New York State Biomonitoring Program for Trace …...This report summarizes performance for the...

New York State BiomonitoringProgram for Trace Elements

Trace Elements in Whole Blood,Urine, and Serum

Event #2, 2018

September, 2018

1

Sincerely,

Patrick J. Parsons, PhDChief, Inorganic and Nuclear Chemistry,Division of Environmental SciencesWadsworth Center

Aubrey L. Galusha, PhDCoordinator, Biomonitoring PT Program,Division of Environmental SciencesWadsworth Center

Event #2, 2018:Trace Elements in Whole Blood, Urine, and Serum

9/10/2018Dear Laboratory Director,

This report summarizes performance for the second biomonitoring proficiency test (PT) event of 2018for Trace Elements in Whole Blood, Urine, and Serum. One of the key goals of this PT program is toachieve harmonization of biomonitoring data for trace elements.

Target Value Assignment and Performance Evaluation:For these PT materials, target values have been assigned for a limited number of trace elements thatare gradable under criteria set by the NYS DOH Biomonitoring PT program. See assay-specificnarratives for details. Data for additional trace elements are reported and are included here in orderto characterize the PT materials more completely. Participant data and descriptive statistics areprovided for educational purposes. No target value or acceptable range is implied.

Where the data permit, robust statistics were used to assign target values based on Algorithm A asdefined by ISO 13528:2005E Statistical methods for use in proficiency testing by inter-laboratorycomparisons [1]. Acceptable ranges for the graded elements are based on consensus criteria and/orthose set by the NYS DOH’s PT program. For example, some are fixed based on US regulatoryguidelines (Pb, Cd) while for other elements the criteria are based on a consensus of the Network ofPT scheme organizers for trace elements in occupational and environmental laboratory medicine [2].Quality specifications are element and matrix specific; full details are provided under each elementspecific narrative.

A confidential, three-digit code number assigned by PT program staff identifies all laboratoryparticipants.

Samples for the next PT event (Event #3, 2018) will be shipped October 10, 2018. Comments aboutthis report may be directed to [email protected].

2

Trace Elements inWhole Blood

Event #2, 2018

3

PT Materials

Graded Elements

Additional Elements

Event #2, 2018:Trace Elements in Whole Blood

Human whole blood was purchased from Zen-Bio, Inc. and preserved with K2EDTA. The companycertifies that this material was "non-reactive" for HBsAg, HBV DNA, HIV-1,2 Ab, HIV-1 RNA, HCV Ab,HCV RNA, and STS.Units of whole blood were filtered into polypropylene containers throughcheesecloth to remove particulates and supplemented with arsenic (As), cadmium (Cd), cobalt (Co),chromium (Cr), mercury (Hg), manganese (Mn), lead (Pb), barium (Ba), beryllium (Be), copper (Cu),molybdenum (Mo), nickel (Ni), platinum (Pt), antimony (Sb), selenium (Se), tin (Sn), titanium (Ti),thallium (Tl), uranium (U), vanadium (V), tungsten (W), and zinc (Zn). Whole blood samples werehomogenized overnight prior to aliquoting 2-mL into polypropylene vials. PT samples were stored at-80°C until the week of the PT event, when they were thawed at 4°C prior to circulation to laboratoriesfor analysis.

Seven elements in whole blood are formally graded: As, Cd, Co, Cr, Hg, Mn, and Pb. Target values forthe graded elements are assigned to these pools based on (a) the robust mean calculated from datareported by all laboratories, or (b) if a robust mean is not possible, the arithmetic mean after outlierdeletion.

An additional 25 elements were reported by at least one participant: Ag, Al, Ba, Be, Bi, Cs, Cu, I, Li,Mg, Mo, Ni, Pt, Sb, Se, Sn, Sr, Te, Th, Ti, Tl, U, V, W, and Zn. These data are included here to providea more complete characterization of the PT materials. All results reported by participant laboratoriesare tabulated and organized by lab code. The PT data are graphed for visual comparison purposes forall elements where at least five laboratories reported a value greater than the LOD. A statisticalsummary table is provided for samples where at least two comparable values were reported as abovethe LOD.

The summary statistics for the additional elements are provided for educational purposes only, i.e., noacceptable response is implied. However, it is expected that each laboratory would wish to investigatea potential source of bias if warranted by these data. Future events might result in additional elementsbecoming graded if a consensus can be reached regarding desired quality specifications.

4

Whole Blood As (µg/L)BE18-06 BE18-07 BE18-08 BE18-09 BE18-10

Results for Event #2, 2018:Summary Statistics

Target (Arithmetic Mean (x̅)) 19.5 40.3 6.5 29.3 13.125.5 48.4 12.5 35.313.5 32.2 0.5 23.3

19.1Upper LimitLower Limit

Arithmetic SD (s)Arithmetic RSD (%)Number of SampleMeasurements (N)

1.0 2.4 0.8 2.0 0.55.1 6.0 12.3 6.8 3.8

7 8 8 8 7

7.1

The acceptable range is based on quality specifications:±6 µg/L or ±20% around the target value, whichever is greater; thus, it is fixed at ±6 µg/L at concentrationsless than or equal to 30 µg/L. These quality specifications were established by New York State Departmentof Health's Wadsworth Center, the PT Program organizer.

5

Lab Code MethodWhole Blood As (µg/L)

19.5 40.3 6.5 29.3 13.1

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10

Results for Event #2, 2018:Performance of Participating Laboratories

Target 19.5 40.3 6.5 29.3 13.1

103 19.5 42.1 6.45 30.5 13.3DRC/CC-ICP-MS

110 18.4 39.5 6.8 27.8 12.5DRC/CC-ICP-MS

147 18.9 40.5 6.07 29.0 12.6ICP-MS

293 20.31 42.32 6.38 31.51 13.63DRC/CC-ICP-MS

391 21.106 42.43 7.577 31.703 13.125DRC/CC-ICP-MS

597 19.8 42.0 7.13 30.4 13.5DRC/CC-ICP-MS

598 *14.67 37.35 4.96 26.22 *10.55DRC/CC-ICP-MS

599 18.2 36.4 6.50 27.5 12.7DRC/CC-ICP-MS

Based on the grading criteria for As in Whole Blood, 100% of results were satisfactory, with 0 of the 8laboratories reporting 2 or more of the 5 results outside of the acceptable ranges.

6

Whole Blood As

Results for Event #2, 2018:Summary Figures

BE18-06

598

599

110

147

103

597

293

39112.0

20.0

28.0

Lab Code

As (µ

g/L)

BE18-07

599

598

110

147

597

103

293

39130.0

40.0

50.0

Lab CodeAs

(µg/

L)

BE18-08

598

147

293

103

599

110

597

3910.0

7.0

14.0

Lab Code

As (µ

g/L)

BE18-0959

8

599

110

147

597

103

293

39120.0

29.0

38.0

Lab Code

As (µ

g/L)

BE18-10

598

110

147

599

391

103

597

2934.0

13.0

22.0

Lab Code

As (µ

g/L)

CHEAR Labs ● Other LabsHorizontal purple line = assigned target valuebased on the arithmetic mean of all laboratories.Gray area = acceptable range based on qualityspecifications:±6 µg/L or ±20% around the target value,whichever is greater; thus, it is fixed at ±6 µg/L atconcentrations less than or equal to 30 µg/L.

Legend:o

7

Whole Blood Cd (µg/L)


BE18-06 BE18-07 BE18-08 BE18-09 BE18-10Target (Robust Mean (x*))

0.3 0.1 0.2 0.4 0.3

15 15 15 15

0.106 0.045 0.070 0.118

15

7.0 1.4 5.8 13.9 3.58.1 2.4 6.8 16.05.9 0.4 4.8 11.8

4.3 7.1 3.4 2.9


0.087

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±1 µg/L or ±15% around the target value, whichever is greater; thus, it is fixed at ±1 µg/L at concentrationsless than or equal to 6.7 µg/L. These quality specifications are based on those used by US OSHA foroccupational exposure.

2.5

8.6

8

Lab Code MethodWhole Blood Cd (µg/L)

7.0 1.4 5.8 13.9 3.5

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10


Target 7.0 1.4 5.8 13.9 3.5

103 7.43 1.61 6.17 14.9 3.75DRC/CC-ICP-MS

107 7.1 1.6 6.1 14 3.8ICP-MS

110 7.08 1.48 5.76 13.9 3.65ICP-MS

116 7.43 1.34 5.74 14.7 3.99ICP-MS/MS

147 7.36 1.42 5.65 14.1 3.44ICP-MS

293 6.83 1.44 5.5 13.41 3.41DRC/CC-ICP-MS

391 6.796 1.43 5.96 13.861 3.394DRC/CC-ICP-MS

399 6.83 1.40 5.68 13.8 3.46DRC/CC-ICP-MS

401 6.6 1.3 5.8 13.7 3.6DRC/CC-ICP-MS

597 7.69 1.67 6.44 14.4 3.82DRC/CC-ICP-MS

598 4.83 1.29 3.67 10.25 2.58DRC/CC-ICP-MS i i i599 6.23 1.36 5.22 12.6 3.10DRC/CC-ICP-MS

605 6.97 1.54 5.82 14.0 3.62ICP-MS

606 6.85 1.03 5.64 13.8 3.29DRC/CC-ICP-MS

686 7.13 1.46 5.84 14.3 3.70ICP-MS

Based on the grading criteria for Cd in Whole Blood, 96% of results were satisfactory, with 1 of the 15laboratories reporting 2 or more of the 5 results outside of the acceptable ranges.

9

Whole Blood Cd


BE18-06

598

599

401

391

399

293

606

605

110

107

686

147

116

103

5974.7

4.95.5

7.0

8.5

Lab Code

Cd

(µg/

L)

BE18-07

606

598

401

116

599

399

147

391

293

686

110

605

107

103

5970.0

1.4

2.8

Lab CodeC

d (µ

g/L)

BE18-08

598

599

293

606

147

399

116

110

401

605

686

391

107

103

5973.2

3.84.5

6.0

7.5

Lab Code

Cd

(µg/

L)

BE18-0959

8

599

293

401

606

399

391

110

605

107

147

686

597

116

1039.0

11.011.5

14.0

16.5

Lab Code

Cd

(µg/

L)

BE18-10

598

599

606

391

293

147

399

401

605

110

686

103

107

597

1162.0

3.5

5.0

Lab Code

Cd

(µg/

L)

CHEAR Labs ● Other LabsHorizontal purple line = assigned target valuebased on the robust mean of all laboratories.Gray area = acceptable range based on qualityspecifications:±1 µg/L or ±15% around the target value,whichever is greater; thus, it is fixed at ±1 µg/L atconcentrations less than or equal to 6.7 µg/L.

Legend:o

10

Whole Blood Co (µg/L)BE18-06 BE18-07 BE18-08 BE18-09 BE18-10





0.2 0.3 0.4 0.3 0.69.1 6.4 5.9 2.1 5.5

9 9 9 8 9

8.7

The acceptable range is based on quality specifications:±1.5 µg/L or ±20% around the target value, whichever is greater; thus, it is fixed at ±1.5 µg/L atconcentrations less than or equal to 7.5 µg/L. These quality specifications were established based ondiscussions with the US FDA, and represent a consensus from a network of Trace Element PT programorganizers

11

Lab Code MethodWhole Blood Co (µg/L)

2.2 4.7 6.8 14.0 10.9

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10


Target 2.2 4.7 6.8 14.0 10.9

103 2.01 4.68 6.70 14.3 11.1DRC/CC-ICP-MS

110 2.1 4.8 6.7 13.5 10.9ICP-MS

147 2.19 4.8 6.79 14.1 10.9ICP-MS

293 1.94 4.46 6.36 13.84 10.87DRC/CC-ICP-MS

391 2.026 4.6 6.931 14.227 9.902DRC/CC-ICP-MS

401 2.3 4.2 6.3 14.0 10.6DRC/CC-ICP-MS

597 2.31 4.83 7.4 14.3 11.4DRC/CC-ICP-MS

598 2.30 4.55 6.55 13.92 10.40ICP-MS

599 2.69 5.26 7.56 *16.1 11.9DRC/CC-ICP-MS

Based on the grading criteria for Co in Whole Blood, 100% of results were satisfactory, with 0 of the 9laboratories reporting 2 or more of the 5 results outside of the acceptable ranges.

12

Whole Blood Co


BE18-06

293

103

391

110

147

401

598

597

5990.0

2.0

4.0

Lab Code

Co

(µg/

L)

BE18-07

401

293

598

391

103

110

147

597

5993.0

5.0

7.0

Lab CodeC

o (µ

g/L)

BE18-08

401

293

598

110

103

147

391

597

5995.0

7.0

9.0

Lab Code

Co

(µg/

L)

BE18-0911

0

293

598

401

147

391

103

597

59910.0

14.0

18.0

Lab Code

Co

(µg/

L)

BE18-10

391

598

401

293

110

147

103

597

5998.0

11.0

14.0

Lab Code

Co

(µg/

L)

CHEAR Labs ● Other LabsHorizontal purple line = assigned target valuebased on the arithmetic mean of all laboratories.Gray area = acceptable range based on qualityspecifications:±1.5 µg/L or ±20% around the target value,whichever is greater; thus, it is fixed at ±1.5 µg/Lat concentrations less than or equal to 7.5 µg/L.

Legend:o

13

Whole Blood Cr (µg/L)BE18-06 BE18-07 BE18-08 BE18-09 BE18-10





0.7 0.5 0.8 0.9 0.44.4 4.4 5.3 13.6 17.4

8 8 8 9 9

0.3

The acceptable range is based on quality specifications:±2 µg/L or ±20% around the target value, whichever is greater; thus, it is fixed at ±2 µg/L at concentrationsless than or equal to 10 µg/L. These quality specifications were established based on discussions with theUS FDA, and represent a consensus from a network of Trace Element PT program organizers

14

Lab Code MethodWhole Blood Cr (µg/L)

15.8 11.4 15.1 6.6 2.3

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10


Target 15.8 11.4 15.1 6.6 2.3

103 15.1 11.1 14.5 6.61 2.18DRC/CC-ICP-MS

110 15.3 11.3 14.4 6.0 2.2DRC/CC-ICP-MS

147 16.0 11.3 15.1 6.89 2.33DRC/CC-ICP-MS

293 15.14 11.3 14.79 6.83 2.81DRC/CC-ICP-MS

391 15.379 11.374 14.717 6.245 2.052DRC/CC-ICP-MS

401 15.5 11.6 15.0 6.8 2.8DRC/CC-ICP-MS

597 16.8 12.5 16.7 7.22 2.83DRC/CC-ICP-MS

598 *10.65 *8.41 *9.36 4.93 1.78DRC/CC-ICP-MS i i i599 16.9 11.0 15.7 8.13 1.91DRC/CC-ICP-MS

Based on the grading criteria for Cr in Whole Blood, 93% of results were satisfactory, with 1 of the 9laboratories reporting 2 or more of the 5 results outside of the acceptable ranges.

15

Whole Blood Cr


BE18-06

598

103

293

110

391

401

147

597

59910.0

11.012.0

16.0

20.0

Lab Code

Cr (µg

/L)

BE18-07

598

599

103

110

293

147

391

401

5978.0

11.0

14.0

Lab CodeC

r (µg

/L)

BE18-08

598

110

103

391

293

401

147

599

5978.0

10.012.0

15.5

19.0

Lab Code

Cr (µg

/L)

BE18-0959

8

110

391

103

401

293

147

597

5994.0

6.5

9.0

Lab Code

Cr (µg

/L)

BE18-10

598

599

391

103

110

147

401

293

5970.0

2.5

5.0

Lab Code

Cr (µg

/L)


Legend:o

16

Whole Blood Hg (µg/L)



0.8 1.4 0.2 0.5 2.8

15 15 15 15

0.274 0.443 0.080 0.172

15

16.6 25.1 3.5 9.8 39.621.6 32.6 6.5 12.811.6 17.6 0.5 6.8

4.8 5.6 5.7 5.1


0.889

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±3 µg/L or ±30% around the target value, whichever is greater; thus, it is fixed at ±3 µg/L at concentrationsless than or equal to 10 µg/L. These quality specifications were established by New York State Departmentof Health's Wadsworth Center, the PT Program organizer.

27.7

7.1

17

Lab Code MethodWhole Blood Hg (µg/L)

16.6 25.1 3.5 9.8 39.6

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10


Target 16.6 25.1 3.5 9.8 39.6

103 16.9 25.2 3.42 9.60 39.3DRC/CC-ICP-MS

107 17 26 3.9 10 44DRC/CC-ICP-MS

110 16.1 24.0 3.22 9.26 36.4ICP-MS

116 17.8 25.5 3.31 10.0 40.7ICP-MS/MS

147 15.8 24.4 3.77 9.63 37.8ICP-MS

293 16.4 24.23 3.73 9.77 38.4DRC/CC-ICP-MS

391 16.04 32.26 6.471 34.57 42.65CV-AAS h399 16.3 24.6 3.40 9.54 38.6DRC/CC-ICP-MS

401 14.8 23.3 3.4 9.2 36.3DRC/CC-ICP-MS

597 16.73 24.78 3.3 10.3 40.6DMA

598 14.51 22.48 3.25 8.05 32.43ICP-MS

599 18.1 26.6 4.59 10.9 41.6DRC/CC-ICP-MS

605 16.5 26.3 3.36 9.43 39.8ICP-MS

606 17.1 24.9 3.12 9.84 40.8DRC/CC-ICP-MS

686 18.2 26.6 3.54 10.2 42.2ICP-MS

Based on the grading criteria for Hg in Whole Blood, 99% of results were satisfactory, with 0 of the 15laboratories reporting 2 or more of the 5 results outside of the acceptable ranges.

18

Whole Blood Hg


BE18-06

598

401

147

391

110

399

293

605

597

103

107

606

116

599

68610.0

17.0

24.0

Lab Code

Hg

(µg/

L)

BE18-07

598

401

110

293

147

399

597

606

103

116

107

605

686

599

39115.0

25.0

35.0

Lab CodeH

g (µ

g/L)

BE18-08

606

110

598

597

116

605

401

399

103

686

293

147

107

599

3910.0

4.0

8.0

Lab Code

Hg

(µg/

L)

BE18-0959

8

401

110

605

399

103

147

293

606

116

107

686

597

599

3915.0

10.0

15.034.0

35.0

Lab Code

Hg

(µg/

L)

BE18-10

598

401

110

147

293

399

103

605

597

116

606

599

686

391

10720.0

40.0

60.0

Lab Code

Hg

(µg/

L)

CHEAR Labs ● Other LabsHorizontal purple line = assigned target valuebased on the robust mean of all laboratories.Gray area = acceptable range based on qualityspecifications:±3 µg/L or ±30% around the target value,whichever is greater; thus, it is fixed at ±3 µg/L atconcentrations less than or equal to 10 µg/L.

Legend:o

19

Whole Blood Mn (µg/L)



1.3 1.1 1.8 0.9 0.5

11 11 11 11

0.486 0.428 0.680 0.326

11

24.4 18.3 30.6 19.4 9.328.5 21.4 35.8 22.720.3 15.2 25.4 16.1

5.3 6.0 5.9 4.6


0.204

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±3 µg/L or ±17% around the target value, whichever is greater; thus, it is fixed at ±3 µg/L at concentrationsless than or equal to 17.7 µg/L. These quality specifications were recently proposed by a network of TraceElement PT program organizers (Praamsma M, et al. An assessment of clinical laboratory performance forthe determination of manganese in blood and urine. Clinical Chemistry and Laboratory Medicine. 2016 Inpress.)

6.3

5.4

20

Lab Code MethodWhole Blood Mn (µg/L)

24.4 18.3 30.6 19.4 9.3

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10


Target 24.4 18.3 30.6 19.4 9.3

103 26.0 19.7 32.4 21.0 10.4DRC/CC-ICP-MS

107 25 20 33 21 10DRC/CC-ICP-MS

110 22.9 16.9 28.4 17.7 8.9ICP-MS

147 25.2 18.7 31.1 19.4 9.40ICP-MS

293 22.09 17.25 28.98 18.51 9.46DRC/CC-ICP-MS

391 22.425 18.658 30.365 19.102 9.107DRC/CC-ICP-MS

399 23.3 17.7 29.6 18.8 8.74DRC/CC-ICP-MS

401 25.3 19.3 31.6 20.9 10.3DRC/CC-ICP-MS

597 24.8 17.8 32.1 19.2 8.91DRC/CC-ICP-MS

598 25.60 17.59 28.53 19.45 8.83ICP-MS

606 24.2 17.5 30.6 19.3 8.73DRC/CC-ICP-MS

Based on the grading criteria for Mn in Whole Blood, 100% of results were satisfactory, with 0 of the 11laboratories reporting 2 or more of the 5 results outside of the acceptable ranges.

21

Whole Blood Mn


BE18-06

293

391

110

399

606

597

107

147

401

598

10318.0

24.0

30.0

Lab Code

Mn

(µg/

L)

BE18-07

110

293

606

598

399

597

391

147

401

103

10714.0

18.0

22.0

Lab CodeM

n (µ

g/L)

BE18-08

110

598

293

399

391

606

147

401

597

103

10722.0

30.0

38.0

Lab Code

Mn

(µg/

L)

BE18-0911

0

293

399

391

597

606

147

598

401

107

10315.0

20.0

25.0

Lab Code

Mn

(µg/

L)

BE18-10

606

399

598

110

597

391

147

293

107

401

1035.0

10.0

15.0

Lab Code

Mn

(µg/

L)


Legend:o

22

Whole Blood Pb (µg/dL)



0.8 0.13 0.22 0.7 0.3

16 16 16 16

0.248 0.041 0.069 0.229

16

16.4 3.39 5.06 22.9 10.818.4 5.39 7.06 25.214.4 1.39 3.06 20.6

4.9 3.8 4.3 3.1


0.082

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±2 µg/dL or ±10% around the target value, whichever is greater; thus, it is fixed at ±2 µg/L at concentrationsless than or equal to 20 µg/dL. These quality specifications are recommended by the Clinical LaboratoryStandards Institute (CLSI, C40-A2) and have been proposed for use in proficiency testing programsapproved under CLIA by the Centers for Medicare and Medicaid Services (CMS) in the USA. (http://shop.clsi.org/C40.html)

8.8

2.8

23

Lab Code MethodWhole Blood Pb (µg/dL)

16.4 3.39 5.06 22.9 10.8

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10


Target 16.4 3.39 5.06 22.9 10.8

103 16.3 3.43 5.11 22.5 10.7DRC/CC-ICP-MS

107 17 3.5 5.5 23 12ICP-MS

110 16.5 3.36 5.09 23.1 10.8ICP-MS

116 17.6 3.50 5.47 24.0 11.3ICP-MS/MS

147 16.6 3.42 5.16 22.8 10.6ICP-MS

293 15.51 3.31 4.96 22.54 10.55DRC/CC-ICP-MS

343 17.1 3.4 4.9 24.9 10.8ASV-LeadCare

391 16.9 2.83 4.84 23.8 10.7ETAAS-Z

399 16.4 3.47 5.16 23.1 10.8DRC/CC-ICP-MS

401 15.3 3.1 4.8 20.3 10.2DRC/CC-ICP-MS i597 17.6 3.7 5.57 23.2 11.4DRC/CC-ICP-MS

598 15.4 3.31 4.82 20.8 0.81ICP-MS i599 15.8 3.31 4.85 22.2 9.99DRC/CC-ICP-MS

605 16.0 3.53 5.00 21.9 10.8ICP-MS

606 16.5 3.28 5.04 23.0 10.9DRC/CC-ICP-MS

686 16.5 3.44 5.12 22.9 10.9ICP-MS

Based on the grading criteria for Pb in Whole Blood, 98% of results were satisfactory, with 0 of the 16laboratories reporting 2 or more of the 5 results outside of the acceptable ranges.

24

Whole Blood Pb


BE18-06

401

598

293

599

605

103

399

606

110

686

147

391

107

343

116

59714.0

16.5

19.0

Lab Code

Pb (µ

g/dL

)

BE18-07

391

401

606

598

599

293

110

343

147

103

686

399

116

107

605

5971.00

3.50

6.00

Lab CodePb

(µg/

dL)

BE18-08

401

598

391

599

343

293

605

606

110

103

686

147

399

116

107

5972.00

5.00

8.00

Lab Code

Pb (µ

g/dL

)

BE18-0940

1

598

605

599

103

293

147

686

606

107

399

110

597

391

116

34320.0

23.0

26.0

Lab Code

Pb (µ

g/dL

)

BE18-10

598

599

401

293

147

103

391

343

399

110

605

606

686

116

597

1070.7

0.98.0

11.0

14.0

Lab Code

Pb (µ

g/dL

)

CHEAR Labs ● Other LabsHorizontal purple line = assigned target valuebased on the robust mean of all laboratories.Gray area = acceptable range based on qualityspecifications:±2 µg/dL or ±10% around the target value,whichever is greater; thus, it is fixed at ±2 µg/dL atconcentrations less than or equal to 20 µg/dL.

Legend:o

25

Whole Blood Be (µg/L)

Results for Event #2, 2018:Laboratory Data and Summary Statistics

Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10110 3.90 1.76 0.97 1.21 2.50ICP-MS147 3.87 1.77 <1.53 1.11 2.32ICP-MS293 3.77 1.89 0.9 1.24 2.44ICP-MS598 4.11 2.22 0.94 1.64 2.81ICP-MS599 3.71 2.10 0.83 1.04 2.08DRC/CC-ICP-MS

Summary StatisticsBE18-06 BE18-07 BE18-08 BE18-09 BE18-10

0.2 0.2 0.1 0.2 0.35.1 10.5 11.1 16.7 12.5

5 5 4 5 5

Arithmetic Mean (x̅) 3.9 1.9 0.9 1.2 2.4Arithmetic SD (s)Arithmetic RSD (%)Number of SampleMeasurements (N)*Denotes a statistical Outlier.

26

Whole Blood Be


BE18-06

599

293

147

110

5983.4

3.9

4.4

Lab Code

Be (µ

g/L)

BE18-07

110

147

293

599

5981.2

1.9

2.6

Lab CodeBe

(µg/

L)

BE18-08

599

293

598

1100.6

0.9

1.2

Lab Code

Be (µ

g/L)

BE18-0959

9

147

110

293

5980.6

1.2

1.8

Lab Code

Be (µ

g/L)

BE18-10

599

147

293

110

5981.5

2.5

3.5

Lab Code

Be (µ

g/L)

CHEAR Labs ● Other LabsHorizontal purple line = arithmetic mean of alllaboratories.Gray area = ±2SD of the mean.

The mean and ±2SD of all laboratories are not notintended to be quality specifications and areincluded for informational purposes only.

Legend:o

27

Whole Blood Cu (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10110 1970 1240 1380 1660 2600ICP-MS147 2071 1309 1436 1798 2700ICP-MS597 2050 1290 1450 1740 2780DRC/CC-ICP-MS598 1857 1074 1189 1543 2254ICP-MS599 1917 1196 1318 1710 2332DRC/CC-ICP-MS


90 94 106 96 2304.6 7.7 7.8 5.7 9.1

5 5 5 5 5

Arithmetic Mean (x̅) 1973 1222 1355 1690 2533Arithmetic SD (s)Arithmetic RSD (%)Number of SampleMeasurements (N)*Denotes a statistical Outlier.

28

Whole Blood Cu


BE18-06

598

599

110

597

1471700

1950

2200

Lab Code

Cu

(µg/

L)

BE18-07

598

599

110

597

1471000

1250

1500

Lab CodeC

u (µ

g/L)

BE18-08

598

599

110

147

5971100

1350

1600

Lab Code

Cu

(µg/

L)

BE18-0959

8

110

599

597

1471400

1700

2000

Lab Code

Cu

(µg/

L)

BE18-10

598

599

110

147

5971800

2500

3200

Lab Code

Cu

(µg/

L)



Legend:o

29

Whole Blood Sb (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10103 2.95 9.20 4.06 1.98 <0.123DRC/CC-ICP-MS110 2.65 8.35 *3.8 1.71 0.03ICP-MS147 2.78 8.89 4.10 1.89 <0.0548ICP-MS293 2.75 9.11 4.03 2.02 0.04DRC/CC-ICP-MS597 2.90 8.68 4.17 2.00 0.09DRC/CC-ICP-MS598 2.79 9.09 4.09 1.93 <0.5ICP-MS


0.11 0.32 0.05 0.11 NA3.9 3.6 1.2 5.7 NA

6 6 5 6 NA

Arithmetic Mean (x̅) 2.80 8.89 4.09 1.92 NAArithmetic SD (s)Arithmetic RSD (%)Number of SampleMeasurements (N)*Denotes a statistical Outlier.Statistical data were not calculated for BE18-10 based on a lack of consensus among participating labs.

30

Whole Blood Sb


BE18-06

110

293

147

598

597

1032.40

2.80

3.20

Lab Code

Sb (µ

g/L)

BE18-07

110

597

147

598

293

1038.00

9.00

10.00

Lab CodeSb

(µg/

L)

BE18-08

110

293

103

598

147

5973.75

3.853.95

4.10

4.25

Lab Code

Sb (µ

g/L)

BE18-0911

0

147

598

103

597

2931.60

1.90

2.20

Lab Code

Sb (µ

g/L)

BE18-10

110

293

5970.00

0.05

0.10

Lab Code

Sb (µ

g/L)



Legend:o

31

Whole Blood Se (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10103 138 313 183 193 394DRC/CC-ICP-MS107 160 330 210 220 430DRC/CC-ICP-MS110 123 297 162 168 354DRC/CC-ICP-MS147 133 323 188 194 389ICP-MS399 133 313 176 195 389DRC/CC-ICP-MS401 143 345 196 202 420DRC/CC-ICP-MS597 135 320 184 187 394DRC/CC-ICP-MS598 118 283 134 172 395DRC/CC-ICP-MS


13 19 23 16 239.6 6.0 12.8 8.4 5.8

8 8 8 8 8


32

Whole Blood Se


BE18-06

598

110

399

147

597

103

401

107100

140

180

Lab Code

Se (µ

g/L)

BE18-07

598

110

399

103

597

147

107

401260

320

380

Lab CodeSe

(µg/

L)

BE18-08

598

110

399

103

597

147

401

107120

180

240

Lab Code

Se (µ

g/L)

BE18-0911

0

598

597

103

147

399

401

107140

190

240

Lab Code

Se (µ

g/L)

BE18-10

110

399

147

103

597

598

401

107300

400

500

Lab Code

Se (µ

g/L)



Legend:o

33

Whole Blood Tl (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10103 0.941 0.736 0.337 1.75 0.0252DRC/CC-ICP-MS110 1.00 0.76 0.35 1.65 0.02ICP-MS147 0.965 0.754 0.331 1.70 < 0.0388ICP-MS293 0.88 0.72 0.33 1.68 0.02DRC/CC-ICP-MS597 1.07 0.80 0.38 1.73 0.05DRC/CC-ICP-MS598 1.28 *1.01 0.43 1.89 *0.31ICP-MS


0.14 0.03 0.04 0.08 0.0113.7 4.0 11.1 4.6 33

6 5 6 6 4


34

Whole Blood Tl


BE18-06

293

103

147

110

597

5980.50

1.00

1.50

Lab Code

Tl (µ

g/L)

BE18-07

293

103

147

110

597

5980.65

0.75

0.851.00

1.10

Lab CodeTl

(µg/

L)

BE18-08

293

147

103

110

597

5980.20

0.35

0.50

Lab Code

Tl (µ

g/L)

BE18-0911

0

293

147

597

103

5981.50

1.75

2.00

Lab Code

Tl (µ

g/L)

BE18-10

293

110

103

597

5980.00

0.03

0.060.20

0.40

Lab Code

Tl (µ

g/L)



Legend:o

35

Whole Blood V (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10110 1.0 3.7 1.6 0.5 2.2DRC/CC-ICP-MS147 1.00 3.36 1.61 0.458 2.43DRC/CC-ICP-MS293 0.96 3.4 1.73 *0.82 2.33DRC/CC-ICP-MS597 0.971 3.32 1.65 0.435 2.18DRC/CC-ICP-MS598 *0.78 2.58 *1.09 0.38 1.74DRC/CC-ICP-MS


0.02 0.41 0.06 0.05 0.262.0 12.5 3.6 11.4 11.9

4 5 4 4 5


36

Whole Blood V


BE18-06

598

293

597

147

1100.75

0.800.92

0.98

1.04

Lab Code

V (µ

g/L)

BE18-07

598

597

147

293

1102.20

3.20

4.20

Lab CodeV

(µg/

L)

BE18-08

598

110

147

597

2931.08

1.101.50

1.65

1.80

Lab Code

V (µ

g/L)

BE18-0959

8

597

147

110

2930.30

0.45

0.600.80

0.85

Lab Code

V (µ

g/L)

BE18-10

598

597

110

293

1471.40

2.20

3.00

Lab Code

V (µ

g/L)



Legend:o

37

Whole Blood Zn (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10110 4800 5840 6820 7390 6180ICP-MS147 4634 5608 6601 7516 6190ICP-MS597 4940 5890 7250 7520 6450DRC/CC-ICP-MS598 4433 5032 5767 6817 5370ICP-MS599 5120 6070 7040 8320 6430DRC/CC-ICP-MS


266 402 573 536 4405.6 7.1 8.6 7.1 7.2

5 5 5 5 5


38

Whole Blood Zn


BE18-06

598

147

110

597

5994000

4750

5500

Lab Code

Zn (µ

g/L)

BE18-07

598

147

110

597

5994500

5750

7000

Lab CodeZn

(µg/

L)

BE18-08

598

147

110

599

5975000

6500

8000

Lab Code

Zn (µ

g/L)

BE18-0959

8

110

147

597

5996000

7500

9000

Lab Code

Zn (µ

g/L)

BE18-10

598

110

147

599

5975000

6250

7500

Lab Code

Zn (µ

g/L)



Legend:o

39

Whole Blood Ba (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10110 10.9 4.3 8.4 1.6 14.4ICP-MS147 11.5 4.35 8.17 1.99 14.1ICP-MS597 12.3 4.43 9.06 2.00 15.7DRC/CC-ICP-MS598 10.93 4.32 7.95 1.93 14.54ICP-MS


0.7 0.1 0.5 0.2 0.76.1 2.3 6.0 10.5 4.8

4 4 4 4 4


40

Whole Blood Cs (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10110 1.3 1.4 1.4 1.2 1.3ICP-MS597 1.39 1.60 1.56 1.33 1.52DRC/CC-ICP-MS598 1.83 1.51 1.46 1.28 1.36ICP-MS599 1.23 1.31 1.35 1.15 1.30DRC/CC-ICP-MS


0.3 0.1 0.1 0.1 0.121 6.7 7.1 8.3 7.1

4 4 4 4 4


41

Whole Blood Mo (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10103 12.1 0.345 5.44 4.27 9.94DRC/CC-ICP-MS147 12.3 0.587 5.22 4.45 9.58ICP-MS597 12.1 0.605 5.19 3.98 9.53DRC/CC-ICP-MS598 9.38 0.64 3.77 3.52 7.89DRC/CC-ICP-MS


1.4 0.135 0.76 0.41 0.9212.2 25 15.5 10.1 10.0

4 4 4 4 4


42

Whole Blood Ni (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10110 9.20 2.5 3.3 7.2 5.5DRC/CC-ICP-MS147 9.40 2.64 3.55 8.20 5.46ICP-MS597 10.4 2.62 3.86 8.26 5.66DRC/CC-ICP-MS598 10.15 2.87 3.62 8.21 5.56ICP-MS


0.6 0.2 0.2 0.5 0.16.1 7.4 5.6 6.3 1.8

4 4 4 4 4


43

Whole Blood Pt (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10110 7.6 0.6 4.6 0.9 2.6ICP-MS598 7.08 0.56 4.37 0.89 1.93ICP-MS


0.4 0.03 0.2 0.01 0.55.5 5.2 4.4 1.1 22

2 2 2 2 2


44

Whole Blood Sn (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10110 1.0 3.9 4.9 1.6 2.9ICP-MS147 1.02 3.72 4.82 1.69 2.83ICP-MS597 1.07 4.19 5.25 1.71 3.20DRC/CC-ICP-MS598 0.97 3.95 5.08 1.45 2.83ICP-MS


0.04 0.2 0.2 0.1 0.23.9 5.1 4.0 6.3 6.9

4 4 4 4 4


45

Whole Blood U (µg/L)


Lab Code Method BE18-06 BE18-07 BE18-08 BE18-09 BE18-10103 < 0.0250 0.0556 0.325 0.0710 0.0698DRC/CC-ICP-MS110 0.023 0.059 0.320 0.076 0.078ICP-MS147 < 0.0200 0.0464 0.326 0.0707 0.0733ICP-MS598 0.1 *0.13 0.34 *0.12 *0.1ICP-MS


NA 0.007 0.009 0.003 0.004NA 12.1 2.6 4.1 5.6

NA 3 4 3 3

Arithmetic Mean (x̅) NA 0.054 0.328 0.073 0.074Arithmetic SD (s)Arithmetic RSD (%)Number of SampleMeasurements (N)*Denotes a statistical Outlier.Statistical data were not calculated for BE18-06 based on a lack of consensus among participating labs.

46

Results for Event #2, 2018:Additional Elements in Whole Blood

Lab Code MethodWhole Blood Ag (µg/L)

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10147 < 0.173 < 0.173 < 0.173 < 0.173 < 0.173ICP-MS

Lab Code MethodWhole Blood Al (µg/L)

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10147 NR 6.53 6.85 <5.40 <5.40ICP-MS597 18.7 18.1 22.4 22.0 99.0DRC/CC-ICP-MS

Lab Code MethodWhole Blood Bi (µg/L)


Lab Code MethodWhole Blood I (µg/L)

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10147 31.6 29.2 27.7 33.8 28.7ICP-MS

Lab Code MethodWhole Blood Li (µg/L)

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10147 0.520 0.497 0.441 0.491 0.541ICP-MS

Lab Code MethodWhole Blood Mg (µg/L)

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10597 27900 29800 33700 25900 29600DRC/CC-ICP-MS

Lab Code MethodWhole Blood Sr (µg/L)

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10103 24.5 20.5 22.8 25.1 17.7DRC/CC-ICP-MS

Lab Code MethodWhole Blood Te (µg/L)


Lab Code MethodWhole Blood Th (µg/L)


Lab Code MethodWhole Blood Ti (µg/L)

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10200 5.7 1.5 4.6 8.8 8.1DRC/CC-ICP-MS

Lab Code MethodWhole Blood W (µg/L)

BE18-06 BE18-07 BE18-08 BE18-09 BE18-10110 0.21 0.41 0.13 0.59 0.29ICP-MS200 2.4 2.5 3.1 2.3 2ICP-MS598 0.53 0.69 0.32 0.83 0.46ICP-MS

47

Trace Elements inUrine

Event #2, 2018

48

PT Materials

Graded Elements

Additional Elements

Event #2, 2018:Trace Elements in Urine

Urine was collected from volunteer donors into polyethylene containers and stored at 4°C. Followingcollection, urine was acidified to 1% (v/v) with nitric acid and mixed with a sulfamic acid solution (stocksolution contained 200 mg/mL sulfamic acid and 10% (v/v) Triton-X 100) to a final concentration of 1%(v/v) to stabilize Hg. Urine was stored frozen at -80°C pending further preparation. The urine was thawedat room temperature and precipitated salts removed by centrifugation. Urine supernatants were combinedinto five separate pools. Each urine pool was supplemented with arsenic (As), barium (Ba), beryllium(Be), cadmium (Cd), cobalt (Co),chromium (Cr), mercury (Hg), manganese (Mn), lead (Pb), thallium (Tl),uranium (U), aluminum (Al), cesium (Cs), copper (Cu), molybdenum (Mo), nickel (Ni), platinum (Pt),antimony (Sb) selenium (Se), tin (Sn), strontium (Sr), tellurium (Te), vanadium (V), tungsten (W), and zinc(Zn) and were homogenized overnight prior to aliquoting 10-mL into polypropylene vials. PT sampleswere stored at -80°C until the week of the PT event, when they were thawed at 4°C prior to circulation tolaboratories for analysis.

Eleven elements in urine are formally graded: As, Ba, Be, Cd, Co, Cr, Hg, Mn, Pb, Tl, and U. Targetvalues for the graded elements are assigned to these pools based on (a) the robust mean calculatedfrom data reported by all laboratories, or (b) if a robust mean is not possible, the arithmetic mean afteroutlier deletion.

An additional 21 elements were reported by at least one participant: Ag, Al, B, Bi, Cs, Cu, Fe, I, Li, Mg,Mo, Ni, Pt, Sb, Se, Sn, Sr, Th, V, W, and Zn. These data are included here to provide a more completecharacterization of the PT materials. All results reported by participant laboratories are tabulated andorganized by lab code. The PT data are graphed for visual comparison purposes for all elements whereat least five laboratories reported a value greater than the LOD. A statistical summary table is providedfor samples where at least two comparable values were reported as above the LOD.

The summary statistics for the additional elements are provided for educational purposes only, i.e., noacceptable response is implied. However, it is expected that each laboratory would wish to investigate apotential source of bias if warranted by these data. Future events might result in additional elementsbecoming graded if a consensus can be reached regarding desired quality specifications.

49

Urine As (µg/L)


UE18-06 UE18-07 UE18-08 UE18-09 UE18-10Target (Robust Mean (x*))

1.6 0.7 8 3.8 4.7

21 21 21 21

0.433 0.190 2.21 1.03

21

34.4 10.2 175 61.4 81.741.3 16.2 210 73.727.5 4.2 140 49.1

4.7 6.9 4.6 6.2


1.29

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±6 µg/L or ±20% around the target value, whichever is greater; thus, it is fixed at ±6 µg/L at concentrationsless than or equal to 30 µg/L. These quality specifications are based on the same criteria used by the USCenters for Disease Control Prevention (CDC) for public health labs participating in the LaboratoryResponse Network (LRN) PT program for Toxic Metals.

65.4

5.8

50

Lab Code MethodUrine As (µg/L)

34.4 10.2 175 61.4 81.7

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10


Target 34.4 10.2 175 61.4 81.7

103 34.7 10.0 180 61.7 82.7DRC/CC-ICP-MS

107 29 9.7 150 54 73DRC/CC-ICP-MS

110 35.5 11.3 183 63.9 85.8DRC/CC-ICP-MS

116 38.2 11.6 193 67.1 88.8ICP-MS/MS

147 36.1 10.6 175 61.6 81.6ICP-MS

293 34.21 9.53 170.69 59.56 77.7DRC/CC-ICP-MS

324 34.768 10.161 175.308 61.055 79.243ICP-MS

391 34.815 10.013 175.28 65.168 81.892DRC/CC-ICP-MS

399 35.2 10.0 178 61.0 82.4DRC/CC-ICP-MS

401 33.8 10.1 174 58.3 79.8DRC/CC-ICP-MS

597 31.8 11.2 171.4 62.5 83.4DRC/CC-ICP-MS

598 30.70 9.49 158 53.20 70.28DRC/CC-ICP-MS

599 28.3 9.33 158 54.3 72.3DRC/CC-ICP-MS

604 32.4 9.50 166 57.8 77.4DRC/CC-ICP-MS

605 32.0 9.94 165 57.9 78.4ICP-MS

606 36.5 11.0 193 67.6 91.1DRC/CC-ICP-MS

630 34 10 171 61.5 83DRC/CC-ICP-MS

632 44.6 23.3 190 79.7 95.0DRC/CC-ICP-MS h h h676 33.9 10.7 176 62 82.2DRC/CC-ICP-MS

684 35.3 10.6 178 63.6 82.9DRC/CC-ICP-MS

686 34.7 9.95 180 61.8 84.2DRC/CC-ICP-MS

Based on the grading criteria for As in Urine, 97% of results were satisfactory, with 1 of the 21 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

51

Urine As


UE18-06

599

107

598

597

605

604

401

676

630

293

686

103

324

391

399

684

110

147

606

116

63225.0

35.0

45.0

Lab Code

As (µ

g/L)

UE18-07

599

598

604

293

107

605

686

630

399

103

391

401

324

147

684

676

606

597

110

116

6322.0

10.0

18.023.2

23.4

Lab CodeAs

(µg/

L)

UE18-08

107

598

599

605

604

293

630

597

401

147

391

324

676

399

684

103

686

110

632

116

606120

170

220

Lab Code

As (µ

g/L)

UE18-0959

810

759

960

460

540

129

339

932

463

014

710

368

667

659

768

411

039

111

660

663

240.0

60.0

80.0

Lab Code

As (µ

g/L)

UE18-10

598

599

107

604

293

605

324

401

147

391

676

399

103

684

630

597

686

110

116

606

63260.0

80.0

100.0

Lab Code

As (µ

g/L)


Legend:o

52

Urine Ba (µg/L)



0.4 0.2 0.1 0.1 0.1

14 14 14 14

0.118 0.064 0.021 0.028

14

8.9 4.9 4.2 3.2 0.910.7 5.9 5.2 4.27.1 3.9 3.2 2.2

4.5 4.1 2.4 3.1


0.024


0.0

11.1

53

Lab Code MethodUrine Ba (µg/L)

8.9 4.9 4.2 3.2 0.9

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10


Target 8.9 4.9 4.2 3.2 0.9

107 8 4.6 3.7 3.1 0.86ICP-MS

110 9.12 5.00 4.22 3.31 0.96ICP-MS

116 9.40 5.13 4.28 3.35 1.05ICP-MS/MS

147 8.08 4.48 3.57 2.79 0.757ICP-MS

399 8.88 4.93 4.21 3.23 0.944ICP-MS

597 8.21 5.64 4.17 3.66 0.95DRC/CC-ICP-MS

598 8.99 4.83 4.17 3.23 0.93ICP-MS

599 8.25 4.80 4.28 3.28 1.08DRC/CC-ICP-MS

605 9.15 4.89 4.20 3.14 0.915ICP-MS

606 8.92 4.73 3.93 3.24 0.857DRC/CC-ICP-MS

607 9.13 4.99 4.29 3.27 0.988ICP-MS

632 8.94 4.98 4.24 3.24 0.991ICP-MS

676 8.75 4.95 4.19 3.18 0.883ICP-MS

686 9.16 5.11 4.23 3.28 0.960ICP-MS

Based on the grading criteria for Ba in Urine, 100% of results were satisfactory, with 0 of the 14 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

54

Urine Ba


UE18-06

107

147

597

599

676

399

606

632

598

110

607

605

686

1166.0

9.0

12.0

Lab Code

Ba (µ

g/L)

UE18-07

147

107

606

599

598

605

399

676

632

607

110

686

116

5973.5

5.0

6.5

Lab CodeBa

(µg/

L)

UE18-08

147

107

606

598

597

676

605

399

110

686

632

599

116

6072.5

4.0

5.5

Lab Code

Ba (µ

g/L)

UE18-0914

7

107

605

676

598

399

606

632

607

686

599

110

116

5971.5

3.0

4.5

Lab Code

Ba (µ

g/L)

UE18-10

147

606

107

676

605

598

399

597

686

110

607

632

116

5990.0

1.1

2.2

Lab Code

Ba (µ

g/L)


Legend:o

55

Urine Be (µg/L)



0.3 0.05 0.4 0.2 0.08

13 13 13 13

0.104 0.019 0.137 0.059

13

2.9 0.86 5.1 2.4 0.763.9 1.86 6.1 3.41.9 0.00 4.1 1.4

10.3 5.8 7.8 8.3


0.028


0.00

10.5

56

Lab Code MethodUrine Be (µg/L)

2.9 0.86 5.1 2.4 0.76

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10


Target 2.9 0.86 5.1 2.4 0.76

107 2.6 0.86 4.5 2.4 0.7ICP-MS

110 2.67 0.847 4.65 2.27 0.718ICP-MS

116 2.57 0.797 4.45 2.19 0.608ICP-MS/MS

147 3.15 0.889 5.43 2.34 0.857ICP-MS

293 2.8 0.87 4.98 2.32 0.77ICP-MS

399 2.92 0.861 5.07 2.47 0.772ICP-MS

598 3.10 0.85 5.36 2.58 0.86ICP-MS

599 2.30 0.73 4.31 2.13 0.64DRC/CC-ICP-MS

605 3.14 0.893 5.33 2.51 0.775ICP-MS

607 2.94 0.792 5.13 2.30 0.726ICP-MS

632 3.10 0.930 5.29 2.53 0.797ICP-MS

676 3.34 1.01 5.65 2.63 0.855ICP-MS

686 3.06 0.903 5.14 2.48 0.784ICP-MS

Based on the grading criteria for Be in Urine, 100% of results were satisfactory, with 0 of the 13 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

57

Urine Be


UE18-06

599

116

107

110

293

399

607

686

598

632

605

147

6761.5

3.0

4.5

Lab Code

Be (µ

g/L)

UE18-07

599

607

116

110

598

107

399

293

147

605

686

632

6760.0

1.0

2.0

Lab CodeBe

(µg/

L)

UE18-08

599

116

107

110

293

399

607

686

632

605

598

147

6763.0

5.0

7.0

Lab Code

Be (µ

g/L)

UE18-0959

9

116

110

607

293

147

107

399

686

605

632

598

6761.0

2.5

4.0

Lab Code

Be (µ

g/L)

UE18-10

116

599

107

110

607

293

399

605

686

632

676

147

5980.0

1.0

2.0

Lab Code

Be (µ

g/L)


Legend:o

58

Urine Cd (µg/L)



0.14 0.09 0.03 0.23 0.12

21 20 20 21

0.037 0.026 0.0077 0.063

21

2.85 0.70 0.45 5.23 3.633.85 1.70 1.45 6.231.85 0.00 0.00 4.23

4.9 12.9 6.7 4.4


0.034

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±1 µg/L or ±15% around the target value, whichever is greater; thus, it is fixed at ±1 µg/L at concentrationsless than or equal to 6.6 µg/L. These quality specifications are based on the same criteria used by the USCenters for Disease Control Prevention (CDC) for public health labs participating in the LaboratoryResponse Network (LRN) PT program for Toxic Metals.

2.63

3.3

59

Lab Code MethodUrine Cd (µg/L)

2.85 0.70 0.45 5.23 3.63

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10


Target 2.85 0.70 0.45 5.23 3.63

103 3.03 0.667 0.472 5.61 3.75DRC/CC-ICP-MS

107 2.6 0.58 0.41 5.2 3.7DRC/CC-ICP-MS

110 2.84 0.584 0.444 5.30 3.54ICP-MS

116 3.25 0.704 0.477 5.80 3.90ICP-MS/MS

147 3.12 0.626 0.425 5.34 3.82ICP-MS

293 2.94 0.74 0.48 5.25 3.68DRC/CC-ICP-MS

324 2.904 <1 <1 5.046 3.636ICP-MS

391 2.71 0.829 0.423 4.899 3.463DRC/CC-ICP-MS

399 2.90 0.677 0.460 5.24 3.68DRC/CC-ICP-MS

401 2.92 0.67 0.45 5.40 3.60DRC/CC-ICP-MS

597 2.63 0.72 0.40 5.50 3.56DRC/CC-ICP-MS

598 2.45 0.63 0.39 4.45 3.10DRC/CC-ICP-MS

599 2.59 0.72 0.44 4.91 3.42DRC/CC-ICP-MS

604 2.90 0.606 0.472 5.26 3.52DRC/CC-ICP-MS

605 2.90 0.734 0.458 5.38 3.72ICP-MS

606 2.80 0.633 0.422 5.22 3.64DRC/CC-ICP-MS

607 2.83 1.20 0.472 5.02 3.70ICP-MS

630 2.83 1.11 0.452 5.09 3.6ICP-MS

632 2.82 0.680 0.453 5.29 3.64DRC/CC-ICP-MS

676 2.78 0.92 0.467 4.99 3.58ICP-MS

686 2.97 0.793 0.472 5.31 3.75ICP-MS

Based on the grading criteria for Cd in Urine, 100% of results were satisfactory, with 0 of the 21 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

60

Urine Cd


UE18-06

598

599

107

597

391

676

606

632

630

607

110

604

399

605

324

401

293

686

103

147

1161.00

2.50

4.00

Lab Code

Cd

(µg/

L)

UE18-07

107

110

604

147

598

606

103

401

399

632

116

597

599

605

293

686

391

676

630

6070.00

1.00

2.00

Lab CodeC

d (µ

g/L)

UE18-08

598

597

107

606

391

147

599

110

401

630

632

605

399

676

607

604

686

103

116

2930.00

0.50

1.00

1.50

Lab Code

Cd

(µg/

L)

UE18-0959

839

159

967

660

732

463

010

760

639

929

360

463

211

068

614

760

540

159

710

311

64.00

5.25

6.50

Lab Code

Cd

(µg/

L)

UE18-10

598

599

391

604

110

597

676

401

630

324

606

632

293

399

607

107

605

686

103

147

1162.00

3.50

5.00

Lab Code

Cd

(µg/

L)


Legend:o

61

Urine Co (µg/L)



0.2 0.1 0.2 0.1 0.06

16 16 16 16

0.072 0.026 0.052 0.044

15

4.3 1.1 3.2 2.5 0.735.8 2.6 4.7 4.02.8 0.0 1.7 1.0

4.7 9.1 6.3 4.0


0.019

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±1.5 µg/L or ±15% around the target value, whichever is greater; thus, it is fixed at ±1.5 µg/L atconcentrations less than or equal to 10 µg/L. These quality specifications were established based ondiscussions with the US FDA, and represent a consensus from a network of Trace Element PT programorganizers

0.00

8.2

62

Lab Code MethodUrine Co (µg/L)

4.3 1.1 3.2 2.5 0.73

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10


Target 4.3 1.1 3.2 2.5 0.73

103 4.44 1.09 3.37 2.56 0.745DRC/CC-ICP-MS

107 4.4 1.2 3.4 2.7 0.75ICP-MS

110 4.57 1.19 3.31 2.70 0.775ICP-MS

116 3.86 1.12 2.72 2.25 0.816ICP-MS/MS

147 4.43 1.12 3.28 2.47 0.742ICP-MS

324 4.284 1.072 3.144 2.414 <1ICP-MS

391 4.112 1.004 2.998 2.4 0.658DRC/CC-ICP-MS

399 4.24 1.07 3.23 2.49 0.723DRC/CC-ICP-MS

401 4.25 1.03 3.13 2.35 0.68DRC/CC-ICP-MS

597 4.04 1.21 3.17 2.44 0.73DRC/CC-ICP-MS

598 4.26 1.09 3.31 2.51 0.74ICP-MS

599 3.47 0.93 2.90 2.11 0.63DRC/CC-ICP-MS

605 4.36 1.05 3.24 2.46 0.701ICP-MS

606 4.17 1.07 3.20 2.52 0.669DRC/CC-ICP-MS

632 4.55 1.20 3.53 2.77 0.809ICP-MS

676 4.51 1.22 3.56 2.69 0.789ICP-MS

Based on the grading criteria for Co in Urine, 100% of results were satisfactory, with 0 of the 16 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

63

Urine Co


UE18-06

599

116

597

391

606

399

401

598

324

605

107

147

103

676

632

1102.0

4.5

7.0

Lab Code

Co

(µg/

L)

UE18-07

599

391

401

605

606

399

324

598

103

116

147

110

107

632

597

6760.0

1.5

3.0

Lab CodeC

o (µ

g/L)

UE18-08

116

599

391

401

324

597

606

399

605

147

598

110

103

107

632

6761.0

3.0

5.0

Lab Code

Co

(µg/

L)

UE18-0959

9

116

401

391

324

597

605

147

399

598

606

103

676

107

110

6320.0

2.5

5.0

Lab Code

Co

(µg/

L)

UE18-10

599

391

606

401

605

399

597

598

147

103

107

110

676

632

1160.00

1.25

2.50

Lab Code

Co

(µg/

L)

CHEAR Labs ● Other LabsHorizontal purple line = assigned target valuebased on the robust mean of all laboratories.Gray area = acceptable range based on qualityspecifications:±1.5 µg/L or ±15% around the target value,whichever is greater; thus, it is fixed at ±1.5 µg/Lat concentrations less than or equal to 10 µg/L.

Legend:o

64

Urine Cr (µg/L)



0.09 0.7 0.2 0.2 0.3

10 12 12 12

0.035 0.257 0.079 0.054

12

0.49 11.1 1.8 3.2 6.63.49 14.1 4.8 6.20.00 8.1 0.0 0.2

18.4 6.3 11.1 6.3


0.093

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±3 µg/L or ±20% around the target value, whichever is greater; thus, it is fixed at ±3 µg/L at concentrationsless than or equal to 15 µg/L. These quality specifications were established based on discussions with theUS FDA, and represent a consensus from a network of Trace Element PT program organizers

3.6

4.5

65

Lab Code MethodUrine Cr (µg/L)

0.49 11.1 1.8 3.2 6.6

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10


Target 0.49 11.1 1.8 3.2 6.6

103 <1.00 11.5 1.83 3.40 6.67DRC/CC-ICP-MS

107 0.49 11 1.6 3.2 5.8DRC/CC-ICP-MS

110 0.52 11.6 1.92 3.47 6.82DRC/CC-ICP-MS

116 0.47 10.94 1.60 3.06 6.22ICP-MS/MS

147 0.490 11.1 1.64 3.09 6.45DRC/CC-ICP-MS

324 <1 11.699 1.935 3.347 6.764ICP-MS

391 0.322 10.033 1.544 3.223 6.862DRC/CC-ICP-MS

401 0.45 11.1 1.97 3.18 6.72DRC/CC-ICP-MS

597 0.58 12.1 1.869 3.23 6.78DRC/CC-ICP-MS

598 0.32 9.76 1.48 2.54 5.50DRC/CC-ICP-MS

599 0.71 10.5 2.01 3.24 6.41DRC/CC-ICP-MS

632 0.555 11.5 2.00 3.30 6.87DRC/CC-ICP-MS

Based on the grading criteria for Cr in Urine, 100% of results were satisfactory, with 0 of the 12 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

66

Urine Cr


UE18-06

598

391

401

116

107

147

110

632

597

5990.00

1.20

2.40

3.60

Lab Code

Cr (µg

/L)

UE18-07

598

391

599

116

107

147

401

103

632

110

324

5977.0

11.0

15.0

Lab CodeC

r (µg

/L)

UE18-08

598

391

116

107

147

103

597

110

324

401

632

5990.0

3.0

6.0

Lab Code

Cr (µg

/L)

UE18-0959

8

116

147

401

107

391

597

599

632

324

103

1100.0

3.5

7.0

Lab Code

Cr (µg

/L)

UE18-10

598

107

116

599

147

103

401

324

597

110

391

6323.0

6.5

10.0

Lab Code

Cr (µg

/L)


Legend:o

67

Urine Hg (µg/L)



1.9 1.7 0.7 5.2 0.4

17 17 17 16

0.563 0.527 0.224 1.61

17

10.4 23.1 7.9 60.9 3.513.5 30.0 10.9 79.27.3 16.2 4.9 42.6

18.3 7.4 8.9 8.5


0.108

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±3 µg/L or ±30% around the target value, whichever is greater; thus, it is fixed at ±3 µg/L at concentrationsless than or equal to 10 µg/L. These quality specifications were established by New York State Departmentof Health's Wadsworth Center, the PT Program organizer.

0.5

11.4

68

Lab Code MethodUrine Hg (µg/L)

10.4 23.1 7.9 60.9 3.5

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10


Target 10.4 23.1 7.9 60.9 3.5

103 9.76 23.7 7.84 64.5 3.57DRC/CC-ICP-MS

107 13 18 8.9 65 3DRC/CC-ICP-MS

110 11.6 23.2 8.55 61.2 3.49ICP-MS

147 11.3 23.9 8.16 62.3 3.55CV-AAS

293 11.84 23.72 8.75 60.84 3.91DRC/CC-ICP-MS

391 8.977 23.706 6.475 56.984 3.318DRC/CC-ICP-MS

401 8.48 27.1 7.58 64.0 3.85DRC/CC-ICP-MS

589 7.055 9.85 6.0175 20.905 5.05CV-AAS i i i597 10.86 23.50 8.13 60.49 3.43DMA

598 9.14 20.14 7.09 52.82 3.30ICP-MS

599 6.83 20.3 7.05 52.9 3.12DRC/CC-ICP-MS i604 12.3 21.2 8.27 60.5 3.09DRC/CC-ICP-MS

605 12.1 24.1 8.28 67.6 3.70ICP-MS

606 11.5 24.5 8.75 >50 3.93DRC/CC-ICP-MS

632 9.52 21.6 7.97 59.4 3.51DRC/CC-ICP-MS

676 9.11 27.8 7.64 69.1 3.6ICP-MS

684 11.4 23.3 7.51 62.6 2.83DRC/CC-ICP-MS

Based on the grading criteria for Hg in Urine, 95% of results were satisfactory, with 1 of the 17 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

69

Urine Hg


UE18-06

599

589

401

391

676

598

632

103

597

147

684

606

110

293

605

604

1075.0

10.0

15.0

Lab Code

Hg

(µg/

L)

UE18-07

589

107

598

599

604

632

110

684

597

103

391

293

147

605

606

401

6769.8

9.916.0

24.0

32.0

Lab CodeH

g (µ

g/L)

UE18-08

589

391

599

598

684

401

676

103

632

597

147

604

605

110

293

606

1074.0

8.0

12.0

Lab Code

Hg

(µg/

L)

UE18-0958

9

598

599

391

632

597

604

293

110

147

684

401

103

107

605

67620.0

22.035.0

60.0

85.0

Lab Code

Hg

(µg/

L)

UE18-10

684

107

604

599

598

391

597

110

632

147

103

676

605

401

293

606

5890.0

4.0

8.0

Lab Code

Hg

(µg/

L)


Legend:o

70

Urine Mn (µg/L)



0.2 0.3 0.4 0.2 0.17

16 16 16 16

0.052 0.085 0.127 0.057

15

3.4 5.4 7.5 2.4 0.804.3 6.8 9.4 3.02.5 4.0 5.6 1.8

5.9 5.6 5.3 8.3


0.055

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±0.55 µg/L or ±25% around the target value, whichever is greater; thus, it is fixed at ±0.55 µg/L atconcentrations less than or equal to 2.2 µg/L. Quality specifications for Mn are consistent with those usedby other External Quality Assessment Schemes for trace elements. (Praamsma M, et al. Clinical Chemistryand Laboratory Medicine.2016; 54(12): 1921-1928)

0.25

21.3

71

Lab Code MethodUrine Mn (µg/L)

3.4 5.4 7.5 2.4 0.80

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10


Target 3.4 5.4 7.5 2.4 0.80

103 3.54 5.55 7.88 2.51 0.795DRC/CC-ICP-MS

107 3.3 5.1 6.8 2.4 0.73DRC/CC-ICP-MS

110 3.39 5.37 7.51 2.31 0.589DRC/CC-ICP-MS

116 3.00 4.81 6.71 2.13 0.662ICP-MS/MS

147 3.39 5.42 7.31 2.31 0.665DRC/CC-ICP-MS

324 3.535 5.431 7.512 2.517 <1ICP-MS

391 3.506 5.336 7.116 3.477 1DRC/CC-ICP-MS h399 3.37 5.35 7.53 2.39 0.751DRC/CC-ICP-MS

597 3.28 6.54 7.64 2.67 0.97DRC/CC-ICP-MS

598 3.43 5.32 7.77 2.59 0.94ICP-MS

604 3.24 5.01 7.03 2.25 0.699DRC/CC-ICP-MS

605 3.35 5.18 7.27 2.32 0.701ICP-MS

606 3.16 5.20 7.51 2.34 0.581DRC/CC-ICP-MS

630 3.41 5.41 7.45 2.44 0.907DRC/CC-ICP-MS

632 3.60 5.81 8.48 2.74 0.944DRC/CC-ICP-MS

676 3.99 6.07 8.75 2.63 1.01DRC/CC-ICP-MS

Based on the grading criteria for Mn in Urine, 99% of results were satisfactory, with 0 of the 16 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

72

Urine Mn


UE18-06

116

606

604

597

107

605

399

110

147

630

598

391

324

103

632

6762.0

3.5

5.0

Lab Code

Mn

(µg/

L)

UE18-07

116

604

107

605

606

598

391

399

110

630

147

324

103

632

676

5973.0

5.5

8.0

Lab CodeM

n (µ

g/L)

UE18-08

116

107

604

391

605

147

630

110

606

324

399

597

598

103

632

6765.0

7.5

10.0

Lab Code

Mn

(µg/

L)

UE18-0911

6

604

110

147

605

606

399

107

630

103

324

598

676

597

632

3911.5

2.5

3.5

Lab Code

Mn

(µg/

L)

UE18-10

606

110

116

147

604

605

107

399

103

630

598

632

597

391

6760.00

1.00

2.00

Lab Code

Mn

(µg/

L)

CHEAR Labs ● Other LabsHorizontal purple line = assigned target valuebased on the robust mean of all laboratories.Gray area = acceptable range based on qualityspecifications:±0.55 µg/L or ±25% around the target value,whichever is greater; thus, it is fixed at ±0.55 µg/Lat concentrations less than or equal to 2.2 µg/L.

Legend:o

73

Urine Pb (µg/L)



0.5 0.1 0.1 0.3 0.7

18 18 18 18

0.136 0.018 0.029 0.090

18

10.7 1.5 2.2 7.9 13.512.8 2.5 3.2 9.58.6 0.5 1.2 6.3

4.7 6.7 4.5 3.8


0.192


10.8

5.2

74

Lab Code MethodUrine Pb (µg/L)

10.7 1.5 2.2 7.9 13.5

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10


Target 10.7 1.5 2.2 7.9 13.5

103 11.2 1.50 2.36 8.25 14.4DRC/CC-ICP-MS

107 11 1.5 2.1 8 14ICP-MS

110 10.9 1.48 2.27 8.11 13.6ICP-MS

116 10.97 1.45 2.24 8.03 13.37ICP-MS/MS

147 10.8 1.34 2.07 7.65 13.6ICP-MS

293 10.5 1.47 2.19 7.73 13.17DRC/CC-ICP-MS

324 10.846 1.559 2.307 8.138 13.376ICP-MS

391 9.78 1.34 1.991 7.236 12.213DRC/CC-ICP-MS

399 11.1 1.46 2.28 8.03 13.9ICP-MS

597 9.38 1.6 2.14 7.55 12.77DRC/CC-ICP-MS

598 10.2 1.36 2.14 7.43 12.5ICP-MS

599 9.34 1.44 2.19 7.48 12.6DRC/CC-ICP-MS

605 11.2 1.48 2.28 8.16 13.9ICP-MS

606 10.4 1.37 2.08 7.71 13.2ICP-MS

607 11.3 1.56 2.30 8.34 14.2ICP-MS

632 10.4 1.44 2.25 7.82 13.3ICP-MS

676 10.99 1.45 2.34 8.09 14.1ICP-MS

686 11.0 1.50 2.30 8.06 13.7ICP-MS

Based on the grading criteria for Pb in Urine, 100% of results were satisfactory, with 0 of the 18 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

75

Urine Pb


UE18-06

599

597

391

598

606

632

293

147

324

110

116

676

107

686

399

605

103

6078.0

11.0

14.0

Lab Code

Pb (µ

g/L)

UE18-07

391

147

598

606

599

632

116

676

399

293

110

605

107

686

103

324

607

5970.0

1.5

3.0

Lab CodePb

(µg/

L)

UE18-08

391

147

606

107

598

597

599

293

116

632

110

399

605

686

607

324

676

1030.6

2.2

3.8

Lab Code

Pb (µ

g/L)

UE18-0939

159

859

959

714

760

629

363

210

711

639

968

667

611

032

460

510

360

76.0

8.0

10.0

Lab Code

Pb (µ

g/L)

UE18-10

391

598

599

597

293

606

632

116

324

110

147

686

399

605

107

676

607

1039.0

13.0

17.0

Lab Code

Pb (µ

g/L)


Legend:o

76

Urine Tl (µg/L)



0.07 0.01 0.14 0.02 0.05

15 15 15 15

0.023 0.0046 0.044 0.0059

15

2.12 0.89 4.02 0.47 1.072.54 1.09 4.82 0.671.70 0.69 3.22 0.27

3.3 1.1 3.5 4.3


0.016

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±0.2 µg/L or ±20% around the target value, whichever is greater; thus, it is fixed at ±0.2 µg/L atconcentrations less than or equal to 1 µg/L. These quality specifications are based on the same criteriaused by the US Centers for Disease Control Prevention (CDC) for public health labs participating in theLaboratory Response Network (LRN) PT program for Toxic Metals.

0.86

4.7

77

Lab Code MethodUrine Tl (µg/L)

2.12 0.89 4.02 0.47 1.07

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10


Target 2.12 0.89 4.02 0.47 1.07

103 2.17 0.891 4.15 0.487 1.12DRC/CC-ICP-MS

107 2 0.89 4.1 0.48 1ICP-MS

110 2.12 0.887 4.03 0.462 1.07ICP-MS

116 2.11 0.86 3.96 0.45 1.05ICP-MS/MS

147 2.13 0.887 3.92 0.446 1.08ICP-MS

293 2.15 0.9 4.11 0.47 1.1DRC/CC-ICP-MS

399 2.10 0.903 4.03 0.471 1.08DRC/CC-ICP-MS

597 1.83 0.92 3.586 0.48 1.03DRC/CC-ICP-MS

598 1.98 0.82 3.77 0.44 0.97ICP-MS

605 2.20 0.896 4.03 0.465 1.08ICP-MS

606 2.04 0.818 3.84 0.425 1.02ICP-MS

607 2.13 0.895 4.00 0.481 1.09ICP-MS

632 2.28 0.966 4.45 0.524 1.19ICP-MS

676 2.2 0.958 4.27 0.509 1.26ICP-MS

686 2.16 0.902 4.04 0.478 1.08ICP-MS

Based on the grading criteria for Tl in Urine, 100% of results were satisfactory, with 0 of the 15 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

78

Urine Tl


UE18-06

597

598

107

606

399

116

110

147

607

293

686

103

605

676

6321.60

2.10

2.60

Lab Code

Tl (µ

g/L)

UE18-07

606

598

116

147

110

107

103

607

605

293

686

399

597

676

6320.60

0.90

1.20

Lab CodeTl

(µg/

L)

UE18-08

597

598

606

147

116

607

110

605

399

686

107

293

103

676

6323.00

4.00

5.00

Lab Code

Tl (µ

g/L)

UE18-0960

6

598

147

116

110

605

293

399

686

107

597

607

103

676

6320.20

0.50

0.80

Lab Code

Tl (µ

g/L)

UE18-10

598

107

606

597

116

110

686

399

605

147

607

293

103

632

6760.80

1.10

1.40

Lab Code

Tl (µ

g/L)

CHEAR Labs ● Other LabsHorizontal purple line = assigned target valuebased on the robust mean of all laboratories.Gray area = acceptable range based on qualityspecifications:±0.2 µg/L or ±20% around the target value,whichever is greater; thus, it is fixed at ±0.2 µg/Lat concentrations less than or equal to 1 µg/L.

Legend:o

79

Urine U (µg/L)



0.001 0.004 0.003 0.003 0.002

12 18 18 18

0.00050 0.0013 0.0010 0.00082

18

0.010 0.055 0.138 0.025 0.0420.040 0.085 0.168 0.0550.000 0.025 0.108 0.000

10.0 7.3 2.2 12.0


0.00067

Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)The acceptable range is based on quality specifications:±0.03 µg/L or ±20% around the target value, whichever is greater; thus, it is fixed at ±0.03 µg/L atconcentrations less than or equal to 0.15 µg/L. These quality specifications are based on the same criteriaused by the US Centers for Disease Control Prevention (CDC) for public health labs participating in theLaboratory Response Network (LRN) PT program for Toxic Metals.

0.012

4.8

80

Lab Code MethodUrine U (µg/L)

0.010 0.055 0.138 0.025 0.042

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10


Target 0.010 0.055 0.138 0.025 0.042

103 < 0.0200 0.0548 0.138 0.0216 0.0408DRC/CC-ICP-MS

107 0.0097 0.06 0.16 0.028 0.045ICP-MS

110 0.0102 0.0543 0.139 0.0264 0.0434ICP-MS

116 <0.015 0.0543 0.141 0.0262 0.0426ICP-MS/MS

147 < 0.0164 0.0488 0.116 0.0193 0.0329ICP-MS

324 0.009 0.053 0.140 0.024 0.042ICP-MS

399 0.009 0.058 0.140 0.020 0.045ICP-MS

598 0.02 0.07 0.13 0.03 0.04ICP-MS

599 0.02 0.06 0.13 0.03 0.04DRC/CC-ICP-MS

604 < 0.009 0.050 0.127 0.021 0.037ICP-MS

605 0.009 0.055 0.141 0.025 0.042ICP-MS

606 0.006 0.048 0.136 0.023 0.040ICP-MS

607 0.010 0.058 0.140 0.025 0.043ICP-MS

630 0.0101 0.0524 0.137 0.0250 0.0401ICP-MS

632 <0.015 0.0557 0.140 0.0254 0.0432ICP-MS

676 0.008 0.05 0.133 0.023 0.042ICP-MS

684 0.0100 0.0564 0.145 0.0256 0.0439ICP-MS

686 < 0.015 0.0547 0.139 0.0246 0.0419ICP-MS

Based on the grading criteria for U in Urine, 100% of results were satisfactory, with 0 of the 18 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

81

Urine U


UE18-06

606

676

324

605

399

107

684

607

630

110

599

5980.000

0.020

0.040

0.060

Lab Code

U (µ

g/L)

UE18-07

606

147

604

676

630

324

110

116

686

103

605

632

684

399

607

599

107

5980.020

0.060

0.100

Lab CodeU

(µg/

L)

UE18-08

147

604

598

599

676

606

630

103

686

110

399

324

607

632

605

116

684

1070.100

0.140

0.180

Lab Code

U (µ

g/L)

UE18-0914

739

960

410

360

667

632

468

663

060

560

763

268

411

611

010

759

859

90.000

0.030

0.060

Lab Code

U (µ

g/L)

UE18-10

147

604

598

606

599

630

103

686

324

605

676

116

607

632

110

684

399

1070.000

0.040

0.080

Lab Code

U (µ

g/L)

CHEAR Labs ● Other LabsHorizontal purple line = assigned target valuebased on the robust mean of all laboratories.Gray area = acceptable range based on qualityspecifications:±0.03 µg/L or ±20% around the target value,whichever is greater; thus, it is fixed at ±0.03 µg/Lat concentrations less than or equal to 0.15 µg/L.

Legend:o

82

Urine Cs (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10107 5 7.8 2.7 4.8 8.9ICP-MS110 5.61 8.26 3.07 5.12 9.95ICP-MS147 4.97 7.58 2.71 4.51 8.85ICP-MS399 5.41 7.93 2.99 4.83 9.54ICP-MS597 5.24 8.50 2.94 4.91 9.60DRC/CC-ICP-MS598 5.86 7.95 3.19 4.95 9.67ICP-MS599 5.13 7.89 3.01 4.76 9.28DRC/CC-ICP-MS605 5.68 7.96 3.06 4.95 9.66ICP-MS606 5.27 7.76 2.95 4.62 9.53DRC/CC-ICP-MS632 5.63 8.16 3.20 5.16 10.0ICP-MS676 5.52 8.39 3.09 5.05 9.76ICP-MS

Summary StatisticsUE18-06 UE18-07 UE18-08 UE18-09 UE18-10

Robust Mean (x*)Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)Standard Uncertainty (u)

5.40.35.6

0.125

11

8.00.33.8

0.110

11

3.00.13.3

0.046

11

4.90.24.1

0.079

11

9.60.33.1

0.109

11

83

Urine Cs


UE18-06

147

107

599

597

606

399

676

110

632

605

5984.5

5.5

6.5

Lab Code

Cs

(µg/

L)

UE18-07

147

606

107

599

399

598

605

632

110

676

5977.0

8.0

9.0

Lab CodeC

s (µ

g/L)

UE18-07

147

606

107

599

399

598

605

632

110

676

5977.0

8.0

9.0

Lab Code

Cs

(µg/

L)

UE18-0914

7

606

599

107

399

597

605

598

676

110

6324.0

5.0

6.0

Lab Code

Cs

(µg/

L)

UE18-10

147

107

599

606

399

597

605

598

676

110

6328.0

9.5

11.0

Lab Code

Cs

(µg/

L)

CHEAR Labs ● Other LabsHorizontal purple line = robust mean of alllaboratories.Gray area = ±2SD of the mean.


Legend:o

84

Urine Cu (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10110 106 39.3 89.8 67.8 26.9ICP-MS116 98.1 35.5 83.8 63.8 24.0ICP-MS/MS147 111 40.8 91.5 69.3 29.7ICP-MS293 111.25 36.24 87.09 66.12 24.79DRC/CC-ICP-MS324 102.719 37.740 88.902 66.862 26.521ICP-MS391 111.1 36.171 97.382 100.388 26.297DRC/CC-ICP-MS401 101 35.0 84.5 61.6 23.5DRC/CC-ICP-MS597 97.4 41.8 86.2 67.5 26.5DRC/CC-ICP-MS598 95.3 34.2 83.0 62.7 24.9ICP-MS599 86.7 36.3 81.3 61.2 26.6DRC/CC-ICP-MS



10287.8

3.33

10

36.92.15.7

0.850

10

86.94.45.1

1.75

10

65.93.95.9

1.56

10

25.91.55.8

0.591

10

85

Urine Cu


UE18-06

599

598

597

116

401

324

110

147

391

29380

100

120

Lab Code

Cu

(µg/

L)

UE18-07

598

401

116

391

293

599

324

110

147

59730.0

37.0

44.0

Lab CodeC

u (µ

g/L)

UE18-08

599

598

116

401

597

293

324

110

147

39170.0

85.0

100.0

Lab Code

Cu

(µg/

L)

UE18-0959

9

401

598

116

293

324

597

110

147

39150.0

65.0

80.095.0

105.0

Lab Code

Cu

(µg/

L)

UE18-10

401

116

293

598

391

597

324

599

110

14722.0

26.0

30.0

Lab Code

Cu

(µg/

L)



Legend:o

86

Urine Mo (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10103 66.6 257 17.1 85.5 173DRC/CC-ICP-MS107 67 260 17 87 180ICP-MS110 71.0 277 18.3 91.8 183ICP-MS147 63.9 253 16.4 82.5 165ICP-MS293 61.29 248.96 18.07 81.87 169.22DRC/CC-ICP-MS324 66.709 260.840 17.453 86.806 173.046ICP-MS399 68.2 265 17.3 87.9 177ICP-MS597 58.7 270 15.6 84.0 167DRC/CC-ICP-MS598 58.1 241.9 15.4 76.5 157.3DRC/CC-ICP-MS599 57.4 235 16.1 78.8 161DRC/CC-ICP-MS605 66.0 255 16.3 83.9 168ICP-MS606 65.7 259 15.5 85.0 173DRC/CC-ICP-MS632 71.9 279 18.6 92.5 187DRC/CC-ICP-MS676 65.9 258 17.4 86.4 175ICP-MS



65.43.85.8

1.26

14

259103.9

3.37

14

16.91.27.1

0.395

14

85.13.64.2

1.21

14

17295.2

2.85

14

87

Urine Mo


UE18-06

599

598

597

293

147

606

676

605

103

324

107

399

110

63250.0

65.0

80.0

Lab Code

Mo

(µg/

L)

UE18-07

599

598

293

147

605

103

676

606

107

324

399

597

110

632220

260

300

Lab CodeM

o (µ

g/L)

UE18-08

598

606

597

599

605

147

107

103

399

676

324

293

110

63214.0

17.0

20.0

Lab Code

Mo

(µg/

L)

UE18-0959

8

599

293

147

605

597

606

103

676

324

107

399

110

63275.0

85.0

95.0

Lab Code

Mo

(µg/

L)

UE18-10

598

599

147

597

605

293

606

103

324

676

399

107

110

632140

170

200

Lab Code

Mo

(µg/

L)



Legend:o

88

Urine Ni (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10107 2.2 5.8 7.8 3.2 6.5DRC/CC-ICP-MS110 2.30 5.80 8.15 3.25 6.97ICP-MS293 2.3 5.45 8.13 2.97 6.91DRC/CC-ICP-MS324 2.305 5.788 8.093 3.191 6.898ICP-MS401 2.00 5.22 7.92 2.52 6.57DRC/CC-ICP-MS597 2.10 6.13 7.85 3.06 6.89DRC/CC-ICP-MS598 1.89 4.90 7.71 2.85 6.1ICP-MS599 1.88 5.18 7.80 2.74 6.38DRC/CC-ICP-MS605 2.14 5.68 8.67 3.04 7.19ICP-MS


0.2 0.4 0.3 0.2 0.39.5 7.3 3.8 6.7 4.5

9 9 9 9 9


89

Urine Ni


UE18-06

599

598

401

597

605

107

293

110

3241.6

2.1

2.6

Lab Code

Ni (µg

/L)

UE18-07

598

599

401

293

605

324

107

110

5974.5

5.5

6.5

Lab CodeN

i (µg

/L)

UE18-08

598

599

107

597

401

324

293

110

6057.0

8.0

9.0

Lab Code

Ni (µg

/L)

UE18-0940

1

599

598

293

605

597

324

107

1102.0

3.0

4.0

Lab Code

Ni (µg

/L)

UE18-10

598

599

107

401

597

324

293

110

6055.5

6.5

7.5

Lab Code

Ni (µg

/L)



Legend:o

90

Urine Pt (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10107 2.3 0.77 4 1.1 0.23ICP-MS110 2.53 0.758 3.97 1.03 0.198ICP-MS147 2.4 0.712 3.84 1.02 0.167ICP-MS399 2.48 0.744 3.94 1.02 0.196ICP-MS598 2.57 0.81 4.12 1.07 0.26ICP-MS605 2.59 0.769 3.97 1.10 0.196ICP-MS632 2.37 0.713 3.80 0.998 0.195ICP-MS676 2.5 0.842 4.08 1.11 0.255ICP-MS


0.10 0.04 0.11 0.04 0.034.0 5.3 2.8 3.8 14.3

8 8 8 8 8


91

Urine Pt


UE18-06

107

632

147

399

676

110

598

6052.20

2.50

2.80

Lab Code

Pt (µ

g/L)

UE18-07

147

632

399

110

605

107

598

6760.65

0.75

0.85

Lab CodePt

(µg/

L)

UE18-08

632

147

399

110

605

107

676

5983.60

4.00

4.40

Lab Code

Pt (µ

g/L)

UE18-0963

2

147

399

110

598

605

107

6760.90

1.05

1.20

Lab Code

Pt (µ

g/L)

UE18-10

147

632

399

605

110

107

676

5980.10

0.20

0.30

Lab Code

Pt (µ

g/L)



Legend:o

92

Urine Sb (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10103 0.374 0.694 1.34 2.20 0.181DRC/CC-ICP-MS107 0.42 0.74 1.2 2.2 0.21ICP-MS110 0.455 0.795 1.39 2.27 0.221ICP-MS147 0.64 0.821 1.42 2.37 0.269ICP-MS293 0.45 0.85 1.43 2.33 0.29DRC/CC-ICP-MS399 0.442 0.764 1.37 2.27 0.240ICP-MS597 0.447 0.833 1.38 2.36 0.367DRC/CC-ICP-MS598 0.47 0.83 1.45 2.34 0.23ICP-MS606 0.386 0.723 1.31 2.25 0.170DRC/CC-ICP-MS632 0.387 0.828 1.46 2.31 <0.24ICP-MS676 0.461 0.809 1.47 2.4 0.224ICP-MS



0.440.049.1

0.014

11

0.800.045.0

0.015

11

1.390.075.0

0.026

11

2.300.083.5

0.029

11

0.230.0521.7

0.019

10

93

Urine Sb


UE18-06

103

606

632

107

399

597

293

110

676

598

1470.35

0.45

0.550.63

0.65

Lab Code

Sb (µ

g/L)

UE18-07

103

606

107

399

110

676

147

632

598

597

2930.65

0.80

0.95

Lab CodeSb

(µg/

L)

UE18-08

107

606

103

399

597

110

147

293

598

632

6761.10

1.35

1.60

Lab Code

Sb (µ

g/L)

UE18-0910

3

107

606

110

399

632

293

598

597

147

6762.00

2.30

2.60

Lab Code

Sb (µ

g/L)

UE18-10

606

103

107

110

676

598

399

147

293

5970.10

0.25

0.40

Lab Code

Sb (µ

g/L)



Legend:o

94

Urine Se (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10103 163 37.2 244 26.4 65.0DRC/CC-ICP-MS110 174 50.7 252 39.7 72.8DRC/CC-ICP-MS147 174 37.1 238 25.6 64.9ICP-MS597 149 38.1 227 25.2 64.0DRC/CC-ICP-MS598 132.2 32.0 204.4 19.7 47.9DRC/CC-ICP-MS599 130 37.3 205 27.5 60.4DRC/CC-ICP-MS630 184 46.2 255 36.1 82.4ICP-MS632 158 34.1 225 22.4 56.5DRC/CC-ICP-MS684 166 33.8 234 24.5 63.3DRC/CC-ICP-MS


19 6.1 18 6.4 9.711.9 15.8 7.8 23 15.1

9 9 9 9 9

Arithmetic Mean (x̅) 159 38.5 232 27.5 64.1Arithmetic SD (s)Arithmetic RSD (%)Number of SampleMeasurements (N)*Denotes a statistical Outlier.

95

Urine Se


UE18-06

599

598

597

632

103

684

147

110

630100

160

220

Lab Code

Se (µ

g/L)

UE18-07

598

684

632

147

103

599

597

630

11025.0

40.0

55.0

Lab CodeSe

(µg/

L)

UE18-08

598

599

632

597

684

147

103

110

630180

230

280

Lab Code

Se (µ

g/L)

UE18-0959

8

632

684

597

147

103

599

630

11010.0

30.0

50.0

Lab Code

Se (µ

g/L)

UE18-10

598

632

599

684

597

147

103

110

63040.0

65.0

90.0

Lab Code

Se (µ

g/L)



Legend:o

96

Urine Sn (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10107 0.96 6.4 1.4 3.3 0.95ICP-MS110 1.08 6.19 1.33 3.07 0.93ICP-MS147 0.789 6.05 1.29 3.04 *1.17ICP-MS399 0.724 6.01 1.27 3.00 0.913ICP-MS597 0.654 6.49 1.30 2.95 0.952DRC/CC-ICP-MS598 0.71 5.75 1.25 2.77 0.91ICP-MS676 0.791 6.51 1.36 3.14 0.952ICP-MS


0.15 0.28 0.05 0.16 0.0218.3 4.5 3.8 5.3 2.2

7 7 7 7 6


97

Urine Sn


UE18-06

597

598

399

147

676

107

1100.30

0.80

1.30

Lab Code

Sn (µ

g/L)

UE18-07

598

399

147

110

107

597

6765.25

6.25

7.25

Lab CodeSn

(µg/

L)

UE18-08

598

399

147

597

110

676

1071.10

1.30

1.50

Lab Code

Sn (µ

g/L)

UE18-0959

8

597

399

147

110

676

1072.60

3.10

3.60

Lab Code

Sn (µ

g/L)

UE18-10

598

399

110

107

597

676

1470.88

0.94

1.001.10

1.20

Lab Code

Sn (µ

g/L)



Legend:o

98

Urine Sr (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10103 332 67.0 19.2 162 414DRC/CC-ICP-MS107 350 70 21 170 420ICP-MS200 336 67.4 19.3 171 407ICP-MS399 346 70.8 20.5 170 433DRC/CC-ICP-MS605 351 69.7 19.7 166 420ICP-MS676 361 74.1 20.9 181 455ICP-MS


11 2.6 0.8 6 173.2 3.7 4.0 3.5 4.0

6 6 6 6 6

Arithmetic Mean (x̅) 346 69.8 20.1 170 425Arithmetic SD (s)Arithmetic RSD (%)Number of SampleMeasurements (N)*Denotes a statistical Outlier.

99

Urine Sr


UE18-06

103

200

399

107

605

676320

350

380

Lab Code

Sr (µ

g/L)

UE18-07

103

200

605

107

399

67660.0

70.0

80.0

Lab CodeSr

(µg/

L)

UE18-08

103

200

605

399

676

10718.0

20.0

22.0

Lab Code

Sr (µ

g/L)

UE18-0910

3

605

107

399

200

676150

170

190

Lab Code

Sr (µ

g/L)

UE18-10

200

103

605

107

399

676380

430

480

Lab Code

Sr (µ

g/L)



Legend:o

100

Urine V (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10116 0.646 6.02 3.26 1.66 0.189ICP-MS/MS147 0.561 5.05 2.62 1.41 0.178DRC/CC-ICP-MS293 0.67 5.56 3.04 1.66 0.26DRC/CC-ICP-MS597 0.555 5.65 2.77 1.54 0.263DRC/CC-ICP-MS598 0.56 5.31 2.72 1.48 0.17DRC/CC-ICP-MS605 0.808 5.73 3.26 1.77 0.237ICP-MS


0.099 0.34 0.28 0.13 0.04215.6 6.1 9.5 8.2 19.4

6 6 6 6 6


101

Urine V


UE18-06

597

598

147

116

293

6050.350

0.600

0.850

Lab Code

V (µ

g/L)

UE18-07

147

598

293

597

605

1164.50

5.50

6.50

Lab CodeV

(µg/

L)

UE18-08

147

598

597

293

116

6052.00

3.00

4.00

Lab Code

V (µ

g/L)

UE18-0914

7

598

597

116

293

6051.20

1.60

2.00

Lab Code

V (µ

g/L)

UE18-10

598

147

116

605

293

5970.050

0.200

0.350

Lab Code

V (µ

g/L)



Legend:o

102

Urine W (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10107 0.27 0.27 0.14 0.14 0.46ICP-MS110 0.292 0.261 0.154 0.131 0.450ICP-MS147 0.281 0.291 0.142 0.145 0.410ICP-MS200 0.2 0.3 0.1 0.1 0.5ICP-MS324 <1 <1 <1 <1 <1ICP-MS399 0.279 0.251 0.149 0.154 0.463ICP-MS598 0.34 0.33 0.18 0.15 0.54ICP-MS605 0.273 0.264 <0.180 <0.180 0.427ICP-MS606 0.284 1.06 0.097 0.113 0.411DRC/CC-ICP-MS632 0.362 0.262 <0.18 <0.18 0.440ICP-MS676 0.276 0.282 0.143 0.129 0.41ICP-MS


Robust Mean (x*)Robust SD (s*)Robust RSD (%)Number of SampleMeasurements (N)

An arithmetic mean, SD, RSD, and n are provided for sample UE18-08 and UE18-09.Standard Uncertainty (u)

0.280.013.6

0.0056

10

0.280.027.1

0.0096

10

0.140.0321

NA

8

0.130.0215.4

NA

8

0.450.048.9

0.016

10

103

Urine W


UE18-06

200

107

605

676

399

147

606

110

598

6320.19

0.21

0.25

0.28

0.310.34

0.38

Lab Code

W (µ

g/L)

UE18-07

399

110

632

605

107

676

147

200

598

6060.20

0.27

0.341.00

1.10

Lab CodeW

(µg/

L)

UE18-08

606

200

107

147

676

399

110

5980.06

0.14

0.22

Lab Code

W (µ

g/L)

UE18-0920

0

606

676

110

107

147

598

3990.08

0.13

0.18

Lab Code

W (µ

g/L)

UE18-10

147

676

606

605

632

110

107

399

200

5980.35

0.45

0.55

Lab Code

W (µ

g/L)



Legend:o

104

Urine Zn (µg/L)


Lab Code Method UE18-06 UE18-07 UE18-08 UE18-09 UE18-10110 77.2 244 532 433 703ICP-MS147 92.8 272 600 486 804ICP-MS293 *133.99 237.91 547.06 431.37 686.27DRC/CC-ICP-MS324 77.705 235.167 531.167 423.309 674.891ICP-MS401 72 242 549 438 719DRC/CC-ICP-MS597 85.5 *109 393 434 579DRC/CC-ICP-MS598 65.8 197 471 373 589ICP-MS599 85.8 227 453 376 569DRC/CC-ICP-MS


9 22 66 36 8211.3 9.3 12.9 8.5 12.3

7 7 8 8 8


105

Urine Zn


UE18-06

598

401

110

324

597

599

147

29360

80

100133

135

Lab Code

Zn (µ

g/L)

UE18-07

597

598

599

324

293

401

110

147108

110180

240

300

Lab CodeZn

(µg/

L)

UE18-08

597

599

598

324

110

293

401

147300

500

700

Lab Code

Zn (µ

g/L)

UE18-0959

8

599

324

293

110

597

401

147325

425

525

Lab Code

Zn (µ

g/L)

UE18-10

599

597

598

324

293

110

401

147450

650

850

Lab Code

Zn (µ

g/L)



Legend:o

106

Results for Event #2, 2018:Additional Elements in Urine

Lab Code MethodUrine Ag (µg/L)

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10147 < 0.507 < 0.507 < 0.507 < 0.507 < 0.507ICP-MS

Lab Code MethodUrine Al (µg/L)

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10147 <18.1 <18.1 <18.1 <18.1 <18.1DRC/CC-ICP-MS324 9.223 15.448 18.495 12.032 15.448ICP-MS597 17.0 27.3 30.1 20.3 24.6DRC/CC-ICP-MS

Lab Code MethodUrine B (µg/L)

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10200 335 833 470 599 688ICP-MS

Lab Code MethodUrine Bi (µg/L)


Lab Code MethodUrine Fe (µg/L)

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10324 2.921 6.328 4.203 4.821 7.648ICP-MS

Lab Code MethodUrine I (µg/L)

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10107 48 94 75 59 28ICP-MS

Lab Code MethodUrine Li (µg/L)

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10147 5.84 10.7 14.8 7.43 6.12ICP-MS

Lab Code MethodUrine Mg (µg/L)

UE18-06 UE18-07 UE18-08 UE18-09 UE18-10597 4081 42768 12502 29588 23209DRC/CC-ICP-MS

Lab Code MethodUrine Th (µg/L)


107

Trace Elements inSerum

Event #2, 2018

108

PT Materials

Graded Elements

Additional Elements

Event #2, 2018:Trace Elements in Serum

Test materials were prepared from human serum obtained from Zen-Bio, Inc. The company certifies thatthese materials were tested by FDA approved methods and found to be negative for HIV 1Ž2 and HIV-1RNA, and non-reactive to HBsAg, HCV3 and STS. Units of serum were filtered into polypropylenecontainers through cheesecloth to remove particulates and supplemented with aluminum (Al), cobalt (Co),chromium (Cr), copper (Cu), selenium (Se), zinc, (Zn), arsenic (As), beryllium (Be), cadmium (Cd),mercury (Hg), manganese (Mn), molybdenum (Mo), nickel (Ni), lead (Pb), platinum (Pt), antimony (Sb),tin (Sn), strontium (Sr), titanium (Ti), thallium (Tl), uranium (U), vanadium (V) and tungsten (W). Serumunits were homogenized overnight prior to aliquoting 2-mL into polypropylene vials. PT samples werestored at -80°C until the week of the PT event, when they were thawed at 4°C prior to circulation tolaboratories for analysis.

Six elements in serum are formally graded: Al, Co, Cr, Cu, Se, and Zn. Target values for the gradedelements are assigned to these pools based on (a) the robust mean calculated from data reported by alllaboratories, or (b) if a robust mean is not possible, the arithmetic mean after outlier deletion.

An additional 27 were reported by at least one participant: Ag, As, B, Ba, Be, Bi, Cd, Cs, Fe, Hg, I, Li, Mn,Mo, Ni, Pb, Pt, Sb, Sn, Sr, Te, Th, Ti, Tl, U, V, and W. These data are included here to provide a morecomplete characterization of the PT materials. All results reported by participant laboratories aretabulated and organized by lab code. The PT data are graphed for visual comparison purposes for allelements where at least five laboratories reported a value greater than the LOD. A statistical summarytable is provided for samples where at least two comparable values were reported as above the LOD.

The summary statistics for the additional elements are provided for educational purposes only, i.e., noacceptable response is implied. However, it is expected that each laboratory would wish to investigate apotential source of bias if warranted by these data. Future events might result in additional elementsbecoming graded if a consensus can be reached regarding desired quality specifications.

109

Serum Al (µg/L)SE18-06 SE18-07 SE18-08 SE18-09 SE18-10


Target (Arithmetic Mean (x̅)) 104 57.9 129 170 NA125 69.5 155 20483 46.3 103 136

NAUpper LimitLower Limit


18 11.5 13 21 NA17.3 19.9 10.1 12.4 NA

6 6 6 6 NA

NA


Sample SE18-10 was not graded for Event #2, 2018 due to lack of a consensus value among participatinglabs.

110

Lab Code MethodSerum Al (µg/L)

104 57.9 129 170 NA

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10


Target 104 57.9 129 170 NA

147 85.6 49.7 118 150 27.7ETAAS-Z

293 88.71 47.58 117.74 149.73 23.12DRC/CC-ICP-MS

391 116.10 68.17 146.9 198 38.64ETAAS-Z

485 94.8 50.7 120 160 22.5HR-ICP-MS

597 133 76 141 192 41DRC/CC-ICP-MS h h598 104 55.2 133 169 34.8ICP-MS

Based on the grading criteria for Al in Serum, 93% of results were satisfactory, with 1 of the 6 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

111

Serum Al


SE18-06

147

293

485

598

391

59770

110

150

Lab Code

Al µ

g/L

SE18-07

293

147

485

598

391

59740.0

60.0

80.0

Lab CodeAl

µg/

L

SE18-08

293

147

485

598

597

39180

130

180

Lab Code

Al µ

g/L

SE18-0929

3

147

485

598

597

391120

170

220

Lab Code

Al µ

g/L

SE18-10

485

293

147

598

391

59715.0

30.0

45.0

Lab Code

Al µ

g/L


Legend:o

112

Serum Co (µg/L)SE18-06 SE18-07 SE18-08 SE18-09 SE18-10





0.3 0.3 0.3 1.0 0.25.6 20.0 7.9 9.9 7.1

7 7 7 7 8

1.3

The acceptable range is based on quality specifications:±1.5 µg/L or ±15% around the target value, whichever is greater; thus, it is fixed at ±1.5 µg/L atconcentrations less than or equal to 10 µg/L. These quality specifications were established based ondiscussions with the US FDA, and represent a consensus from a network of Trace Element PT programorganizers

113

Lab Code MethodSerum Co (µg/L)

5.4 1.5 3.8 10.1 2.8

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10


Target 5.4 1.5 3.8 10.1 2.8

103 5.40 1.34 3.79 9.77 2.69DRC/CC-ICP-MS

110 5.36 1.42 3.79 9.98 2.72ICP-MS

147 5.04 1.31 3.32 9.13 2.56ICP-MS

293 5.29 1.28 3.67 9.51 2.61DRC/CC-ICP-MS

485 5.35 1.39 3.83 9.76 2.69HR-ICP-MS

597 *8 2 4 12 3DRC/CC-ICP-MS h h598 6.11 1.57 4.30 10.73 3.03ICP-MS

599 5.32 *3.74 *10.14 *1.36 2.78DRC/CC-ICP-MS h h iBased on the grading criteria for Co in Serum, 88% of results were satisfactory, with 2 of the 8 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

114

Serum Co


SE18-06

147

293

599

485

110

103

598

5973.0

5.0

7.07.5

8.0

Lab Code

Co µg

/L

SE18-07

293

147

103

485

110

598

597

5990.0

2.0

4.0

Lab CodeC

o µg

/L

SE18-08

147

293

103

110

485

597

598

5991.5

3.5

5.510.0

11.0

Lab Code

Co µg

/L

SE18-0959

9

147

293

485

103

110

598

5971.3

1.48.0

10.0

12.0

Lab Code

Co µg

/L

SE18-10

147

293

485

103

110

599

597

5981.0

3.0

5.0

Lab Code

Co µg

/L

CHEAR Labs ● Other LabsHorizontal purple line = assigned target valuebased on the arithmetic mean of all laboratories.Gray area = acceptable range based on qualityspecifications:±1.5 µg/L or ±15% around the target value,whichever is greater; thus, it is fixed at ±1.5 µg/Lat concentrations less than or equal to 10 µg/L.

Legend:o

115

Serum Cr (µg/L)SE18-06 SE18-07 SE18-08 SE18-09 SE18-10





0.5 0.6 1.9 1.2 0.842 20 24 28 12.9

7 7 8 8 8

4.2

The acceptable range is based on quality specifications:±2 µg/L or ±20% around the target value, whichever is greater; thus, it is fixed at ±2 µg/L at concentrationsless than or equal to 10 µg/L. These quality specifications were established based on discussions with theUS FDA, and represent a consensus from a network of Trace Element PT program organizers

116

Lab Code MethodSerum Cr (µg/L)

1.2 3.0 7.9 4.3 6.2

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10


Target 1.2 3.0 7.9 4.3 6.2

103 1.72 3.56 9.12 5.15 6.56DRC/CC-ICP-MS

110 0.9 2.5 8.0 4.2 5.7DRC/CC-ICP-MS

147 1.07 2.64 8.06 4.71 5.56DRC/CC-ICP-MS

293 1.18 3.17 8.33 4.3 6.04DRC/CC-ICP-MS

485 0.857 2.65 8.17 4.25 5.58HR-ICP-MS

597 2 4 10 6 7DRC/CC-ICP-MS h598 0.84 2.65 8.10 4.21 5.63DRC/CC-ICP-MS

599 <0.10 *7.16 3.66 1.78 7.55DRC/CC-ICP-MS h i iBased on the grading criteria for Cr in Serum, 90% of results were satisfactory, with 1 of the 8 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

117

Serum Cr


SE18-06

598

485

110

147

293

103

5970.0

2.0

4.0

Lab Code

Cr µ

g/L

SE18-07

110

147

598

485

293

103

597

5990.5

3.0

5.57.1

7.2

Lab CodeC

r µg/

L

SE18-08

599

110

147

598

485

293

103

5973.6

3.75.0

8.0

11.0

Lab Code

Cr µ

g/L

SE18-0959

9

110

598

485

293

147

103

5970.0

4.0

8.0

Lab Code

Cr µ

g/L

SE18-10

147

485

598

110

293

103

597

5993.0

6.0

9.0

Lab Code

Cr µ

g/L


Legend:o

118

Serum Cu (µg/L)SE18-06 SE18-07 SE18-08 SE18-09 SE18-10


Target (Arithmetic Mean (x̅)) 1421 1750 1459 2528 10991634 2013 1678 29071208 1488 1240 2149

1264Upper LimitLower Limit


68 203 80 339 814.8 11.6 5.5 13.4 7.4

8 9 8 9 9

934

The acceptable range is based on quality specifications:±95 µg/L or ±15% around the target value, whichever is greater; thus, it is fixed at ±95 µg/L atconcentrations less than or equal to 635 µg/L. These quality specifications were established by New YorkState Department of Health's Wadsworth Center, the PT Program organizer.

119

Lab Code MethodSerum Cu (µg/L)

1421 1750 1459 2528 1099

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10


Target 1421 1750 1459 2528 1099

107 1400 1700 1400 2500 1100DRC/CC-ICP-MS

110 1420 1740 1440 2600 1100ICP-MS

147 1442 1798 1499 2541 1099ICP-MS

293 1325.49 1621.74 1396.69 2370.63 987.29DRC/CC-ICP-MS

457 1448 1793 1478 2584 1134ICP-AES/OES

483 1520 1920 1550 2800 1160DRC/CC-ICP-MS

597 *1924 2150 1567 3069 1234DRC/CC-ICP-MS h h h598 1330 1556 1338 2477 971ICP-MS

599 1480 1470 *2630 1810 1110DRC/CC-ICP-MS i h iBased on the grading criteria for Cu in Serum, 87% of results were satisfactory, with 2 of the 9 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

120

Serum Cu


SE18-06

293

598

107

110

147

457

599

483

5971100

1400

17001900

1930

Lab Code

Cu µg

/L

SE18-07

599

598

293

107

110

457

147

483

5971400

1800

2200

Lab CodeC

u µg

/L

SE18-08

598

293

107

110

457

147

483

597

5991000

1400

18002600

2650

Lab Code

Cu µg

/L

SE18-0959

9

293

598

107

147

457

110

483

5971800

18202000

2600

3200

Lab Code

Cu µg

/L

SE18-10

598

293

147

110

107

599

457

483

597800

1100

1400

Lab Code

Cu µg

/L


Legend:o

121

Serum Se (µg/L)SE18-06 SE18-07 SE18-08 SE18-09 SE18-10





16 38 14 8.3 1312.3 13.2 7.1 8.7 7.6

9 9 8 8 9

136


122

Lab Code MethodSerum Se (µg/L)

130 287 197 95 170

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10


Target 130 287 197 95 170

103 128 303 205 95.2 172DRC/CC-ICP-MS

107 120 290 190 92 160DRC/CC-ICP-MS

110 116 277 191 87 160DRC/CC-ICP-MS

147 112 259 167 84.5 154ICP-MS

293 122.34 284.93 198.11 91.55 164.96DRC/CC-ICP-MS

483 140 313 210 106 186DRC/CC-ICP-MS

597 165 334 204 108 185DRC/CC-ICP-MS h598 138 319 207 95.9 160DRC/CC-ICP-MS

599 130 205 *106 *305 184DRC/CC-ICP-MS i i hBased on the grading criteria for Se in Serum, 91% of results were satisfactory, with 1 of the 9 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

123

Serum Se


SE18-06

147

110

107

293

103

599

598

483

597100

135

170

Lab Code

Se µ

g/L

SE18-07

599

147

110

293

107

103

483

598

597180

280

380

Lab CodeSe

µg/

L

SE18-08

599

147

107

110

293

597

103

598

483100

110150

200

250

Lab Code

Se µ

g/L

SE18-0914

7

110

293

107

103

598

483

597

59970

95

120300

310

Lab Code

Se µ

g/L

SE18-10

147

598

110

107

293

103

599

597

483120

170

220

Lab Code

Se µ

g/L


Legend:o

124

Serum Zn (µg/L)SE18-06 SE18-07 SE18-08 SE18-09 SE18-10





121 69 86 218 18314.3 10.5 7.3 10.3 10.0

9 8 8 8 9

1554

The acceptable range is based on quality specifications:±15 µg/L or ±15% around the target value, whichever is greater; thus, it is fixed at ±15 µg/L atconcentrations less than or equal to 100 µg/L. These quality specifications were established by New YorkState Department of Health's Wadsworth Center, the PT Program organizer.

125

Lab Code MethodSerum Zn (µg/L)

845 659 1174 2113 1828

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10


Target 845 659 1174 2113 1828

107 810 670 1200 2200 1800DRC/CC-ICP-MS

110 802 631 1180 2120 1820ICP-MS

147 758 624 1033 1922 1667ICP-MS

293 733.99 584.97 1128.76 1931.37 1629.41DRC/CC-ICP-MS

457 769 649 1116 1938 1718ICP-AES/OES

483 857 708 1270 2290 1970DRC/CC-ICP-MS

597 1104 802 1301 2529 2043DRC/CC-ICP-MS h h h598 791 605 1163 1973 1664ICP-MS

599 978 *1420 *2510 *800 2140DRC/CC-ICP-MS h h h i hBased on the grading criteria for Zn in Serum, 82% of results were satisfactory, with 2 of the 9 laboratoriesreporting 2 or more of the 5 results outside of the acceptable ranges.

126

Serum Zn


SE18-06

293

147

457

598

110

107

483

599

597650

900

1150

Lab Code

Zn µ

g/L

SE18-07

293

598

147

110

457

107

483

597

599550

700

8501400

1440

Lab CodeZn

µg/

L

SE18-08

147

457

293

598

110

107

483

597

599900

1150

14002500

2520

Lab Code

Zn µ

g/L

SE18-0959

9

147

293

457

598

110

107

483

597700

9001600

2100

2600

Lab Code

Zn µ

g/L

SE18-10

293

598

147

457

107

110

483

597

5991400

1800

2200

Lab Code

Zn µ

g/L


Legend:o

127

Serum As (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10103 6.31 17.1 11.2 9.56 2.87DRC/CC-ICP-MS110 6.1 15.9 10.6 9.3 3.2DRC/CC-ICP-MS147 4.91 14.3 8.61 7.57 2.12ICP-MS597 7.74 18.4 10.7 10.1 3.20DRC/CC-ICP-MS598 6.74 17.10 11.87 9.51 2.70DRC/CC-ICP-MS599 6.53 10.71 10.08 *16.31 3.58DRC/CC-ICP-MS

Summary StatisticsSE18-06 SE18-07 SE18-08 SE18-09 SE18-10

0.9 2.8 1.1 1.0 0.514.1 17.9 10.5 10.9 17.2

6 6 6 5 6


128

Serum As


SE18-06

147

110

103

599

598

5974.0

6.5

9.0

Lab Code

As µ

g/L

SE18-07

599

147

110

103

598

5978.0

15.0

22.0

Lab CodeAs

µg/

L

SE18-08

147

599

110

597

103

5987.0

10.5

14.0

Lab Code

As µ

g/L

SE18-0914

7

110

598

103

597

5996.0

9.0

12.016.0

17.0

Lab Code

As µ

g/L

SE18-10

147

598

103

110

597

5991.0

3.0

5.0

Lab Code

As µ

g/L



Legend:o

129

Serum Be (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10110 5.95 3.72 0.19 1.38 2.01ICP-MS147 5.47 3.77 < 0.523 1.36 1.94ICP-MS293 5.71 3.74 0.24 1.25 2.14DRC/CC-ICP-MS598 *7.04 4.43 0.31 1.47 2.67ICP-MS599 5.73 *0.05 *1.1 *3.44 1.83DRC/CC-ICP-MS


0.2 0.3 0.06 0.1 0.33.5 7.7 24 7.1 14.3

4 4 3 4 5


130

Serum Be


SE18-06

147

293

599

110

5985.2

5.7

6.27.0

7.1

Lab Code

Be µ

g/L

SE18-07

599

110

293

147

5980.0

0.13.0

4.0

5.0

Lab CodeBe

µg/

L

SE18-08

110

293

598

5990.00

0.25

0.501.00

1.20

Lab Code

Be µ

g/L

SE18-0929

3

147

110

598

5991.0

1.4

1.83.0

4.0

Lab Code

Be µ

g/L

SE18-10

599

147

110

293

5981.0

2.0

3.0

Lab Code

Be µ

g/L



Legend:o

131

Serum Cd (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10103 1.36 4.63 0.648 1.93 2.79DRC/CC-ICP-MS110 1.3 4.7 0.6 1.9 2.7ICP-MS147 1.34 4.65 0.923 2.01 2.36ICP-MS598 1.36 4.32 0.59 1.83 2.60DRC/CC-ICP-MS599 1.33 *0.71 *1.88 *4.21 2.66DRC/CC-ICP-MS


0.02 0.2 0.16 0.1 0.21.5 4.3 23 5.3 7.7

5 4 4 4 5


132

Serum Cd


SE18-06

110

599

147

598

1031.25

1.35

1.45

Lab Code

Cd µg

/L

SE18-07

599

598

103

147

1100.0

1.04.0

4.6

5.2

Lab CodeC

d µg

/L

SE18-08

598

110

103

147

5990.20

0.70

1.201.80

1.90

Lab Code

Cd µg

/L

SE18-0959

8

110

103

147

5991.6

1.9

2.24.1

4.3

Lab Code

Cd µg

/L

SE18-10

147

598

599

110

1032.0

2.6

3.2

Lab Code

Cd µg

/L



Legend:o

133

Serum Hg (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10103 4.63 6.33 0.526 2.76 0.921DRC/CC-ICP-MS110 4.5 5.7 0.5 2.7 0.9ICP-MS147 5.38 8.3 0.885 3.89 0.881ICP-MS597 4.8 6.48 0.37 2.74 0.87DMA598 4.58 6.31 0.59 2.86 1.01ICP-MS599 4.29 *0.62 *2.75 *5.95 1.04DRC/CC-ICP-MS


0.4 1.0 0.2 0.5 0.18.5 15.2 33 16.7 11.1

6 5 5 5 6


134

Serum Hg


SE18-06

599

110

598

103

597

1473.0

4.5

6.0

Lab Code

Hg µg

/L

SE18-07

599

110

598

103

597

1470.0

1.04.0

7.0

10.0

Lab CodeH

g µg

/L

SE18-08

597

110

103

598

147

5990.1

0.6

1.12.7

2.8

Lab Code

Hg µg

/L

SE18-0911

0

597

103

598

147

5991.5

3.0

4.55.0

6.0

Lab Code

Hg µg

/L

SE18-10

597

147

110

103

598

5990.6

0.9

1.2

Lab Code

Hg µg

/L



Legend:o

135

Serum Mn (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10103 7.26 4.12 12.6 5.99 2.82DRC/CC-ICP-MS110 7.4 4.2 12.8 6.1 3.0ICP-MS147 6.70 3.85 10.9 5.47 2.73ICP-MS293 7.29 4.09 11.7 5.45 2.77DRC/CC-ICP-MS597 9.70 5.31 13.1 7.72 3.77DRC/CC-ICP-MS598 8.46 4.48 13.94 6.81 3.35ICP-MS


1.1 0.5 1.1 0.9 0.414.1 11.6 8.8 14.3 12.9

6 6 6 6 6


136

Serum Mn


SE18-06

147

103

293

110

598

5975.0

8.0

11.0

Lab Code

Mn µg

/L

SE18-07

147

293

103

110

598

5973.0

4.5

6.0

Lab CodeM

n µg

/L

SE18-08

147

293

103

110

597

59810.0

12.5

15.0

Lab Code

Mn µg

/L

SE18-0929

3

147

103

110

598

5974.0

6.5

9.0

Lab Code

Mn µg

/L

SE18-10

147

293

103

110

598

5972.0

3.0

4.0

Lab Code

Mn µg

/L



Legend:o

137

Serum Mo (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10103 2.76 7.21 1.08 4.46 5.60DRC/CC-ICP-MS110 3.2 7.9 1.3 4.9 6.2ICP-MS147 2.76 6.13 0.998 4.19 5.27ICP-MS293 2.74 7.32 1.17 4.24 5.54DRC/CC-ICP-MS485 2.75 6.87 2.35 4.32 5.47HR-ICP-MS597 *3.89 8.38 1.54 5.19 6.18DRC/CC-ICP-MS598 3.02 7.54 1.30 4.66 6.02DRC/CC-ICP-MS599 2.97 *1.43 *4.94 *7.2 *7.43DRC/CC-ICP-MS


0.18 0.7 0.46 0.37 0.376.2 9.6 33 8.1 6.4

7 7 7 7 7


138

Serum Mo


SE18-06

293

485

147

103

599

598

110

5972.40

2.90

3.403.80

3.90

Lab Code

Mo µg

/L

SE18-07

599

147

485

103

293

598

110

5970.0

2.05.0

7.5

10.0

Lab CodeM

o µg

/L

SE18-08

147

103

293

598

110

597

485

5990.00

1.50

3.004.00

5.00

Lab Code

Mo µg

/L

SE18-0914

7

293

485

103

598

110

597

5993.50

4.50

5.507.00

7.20

Lab Code

Mo µg

/L

SE18-10

147

485

293

103

598

597

110

5994.50

5.50

6.507.30

7.50

Lab Code

Mo µg

/L



Legend:o

139

Serum Ni (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10110 14.0 3.6 9.0 5.5 2.7DRC/CC-ICP-MS147 15.4 4.89 10.3 7.40 2.82ICP-MS293 14.54 3.93 9.03 5.38 2.69DRC/CC-ICP-MS485 13.5 3.73 9.38 5.15 2.40HR-ICP-MS598 15.60 4.31 10.21 6.36 3.49ICP-MS599 13.97 *9.4 *6.18 4.53 4.75DRC/CC-ICP-MS


0.8 0.5 0.6 1.0 0.95.5 12.2 6.3 17.5 29

6 5 5 6 6


140

Serum Ni


SE18-06

485

599

110

293

147

59812.0

14.5

17.0

Lab Code

Ni µ

g/L

SE18-07

110

485

293

598

147

5992.5

4.0

5.59.0

10.0

Lab CodeN

i µg/

L

SE18-08

599

110

293

485

598

1476.1

6.38.0

9.5

11.0

Lab Code

Ni µ

g/L

SE18-0959

9

485

293

110

598

1473.0

5.5

8.0

Lab Code

Ni µ

g/L

SE18-10

485

293

110

147

598

5991.0

3.5

6.0

Lab Code

Ni µ

g/L



Legend:o

141

Serum Pb (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10103 11.4 3.16 5.83 7.60 8.97DRC/CC-ICP-MS110 10.8 3.1 5.6 7.6 8.9ICP-MS147 10.8 2.84 4.83 6.84 8.50ICP-MS597 *15.2 4.02 6.34 9.33 10.4DRC/CC-ICP-MS598 10.28 2.89 5.19 6.97 8.05ICP-MS599 10.61 5.43 7.27 3.11 8.63DRC/CC-ICP-MS


0.4 1.0 0.9 2.1 0.83.7 28 15.5 30 9.0

5 6 6 6 6


142

Serum Pb


SE18-06

598

599

147

110

103

5979.5

11.0

12.515.0

16.0

Lab Code

Pb µ

g/L

SE18-07

147

598

110

103

597

5991.0

3.5

6.0

Lab CodePb

µg/

L

SE18-08

147

598

110

103

597

5993.0

5.5

8.0

Lab Code

Pb µ

g/L

SE18-0959

9

147

598

110

103

5971.0

7.0

13.0

Lab Code

Pb µ

g/L

SE18-10

598

147

599

110

103

5977.0

9.0

11.0

Lab Code

Pb µ

g/L



Legend:o

143

Serum Sb (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10103 1.71 0.358 4.68 1.28 2.96DRC/CC-ICP-MS110 1.60 0.37 4.30 1.22 2.81ICP-MS147 1.74 0.323 3.45 1.36 3.01ICP-MS597 2.41 0.652 4.90 1.67 3.28DRC/CC-ICP-MS598 1.85 0.46 4.93 1.40 2.95ICP-MS599 1.92 *4.74 1.60 0.53 3.36DRC/CC-ICP-MS


0.3 0.13 1.3 0.4 0.215.8 30 33 33 6.5

6 5 6 6 6


144

Serum Sb


SE18-06

110

103

147

598

599

5971.0

2.0

3.0

Lab Code

Sb µ

g/L

SE18-07

147

103

110

598

597

5990.00

0.40

0.804.00

5.00

Lab CodeSb

µg/

L

SE18-08

599

147

110

103

597

5980.0

4.0

8.0

Lab Code

Sb µ

g/L

SE18-0959

9

110

103

147

598

5970.0

1.5

3.0

Lab Code

Sb µ

g/L

SE18-10

110

598

103

147

597

5992.6

3.1

3.6

Lab Code

Sb µ

g/L



Legend:o

145

Serum V (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10110 8.6 1.0 2.1 5.6 1.4DRC/CC-ICP-MS147 7.70 0.980 1.82 5.41 0.959DRC/CC-ICP-MS293 8.57 1.03 2.23 5.97 1.07DRC/CC-ICP-MS485 8.74 0.986 2.13 5.89 1.00HR-ICP-MS597 10.4 1.25 2.21 6.50 1.23DRC/CC-ICP-MS598 9.51 1.11 2.34 6.44 1.16DRC/CC-ICP-MS599 9.85 *2.6 *7.3 *2.01 *1.99DRC/CC-ICP-MS


0.9 0.1 0.2 0.4 0.29.9 9.1 9.5 6.7 18.2

7 6 6 6 6


146

Serum V


SE18-06

147

293

110

485

598

599

5976.0

9.0

12.0

Lab Code

V µg

/L

SE18-07

147

485

110

293

598

597

5990.8

1.1

1.42.5

2.7

Lab CodeV µg

/L

SE18-08

147

110

485

597

293

598

5991.6

2.1

2.67.0

8.0

Lab Code

V µg

/L

SE18-0959

9

147

110

485

293

598

5971.0

3.05.0

6.0

7.0

Lab Code

V µg

/L

SE18-10

147

485

293

598

597

110

5990.6

1.1

1.61.9

2.0

Lab Code

V µg

/L



Legend:o

147

Serum Ba (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10110 1.7 1.7 1.3 1.6 1.3ICP-MS147 1.26 1.62 1.04 1.39 1.20ICP-MS598 1.47 1.80 1.32 1.78 1.32ICP-MS599 1.06 0.93 1.37 1.24 1.11DRC/CC-ICP-MS


0.3 0.4 0.1 0.2 0.121 27 7.7 13.3 8.3

4 4 4 4 4


148

Serum Cs (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10110 0.35 0.34 0.62 0.35 0.62ICP-MS597 0.491 0.526 0.757 0.504 0.829DRC/CC-ICP-MS598 0.422 0.384 0.621 0.352 0.604ICP-MS599 0.36 0.64 0.36 0.36 0.64DRC/CC-ICP-MS


0.1 0.1 0.2 0.1 0.125 20 33 25 14.3

4 4 4 4 4


149

Serum Pt (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10110 1.3 0.1 0.2 0.9 0.5ICP-MS598 1.57 0.06 0.21 0.98 0.47ICP-MS


0.2 0.03 0.01 0.06 0.0214.3 38 5.0 6.4 4.2

2 2 2 2 2


150

Serum Sn (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10110 9.8 2.4 4.9 1.1 7.5ICP-MS597 13.1 2.99 5.50 1.43 8.44DRC/CC-ICP-MS598 10.80 2.50 5.16 1.19 7.47ICP-MS599 8.94 *5.22 *1.9 *2.9 8.14DRC/CC-ICP-MS


1.8 0.3 0.3 0.2 0.516.8 11.5 5.8 16.7 6.3

4 3 3 3 4


151

Serum Sr (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10103 35.2 107 73.6 82.1 48.9DRC/CC-ICP-MS200 35.9 111.3 78 86.7 54.3ICP-MS


0.5 3 3.1 3.3 3.81.4 2.8 4.1 3.9 7.4

2 2 2 2 2

Arithmetic Mean (x̅) 35.6 109 75.8 84.4 51.6Arithmetic SD (s)Arithmetic RSD (%)Number of SampleMeasurements (N)*Denotes a statistical Outlier.

152

Serum Ti (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10200 1.9 3.1 4.9 5.2 2.6DRC/CC-ICP-MS485 2.47 4.10 9.78 6.00 1.57HR-ICP-MS


0.4 0.7 NA 0.6 0.718.2 19.4 NA 10.7 33

2 2 NA 2 2

Arithmetic Mean (x̅) 2.2 3.6 NA 5.6 2.1Arithmetic SD (s)Arithmetic RSD (%)Number of SampleMeasurements (N)*Denotes a statistical Outlier.Statistical data were not calculated for SE18-08 based on a lack of consensus among participating labs.

153

Serum Tl (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10103 4.68 1.07 2.24 3.89 3.28DRC/CC-ICP-MS110 4.57 1.06 2.17 3.93 3.32ICP-MS147 4.35 0.991 1.88 3.52 3.05ICP-MS598 4.31 0.96 1.99 3.56 2.93ICP-MS


0.2 0.1 0.2 0.2 0.24.4 10.0 9.5 5.4 6.5

4 4 4 4 4


154

Serum U (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10103 0.201 0.0790 0.0587 0.126 0.0215DRC/CC-ICP-MS110 0.191 0.089 0.056 0.122 0.014ICP-MS147 0.195 0.0781 0.0414 0.118 0.0176ICP-MS598 0.23 0.09 0.07 0.13 0.03ICP-MS


0.018 0.006 0.012 0.005 0.0078.8 7.1 21 4.0 33

4 4 4 4 4


155

Serum W (µg/L)


Lab Code Method SE18-06 SE18-07 SE18-08 SE18-09 SE18-10110 0.18 0.97 0.38 1.16 0.54ICP-MS147 0.134 0.826 0.263 1.06 0.480ICP-MS200 0.5 1.4 *0.9 1.7 *1.4ICP-MS598 0.35 1.07 0.47 1.24 0.61ICP-MS


NA 0.2 0.1 0.3 0.1NA 18.2 25 23 20

NA 4 3 4 3

Arithmetic Mean (x̅) NA 1.1 0.4 1.3 0.5Arithmetic SD (s)Arithmetic RSD (%)Number of SampleMeasurements (N)*Denotes a statistical Outlier.Statistical data were not calculated for SE18-06 based on a lack of consensus among participating labs.

156

Results for Event #2, 2018:Additional Elements in Serum

Lab Code MethodSerum Ag (µg/L)

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10147 < 0.227 < 0.227 0.228 < 0.227 0.263ICP-MS

Lab Code MethodSerum B (µg/L)

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10200 48 46 62 30 43.0ICP-MS

Lab Code MethodSerum Bi (µg/L)

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10147 < 0.230 < 0.230 < 0.230 < 0.230 < 0.230ICP-MS

Lab Code MethodSerum Fe (µg/L)

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10457 794 244 853 236 883ICP-AES/OES

Lab Code MethodSerum I (µg/L)

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10147 50.8 46.3 57.6 46.3 56.1ICP-MS

Lab Code MethodSerum Li (µg/L)

SE18-06 SE18-07 SE18-08 SE18-09 SE18-10147 0.708 0.593 0.999 0.461 1.01ICP-MS

Lab Code MethodSerum Te (µg/L)


Lab Code MethodSerum Th (µg/L)


157

1. ISO/FDIS-13528 (2005) Statistical methods for use in proficiency testing byinterlaboratory comparisons. International Organization for Standardization, Geneva.

2. Taylor A, Angerer J, Arnaud J, Claeys F, Jones RL, Mazarrasa O, Mairiaux E, MendittoA, Parsons PJ, Patriarca M, Pineau A, Valkonen S, Weber J-P, Weykamp C.Occupational and environmental laboratory medicine: A network of EQAS organisers.Accreditation and Quality Assurance. 2006;11(8-9):435-9. PubMed PMID: 086NJ-0011.

References

158

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