 4: MCV1 coverage1 and measles cases2, 1980-2011

Figure 1: National immunization coverage, 1980-2011

0

20

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over

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BCG 22 67 74 76 84 87 93 89 87 94 94 97

DTP3 8 32 43 54 74 75 89 82 82 89 82 92

OPV3 20 42 50 74 78 91 82 82 93 83 92

MCV1 34 57 56 71 74 85 81 79 90 86 88

1980 1985 1990 1995 2000 2005 2006 2007 2008 2009 2010 2011

Note: DTP-Hib-HepB introduced in 2009 (2005-2008 DTP-HepB)

Page 3: Nepal 2011 - South-East Asia Regional Office expanded programme on immunization (EPI) in Nepal was launched in 1979 ... 2011 0 94 1,733 193 95 (49%) 2,359 1,175 39,023 129 ... epi@ntc.net.np,

Immunization andVaccine Development

South-East Asia Region

1 Country official estimates, 1980-20112 WHO vaccine-preventable diseases: monitoring system 2012 global summary

Table 3: OPV supplementary immunization activities, 2008-2011

Figure 7: Network of surveillance medical officers (SMOs) and laboratories, 2011

Year Activity Target population (<5 years) Date of 1st round Date of 2nd round 1st round coverage (%)

2nd round coverage (%)

2008 SNID 2,386,263 15-Mar-08 26-Apr-08 96 94

2008 Mop-up 199,751 6-Aug-08 - 98 -

2008 Mop-up 540,115 10-Sep-08 22-Oct-08 90 93

2008 Mop-up 340,364 22-Nov-08 - 92 -

2009 NID 4,466,960 28-Feb-09 4-Apr-09 93 92

2010 NID 4,466,960 10-Apr-10 22-May-10 88 89

2010 Mop-up 2,873,388 19-Jun-10 - 92 -

2010 Mop-up 1,096,948 17-Jul-10 31-Jul-10 98 98

2010 Mop-up 2,015,085 14-Aug-10 - 96 -

2010 Mop-up 1,096,948 18-Sep-10 - 100 -

2010 Mop-up 436,617 2-Oct-10 30-Oct-10 102 104

2010 Mop-up 436,617 20-Nov-10 - 101 -

2011 NID 4,466,960 12-Feb-11 12-Mar-11 91 92

2011 SNID 1,110,222 12-Nov-11 10-Dec-11 98 99

Figure 6: TT2+ coverage1 and NT cases2, 1980-2011

Source: WHO/UNICEF JRF

• Nepalachievedthematernalneonataltetanus(MNT)eliminationstatusofin2005.

0

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120

140

1980 1985 1990 1995 2000 2005 2006 2007 2008 2009 2010 2011

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over

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NT cases TT2+ coverage

511

Source: WHO/IPD Nepal, August 2012

MCV supplementary immunization activities• Thefirstcatch-upmeaslescampaignwas

conductedinthreephasesin2004-2005targeting9,423,866childrenaged9monthsto<15years.Theachievementwas104%.

• Ameaslesfollow-upcampaignwasconductedin2008targeting3,903,515childrenaged9monthsto5years.Theachievementwas93%.

• Ontheplannedmeasles-rubella(MR)campaignfor2012,Nepal(atthetimeofprintingthisfactsheet)hasconductedthefirstphaseinFebruary2012targeting1,786,088children9monthsto<15years.Theachievementwas103%.

• ThesecondphaseMRcampaignwillbeconductedinSeptember2012andthethirdphaseisplannedfor2012-2013.

• OnedoseOPVisgiventoallchildren<5yearsduringMRcampaign.

National Public Health Laboratory - National measles/rubella laboratory - National Japanese encephalitis (JE)

laboratory BP Koirala Institute of Health Sciences - JE laboratory

Invasive bacterial disease (IBD) laboratories - Patan Hospital - Kanti Children Hospital

Rotavirus laboratory - Tribhuvan University Teaching Hospital

11 Field Offices (15 SMOs)

Central Office, WHO-IPD

Damak, JhapaBiratnagar, MorangLahan, SirahaJanakpur, DhanushaHetauda, MakwanpurKathmandu (Valley)Kathmandu (North)Pokhara, Kaski (East)Pokhara, Kaski (West) Butwal, RupandehiNepalgunj, BankeNepalgunj, Banke (West)Birendranagar, SurkhetDhangadi, Kailali (East)Dhangadi, Kailali (West)

SMO Location:

Page 4: Nepal 2011 - South-East Asia Regional Office expanded programme on immunization (EPI) in Nepal was launched in 1979 ... 2011 0 94 1,733 193 95 (49%) 2,359 1,175 39,023 129 ... epi@ntc.net.np,

World Health Organization• SEARO/FHR/IVD • 29 August 2012 Immunization andVaccine Development

South-East Asia Region

E P I F a c t S h E E t

Indicator 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011

AFP cases 197 192 214 230 364 343 425 451 604 568

Wild polio 0 0 0 4 5 5 6 0 6 0

Compatibles 1 1 0 2 1 0 0 0 0 0

AFP rate 2.01 1.91 2.16 2.31 3.57 3.29 3.99 4.14 5.52 5.11

Non-polio AFP rate1 2.00 1.90 2.16 2.25 3.50 3.24 3.93 4.14 5.47 5.11

Adequate stool collection rate2 87% 86% 84% 84% 86% 83% 87% 88% 88% 89%

Total stool samples collected 387 374 414 443 720 658 782 887 1,134 1,102

% NPEV 33 20 29 20 23 20 18 18 20 17

% Timeliness of primary result reported3 98 100 99 100 98 100 100 100 100 1001 Number of discarded AFP cases per 100,000 children under 15 years of age.2 Percent with 2 specimens 24 hours apart and within 14 days of paralysis onset.3 2002 to 2007 result reported within 28 days and 2008 onwards result reported within 14 days of sample received at laboratory.

Year Polio Diphtheria Pertussis Total Tetanus Neonatal Tetanus (% of all Tetanus)

Measles Rubella Mumps Japanese Encephalitis

2002 0 108 4,683 241 92 (38%) 6,749 ND ND -

2003 0 173 4,479 114 51(45%) 13,344 ND ND -

2004 0 81 3,708 104 27 (26%) 12,047 ND ND 371

2005 4 46 2,170 112 29 (26%) 5,023 ND ND 669

2006 5 72 1,092 240 42 (18%) 2,838 ND ND 295

2007 5 44 879 155 32 (21%) 1,415 227 ND 442

2008 6 149 2,297 308 53 (17%) 2,089 781 ND 339

2009 0 277 2,357 276 18 (7%) 189 1275 27,880 147

2010 6 146 2,293 547 13 (2%) 190 510 29,022 197

2011 0 94 1,733 193 95 (49%) 2,359 1,175 39,023 129

Table 5: Reported cases of vaccine preventable diseases, 2002-2011

Table 4: AFP surveillance performance indicators, 2002-2011

Figure 8: Non-polio AFP rate by district, 2011 Figure 9: Adequate stool collection rate by district, 2011

Data as of 30 July 2012

For contact or feedback:

Expanded Program on Immunization

Child Health Division, Department of Health Services

Teku, Kathmandu, Nepal

Tel: +977-1-4261660, 4261463, Fax: +977-1-4262263

Email: [email protected], [email protected], www.mohp.gov.np

Immunization and Vaccine Development (IVD)WHO-SEARO, IP Estate, MG Marg, New Delhi 110002, India

Tel: +91 11 23370804, Fax: +91 11 23370251

Email: [email protected], www.searo.who.int/vaccine

Non-polio AFP rate = 5.11< 1 1 – 1.99 > 2 No non-polio AFP case

--

Adequate stool collection rate = 89%< 60% 60% – 79% > 80% No AFP case– >

Source: WHO/UNICEF JRF ND = No data

• Lastindigenouswildpoliovirus(WPV3)wasreportedfromSirahadistrictinNovember2000.• Lastimportedwildpoliovirus(WPV1)wasreportedfromRautahatdistrictinAugust2010.


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