NEURO SCIENCE 1
MODULE
STUDY GUIDE KGMC
This Study guide of the module/course outlines
the key components and areas for the
facilitation of the students.
Department of Medical Education
1
Contents
Vision and Mission of KGMC ................................................................................................................................................................................................
Khyber Medical University: Vision .......................................................................................................................................................................................
Khyber Girls Medical College: Vision ...................................................................................................................................................................................
Khyber Girls Medical College: Mission ................................................................................................................................................................................
Curriculum Committee KGMC ..............................................................................................................................................................................................
Module committee ...............................................................................................................................................................................................................
Integrated curriculum: .........................................................................................................................................................................................................
Outcomes of the curriculum: ...............................................................................................................................................................................................
KNOWLEDGE .....................................................................................................................................................................................................................
PSYCH OMOTOR ...............................................................................................................................................................................................................
AFFECTIVE .........................................................................................................................................................................................................................
Introduction to the Course/Module .....................................................................................................................................................................................
General Learning Outcomes of the Module/Course ............................................................................................................................................................
Theme 1 ................................................................................................................................................................................................................................
Specific learning objectives of the theme 1 ..........................................................................................................................................................................
Theme 2 ................................................................................................................................................................................................................................
Theme 3 ................................................................................................................................................................................................................................
Specific learning objectives of the theme 3 ..........................................................................................................................................................................
Theme 4 ................................................................................................................................................................................................................................
Theme 5 ................................................................................................................................................................................................................................
Teaching and learning strategies: .........................................................................................................................................................................................
Time tables: ...........................................................................................................................................................................................................................
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Assessment tools: .................................................................................................................................................................................................................
Internal Evaluation: ...............................................................................................................................................................................................................
Attendance Requirement: ....................................................................................................................................................................................................
Learning resources: ...............................................................................................................................................................................................................
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Vision and Mission of KGMC
Khyber Medical University: Vision
Khyber Medical University will be the global leader in health sciences
academics and research for efficient and compassionate health care.
Khyber Girls Medical College: Vision
Khyber Girls Medical College will promote health care leaders that are critical thinker,
ethical, research oriented, culturally and professionally competent
Khyber Girls Medical College: Mission
To develop competent health care leaders by ensuring appropriate policies,
procedures which reflect ethical, cultural, community orientated and evidence based
practices to achieve best possible health outcomes for society at large.
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Curriculum Committee KGMC
Chair:
Professor Dr. Muhammad Noor Wazir, Dean KGMC.
Co-Chair:
Dr. Sabina Aziz, Associate Dean KGMC.
Clinical Sciences:
• Dr. Said Amin Department of Medicine KGMC/HMC.
• Dr. Sofia Iqbal, Department of Ophthalmology KGMC/HMC.
• Dr. Ghareeb Nawaz Department of ENT KGMC/HMC.
• Dr. Bushra Rauf Department of Gynae KGMC/HMC.
• Dr. Jamshed Alam Department of Surgery KGMC/HMC.
• Dr. Ambreen Ahmad, Department of Pediatrics KGMC/HMC.
• Dr. Ain-ul-Hadi Department of Surgery KGMC/HMC.
• Dr. Fawad Rahim Department of Medicine KGMC/HMC.
Behavioral Sciences:
• Dr. Ameer Abbas Department of Psychiatry KGMC/HMC.
Medical Education
• Dr. Naheed Mahsood, Department of Medical Education, KGMC.
• Dr. Naveed Afzal Khan, Department of Medical Education, KGMC.
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Basic Sciences:
• Dr. Khalid Javed Department of Pathology, KGMC.
• Dr. Zubia Shah Department of Physiology, KGMC.
• Dr. Amin-ul-Haq Department of Biochemistry, KGMC.
• Dr. Naheed Siddique Department of Forensic Medicine, KGMC.
• Dr. Shams Suleman Department of Pharmacology, KGMC.
• Dr. Raheela Amin Department of Community Medicine, KGMC.
• Dr. Shahab-ud-Din, Department of Anatomy, KGMC.
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Module committee
Neuroscience-I 1. Dr. Shahab ud Din Associate Professor Department of Anatomy...Module Coordinator 2. Dr. Naheed Mehsood Assistant Professor DME .................Module Secretory: 3. Dr. Naveed Afzal Khan Coordinator DME ............................Module Secretory 4. Dr. Shams Suleman Associate Admin…………………………….………Member: 5. Dr. Raheela Amin Professor Department of Community Medicine………...Member 6. Dr. Khalid Javed Professor Department of Pathology…………………… Member 7. Dr. Nabila Sher Associate Professor Department of Biochemistry…Module Coordinator 8. Dr. Said Amin Associate Professor Department of Medicine…………Member 9. Dr. Zubia Shah Assistant Professor Department of Physiology………... Member 10. Dr. Zahid Sarfaraz Assistant Professor Department of Anatomy………... Member 11. Dr. Ayesha Jamil Assistant Professor Department of Pharmacology…..Member 12. Dr. M. Zia ul Haq Assistant Professor Department of Surgical A ………Member 13. Dr. Rizwanullah Khattak Assistant Professor Department of Surgical B ….Member 14. Dr. Ameer Abbas Assistant Professor Department of Behavioral Sciences…Member 15. Dr. Afsheen Mehmood Assistant Professor Department of Physiology…….........Member 16. Dr. Shahid Ayub Assistant Professor Department of Neurosurgery…………….Member 17. Dr. Salma Akbar Principal Demonstrator Department of Community Medicine..Member 18. Dr. Naila Anjum Senior Lecturer Department of Pharmacology………….Member 19. Dr. Gulnaz begun Senior Lecturer Department of Biochemistry…………. Member 20. Dr. Asad Jahangir Senior Lecturer Department of Forensic Medicine………….Member 21. Dr onaiza nasim lecturer DME …………………………..Member 22. Miss. Noor Fatima Student of Final Year…………………………………Member 23. Miss. Soaiba Naeem Student of Final Year…………………………………Member
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Integrated curriculum:
An integrated curriculum is all about making connections, whether to real life or across the disciplines, about skills or about
knowledge. An integrated curriculum fuses subject areas, experiences, and real-life knowledge together to make a more fulfilling and
tangible learning environment for students. Integrated teaching means that subjects are presented as a meaningful whole. Students
will be able to have better understanding of basic sciences when they repeatedly learn in relation to clinical examples. Case based
discussions, computer-based assignments, early exposure to clinics, wards, and skills acquisition in skills lab are characteristics of
integrated teaching program.
Outcomes of the curriculum: The outcomes of the curriculum of MBBS According to the PMDC are as follows
• Knowledgeable
• Skilful
• Community Heath Promoter
• Problem-solver
• Professional
• Researcher
• Leader and Role Model
KNOWLEDGE
By the end of five year MBBS program the KGMC student should be able to;
1. Acquire a high level of clinical proficiency in history taking, physical examination, differential diagnosis, and the effective use of
medicine’s evolving diagnostic and procedural capabilities including therapeutic and palliative modalities
2. Manage the common prevalent diseases in community
3. Identify the common medical emergencies
4. Develop plan for prevention of common community diseases
5. Formulate a referral plan
6. Compose a prescription plan
PSYCH OMOTOR By the end of five year MBBS program the KGMC student should be able to;
1. Demonstrate the ability to perform the disease specific relevant examination
2. Respond to common medical emergencies
3. Master the skill of first aid
4. Perform BLS
1
5. Apply the best evidenced practices for local health problems
AFFECTIVE By the end of five year MBBS program the KGMC student should be able to
1. Relate to patient and careers vulnerability
2. Demonstrate ethical self-management
3. Counsel and educate patients and their families to empower them to participate in their care and enable shared decision-
making.
4. Display compassion with patient and colleagues
5. Demonstrate in clinical care an understanding of the impact of psychological, social, and economic factors on human health and
disease
2
Introduction to the Course/Module
This is neuroscience module aimed at learning different areas of brain and its working, along with
different pathologies associated with it.
Neuroscience describes the scientific study of the mechanics of the central nervous system such as its
structure, function, genetics and physiology as well as how this can be applied to understand diseases
of the nervous system.
The outline of the module is under
1) Numbness and tingling 1 week
2) Paraplegia 1 week
3) Syncope 1 week
4) Hemiplegia / Aphasia 1 week
5) Tremors 1 week
6) Headache 1 week
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General Learning Outcomes of the Module/Course By the end of this module the students should be able to;
Knowledge
1) Explain the gross and microscopic structural and functional features of peripheral nerves, spinal cord and brain.
2) Describe the development of forebrain, midbrain and hindbrain
3) Describe the basic functions of synapses, neurotransmitters and mechanisms of electrical events during neuronal excitation
4) Explain the structure and functions of different receptors during neuronal excitation
5) Describe the mechanisms and pathways of sensory inputs in the nervous system
6) Explain the organization, structure, functions, and neurotransmitters of autonomic nervous system
7) Describe the blood supply and venous drainage of brain and spinal cord
8) Describe the organization, structure and functions of motor system of the brain and spinal cord.
9) Describe the functions of limbic system and reticular activating system
10) Describe the pathophysiology and prevention of common diseases like stroke, epilepsy, hydrocephalus and brain injuries.
Skills
1) Identify the microscopic structure of spinal cord, cerebral and cerebellar cortex
2) Examine nervous system of a standardized patient (sensations, motor functions, and higher cortical functions and tendon
reflexes).
Attitude
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1. Demonstrate campassion and care for patients while performing the nervous system examination
2. Demonstrate the team work while working in the hospital envoirment.
3. Show good communication skills while performing tasks.
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Theme 1
Numbness and Tingling
Numbness or tingling is an unpleasant sensation in which there is reduced or absent feeling in the skin or a "pins and needles" sensation. The most common reason for numbness or tingling is a problem with nerve function, either because the nerve itself is injured, something is pressing on the nerve, or an imbalance in the body's chemistry interferes with nerve function. Most causes are not dangerous, but when muscle weakness or paralysis is also present, numbness and tingling should be treated as an emergency. Everyone experiences numbness, tingling, or a burning sensation on occasion. You probably have felt it when you stood up after sitting in one position for a long time. Usually it resolves within minutes
In some cases, feelings of numbness and tingling or burning can indicate a serious injury or medical condition. many pathologies are associated with this theme. Seek urgent care if any of these symptoms are present:
• a back, neck, or head injury
• inability to walk or move
• loss of consciousness, even if only for a short time
• feelings of confusion or trouble thinking clearly
• slurred speech
• vision problems
• feelings of weakness or severe pain
• losing control of your bowels or bladder
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Specific learning objectives of the theme 1
Topic
Learning objectives MIT Assessment strategy
Gross Anatomy overview of nervous system
Describe general features of neurons and its classification. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Differentiate between central and peripheral nervous system INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Describe the general features of brain(forebrain,midbrain and hindbrain)
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Describe the general features of spinal cord including its enlargements at different levels
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Describe the general features of cranial and spinal nerves INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Differentiate between different anatomical aspects of sympathetic and parasympathetic system
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
Embryology
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forebrain, midbrain,hindbrain
Describe the development of primary and secondary brain vesicles INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Enlist the derivates of the brain vesicles. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Describe the development of prosencephalon, mesencephalon and rhombencephalon
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Discuss congenital anomalies associated with each region of brain. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Physiology
(organization of the nervous system)
Describe general design of the nervous system INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe various divisions of the nervous system INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the structional unit of nervous system INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Functional components of Neuron. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
8
Describe Functional and Structural classification of Neurons INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe major levels of central
nervous system function
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Glial cells and their functions. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Compare nervous system to a computer INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Basic Functions of Synapses Define and classify synapses INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Explain physiological structure of synapse INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Mechanism by Which an Action Potential Causes
Transmitter Release from the Presynaptic Terminals
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe synaptic transmission and explain properties of synaptic
transmission.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe mechanism of action of neurotransmitter on the post
synaptic membrane.
INTERACTIVE ACC TO GAGNES 9
MCQ
9
EVENTS OF INSTRUCTION
Describe Second messenger system in the post synaptic neuron INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Functions of
neurotransmitters
Define the characteristics of a neurotransmitter INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Enumerate the neurotransmitters involved in central nervous
system.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Classify neurotransmitters and describe the actions of some
common neurotransmitters in central nervous system.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Electrical events during
neuronal excitation/inhibition
Describe resting membrane potential of the neuronal soma. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Effect of Synaptic Excitation on the Postsynaptic
Membrane—Excitatory Postsynaptic Potential.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Effect of Inhibitory Synapses on the Postsynaptic
Membrane—Inhibitory Postsynaptic Potential.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Generation of Action Potentials in the Initial Segment of
the Axon Leaving the Neuron—Threshold for Excitation
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
10
Sensory receptors Define and classify receptors. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Classify receptors according to their location in the body. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe specific functions of receptors. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Receptor or generation potential INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Discuss mechanism of action of sensory transduction. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Coding of the sensory
information
Describe Doctrine of specific nerve energies INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Modality of Sensation—The “Labeled Line Principle” INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Define and discuss law of projection INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Discuss properties of stimulus; modality, Stimulus location Stimulus
intensity Stimulus duration
INTERACTIVE ACC TO GAGNES 9
MCQ
11
EVENTS OF INSTRUCTION
Describe Frequency of action potentials with threshold level of
receptor potential
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Transmission and Processing
of Signals in CNS
Describe Relaying of signals through
Neuronal pools; Divergence, Convergence, Prolongation of Signals
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Types of nerve fibers, its
regenerationand
degeneration
Describe the mechanism of degeneration & regeneration. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the duration required for regeneration inside & out of
CNS.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Enumerate the causes of degeneration. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Discuss Wallerian degeneration INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Identify the microscopic appearance of degenerating neurons INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Somatic sensations Describe Tactile receptors in the skin and their functions: Pacinian
corpuscles, Meissner’s corpuscles, Ruffini endings, Merkle cell, A-
delta and C free nerve endings
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
12
Transmission in the Dorsal
column–medial
Lemniscal system
Describe ascending pathways and enumerate the differences
between the two.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Transmission in the Dorsal column–medial Lemniscal
system
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Spatial Orientation of the Nerve
Fibers in the Dorsal Column–Medial
Lemniscal System
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe two-point discrimination INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Somatosensory cortex Identify the diagrammatic representation of different areas of the
body in the somatosensory cortex I
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Identify Broadman’s areas of cerebral cortex and correlate each
one of them with their respective functions.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the functions of somatosensory area I. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe layers of the somatosensory cortex and their function. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the functions of somatosensory association area INTERACTIVE ACC TO GAGNES 9
MCQ
13
EVENTS OF INSTRUCTION
Transmission of
Sensory signals in the
Anterolateral pathway
Differentiate the submodalities of nondiscriminative touch,
temperature and nociception based on receptor transduction
mechanism, localization within the spinal gray matter, and central
termination of the pathways.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe functional organization at all levels and sub-modalities
served by the anterolateral system and the equivalent components
of the spinal trigeminal system.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
BIOCHEMISTRY
Neurotransmitters
Explain the biosynthesis of different neurotransmitters INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Brain and nervous tissue
metabolism
Describe the metabolism of brain and nervous tissues INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
GENERAL MEDICINE
Describe the etiology and types of peripheral neuropathies INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Peripheral Neuropathies Discuss the clinical presentation and complications of diabetic
neuropathies
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Skill and Affective domain
14
HISTOLOGY
Transverse section of spinal
cord (cervical level) -1
Identify the slide of transverse section of cervical spinal cord under
the microscope
PRACTICAL/DEMO MCQ,OSPE
PHYSIOLOGY
Examination of sensations
Examine the sensations (tactile, position, pain, thermal, vibration)
of lower limb on a standardized patient
PRACTICAL/DEMO MCQ,OSPE
15
Theme 2
it is impairment in motor or sensory function of the extremeties.it is usually caused by spinal cord injury or a congenital condition that
affects the neural elements of the spinal cord.it is sometimes referred to as partial paralysis in which function is impeded from waist
down. Most people with paraplegia have perfectly healthy legs ,the main problem lies in brain or spinal cord, which cannot receive or
send signals.
Paraplegia
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Specific learning objectives of the theme 2
Topic
Learning objectives MIT Assessment strategy
Gross Anatomy
Externals features of
Spinal Cord
Describe the shape, grooves and sulci and extension of spinal cord
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Enlist the segments of spinal cord INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Differentiate between white and grey matter of spinal cord INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Describe the meningeal covering of spinal cord INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Describe the blood supply of spinal cord INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Grey Matter of Spinal Cord Describe the distribution of spinal cord into horns INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Differentiate between anterior, lateral and posterior horns INTERACTIVE ACC TO GAGNES 9
MCQ,OSPE
17
EVENTS OF INSTRUCTION
Describe the distribution of sensory and motor neuron within the
grey matter
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Explain formation of Rexed lamina of spinal cord INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
White matter of spinal
cord
Enumerate the ascending tracts INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Explain the origin, pathway and termination of dorsal column
medial lemniscal system
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Explain the origin, pathway
and termination of anterolateral spinothalamic tract.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Enumerate the descending tracts INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Explain the origin, pathway and termination of pyramidal tracts INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Explain the origin, pathway and termination of extrapyramidal
tracts
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
18
Differentiate between pyramidal and extrapyramidal tracts INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Embryology
Spinal cord Discuss the development of alar and basal plate and its derivatives INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Histology
Spinal cord Identify the light microscopic transverse section of spinal cord at
cervical, thoracic, lumbar and sacral regions
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Draw and label the transverse section of spinal cord at different
levels
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Physiology
Introduction to Motor
Nervous System (General
Principles)
Describe organization of the spinal cord
for motor functions
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Give an overview of the components of nervous system involved in
motor control
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Identify and differentiate upper and lower motor neurons INTERACTIVE ACC TO GAGNES 9
MCQ
19
EVENTS OF INSTRUCTION
Describe the types of anterior horn cells INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the concept of Final Common Path INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe broad types of motor activities INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Motor functions of Spinal
cord I:
Stretch Reflex
Describe structural organization of the muscle spindle INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Define a reflex action and enlist components of reflex arc. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe types of reflexes and their level of integration. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Stretch Reflex INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Differentiate between Static (Tonic) and Dynamic (Phasic) stretch
reflex
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
20
Describe Functions of muscle spindle INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Discuss physiological significance of these reflexes. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Functions of Gamma efferent system INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the role of the muscle spindle in
voluntary motor activity
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Motor functions of Spinal
cord II:
Golgi Tendon Reflex,
Withdrawal Reflexes
Describe Golgi Tendon Reflex INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Differentiate between muscle spindle and Golgi tendon organ. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe types of polysynaptic reflexes and their level of
integration.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Discuss physiological significance of these reflexes. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe reciprocal inhibition and INTERACTIVE ACC TO GAGNES 9
MCQ
21
reciprocal innervation EVENTS OF INSTRUCTION
Support of the body
against gravity,
Reflexes of Posture And
Locomotion
Describe Positive Supportive Reaction INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Cord “Righting” Reflexes. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe stepping and walking movements INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Excitatory-Inhibitory Antagonism
Between Pontine and Medullary Reticular Nuclei
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Vestibular Sensations and
Maintenance of
Equilibrium
Describe the physiologic anatomy of vestibular apparatus INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe function of the utricle and
saccule in the maintenance of static equilibrium
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe function of semicircular ducts INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Neuronal Connections of the Vestibular Apparatus INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
22
Describe Vestibular mechanism for stabilizing the eyes INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Lesions of the Spinal Cord:
Upper and Lower Motor
Neuron lesion
Define muscle tone and describe its significance. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Explain the sequence of events during development of muscle
tone.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Discuss spinal shock INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Differentiate between signs of the upper and lower motor
neurons.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
General medicine
Hemi-section of spinal
cord
Describe the clinical features of Brown Sequard syndrome INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the etiology, clinical features, investigations and
management of a patient with paraplegia.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Skill and affective domain
HISTOLOGY Transverse section of
thoracic segment of spinal
Identify the slide of transverse section of thoracic segments of
spinal cord under the microscope
PRACTICAL/DEMO MCQ,OSPE
23
cord-2
PHYSIOLOGY
Examination of deep
tendon reflexes-1.
Examine a standardized patient for deep tendon reflexes of lower
limbs
PRACTICAL/DEMO MCQ,OSPE
24
Theme 3
Syncope is temporary loss of consciousness usually related to insufficient blood flow to the brain.it most often occurs when
blood pressure is too low(hypotension) and the heart doesn’t pump enough oxygen to the brain.it can be benign or symptom of
an underlying medical condition. There are many types of syncope
• vasovagal syncope
• situational syncope
• postural syncope
• neurologic syncope
• postural tachycardia syndrome
• unknown syncope
syncope
25
Specific learning objectives of the theme 3
Topic
Learning objectives MIT Assessment strategy
Gross Anatomy
Medulla Enlist the components of brain stem LGF/INTEARCTIVE MCQ,OSPE
Describe the external features of brainstem INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Describe the transverse section of medulla at the level of sensory
decussation, motor decussation and inferior Olivary nuclei
LGF/INTEARCTIVE MCQ,OSPE
Enumerate the cranial nerves nuclei present within the medulla INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Pons Describe the transverse section of pons at the level of cranial and
caudal parts
LGF/INTEARCTIVE MCQ,OSPE
Enumerate the cranial nerves nuclei present within the pons INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Midbrain Describe the transverse section of pons at the level of superior
colliculus and inferior colliculus
LGF/INTEARCTIVE MCQ,OSPE
Enumerate the cranial nerves nuclei present within the midbrain INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
PHYSIOLOGY
26
Involuntary function of
brain
Describe the involuntary functions of the brain
LGF/INTEARCTIVE MCQ
Functions of reticular
activating system
Describe the structure and functions of RAS INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Coma and brain death LGF/INTEARCTIVE MCQ
The Autonomic Nervous
System 1
Describe the differences in the locations, level and organization of
sympathetic and parasympathetic nervous system.
LGF/INTEARCTIVE MCQ
Identify the target organs of sympathetic and parasympathetic
nervous system.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the distribution of afferent and efferent sympathetic and
parasympathetic fibers to their respective target organs.
LGF/INTEARCTIVE MCQ
Contrast the sympathetic and parasympathetic branches of the
autonomic nervous system based on: spinal cord division of origin,
length of preganglionic and postganglionic neurons,
neurotransmitters and receptors at the ganglionic and target organ
synapse.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
The Autonomic Nervous
System 2
Discuss basic characteristics of sympathetic and parasympathetic
functions
LGF/INTEARCTIVE MCQ
Describe receptors on the effector organs INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe function of the adrenal medullae LGF/INTEARCTIVE MCQ
Describe sympathetic and parasympathetic “tone” INTERACTIVE ACC TO GAGNES 9
MCQ
27
EVENTS OF INSTRUCTION
Describe “alarm” or “stress” response of
the sympathetic nervous system
LGF/INTEARCTIVE MCQ
Drugs acting on
sympathetic nervous
system
Enlist the drugs acting on SNS and describe their mechanism of
actions
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Drugs acting on
parasympathetic nervous
system
Enlist the drugs acting on PNS and describe their mechanism of
action
LGF/INTEARCTIVE MCQ
Forensic Medicine
Brain death
Certify brain death LGF/INTEARCTIVE MCQ
Describe the medico legal importance of brain death INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Skill and Affective domain
Histology
Transverse section of
lumbar spinal cord-3
Identify the slide of transverse section of Lumbar segment of spinal
cord under the microscope
PRACTICAL/DEMO OSPE,MCQ
Physiology
Examination of deep
Examine a standardized patient for upper limbs tendon reflexes PRACTICAL/DEMO OSPE,MCQ
29
Theme 4
Hemiplegia is paralysis of one side of the body ,it can be muscles of the face,arm or legs on one side of the body.the most
common cause of hemiplegia is stroke,which damages the corticospinal tracts in one hemisphere of the brain…other causes
may include trauma such as
• spinal cord injury,
• brain tumour and
• brain infections.
Hemiplegia
30
Topic
Learning objectives MIT Assessment strategy
Gross Anatomy
Cerebrum
• Grey matter of
cerebrum
• White matter of
• cerebrum
Division of cerebrum into different lobes, its surfaces, sulci and gyri
DISSECTION/DEMO
MCQ,OSPE
Distribution of grey matter in cerebral hemispheres
DISSECTION/DEMO MCQ,OSPE
Enumerate the types of white matter fibers DISSECTION/DEMO MCQ,OSPE
Differentiate between association, projection and commissural
fibers
DISSECTION/DEMO MCQ,OSPE
Detailed account of corpus callosum DISSECTION/DEMO MCQ,OSPE
Diencephalon Structure and important nuclei of Thalamus and Hypothalamus DISSECTION/DEMO MCQ,OSPE
Blood supply of brain Describe the formation of circle of Willis MCQ,OSPE
Histology
Cerebral cortex
Identify the cerebral cortex on light microscope DISSECTION/DEMO MCQ,OSPE
31
Enlist the different histological layers of cerebral cortex DISSECTION/DEMO MCQ,OSPE
Physiology
Cortical Control of Motor
Functions
Describe Motor Functions of Specific Cortical Areas INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe transmission of signal from the motor cortex to the
muscles. (Pyramidal and extrapyramidal).
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Explain the excitation of the spinal cord motor control areas by the
primary motor cortex and red nucleus.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Functions of Descending
Tracts
Describe the functions of Descending Tracts INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Decerebrate and Decorticate Rigidity INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Community Medicine INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
Risk factors of
cerebrovascular diseases
Describe risk factors for the development of cerebrovascular
diseases
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Explain the strategies to prevent cerebrovascular diseases INTERACTIVE ACC TO GAGNES 9
MCQ
32
EVENTS OF INSTRUCTION
General medicine
Stroke
Differentiate between hemorrhagic and ischemic stroke INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the etiology, clinical features, investigations and
prevention of stroke
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Skill and Affective domain
Histology
Cerebral cortex
Identify the histological layers of cerebral cortex under the
microscope
PRACTICAL/DEMO MCQ,OSPE
Physiology
Examination of motor
functions of brain and
spinal cord
Examine a standardized patient for power, tone and movements of
upper and lower limbs, speech, memory and other higher cortical
functions
PRACTICAL/DEMO MCQ,OSPE
33
Theme 5
It is involuntary,rhythmic muscle contraction leading to shaking movements in one or more parts of the body.it is common movement disorder that most often affects the hands but can also occur in the arms,head.vocal cords,torso and legs.tremors may be intermittent or constant.it can occur sporadically or happen as result of another disorder.it is not life threatening ,however it can be embarrsing and even disabling making it difficult or even impossible to perform work and daily life tasks.
Tremors
34
SPECIFIC LEARNING OBJECTIVES THEME 5
Topic
Learning objectives MIT Assessment strategy
Gross Anatomy
Basal nuclei
Enumerate the components of basal nuclei
Describe the structure and relation of corpus striatum, red nucleus and
substantia nigra
DISSECTION/DEMO MCQ,OSPE
Cerebellum Describe the general features of cerebellum DISSECTION/DEMO MCQ,OSPE
Name the lobes of cerebellum and discuss its anatomical and
physiological classification
DISSECTION/DEMO MCQ,OSPE
Enumerate the intracerebellar nuclei of cerebellum DISSECTION/DEMO MCQ,OSPE
Describe the input and output of cerebellum
DISSECTION/DEMO MCQ,OSPE
HISTOLOGY
cerebellum
Identify the cerebellar cortex on light microscope PRACTICAL/DEMO MCQ,OSPE
Enlist the different histological layers of cerebellar cortex PRACTICAL/DEMO MCQ,OSPE
PHYSIOLOGY
Cerebellum I:
Basic Circuit and
Connections
Describe the divisions of cerebellum into 3 lobes and their connections.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Interconnections of neurons of cerebellar cortex INTERACTIVE ACC TO GAGNES 9
MCQ
35
EVENTS OF INSTRUCTION
Describe Cerebellar afferent fibers INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Cerebellar efferent fibers INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the functional circuits of cerebellum INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Cerebellum II: Functions
and Disorders
Explain the functional differences between vermis and cerebellar
hemispheres.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Functions of vestibulocerebellum INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Functions of spinocerebellum INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Functions of cerebrocerebellum INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the clinical abnormalities of cerebellum INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
36
Basal Ganglia I:
Pathways and
connections
Describe the anatomical and physiological classification of basal
ganglia.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the functional circuits of basal ganglia. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe connections of putamen circuit. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe connections of caudate circuit. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Enlist the differences between direct and indirect pathways INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Basal Ganglia II:
Functions and Diseases
Describe functions of putamen circuit. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe functions of caudate circuit. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Explain the clinical problems related to basal ganglia INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
BIOCHEMISTRY
37
Phosphosphingolipids Describe the metabolism of phosphosphingo lipids INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
PHARMACOLOGY
Drugs used in
Parkinson’s disease
Describe the groups of drugs used in Parkinson`s disease and their
mechanism of actions
LGF/INTEARCTIVE MCQ
Medicine
Parkinson`s disease
Describe the pathology, clinical features and treatment of Parkinson`s
disease
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Differentiate between cerebellar and parkinsonian tremors INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Skills and Affective Domain
Histology
Cerebellar cortex
Identify the histological layers of cerebellar cortex under the
microscope
PRACTICAL/SGD MCQ,OSPE
Physiology
Examination of
cerebellum
Illicit cerebellar signs in a standardized patient PRCTICAL/SGD MCQ,OSPE
38
Theme 6
Headaches are pain in any region of the head,the cause ,duration,intensity of this pain can vary according to the type of
headache.nearly everyone experiences some sort of headache ,but it usually subsides on its own or help of painkiller.in some cases it
may require medical attention, there are primary and secondary causes of headache
Headaches
39
Topic
Learning objectives MIT Assessment strategy
Gross Anatomy
Dural venous sinus
Differentiate between paired and unpaired venous sinuses
Discuss the structure and drainage of individual venous sinuses
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE,
CSF in ventricular
system
Discuss the structure of choroidal plexus and the formation of
CSF in ventricles
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ,OSPE
Physiology
Pain Sensation
Pathways
Describe pain receptors and type of stimuli causing pain. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe types of pain. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Explain in detail the pathway for pain. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Pain suppression
(analgesia)
System in the brain and
Define analgesia MCQ
40
Spinal cord
Explain pain suppression system in the brain and spinal cord. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Gate control theory and Brain Opiate system INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe clinical abnormalities of pain:
Primary and Secondary Hyperalgesia
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Headache,
Referred Pain
Define referred pain and describe its mechanism. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the clinical significance of referred pain with
examples.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Enumerate the causes of referred pain. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Enlist the causes of intra-cranial and extra-cranial headache
and correlate with the underlying mechanism of pain.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Thermal Sensations Describe thermal receptors and their excitation INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
41
Describe mechanism of stimulation of thermal receptors INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe transmission of thermal signals
in the nervous system
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Functions of Specific
Cortical Areas (Concept
of Dominant
Hemisphere)
Name the association areas of brain. Briefly describe their
location and function?
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Draw the diagram of cerebral cortex to show the different
functional areas
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Language and Speech Define and classify speech INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe how the brain performs the function of speech. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Broca’s area in the brain, and its function. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe wernicke’s area in the brain, and its function. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the speech pathways for perceiving a heard word and INTERACTIVE ACC TO GAGNES 9
MCQ
42
then speaking the same word & perceiving a written word and
repeating it and correlate it with their clinical significance
EVENTS OF INSTRUCTION
Describe the effects of damage to broca’s area and wernicke’s
area
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe disorders related to speech. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Learning and Memory Define and classify memory and explain its basic mechanism. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the mechanism of synaptic facilitation and synaptic
inhibition
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe consolidation of memory, and briefly describe one of
its most important features.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Codifying of new memories INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Role of specific parts of the brain in the memory process INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Explain disorders related to memory. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
43
Activating-Driving
Systems of the Brain
Describe bulboreticular facilitatory area.
Explain continuous stimulation from lower brain by four
neurohormonal systems.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Explain continuous stimulation from lower brain by four
neurohormonal systems.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Limbic System Describe the principal components of the limbic system:
hippocampus, amygdala, prefrontal cortex, and nucleus
accumbens), the pathways connecting them and their
functions.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Discuss the anatomy of memory and emotion in relation to the
limbic system
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Functions of limbic system INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the connection of hypothalamus with different areas
of brain.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the vegetative and endocrine functions of
hypothalamus.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the behavioral functions of hypothalamus. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Brain Waves and Sleep Describe brain waves. INTERACTIVE ACC TO GAGNES 9
MCQ
44
EVENTS OF INSTRUCTION
Describe the clinical significance of EEG. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Define sleep. Describe its various types and characteristics. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe basic theories of sleep. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe genesis of n-REM and REM sleep. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Enumerate the neurotransmitters involved in sleep. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe various sleep disorders. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Seizures and Epilepsy Define seizure and epilepsy. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Classify seizures & epilepsies INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
45
Enumerate causes of seizure and epilepsy. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Discuss the clinical features of patient presents with epilepsy. INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Discuss the significance of electrophysiologic studies imaging
and other investigations in epilepsy.
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe briefly about pharmacologic treatment. MCQ
CSF formation,
circulation and
functions
Describe regulation of cerebral
blood flow
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe formation, flow, and absorption
of cerebrospinal fluid
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe Blood–Cerebrospinal Fluid and
Blood-Brain Barriers
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
pAlzheimer’s disease Explain the pathogenesis and microscopic findings of
Alzheimer`s disease and its types
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Inflammation of brain Describe the inflammatory processes related to meninges and
brain parenchyma
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
46
Describe the pathogenic mechanisms of meningitis and
encephalitis
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
GENERAL MEDICINE
Epilepsy Explain the types of epilepsy INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe the investigations and enlist anti-epileptic drugs INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Hydrocephalus Describe the etiology, pathogenesis and clinical features of
hydrocephalus
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
RADIOLOGY
Neuroradiology- CT
scans
Describe relevant CT scan findings of intracerebral bleeds,
hematomas and subarachnoid hemorrhage
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe relevant CT scan findings of ischemic strokes INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Neuroradiology- MRI
scans
Describe relevant MR scan findings of intracerebral bleeds,
hematomas
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Describe relevant MR scan findings of ischemic strokes INTERACTIVE ACC TO GAGNES 9
MCQ
47
EVENTS OF INSTRUCTION
Neurosurgery
Brain injuries Describe the types, clinical presentations and investigations of
a patient with head injury
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Brain and spinal tumors Explain the types, clinical features and investigations of brain
and spinal tumors
INTERACTIVE ACC TO GAGNES 9 EVENTS OF INSTRUCTION
MCQ
Skill and affective domain
HISTOLOGY
Slides of the sacral
segments and overview
of nervous tissue
Identify the slides of different neural structures under
microscope
PRACTICAL/DEMO MCQ,OSPE
Physiology
Neurological
examination of upper
and lower limbs
Examine a standardized patient for neurological system of
upper and lower limbs
PRACTICAL/DEMO MCQ,OSPE
48
Teaching and learning strategies:
The following teaching / learning methods are used to promote better understanding:
• Interactive Lectures
• Hospital / Clinic visits
• Small Group Discussion
• Skills session
• Self-Directed Study
49
Interactive lectures:
An interactive lecture is an easy way for instructors to intellectually engage and involve students as active participants in a lecture-
based class of any size. Interactive lectures are classes in which the instructor breaks the lecture at least once per class to have students
participate in an activity that lets them work directly with the material.
• The instructor might begin the interactive segment with an engagement trigger that captures and maintains student attention.
• Then the instructor incorporates an activity that allows students to apply what they have learned or give them a context for
upcoming lecture material.
• As the instructor feels more comfortable using interactive techniques he or she might begin to call upon a blend of various
interactive techniques all in one class period.
Hospital / Clinic visits:
In small groups, students observe patients with signs and symptoms in hospital or clinical settings. This helps students to relate
knowledge of basic and clinical sciences of the relevant module.
50
Small group discussion (SGD):
The shy and less articulate are more able to contribute. Students learn from each other. Everyone gets more practice at
expressing their ideas. A two way discussion is almost always more creative than individual thoughts. Social skills are practiced in a
'safe' environment e.g. tolerance, cooperation. This format helps students to clarify concepts acquire skills or attitudes. Students
exchange opinions and apply knowledge gained from lectures, tutorials and self-study. The facilitator role is to ask probing questions,
summarize, or rephrase to help clarify concepts.
Skills/Practical session:
Skills relevant to respective module are observed and practiced where applicable in skills laboratory or Laboratories of various
departments.
Self-Directed learning (SDL):
Self-directed learning, which involves studying without direct supervision in a classroom/Library, is a valuable way to learn and
is quickly growing in popularity among parents and students. Students’ assume responsibilities of their own learning through individual
study, sharing and discussing with peers, seeking information from Learning Resource Centre, teachers and resource persons within
and outside the college. Students can utilize the time within the college scheduled hours of self-study.
51
Time tables:
The timetables for the module will be shared via Edmodo and the notice boards in advance.
Assessment tools:
Theoretical knowledge is tested by a written examination system constituted by multiple choice questions (MCQs). The assessment of
practical knowledge involves oral, spot, or objective structured practical examinations (OSPE).
Multiple Choice Questions (MCQs):
• Multiple choice questions (MCQs) are a form of assessment for which students are asked to select the best choice from a list of
answers.
• MCQ consists of a stem and a set of options. The stem is usually the first part of the assessment that presents the question as a
problem to be solved; the question can be an incomplete statement which requires to be completed and can include a graph, a
picture or any other relevant information. The options are the possible answers that the student can choose from, with the
correct answer called the key and the incorrect answers called distractors.
• Correct answer carries one mark, and incorrect ‘zero mark’. There is NO negative marking.
• Students mark their responses on specified computer-based sheet designed for the college.
52
• The block exam will comprise of 120 MCQs and will be compiled according to the shared blueprint.
Objective Structured Practical Examination (OSPE):
• The content may assess application of knowledge, or practical skills.
• Student will complete task in define time at one given station.
• All the students are assessed on the same content by the same examiner in the same allocated time.
• A structured examination will have observed, unobserved, interactive and rest stations.
• Observed and interactive stations will be assessed by internal or external examiners.
• Unobserved will be static stations in which students will have to answer the questions related to the given pictures, models or
specimens the provided response sheet.
• Rest station is a station where there is no task given, and in this time student can organize his/her thoughts.
• The Block OSPE will be comprise of 18 examined station and 7 rest stations. The stations will be assigned according to the shred
blueprint.
53
Internal Evaluation:
Internal evaluation is a process of quality review undertaken within an institution for its own ends. 10% marks of internal evaluation
will be added to final marks. This 10% will be based on
Distribution of 14 Marks for paper
Marks obtained Average of Percentage in Block exam
and Pre proffesional exam
Distribution of 10 Marks for Block A OSPE/OSCE
Marks obtained Average of percentage in Block OSPE
Exam and Block Pre Prof OSPE
Practical copies
54
Attendance Requirement:
More than 75% attendance is mandatory to sit for the modular examinations.
Learning resources: The learning resources are as follow
Anatomy
• Snell Neuroanatomy
• B.D Churasia
• Nelter Atlas
• Langman embryology
• Keithalmore embryology
• Laiq Hassain Basic Histology
• Difore Atlas Histology
Physiology
• Guyton nd Hall physiology
• Human Physiology from cells to systems by lauralee sherwood
• Ganong physiology
• BRS Physiology
• Neuroscience by Dale Purves
55
Biochemistry
• Chatterjee text book of Biochemistry
• Harpers Biochemistry
• Lippincotts Biochemistry
• Satya Narayan biochemistry
Apart from these resource learning ,students can consult books available in library or recommended by the specialty experts.