Neuroanatomy
KTH Neuroscience @ KI 2011
Lennart Brodin
Department of Neuroscience
brain
spinal cord
cranial nerves
spinal nerves
The components of the CNS
Telencephalon
Diencephalon
Brainstem
Cerebellum
Spinal cord
Telencephalon
Cerebellum
Cerebral Cortex
Brainstem
Telencephalon:
Hemispheres
Cerebral Cortex
Cerebellum
Telencephalon
Brainstem
Spinal cord
Sectioning the brain - nomenclature
Coronal section
Grey matter: cell bodies
of neuronsWhite matter: nerve tracts,
Myelin gives the white color
Thalamus
Spinal cord
CerebellumHypothalamus
Die
nce
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alo
n
Telencephalon
Brainstem
Sagittal section
Corpus callosum:
Connects the hemi-
spheres
Telencephalon
Thalamus
CerebellumHjärnstammen
Ryggmärgen
Hypothalamus
From CNS Visual Perspectives: www.3d-brain.ki.se
© Anna Josephsson
Die
nce
ph
alo
n
The Cerebral Cortex
SulcusGyrus
The Cerebral Cortex
Grey matter
White matter
Gyrus precentralis:
Motor functions
Gyrus postcentralis:
Sensory functions
Sulcus centralis
moto
r
sensory
vision
Primary areas
hearing
Association areas
The Cerebral Cortex – Division into Functional Areas
Left Right
Cerebral cortex, division into hemispheres
Sulcus centralis
The Cerebral Cortex – Division into Lobes
Frontal lobe
Temporal lobe
Sulcus centralis
The Cerebral Cortex – Division into Lobes
Frontal lobe
Temporal lobe
Sulcus centralis
The Cerebral Cortex – Division into Lobes
Frontal lobe
Parietal lobe
Temporal lobe
Occipital lobe
Sulcus centralis
The Cerebral Cortex – Division into Lobes
Frontal lobe
Parietal lobe
Frontal lobe
Occipital lobe
Temporal lobe
Parietal lobe
The Cerebral Cortex – Division into Lobes
Tinninglob
Hjässlob
Nacklob
Localization of functions to lobes
The Frontal lobe
1848: The famous case of the
railway worker Phineas Gage
gave the first insigths into the
functions of the frontal lobe
The Frontal lobe
Personality
Social competence
Motivation
The Frontal lobe
TemporallobThe temporal lobe recognition
Activation of the temporal lobe during
recognition of a known face
fMRI signal indicates
increased activity
Temporallob
The parietal lobe
attention
Damage of the right parietal lobe
Damage of the right parietal lobe
Temporallob
The occipital lobe
Receives and
processes
visual information
Language: specific regions in the
frontal and temporal lobes
Wernickes area: language perception
Damage results in sensory aphasia
Broca´s area: language expression
Damage results in motor aphasia
Language: specific regions in the
frontal and temporal lobes
Deep brain structures:
subcortical nuclei
Nucleus caudatus
Putamen
Globus pallidus
Telencephalon:
The basal ganglia
Striatum
Subcortikal nuclei
Nucleus caudatus
Putamen
The Basal Ganglia
Putamen
Nucleus
caudatus
The Basal Gangliacoronal section
putamen
globus
pallidus
nucleus
caudatus
The Basal Gangliacoronal section
The Basal Gangliacoronal section
Nucleus
caudatus
Putamen
Globus
pallidus
The Basal Gangliahorisontal section
Nucleus caudatus
Putamen
Globus pallidus
Motor control
Cognition
Emotions
Telencephalon:
The basal ganglia
Striatum
Subcortikal nuclei
Thalamus
Diencephalonhorisontal section
Nucleus caudatus
Putamen
Diencephalon
Thalamus
Diencephalon
Thalamus
Hypothalamus
Diencephaloncoronalsnitt
Thalamus
From CNS Visual Perspectives: www.3d-brain.ki.se
© Anna Josephsson
Hypothalamus
the brains “switch board”:
relays sensory input to the
cerebral cortex
Diencephalon
Thalamus:
Thalamus relays sensory input to the cerebral cortex
cortex
thalamus
nerve fiber from the skin
Hypothalamus
Homeostasis:
Body temperature
Hunger-satiety
Thirst
Emotions
Diencephalon
Hypothalamus
Homeostasis:
Body temperature
Hunger-satiety
Thirst
Emotions
Diencephalon
The pituitary gland:
controls different
hormonal glands
(adrenals, thyroid gland)
The anatomy of emotions
The Limbic System
The “old” view of the limbic system
The anatomy of emotions
The “modern” view of the limbic system:
Anterior part: emotions; Posterior part: memory
Amygdala
The anatomy of emotions
The anatomy of emotions
The “modern” view of the limbic system:
Anterior part: emotions; Posterior part: memory
The Anatomy of Memory
Different Forms of Memory
Declarative memory Non-declarative memory
Memories that can be
described in words
Can not be described
(e.g how to ride a
bicycle)
Brain structures participating in declarative memory:
The posterior part of the limbic system
Hippocampus
Brain structures participating in declarative memory:
The posterior part of the limbic system
Hippocampus seen from below (parts of the temporal lobes removed)
Anatomical Substrates of Different Forms of Memory
Declarative memory Non-declarative memory
Hippocampus
Fornix
Corpus mammilare
Basal ganglia
Cerebellum
Cerebral cortex
The Brainstem
The Brainstem
Mesencephalon
Pons
Medulla oblongata
(I. N. Olfactorii)
(II. N. Opticus)
III. N.Oculomotorius
IV. N.Trochlearis
V. N.Trigeminus
VI. N. Abducens
VII. N. Facialis
VIII. N.Vestibulo-
cochlearis
IX. N. Glosso
-pharyngeus
X. N. Vagus
XI. N. Accesorius
XII. N. Hypoglossus
Cranial nerves emerging from the
brainstem mediate sensory and motor
functions in the head
The Reticular Formation
Descending part:
Motor functions
Ascending part:
Conciousness
The Brainstem - Summary
Cranial nerves: sensory and motor functions in the head incl eye
movements, hearing, balance, inner organs
Reticular
Formation: consciousness, motor functions
Dopamine
systems: motivation, reward, motor functions
Serotonin
systems: mood, emotions, hunger-satiety, motor functions
Other
functions: breathing, swalloving
Cerebellum
Cerebellum: connected to pons via the peduncles
Pons
Medulla
oblongata
Peduncle
Peduncle
Cerebellum
Fine-tuning
of motor
functions
Motor
learning
Cognition
The Spinal Cord
The Spinal Cord
Grey matter
White matter
Dorsal horn - sensory
Ventral horn - motor
cervical
lumbar
thoracic
sacral
sensory nerves
motor nerves
The Spinal Cord
The meninges and the
cerebrospinal fluid
surrounding the brain
The Meninges
Dura mater Arachnoidea mater
Dura materPia mater
The Meninges
Dura mater
Pia mater
Scull bone
Hjärnan
Arachnoidea
Subarach-
noidal space(cerebrospinal
fliud)
The Meninges
The Meninges
Ventricles
Subarach-
noidal space(cerebrospinal
fluid)
The Ventricular System
right lateral ventricleleft lateral ventricle
3rd ventricle4th ventricle
Choroid
plexus
The Ventricular System
The lateral ventricles - horisontal section
From CNS Visual Perspectives: www.3d-brain.ki.se
© Anna Josephsson
Circulation of the cerebrospinal fluid
Reabsorption of cerebrospinal fluid into the blood
Extensions (villi) of the arachnoidea extends into large veins
Blood Supply
A. carotis interna
A. vertebralis
Main arteries supplying oxygenated blood
Aorta
Circulus
Willisi
A.basilaris
A. vertebralis
A.carotis
interna