Neuroscience Outlook Spring 2015 Newsletter

NEWS AND RESEARCH FROM THE DEPARTMENTS OF NEUROLOGY AND NEUROSURGERY AT GEORGIA REGENTS NEUROSCIENCE CENTER

NEUROSCIENCE OUTLOOKVOL. 12 | ISSUE 1

The department of neurosurgery’s International Program fosters global partnershipsWORLD-CLASS CARE

2 NEUROSCIENCE OUTLOOK Volume 12 | Issue 1

NEUROSCIENCE OUTLOOK

FROM THE CHAIRMEN

DEPARTMENT NEWS

Cargill H. Alleyne Jr., MD, and David C.

Hess, MD

A publication of the Georgia Regents University Departments of Neurology and Neurosurgery

Editor-in-chief: Cargill H. Alleyne Jr., MDEditor: Phil MalkinsonIllustrations: Colby Polonsky, MSContributors: Haroon F. Choudhri, MD, Kim Bolodosky, CMTP, Cargill H. Alleyne Jr., MD, Subhashini Ramesh, MD, K. Alfredo Garcia, MD

Welcome to the 24th issue of Neuroscience Outlook, the newsletter of the departments of neurology and neurosurgery. This issue marks the second decade of its publication, and we are proud of the significant accomplishments we have made in the last decade. In the Department News section, we are delighted to report that our institution was named one of the top 25 for Best Practices in Patient and Family Engagement. In the same section, we welcome Dr. Kurek, a neurologist specializing in movement and cognitive disorders, and provide an update on our Comprehensive Stroke Center, the first in Georgia to be certified by The Joint Commission. In the Clinical Spotlight, we focus on the expanding International Program in the neurosurgery department and the advances in neurocritical care in our combined unit. We complete this issue with a list of our philanthropic donors to whom we are deeply grateful, faculty accomplishments, and publications and presentations in our combined departments. As always, we hope these pages give our readers insight into the progress we have made as we strive to maintain excellence in our tripartite missions.

Cargill H. Alleyne Jr., MDProfessor and Marshall Allen Distinguished Chair of [email protected]

David C. Hess, MDProfessor and Presidential Distinguished Chair of [email protected]

Georgia Regents Medical Center (GRMC) houses the region’s only Comprehensive Stroke Center (CSC), providing acute and complete stroke care to Augusta, the Central Savannah River Area, and rural counties throughout Georgia and into South Carolina. The CSC consists of the GRMC Emergency Department (ED), an 18-bed neurointensive care unit staffed by fellowship-trained neurointensivists, and an adjacent 16-bed medical/surgical stroke ward. In-house neurology and neurosurgery coverage is available 24/7/365.

Through the use of telemedicine via the Remote Evaluation for Acute Ischemic Stroke (REACH) network, GRMC provides telestroke and teleneurology consults to 26 hospitals in Georgia and South Carolina. Having a vascular neurologist virtually at the bedside facilitates decisions regarding rt-PA administration and acute management. Patients can then be transferred to a higher level of care or hub if needed for neurointensive care, endovascular therapy, or neurosurgical intervention.

Last year, 254 stroke patients were admitted to GRMC through the ED (211 ischemic strokes and TIAs, 10 SAH, and 33 ICH) and another 279 stroke patients were transferred in from other hospitals, mostly from REACH referrals (178 ischemic strokes and TIAs, 30 SAH, and 71 ICH). Thirty-three (16 percent) received rt-PA in the GRMC ED, and REACH recommended the administration of rt-PA 182 times. Among the 163 ischemic stroke patients transferred from an outside ED, 34 (21 percent) were treated with rt-PA over REACH.

Subarachnoid hemorrhage cases are managed collaboratively by specialists with expertise in endovascular neurosurgery and neurointensive care.

GRMC was the first Joint Commission-certified CSC in Georgia. Recent accolades include American Heart Association Target Stroke Honor Roll Elite and Get with the Guidelines–Stroke Gold Plus recognition for 2014. Target Stroke Honor Roll Elite status is awarded to facilities with a door-to-needle time of less than 60 minutes in 75 percent or more of patients treated with rt-PA. Guidelines–Stroke Gold Plus recognition is the highest award given to stroke centers that consistently adhere to stroke treatment quality measures for a timeframe greater than 24 months. GRMC is dedicated to being the regional leader in stroke care by providing exceptional, state-of-the-art quality and expertise in patient care; by educating our patients, community, health care partners, and trainees in stroke prevention and treatment; and by fostering research into innovative treatments for stroke patients.

Jeffrey Switzer, DO, and William Todd, MSN, FNP

Comprehensive Stroke CareGRMC is a regional leader in stroke care, fostering innovative treatments and delivering state-of-the-art patient care

GRMC was the first Joint Commission-certified CSC in Georgia. Recent accolades include American Heart Association Target Stroke Honor Roll Elite and Get with the Guidelines– Stroke Gold Plus recognition for 2014.

3Volume 12 | Issue 1 gru.edu/neuro

FACULTY & STAFF UPDATESCargill H. Alleyne Jr., MD, (department of neurosurgery) submitted a patent application (Patent filed 9/22/14). Alleyne CH, Dhandapani KM, Wen K, Ma M, Hu

W, with Georgia Regents University. Protective effects of curcumin against hemorrhagic stroke injury GRU 2007-048.

Krishnan M. Dhandapani, PhD, (department of neurosurgery) chaired the American Heart Association Brain 2 Study Section and the VA Neurobiology C

(NURC) Study Section. He was also an ad hoc reviewer for the Henry M. Jackson Foundation. In addition, he submitted a patent with Dr. Alleyne (see above).

Ian Heger, MD, (department of neurosurgery) was recently inducted into the Alpha Omega Alpha Honor Medical Society.

David C. Hess, MD, (department of neurology) was moderator and session organizer at the session on “Peripheral to Central Signaling,” Brain

Edema 2014 and 2nd Preconditioning Conference, Huntington Beach, California, in September 2014. He was also an NIH study section reviewer at the NSD-K Study Section and the Udall Study Section in November and December, respectively.

Sergei A. Kirov, PhD, (department of neurosurgery) was awarded an R01 grant (R01NS083858); PI, “Synaptic Circuitry in Stroke” National Institute

of Neurological Disorders and Stroke. Sept 14, 2014–May 31, 2018; Percentile: 6.0; Impact score: 20; Funding: $1,438,360. He was also an American Heart Association Grant Reviewer for the National Innovative Research Grant (IRG) Vascular Sciences (Brain) BSc1in October 2014.

Julie Kurek, MD, joined the department of neurology Nov. 1, 2014, as Assistant Professor in the movement and cognitive disorders section. Julie completed her neurology residency at Columbia in NYC and a Movement Disorder fellowship at North Shore Long Island Jewish Medical Center. Dr. Kurek is interested in deep brain stimulation, Parkinson’s disease, and movement disorders.

Figure 1. Ischemic strokes and TIAs by county; FY 2014

Figure 2. SAH by county; FY 2014

Figure 3. ICHs by county; FY 2014

Patient-Centered CareGeorgia Regents Medical Center was named to a list of 25 of the Nation’s Best Practices in Patient and Family Engagement by Caregiver Action Network (one of the nation’s leading family caregiver organizations). Only nine U.S. hospital systems were recognized, and GRMC was the only one in Georgia so named. Our neuroscience unit was the first adult service at GRU to adopt a patient-centered care approach and was featured on the PBS home video “Remaking American Medicine—Healthcare for the 21st Century” in 2006. Formerly the National Family Caregivers Association, CAN is a nonprofit organization providing complimentary education, peer support, and resources to family caregivers across the nation.

Welcome…


CLINICAL SPOTLIGHT

The department of neurosurgery at GRU has a long history of collaboration with colleagues throughout the United States and around the world. These ties have grown exponentially in recent years and are reflected in all aspects of our tripartite mission.

TEACHINGIn addition to publications in a variety of international journals, our faculty members have been invited to speak at many international meetings and to be visiting professors at prestigious institutions around the world. We have hosted medical students, residents, and consultant faculty from many countries who have come to observe surgeries here at GRU. The “Neurosurgery Board Review” textbook (first edition) by Dr. Cargill H.

Alleyne Jr., has been translated into Mandarin and is available throughout China. Also, Dr. Scott Y. Rahimi, Alleyne, and several neurosurgery residents have contributed a chapter (to be translated into Greek) on intracranial aneurysms in a neurosurgical text being published by the neurosurgery department at University of Thessaly, Greece.

RESEARCHThe cerebrovascular lab with Alleyne and Dr. Krishnan Dhandapani conducts a variety of translational research projects, including investigations into mechanisms of neuroprotection from stroke from curcumin, a component of turmeric that is a key ingredient in curry powder. The lab was the first to show beneficial results of curcumin in a murine SAH model. The

Connect the dotsThe department of neurosurgery’s International Program at GRU fosters partnerships around the globe

Haroon F. Choudhri, MD, Kim Bodolosky, CMPT, and Cargill H. Alleyne, Jr., MD


compound also works well in ischemia models and ICH models. Our lab has collaborated with scientists at East China Normal University to increase the bioavailability and efficacy of curcumin by modifying its chemical structure. This collaboration has led to the discovery of novel curcumin analogues for which a patent application has been filed.

Additionally, Dr. Haroon F. Choudhri has mentored students in Saudi Arabia and Egypt in the preparation of grant applications and the ensuing basic science research.

PATIENT CAREColleagues throughout the United States and around the globe have availed themselves of our Case Review program. Both physicians and patients have sent hundreds of cases to GRU neurosurgical specialists for their opinion. Choudhri has been coordinating this effort and accepts referrals at [email protected]. In addition to answering questions and sharing opinions, we have been honored that patients from many foreign countries have traveled to GRU to receive their neurosurgical care. The large number of international patients we receive prompted us to hire a concierge in 2012 (see sidebar below). Kim Bodolosky, a certified Medical Tourism Professional, coordinates their arrivals and travel/housing logistics, provides guidance on obtaining U.S. visas, and helps to obtain quotations for medical care. Our Cultural and Linguistically Appropriate Services (CLAS) program provides certified medical translators for a large number of languages and facilitates our guests by recognizing cultural needs such as dietary restrictions and houses of worship. In 2014, the International Neurospinal Program was launched to organize patient care, fellowship training for some international trainees, and charitable outreach.

Lecturing by GRU FacultyCanadaChinaEgyptFranceGermanyGreeceGuyanaItalyKingdom of Saudi ArabiaKuwaitMoroccoPakistanPuerto RicoTunisiaUnited Arab Emirates

Medical Students, Residents, and Consultant Faculty visiting GRUChinaEgyptEl SalvadorGhanaGreeceHaitiIndia

JapanKingdom of Saudi ArabiaKuwaitPakistanScotlandSyriaTurkeyUnited Arab Emirates

Research PartnershipsChinaEgyptKingdom of Saudi Arabia

Charity Missions Involving GRU FacultyAlgeriaEgyptMoroccoPakistan

International Patients coming to GRU for CareAfghanistanAlgeriaCanadaEgyptGreeceKingdom of Saudi Arabia

INTERNATIONAL CONNECTIONSKuwaitLebanonMexicoPakistanUnited Arab Emirates

Internet ConsultationsAfghanistanAustraliaCanadaChinaGreeceEgyptFranceGermanyIranItalyKingdom of Saudi ArabiaKuwaitMoroccoNigeriaOmanPakistanPuerto RicoRussiaSudanTunisiaUnited Arab EmiratesUnited Kingdom

International Patient Concierge From the time of arrival to the completion of care at Georgia Regents Medical Center, the International Patient Concierge is here to assist our international patients. Travel to another country for health care can be overwhelming. The concierge greets patients, presents them with a welcome binder written in their language, and guides them through the challenges of being in an

unfamiliar environment. The concierge is a contact person available to the patient 24 hours a day, seven days a week.

Our International Patient Concierge specializes in and provides many services to our international patients, including:

` Familiarizing our international patients with the hospital and areas of treatment

` Assisting with housing and meal accommodations` Assisting with air and ground travel` Assisting with translation needs` Assisting with pharmacy needs and obtaining prescriptions` Familiarizing our international patients with local customs and culture` Being familiar with the cultural differences

and religious needs and ensuring the proper respect and observations` Escorting patients to appointments for tests, lab work, etc.

The International Patient Concierge visits with our international patients and their families daily to provide comfort and assess additional needs and expectations. Kim Bodolosky, CMPT

In addition to publications in a variety of international journals, our faculty members have been invited to speak at many international meetings and to be visiting professors at prestigious institutions around the world. We have hosted medical students, residents, and consultant faculty from many countries who have come to observe surgeries here at GRU.


CLINICAL SPOTLIGHT

Neurocritical care is the intensive care management of patients with life-threatening neurosurgical and neurological illnesses such as stroke, bleeding in and around the brain (subarachnoid hemorrhage, intracerebral hemorrhage, subdural hematoma, intraventricular hemorrhage), brain tumors, brain trauma, status epilepticus, nerve and muscle diseases (myasthenia gravis, Guillain-Barré syndrome), spinal cord disorders, and the cardiopulmonary complications of brain injury.

Neurocritical care units specialize in managing the unique needs of such critically ill patients. In a neuro ICU, specialized nurses and physicians care for critically ill patients with diseases of the brain, spinal cord, and nerves that often have associated medical problems complicating their care. Neurological intensive care is one of the newest and fastest-growing specialties in medicine today. The first modern academic neuro ICUs in the United States were established in the early 1980s. At the present time, there are approximately 50 academic neuro ICUs directed by full-time staff in North America, and this number is growing rapidly.

Neuro ICUs are unique in that they bring together specially trained physicians and nurses and advanced technology, all focused on treating life-threatening neurological diseases. Neurological diseases tend to be complex and relatively uncommon and are best treated by specialists who have experience in applying neuroimaging and critical care techniques to the specific needs of neurological patients. Another major advantage to care in a neuro ICU is the constant observation and

immediate action that is required to detect and treat neurological deterioration. Constant surveillance by neuro-nurses and the immediate availability of neuroimaging, on-call physicians, and specialized interventions make it possible to act immediately to correct or reverse worsening medical conditions that might otherwise lead to permanent brain damage.

HISTORY OF NEUROCRITICAL CAREWhile the beginnings of the neurosciences ICU — defining it as a combined neurology and neurosurgery ICU — are largely unknown and difficult to tease out, some important developments in the evolution of neurocritical care should be recognized. Many of these first units were either for neurosurgical or neurologic patients. In a broader sense, little is known about the triage of patients with acute neurologic conditions in those days.

Historically, neurosurgeon Walter Dandy has been credited with opening the first neurosurgical ICU at Johns Hopkins Hospital in 1932. Indeed, Dandy had the insight to understand that some neurosurgical patients needed special care, and he chose a ward that he dedicated to the care of the sicker postoperative neurosurgical patients. In London, the Batten Respiratory Unit at the Institute of Neurology and National Hospital for Nervous Diseases opened in 1954 to treat mostly patients with acute neuromuscular disease, as well as those with stroke and spinal cord disorders who required mechanical ventilation. The development of the Neurosciences ICU at Mayo Clinic at Saint Mary’s Hospital was one of the first newly built combined neurosciences ICUs in the United

Neurocritical Care

Subhashini Ramesh, MD, and K. Alfredo Garcia, MD

Managing the unique needs of patients requiring neurocritical care is a rapidly expanding specialty

Specially trained physicians and nurses at

neuro ICUs use advanced technology to treat serious

neurological diseases.


States. It started as a unit with predominantly neurosurgical patients, and most of the expertise was developed in the care of these patients. Soon, acutely ill neurologic patients were admitted. A new culture of neurosciences was nurtured with specific attention to the care of the neediest patients.

In the United States, most neurosciences ICUs combined neurosurgical and neurologic patients. This would seem logical because acutely ill neurologic patients could need neurosurgical intervention (e.g., cerebral hematoma), and acutely ill neurosurgical patients could benefit from neurologic expertise (e.g., seizure management). Because of the open nature of the neurosciences ICU, physicians from multiple disciplines would closely cooperate in patient management. Often, a close cooperation between neurology and neurosurgery consultants in the neurosciences ICU was needed. There was a renewed interest in closely studying and treating acute neurologic and neurosurgical conditions, and this led to a better understanding of the risks for deterioration.

Several other landmark developments should be noted. First, neurologists became interested in acute neurologic conditions (e.g., coma) after patients survived as a result of more advanced resuscitation. Neurologists often were asked to judge the severity of injury and to prognosticate. Neurologists Fred Plum, Raymond Adams, and C. Miller Fisher were the first to describe causes of coma and other acute conditions (e.g., brain death, locked-in syndrome, anoxic-ischemic encephalopathy). A better understanding of neurologic complications of critical illness soon followed, and consultations in ICUs increased.

Second, with the emergence of neurosciences ICUs, coverage was needed. In the 1980s, neurologists would be stationed in these units. The presence of a neurologist in the neurosciences ICU provided a major benefit to neurosurgeons who would not always have the opportunity to immediately go to the bedside (e.g., during a long and complex neurosurgical procedure). Neurologists became more knowledgeable in management of acute neuromuscular respiratory failure, treatment of increased intracranial pressure, and systemic complications specific for acute neurologic disease. Neurologists would join intensivists (mostly anesthesiologists) and developed sufficient hands-on training that would allow them to fully manage these complicated patients.

Third, a flurry of scientific publications followed that would further define the field and its boundaries. Better understanding of causes of deterioration and recognition of opportunities of early intervention would lead to more complex and specialized care.

CREATION OF THE NEUROCRITICAL CARE SOCIETYThere had been several attempts to form neurocritical care organizations throughout the world prior to the formation of the Neurocritical Care Society. In the U.S. alone, there are critical care sections in the American Academy of Neurology, American Association of Neurological Surgeons, and Society of Neuroscience in Anesthesiology and Critical Care, as well as a neuroscience section of the Society of Critical Care Medicine. In Europe, there is the Neuro-Intensive Care Section of the European Society of Intensive Care Medicine. Perhaps the oldest neurocritical care society is the DGNI: Deutschen Gesellschaft für Neurointensiv-und Notfallmedizin (German Society for Neuro-Intensive Care and Emergency Medicine), which marked its 30th anniversary in 2013. Other multidisciplinary organizational attempts had been started as well, but it wasn’t until 1999 when seven neurointensivists (founding members: Bill Coplin, Jeff Frank, Claude Hemphill, Ed Manno, Stephan Mayer, Wade Smith, and Gene Sung) decided to collaborate that an independent, international, multidisciplinary organization was started — the Neurocritical Care Society. Each member donated their own money and time to begin the process of starting a nonprofit organization, and after several planning meetings, the first official annual meeting was held in Phoenix in 2003. The founding members recused themselves from leadership positions and the first officers were elected: Tom Bleck, president; Michael Diringer, vice president; Raj Narayan, secretary; and Thorsten Steiner, treasurer. Since then, the Neurocritical Care Society has continued to grow steadily with increased membership, increased meeting attendance, improved journal circulation and impact score, increasing NCS projects, and increased revenue and reserves.

The physical presence of a neurointensivist in a neurosciences ICU should improve care and outcomes. Multiple — albeit retrospective — studies have shown that outcomes in certain conditions can be improved with an attending neurointensivist. Benchmarks can be defined such as mortality, morbidity, length of stay, number of consultations, and actual costs.

Mayo Clinic Neuro ICU at St. Mary’s Hospital circa 1958. This Neuro ICU was one of the first newly built combined neurosciences ICUs in the U.S.


CLINICAL SPOTLIGHT

GEORGIA REGENTS MEDICAL CENTER NEUROSCIENCES ICUThe Neurosciences ICU at Georgia Regents University Medical Center was renovated and opened its doors in December 2003. In September 2009, another major renovation was completed, the floor was separated from the ICU, and the number of ICU beds increased from 14 to 18 universal ICU beds in 2010. The Neurosciences ICU at Georgia Regents University is one of the largest dedicated Neuro intensive care units in the region. It is an 18-bed ICU that cares exclusively for patients with strokes, cerebral aneurysms, brain tumors, trauma, and neuromuscular failure, as well as status epileptics, treating some of the region’s most critically ill patients. Our services include two fellowship-trained dedicated neurointensivists, a nurse-patient ratio of 1:2, and an integrated and patient/family-focused approach to care. We have strong neurology and neurosurgical residency programs, and in-house residents cover the ICU. We also have the capability of performing 24/7 neurointerventional procedures by two dually trained, fellowship-trained cerebrovascular neurosurgeons. We are also able to provide 24/7 continuous VEEG monitoring. Our Neuro ICU was recently cited as one of several services key to our designation as an Advanced Comprehensive Stroke Center by the Joint Commission — one of

only 15 hospitals in the nation to be so named at the time of designation in 2013.

In today’s changing health care landscape, family members of critically ill patients are taking a more active, hands-on role in the care and recovery of their loved ones. Families not only provide patients with vital emotional and social support

during critical illness, they themselves benefit from enhanced connectivity. The growing trend toward patient- and family-centered care (PFCC) in the

intensive care unit invites families to participate more fully in the care of their loved ones, while helping to bring wholeness to the patient through partnerships with the critical-care team and personalized care that respects the values, beliefs, and experiences of the individual.

A particular focus on departmental changes — such as the elimination of restricted visiting hours — is helping transform the perception of family members from visitors to full participants. In relation to the built environment, PFCC is often expressed through the expansion and differentiation of facilities for family members, including sleeping accommodations in patient rooms and amenities on nursing units — all measures that serve to break down barriers between clinician and family. Georgia Regents Medical Center is a pioneer in the concept of patient- and family-centered care, an approach that removes the barriers to having collaborative partnerships between health care providers, patients, and families. This means that we put patients and families first. We believe that families are an extension of the patient, not an imposition. The more involved a family is, the more our quality and safety improve along with your satisfaction. We don’t just have visitors in our hospitals, we have health care partners, and they are an integral part of the health care team.

Patient satisfaction scores are also increasing for the new Neuroscience Center. This nursing unit recently enjoyed some of its highest scores since tracking began over three years ago. Results are being closely monitored to determine the full impact of the new unit. Three years of quality improvement data for the Georgia Regents Adult Center for Excellence in Neuroscience reveal the following:` Patient satisfaction increased from 10th to 95th percentile.` Neurosurgery length of stays decreased by 50 percent.` Medical errors were reduced by 62 percent.` The number of patients discharged increased by 15.5 percent.This is an exciting time in neurosciences and

especially in neurocritical care. The brain is the great and final frontier in medicine. We at GRMC Neuro ICU look forward to providing excellence in critical care to patients with devastating neurological and neurosurgical injuries in the years to come.

The Mayo Clinic ICU circa 1958 started with neurosur-gical patients, and then added acutely ill neurologic patients.


PUBLICATIONS & PRESENTATIONS

Names in blue indicate faculty members or residents in the Georgia Regents University neurosurgery or neurology departments.

PUBLICATIONS

PRESENTATIONS

16th Annual Cooperative Studies on Brain Injury Depolarizations (COSBID) Meeting, Boston, Mass., October 2014

Sukumari Ramesh S, Alleyne CH, Dhandapani KMSuberoylanilide hydroxamic acid (SAHA) attenuates neurodegeneration and glial activation after intracerebral hemorrhage. Congress of Neurological Surgeons Annual Meeting, Boston, Mass., October 2014

Hess DCRemote ischemic conditioning: Is it time for clinical trials?—debate. UCLA-NIH Conference on Collateral Circulation.

Hess DCRemote ischemic conditioning in stroke and intracranial atherosclerosis. 7th International Congress of Intracranial Atherosclerosis (ICAS 2014), Chengdu, China, September 2014

Hess DCRemote ischemic conditioning. Session on peripheral to central signaling. Brain Edema 2014 and 2nd Preconditioning Conference, Huntington Beach, Calif., September 2014

Kirov SAWindow into the injured cerebral cortex: live imaging of pathological depolarizations and their

impact on the integrity of synaptic circuitry. Albany Medical College, Center for Neuropharmacology and Neuroscience (CNN) Seminar Series, Albany, N.Y., September 2014

Kirov SAWindow into the injured brain: live imaging of brain injury depolarizations and their impact on the integrity of synaptic circuitry. University of Alabama at Birmingham, Neurobiology Seminar Series, Birmingham, Ala., October 2014

Kirov SANeuronal and astroglial structural integrity during cortical spreading depolarization.

Sept–Dec 2014

Alleyne CH Comment on validation of the supplemented Spetzler-Martin grading system for brain arteriovenous malformations in a multicenter cohort of 1009 surgical patients. Neurosurgery 76:31, 2014

Hoda MN, Fagan SC, Khan MB, Vaibhav K, Chaudhary A, Wang P, Dhandapani KM, Waller JL, Hess DC A 2 × 2 factorial design for the combination therapy of minocycline and remote ischemic perconditioning: efficacy in a preclinical

trial in murine thromboembolic stroke model. Exp Transl Stroke Med. 2014 Oct 9;6:10. doi: 10.1186/2040-7378-6-10. eCollection 2014

Khan MB, Hoda MN, Vaibhav K, Giri S, Wang P, Waller JL, Ergul A, Dhandapani KM, Fagan SC, Hess DC Remote ischemic postconditioning: Harnessing endogenous protection in a murine model of vascular cognitive impairment. Transl Stroke Res. 2014 Oct. 29. [Epub ahead of print, PMID:25351177]

Patel C, Narayanan SP, Zhang W, Xu Z, Sukumari-Ramesh S, Dhandapani KM, Caldwell RW, Caldwell RBActivation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy. Am J Pathol 11:3040-51, 2014 (doi: 10.1016/j.ajpath.2014.07.012. Epub 2014 September 6)

Heck CN, King-Stephens D, Massey AD, Nair DR, Jobst BC, Barkley GL, Salanova V, Cole AJ, Smith MC, Gwinn RP, Skidmore C, Van Ness PC, Bergey GK, Park YD,

Miller I, Geller E, Rutecki PA, Zimmerman R, Spencer DC, Goldman A, Edwards JC, Leiphart JW, Wharen RE, Fessler J, Fountain NB, Worrell GA, Gross RE, Eisenschenk S, Duckrow RB, Hirsch LJ, Bazil C, O’Donovan CA, Sun FT, Courtney TA, Seale CG, Morrell MJTwo-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial. Epilepsia 55:432-441, 2014

Riccio CA, Pliego, Cohen M, Park YDExecutive function performance for children with epilepsy localized to the frontal or temporal lobes. Applied Neuropsychology: Child (DOI:10.1080/21622965.2014.923774), 2014

Viers A, Smith JA, Alleyne CH, Allen MB Neurosurgery at Medical College of Georgia, Georgia Regents University in Augusta (1956-2013). Neurosurgery 75:295-305, 2014

UCLA, Los Angeles, Calif., November 2014

Hess DCMultistem (MASTERs) clinical trial. Presentation to Japanese Neurologists and Neurosurgeons. Okayama, Japan, November 2014

Kirov SAMechanisms underlying spreading depolarization-induced dendritic beading. The 44th SFN Annual Meeting, Washington D.C., November 2014 (poster)

Steffensen AB, Sword J, Croom D, Kirov SA, MacAulay NMechanisms underlying spreading

depolarization-induced dendritic beading. The 44th SFN Annual Meeting, Washington D.C., November 2014 (abstract)

Giller CASurgery for essential tremor. Updates for best medications and strategies, Georgia Regents University, December 2014

Shakir B, Choudhri HF, Solares AC1 lateral mass reconstruction after nerve sheath tumor resection. Georgia Neurosurgical Society Fall Meeting, Greensboro, Ga., December 2014

THANKS TO OUR DONORS Your support is essential to advancing the research and community care goals of the neurosurgery and neurology departments.


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High SchoolLeah HaworthNavicent HealthEdwina F. HeathGlenn HeffnerCarol C. HendersonWilliam A. HenshallDavid HewittLinda HigginsMildred L. HobbsSally C. HollandRon HoneycuttDonna S. HoodKim HooksThomas HooverManton HortonRichard HortonJames M. HouserHelen S. HughesDavid HuskeyGina P. HuttoBen InabinetAshlee H. InmanJanet Inman

Integrity MedicalBarbara B. JacksonMarlee JamisonReynolds G. JarvisCheryle L. JenningsKay JesseJohn L. Armstrong Inc.Daniel L. JohnsonMatthew JohnsonMaxine G. JohnsonMeredith D. JohnsonSheri JohnsonTheodore S. JohnsonAmanda JohnstonRebecca JohnstonManja F. JonasAnthony JonesDallas JonesRandall JonesRobert H. JonesWalter R. JonesWendy JordanJourneys of Wesley United

Methodist ChurchJust Scott Designs Inc.

d/b/a Frills & FanciesToni JustusPeter KaedingDennis KaseKathy Hodge Oakbrook

Elem. SchoolAnne KatzerJulie S. KelleyNancy KiernanC.L. KightKenneth R. KimberlyKimberly-Clark

Corporation–Beech Island Mill

Kimberly-Clark Foundation

Pamela W. KingSandra J. KingPhilip KinzerDiane KirkGeri Klein-ShankBernard KostCatherine KottyanJason KozelPhilip J. KrakerJudith L. KriegelJeanette KrogerDeanna KwanLando Church of GodMolly LaneFrank T. LanierRussell LarcombeDoreen LarimerAmanda LawrenceStanley LawrenceKi H. LeeNatalie H. LeeCarolyn LeggioJodi W. Lerman


Susan K. LesshafftCameron LewisCarolyn LiebauMatthew LiebmanAlton L. LightseyLesley LightseyLindblom Class of 1974Brad LindseyJanis LindseyMartha LivesayJanie LivingstonLance LoganJulie E. LogueLaura S. LogueLouisville & Wadley

Railway CompanyTimothy B. LumpkinLundbeck LLCCandace LydakisWilliam L. MacuchRebecca J.

Magnotta-EasleyKhalid MalikLisa MalloryCarol G. MannMark MansfieldWade J. MarchmanMark C. MarcumMary MarkleJames MarthallerCynthia MartinAngela M. MaskeyLisa MatfessCarol MavityJill MaxwellAmber MayoCarol F. MaysF.L. MaysMaria A. MaysShanna H. McBrideAshlie McClellanKathryn McCoyDionne H. McCrackenMichael McDarghBarbara McDougaldMichelle E. McGeeHerbert E. McGintyLisa McGrathPamela C. McGrawDonny B. McKellarDaniel McKeonKathleen M. McKieNancy L. McNairKenneth McPhersonMedical Services of

America Inc.MedtronicAnnice MeelerLauren Megill-MiltonLin MeiAshley MeltonCliff MeltonCatherine MerrillsMary MerzMeybohm Realtors LLCIris Middleton

Kathleen MihalyakGrace MilfordBarbara MillerLinda MillerStacie MillerBrian W. MitchellRebecca C. MobleyJudith A. MontgomeryAlan MorrisBrenda MorrisMorris MarketingKarl J. MunschyMerv MurdockLynn B. MurrayTammy MurrellChristine NelsonRaymond NelsonTommy NewLaura B. NewtonJaidyn NguyenWilliam L. NicholsAnne NorvielSherryl NorvielD. Kevin NusbaumDean E. NusbaumHeidi OatesSusan O’BrienPatricia S. OdomBillie S. OldhamPatricia O’NeillRandie OsgoodMelissa PadgettFrancesco PalumboHolly PapsteinPAR Fore Parkinson’s Inc.Nancy M. ParksSonja ParksDavid PatersonRyan PatrickSusan PaynePCS Administration Inc.Richard H. PeacockArtince PearsonYelena PechenyCarol L. PetersBrad PetersenJudy PetersonJayne PetrakJane S. PetroMarilyn PettyPhi Mu-Kappa ChapterPhotography by

Anna BowickPierson Property LLCAnn M. PittelPlanters First Bank–PerryKevin D. PlummerRobert J. PollockDonna W. PoseyChera L. PoulinCheryl P. PoundsAlison B. PowellKaren PowellPrecision PalletJoyce P. PresbyBarbara Pressey

Jeffrey PrivettChristine ProbertDagmara PychynskiBrandy M. QuarlesSheryl J. QuickMary Sue RachelsKeith RadickCatherine RamseyDonna K. RaynerCathy ReeceMarian D. ReevesSuzanne N. ReevesGary A. ReitzJanice RepetskeResMedResolute Forest ProductsJames ReynoldsFrederick W. RicketsonBetty RickettsAnn RileyFelix RiveraMichael H. RivnerRoger RivnerAnne T. RizzoGenevieve RizzoDonald N. RobersonIdelle H. RobersonJody C. RockerKing RockerRockwood Trust (The)Sandra RoeKimberly B. RogersJane N. RohrbaughPhilip RoscheRoundstone

International Inc.Stephanie RountreeBarbara A. RoweStacey L. RuckerLinda RushingDebra RussellMatt RussoAmy RyanMihaela SalerJone SalterJuan SanchezBetty J. SandersKara SandersDaisy SandlinJennifer B. SandlinSarah SaundersStephanie ScangasPearl SchmitzRoger P. SchurigPaula L. SchwartzmanCarroll I. ScottMaree M. SeiglerElizabeth A. SekulErin SelbyRoseanne M. SelbyEdouard J. ServyKapil D. SethiDana SeymoreHemang H. ShahJeanne K. SharpePatricia Shea

Cindy SheheeBarbara R. ShelleyChengyong ShenCindy W. SheppardJack SheppardSusan M. SheppardGloria D. ShiversBarbara W. SimsCarleen D. SkilesWallace L. SlaterSLB Management

Group Inc.Gloria SmithLaurie O. SmithMary M. SmithMelody SmithWalter B. SmithDana SouleSoutheastern Medical

Brokers Inc. d/b/a Integrity Medical

Deanna SowaConnie SpannLarry SpencerStephanie SpinksSportscuts of Sportscuts

of AugustaW.H. SpratlingJeana StanfieldAndrew StashJoan H. SteinbergAnne K. StillThomas StillYvonne O. StoneMarjorie M. StoryPamela StricklerAlicia StrobleRobert SullivanSupernus

Pharmaceuticals Inc.Annie SwanCarolyn L. SwanLaura B. SwanKim SwigartT. W. Josey High SchoolTakosushi, Inc.Cathy C. TankersleyJames D. TarverMelanie A. TaylorNancy C. TaylorRobert L. ThatcherTeresa H. ThirkellDominee ThomasThomas Jefferson

AcademyJon ThompsonWilliam R. ThompsonMae S. TimmermanEve TomberlinTonya J. TorekRita TornerMartin B. TravisMark TribbyBonnie M. TroianoChris TuckJames Turner

Varena M. TurnerHenderson C. UpchurchThomas VandellNitzmari M. VazquezViaCordSydnee VoigtW O W Camp #1436Anthony E. WagnerJames L. WagnerJoann WaldenJerri WallTammy L. Wallace(No First Name) WalterRebecca B. WardCorrina WarnerWarren Baptist ChurchVanessa L.

Washington-GriffinSherry A. WatersClifford WatsonAlan W. WattsKaye W. WeathersCarrie WeaverHolly B. WeaverMarsha WeaverKim WebbDenise R. WebsterDianne G. WeeksRichard WeiersTina WeinsteinBethany L. WelshEdward J. WestbrookRonni WhitebookMargaret O. WilkesAmy WilliamsHarry WilliamsSusan M. WilliamsGene WillichRhonda WillisAndrew WilsonJim WilsonJulie A. WilsonMary E. WingateMichael WoffordChristopher WolfeWomble Carlyle

Sandridge & Rice LLPCourtney WoodRobert WoodDeborah WrightLouise M. WrightRoy WrightTheresa WrightJames WyantRoger L. YanceyNicole YarabAnnetta YorkLinda YoumansShirley H. YoungsmanRobert K. YuJames H. ZamoraJoshua Ziolkowski

CONFERENCE SCHEDULES

NON-PROFITUS POSTAGE

PAIDGEORGIA REGENTS

UNIVERSITY

GRU-015

Georgia Regents University1120 15th St., T101Augusta, GA 30912

Neurosurgery

Neurology

Meeting Schedule

January–April 2015

Jan. 1 No Grand Rounds: Holiday

Jan. 8 Dr. Ned Pruitt

Jan. 15 Dr. Yong Park Epilepsy

Jan. 22 Dr. Klepper Garcia Neuro Critical Care

Jan. 29 Dr. Askiel Bruno Resident Rank Meeting

Feb. 5 Dr. Anthony Murro Epilepsy

Feb. 12 Dr. Tom Swift Case Presentation

Feb. 19 Dr. John Morgan Movement Disorders

Feb. 26 Dr. Elizabeth Sekul Child Neurology

March 5 Dr. Suzanne Smith Multiple Sclerosis

March 12 Dr. Tom Swift Case Presentation

March 19 Dr. Jeff Switzer Stroke

March 26 Dr. Michael Rivner Neuromuscular

April 2 Dr. Nancy McNair

April 9 No Grand Rounds: Masters Week

April 16 Dr. Debra Moore-Hill Epilepsy

April 23 No Grand Rounds: AAN Meeting

April 30 Dr. Subhashini Ramesh Neuro Critical Care

AANS/CNS Section on Cerebrovascular Surgery, Feb. 9–10, Nashville, Tenn.

International Stroke Conference, Feb. 11–13, Nashville, Tenn.

AANS/CNS Section on Disorders of the Spine & Peripheral Nerves, March 4–7, Phoenix, Ariz.

Southern Neurosurgical Society, March 25–28, Naples, Fla.

Comprehensive Stroke Management Update 2015, April 10–12, Hilton Head, S.C.

American Academy of Neurology, April 18–25, Washington, D.C.

American Association of Neurological Surgeons, May 2–6, Washington, D.C.

Jan. 2 No Conference

Jan. 9 Interviews

Jan. 16

10 a.m. Anatomy

11 a.m. Gamma Knife

noon Case Conference

Jan. 23

10 a.m. Oral Board Review

11 a.m. Business


Jan. 30

10 a.m. Pathology — Dr. Sharma

11 a.m. Journal Club

noon M & M

Feb. 611 a.m. Radiology


Feb. 1311 a.m. Gamma Knife


Feb. 20

10 a.m. Anatomy

11 a.m. Neuro 101 — Dr. Woodall


Feb. 27

10 a.m. Resident Meeting


noon M & M

March 611 a.m. Anatomy


March 1311 a.m. Radiology


March 20

10 a.m. Oral Board

11 a.m. Neuro 101 — Dr. Shakir


March 27




noon M&M

April 311 a.m. Radiology


April 10

10 a.m. Gamma Knife

11 a.m. Neuro 101 — Dr. Yowtak


April 17

10 a.m. Board Review

11 a.m. Business


April 24




noon M & M

All neurology conferences are held from 8-9 a.m.

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Neuroscience Outlook Spring 2015 Newsletter

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