The Five Senses In the Brain

Neurological DisordersLesson 2.4

How do our neurons transport the materials they need?

nucleussynapse1. 2. 3. 4. 5.

nucleussynapseDo Now:Complete Part 1 on your worksheets.Sort the components into the appropriate neuronal compartments.

DendritesCell BodyAxonWhat would you find in...DendritesCell BodyAxonWhat would you find in...DendritesCell BodyAxonReceptor proteinsIon channelsGrowth factorsWhat would you find in...DendritesCell BodyAxonReceptor proteinsNucleusIon channelsMitochondriaGrowth factorsGolgi apparatus Endoplasmic reticulumSynaptic vesiclesWhat would you find in...DendritesCell BodyAxonReceptor proteinsNucleusIon channelsIon channelsMitochondriaMitochondriaGrowth factorsGolgi apparatus NeurotransmittersEndoplasmic reticulumSynaptic vesiclesSynaptic vesiclesWhat would you find in...DendritesCell BodyAxonReceptor proteinsNucleusIon channelsIon channelsMitochondriaMitochondriaGrowth factorsGolgi apparatus NeurotransmittersEndoplasmic reticulumSynaptic vesiclesSynaptic vesicles

nucleussynapse1. 2. 3. 4. 5.

nucleussynapseMoving components to and from the synapse

nucleussynapse1. 2. 3. 4. 5. Complete Part 2 on your worksheet.Match the process with the number in the picture.

Vesicles are filled with neurotransmitter and then the action potential makes the vesicles release their neurotransmitter into the synapse

The cell body makes hollow spheres of membrane called vesicles

Vesicles that need repairing are transported back to the cell body

Vesicles can be refilled with transmitter or repaired if they are damaged

Vesicles are transported to the synapse on microtubule tracks. 1. 2. 3. 4. 5. Moving components to and from the synapse

nucleussynapse1. 2. 3. 4. 5. Vesicles are transported to the synapse on microtubules tracks.

Microtubules have plus-ends and minus-ends.Plus-ends are oriented toward the synapse.Minus-ends are oriented toward the cell body.How do we do it and how do we do it fast enough?MicrotubulePlus-endMinus-endhttp://www.ovguide.com/vesicle-transport-along-microtubule-9202a8c04000641f80000000052406d7

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Vesicular TransportWhat did you notice about vesicle transport?

nucleussynapse1. 2. 3. 4. 5. Transport can be in two directions.

The same vesicle can move backwards and forwards

Vesicles dont move all the time.

When they are moving, they move at the same speed.

nucleussynapse1. 2. 3. 4. 5. The vesicles must be motorized to allow them to move up and down.How might transport work?

Motor ProteinsKinesinMoves toward plus-end of microtubulesToward the synapseDyneinMoves toward minus-end of microtubulesToward the cell body

Microtubule Plus-endMicrotubule Minus-endDyneinKinesinVesicleVesicleAxonal TransportComplete Part 3 on your worksheet.

For each component, determine:Where it needs to goWhat direction it will travel on the microtubule tracksWhich motor protein it will useWrap Up:ComponentWhere does it need to go?Direction on microtubulesMotor Protein Nerve growth factorNew synaptic vesicleOld synaptic vesicleHerpes simplex virusMitochondriaWrap Up:ComponentWhere does it need to go?Direction on microtubulesMotor Protein Nerve growth factorFrom the synapse to the cell bodyToward the minus-endDyneinNew synaptic vesicleOld synaptic vesicleHerpes simplex virusMitochondriaWrap Up:ComponentWhere does it need to go?Direction on microtubulesMotor Protein Nerve growth factorFrom the synapse to the cell bodyToward the minus-endDyneinNew synaptic vesicleFrom the cell body to the synapseToward the plus-end KinesinOld synaptic vesicleHerpes simplex virusMitochondriaWrap Up:ComponentWhere does it need to go?Direction on microtubulesMotor Protein Nerve growth factorFrom the synapse to the cell bodyToward the minus-endDyneinNew synaptic vesicleFrom the cell body to the synapseToward the plus-end KinesinOld synaptic vesicleFrom the synapse to the cell bodyToward the minus-endDyneinHerpes simplex virusMitochondriaWrap Up:ComponentWhere does it need to go?Direction on microtubulesMotor Protein Nerve growth factorFrom the synapse to the cell bodyToward the minus-endDyneinNew synaptic vesicleFrom the cell body to the synapseToward the plus-end KinesinOld synaptic vesicleFrom the synapse to the cell bodyToward the minus-endDyneinHerpes simplex virusFrom the synapse to the cell bodyToward the minus-endDyneinMitochondriaWrap Up:ComponentWhere does it need to go?Direction on microtubulesMotor Protein Nerve growth factorFrom the synapse to the cell bodyToward the minus-endDyneinNew synaptic vesicleFrom the cell body to the synapseToward the plus-end KinesinOld synaptic vesicleFrom the synapse to the cell bodyToward the minus-endDyneinHerpes simplex virusFrom the synapse to the cell bodyToward the minus-endDyneinMitochondriaFrom cell body to synapseToward the plus-endKinesinHomeworkComplete Part 4 on the worksheet, addressing the question:

How much energy does neuronal transport use?