EUROPEAN COMMISSION JOINT RESEARCH CENTRE Institute for Health and Consumer Protection European Centre for the Validation of Alternative Methods (ECVAM) ECVAM SCIENTIFIC ADVISORY COMMITTEE (ESAC) CV – Members of the ECVAM Scientific Advisory Committee (ESAC) Page 1 of 10 Curriculum Vitae 1. Name, Gender, Nationality Family Name Name Gender Nationality Hendriksen Coenraad Male Netherlander If you wish you can place a photograph of you here. 2. Overall Scientific Expertise Please specify in keywords (see section 3 of your application form). If you wish you may indicate how you acquired each specific expertise (e.g. through education, in your function as…, through participation in …). Veterinary science education Laboratory animal science post-doc education Vaccinology and vaccine quality control senior scientist at Netherlands Vaccine Institute Three Rs senior scientist and Head Netherlands Centre Alternatives to animal use
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EUROPEAN COMMISSIONJOINT RESEARCH CENTRE
Institute for Health and Consumer ProtectionEuropean Centre for the Validation of Alternative Methods (ECVAM)
ECVAM SCIENTIFIC ADVISORY COMMITTEE (ESAC)
CV – Members of the ECVAM Scientific Advisory Committee (ESAC) Page 1 of 10
Curriculum Vitae1. Name, Gender, Nationality
Family Name Name Gender Nationality
Hendriksen Coenraad Male Netherlander
If you wish you can place a photograph of you here.
2. Overall Scientific Expertise
Please specify in keywords (see section 3 of your application form). If you wish you may indicate how you acquired each specific expertise (e.g. through education, in your function as…, through participation in …).
Veterinary science educationLaboratory animal science post-doc educationVaccinology and vaccine
quality control senior scientist at Netherlands Vaccine InstituteThree Rs senior scientist and Head Netherlands Centre
Alternatives to animal use
EUROPEAN COMMISSIONJOINT RESEARCH CENTRE
Institute for Health and Consumer ProtectionEuropean Centre for the Validation of Alternative Methods (ECVAM)
ECVAM SCIENTIFIC ADVISORY COMMITTEE (ESAC)
CV – Members of the ECVAM Scientific Advisory Committee (ESAC) Page 2 of 10
3. Professional ExperienceProfessional Experience 1 (most recent)Occupation or position held
laboratory animal scientist
Date (starting) 1081989Date (finishing) until nowMain activities monitoring animal welfare, supervising 3R projects including PhD
studies, 3R developmental work and (pre-)validation of 3R methods, coordinating 3R activities at NVI
Main responsibilities Overseeing welfare laboratory animals, evaluation animal experimentation protocols, head NVI institutional centre on 3R methods, development, (pre-)validation of 3R methods, refinement activities
Name of employing organisation
Netherlands Vaccine Institute of the Ministry of Public Health
Address of employing organisation (City, Country sufficient)
Antoni van Leeuwenhoeklaan 11, P.O.Box 457, 3720AL Bilthoven (NL)
Type of sector Governmental
Professional Experience 2 Occupation or position held
Chairholder 'Alternatives to Animal Testing', Faculty Veterianry Medicines, Utrecht University
Date (starting) 1082000Date (finishing) ongoingMain activities 3R research, teaching activities, participation in committees,
boards, working groupsMain responsibilities supervising research projects
Name of employing organisation
Utrecht University
Address of employing organisation (City, Country sufficient)
Yalelaan 2, P.O.Box 80.166, 3508TD Utrecht (NL)
Type of sector Academia
Professional Experience 3 Occupation or position held
Laboratory animal pathologist
Date (starting) 1091975Date (finishing) 1091979Main activities performing pathological screening of toxicology studies.
EUROPEAN COMMISSIONJOINT RESEARCH CENTRE
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ECVAM SCIENTIFIC ADVISORY COMMITTEE (ESAC)
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Main responsibilities laboratory animal pathology, macroscopic examination, histology, reporting
Name of employing organisation
TNO
Address of employing organisation (City, Country sufficient)
Zeist (NL)
Type of sector Public Institution
4. Educational BackgroundEducational qualification 1 (most recent) Description of qualification achieved (e.g. Bachelor of science in tissue engineering)
Master Veterinary medical sciences
Principal subject (e.g. Animal Physiology)
veterinary medicine
Other subjectsDate (starting) 1091968Date (finishing) 1031974Name of organisation (incl. city and country) awarding degree
Faculty Veterinary medicine Utrecht University
Title of degree awarded Msc
Educational qualification 2Description of qualification achieved (e.g. Bachelor of science in tissue engineering)
Doctor Veterinary Medicine
Principal subject (e.g. Animal Physiology)
veterinary medicine
Other subjectsDate (starting) 1051974Date (finishing) 15061975Name of organisation (incl. city and country) awarding degree
Faculty Veterinary medicine Utrecht University
Title of degree awarded DVM
EUROPEAN COMMISSIONJOINT RESEARCH CENTRE
Institute for Health and Consumer ProtectionEuropean Centre for the Validation of Alternative Methods (ECVAM)
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Educational qualification 3Description of qualification achieved (e.g. Bachelor of science in tissue engineering)
PhD
Principal subject (e.g. Animal Physiology)
Alternatives to the use of animals in vaccine quality control
Other subjectsDate (starting) 1051985Date (finishing) 22111989Name of organisation (incl. city and country) awarding degree
Faculty Veterinary medicine Utrecht University
Title of degree awarded PhD
Educational qualification 4Description of qualification achieved (e.g. Bachelor of science in tissue engineering)
Post-doc training Laboratory Animal Science
Principal subject (e.g. Animal Physiology)
laboratory animal science
Other subjectsDate (starting) 1081989Date (finishing) 1121990Name of organisation (incl. city and country) awarding degree
Department Laboratory Animnal Science, Faculty Veterinary Medicine, Utrecht University
Title of degree awarded
5. Fellowships, Awards, Membership in Learned Societies, Editorial Boards and Advisory Bodies
5.1 FellowshipsFellowship ITitle of fellowship -Description of fellowship (type, maximal duration, prestige)
-
Date (starting) -Date (finishing) -Funding/awarding organisation
-
Address (city + country sufficient)
-
EUROPEAN COMMISSIONJOINT RESEARCH CENTRE
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5.2 Awards
Award ITitle of award FISEA awardDescription of award (type, prestige etc.)
Fondation Internationale pour la Substitution de l'Experimen-tation Anima-le (FISEA), Luxemburg, December 1989
Date 20121989Awarding organisation FISEAAddress (city + country sufficient)
Luxembourg
Award IITitle of award Russell and Burch AwardDescription of award (type, prestige etc.)
Activities in the area of 3Rs
Date 111993Awarding organisation Humane Society of the US. Washington (USA)Address (city + country sufficient)
Washington (USA)
Award IIITitle of award Dorothy Hegarty AwardDescription of award (type, prestige etc.)
Best article in ATLA in 1996
Date 31996Awarding organisation Fund for the Replacement of Animals in Medical Experiments (FRAME)Address (city + country sufficient)
Nottingham (UK)
Award IVTitle of award Doerenkamp-Zbinden AwardDescription of award (type, prestige etc.)
Activities in the area of 3Rs
Date 82002Awarding organisation Doerenkamp-Zbinden FoundationAddress (city + country sufficient)
Zurich, Switserland
Award VTitle of award Felix Wankel Tierschutz AwardDescription of award (type, prestige etc.)
Activities in the area of 3Rs
Date 112002Awarding organisation Felix Wankel FoundationAddress (city + country sufficient)
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EUROPEAN COMMISSIONJOINT RESEARCH CENTRE
Institute for Health and Consumer ProtectionEuropean Centre for the Validation of Alternative Methods (ECVAM)
ECVAM SCIENTIFIC ADVISORY COMMITTEE (ESAC)
CV – Members of the ECVAM Scientific Advisory Committee (ESAC) Page 6 of 10
5.3 Membership in learned societies & professional associations & editorial boards
Society / Association / Editorial Board I
Society / Association FELASADescription of society's / association's activities
Laboratory animal science
Membership from … 1989…to (if currently member, please state 'current')
now
Address (city + country sufficient)
UK
Society / Association II
Society / Association Editoreal Board ATLA & ALTEXDescription of society's / association's activities
3Rs
Membership from … 1994 …to (if currently member, please state 'current')
now
Address (city + country sufficient)
ATLA: Nottingham (UK)ALTEX : Zurich (CH)
EUROPEAN COMMISSIONJOINT RESEARCH CENTRE
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5.4 Membership in advisory bodies / committees
Advisory body / committee I
Name of advisory body Central Committee on Animal Experimentation (CCD advisory board to the Minister of Public Health in NL)
EPAA’s Mirror Group
Council Member Institute Laboratory Animal Research (ILAR, US)
ECVAM’s Scientific Advisory Board (ESAC)
ECOPA
Doerenkamp-Zbinden Foundation (DZF)
Royal Netherlands Academy of Arts and Sciences (KNAW)
Biomedical Primate Research Center (BPRC)
OrangeOhouse Description of the roles and responsibilities of the advisory body
CCD: chairman
Mirror Group: committee member
ILAR Council: Committee member
ECVAM’s ESAC : national representative
ECOPA : 3R expert board
DZF : board member and chair Scientific advisory board
KNAW: member committee Laboratory animals & Biotechnology
BPRC : member supervisory board
Orange House: member board Orange House Trust Fund Foundation
Membership from … CCD : 2003 (chairman since 2008)
Mirror Group : 2005
EUROPEAN COMMISSIONJOINT RESEARCH CENTRE
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Orange House : 2010…to (if currently member, please state 'current')
CCD : current
Mirror Group : current
ILAR : 2008
ECVAM ESAC : 2002
ECOPA : 2006
DZF : current
KNAW: current
BPRC : current
Orange House : currentAddress (city + country sufficient)
CCD : The Hague (NL)t
Mirror Group : Brussels (B)
ILAR : Washington (US)
ECVAM ESAC : Ispra (I)
ECOPA : Brussels (B)
DZF : Zurich (CH)
KNAW: Amsterdam (NL)
BPRC : Rijswijk (NL)
Orange House : Brussels (B)
EUROPEAN COMMISSIONJOINT RESEARCH CENTRE
Institute for Health and Consumer ProtectionEuropean Centre for the Validation of Alternative Methods (ECVAM)
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6. Publications
Nr. Citation 1 Coenraad F.M.Hendriksen, Bernward Garthoff, Henrik Agger¬beck, et.al. (1994).
Alter¬natives to animal testing in the quali¬ty control of immunobi¬ologicals: Current status and future pros¬pects. The Report and Recommen¬dations of ECVAM Work¬shop 4. ATLA 22, 420-434.
2 Hendriksen C.F.M., Arciniega J.L., Bruckner L, et.al. (2008) The consistency approach for the quality control of vaccines. Biologicals 36 (1): 73-77.
3 Hendriksen CF. (2009). Replacement, reduction and refinement alternatives to animal use in vaccine potency measurement. Expert Rev.Vaccines 8(3): 313-322
4 Von Hunolstein C, Gomez Miguel MJ, Pezzella C, Scopetti F, Behr-Gross ME, Halder M, Hoffmann S, Levels L, van der Gun J, Hendriksen C. (2008). Evaluation of two serological methods for potency testing of whole cell pertussis vaccines. Pharmeuropa Bio. 1: 7-18.
5 Verwer CM, van der Ark A, van Amerongen G, van den Bos R & Hendriksen CF. (2009). Reducing variation in a rabbit vaccine safety study with particular emphasis on housing conditions and handling. Lab.Animal. 43(2): 155-164
6 Leenaars M & Hendriksen CFM (2005). Critical steps in the production of polyclonal and monoclonal antibodies: evaluation and recommendations. ILAR Journal 46, 3: 269-280.
7 Metz B, Hendriksen CF, Jiskoot W, Kersten GF. (2002). Reduction of animal use in human vaccine quality control. Vaccine. 20 : 2411-30
8 Leenaars PP, Kersten GF, de Bruijn ML, Hendriksen CF. (2001). An in vitro approach in quality control of toxoid vaccines. Vaccine 19(17-19):2729-33
9 Van der Ark A, Van Straaten-Van de Kapelle I, Olander R-M, Enssle K, Jadhav S, Van de Donk H & Hendriksen C. (2000). The pertussis serological potency test collaborative study to evaluate replacement of the mouse protection test. Biologicals, 28: 105-118
10 Winsnes R & Hendriksen C. (2000). Collaborative study for the validation of serological methods for potency testing of tetanus toxoid vaccines for human use. PHARMEUROPA, BIO 2000-1, 83-124.
11 Coenraad F.M.Hendriksen and Bjorn Steen (2000). Refinement of vaccine potency testing with the use of humane endpoints. ILAR Journal 42,2: 105-113
12 Hendriksen C, Spieser J-M, Akkermans A,. et.al. (1998). Validation of Alternative Methods for the Potency Testing of Vaccines. ECVAM Workshop Report 31.ATLA
13 Hendriksen CFM. (1998). A call for a European prohibition of monoclonal antibody production by the ascites procedure in laboratory animals. ATLA, 523-540.
14 Leenaars PPAM, Koedam MA, Wester PW, Baumans V, Claassen E & Hendriksen CFM. (1998). Asessment of side effects induced by injection of different adjuvant/antigen combinations in rabbits and mice. Lab.Animals, 32, 387-406.
15 Hendriksen CFM, Rozing J, Kamp van der M and de Leeuw W. (1996). The production of monoclonal anti-bodies: are animals still needed? ATLA 24: 109-
EUROPEAN COMMISSIONJOINT RESEARCH CENTRE
Institute for Health and Consumer ProtectionEuropean Centre for the Validation of Alternative Methods (ECVAM)
ECVAM SCIENTIFIC ADVISORY COMMITTEE (ESAC)
CV – Members of the ECVAM Scientific Advisory Committee (ESAC) Page 10 of 10
110.16 Hendriksen CFM. (1996). History of the use of animals in vaccine development
and quality control. In: Replacement, Reduction and Refinement in the Development and Control of Biological Products. Brown F, Cussler K and Hendriksen C (eds.). Dev.Biol.Stand. Vol .86, 3-11.
17 Coenraad Hendriksen and Johan van der Gun. (1995). Animal models and alternatives in the quality control of vaccines: are in vitro methods or in vivo methods the scientific equivalent of the emperor's clothes. ATLA 23, 61-73
18 Coenraad F.M.Hendriksen, Jacob Woltjes, Arnoud M.Akkermans, et.al. (1994). Interlaboratory validation of in vitro serological assay systems to assess the potency of tetanus toxoid in vaccines for vete¬ri¬nary use. Biologicals; 22: 257-268
19 Hendriksen CFM, Gun JW van der, Marsman FR and Kreeftenberg JG. (1991). The use of the in vitro toxin binding inhibition (ToBI) test for the estimation of the potency of tetanus toxoid. Biologicals; 19: 23-29.
20 Marieke E. Hoonakker, Nicole Ruiterkamp & Coenraad F.M. Hendriksen. The cAMP assay: a functional in vitro alternative to the in vivo Histamine Sensitization test. Vaccine, accepted for publication.
