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© 2019 From Technologies to Markets Sample Next-Generation Sequencing & DNA Synthesis: Technology, Consumables Manufacturing and Market Trends 2019 report Picture: Courtesy of Roswell Biotechnologies
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Page 1: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

© 2019

From Technologies to Markets

Sample

Next-Generation Sequencing & DNA

Synthesis:

Technology, Consumables Manufacturing and Market

Trends

2019 report

Picture: Courtesy of Roswell Biotechnologies

Page 2: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

2

Biographies & contacts

| Sample | www.yole.fr | ©2019

ABOUT THE AUTHORS

Sébastien Clerc

Sébastien Clerc works as a medical technologies and market analyst at Yole Développement. As part of the Medical Technologies

(MedTech) business unit, Sébastien has authored a collection of market and technology reports dedicated to topics including

microfluidics, POC, and MEMS for healthcare applications and connected medical devices. In parallel, he is regularly involved in

custom projects including strategic marketing, technology scouting, and technology evaluation, designed to help academic and

industrial players in their innovation processes. Leveraging his technology and market expertise, Sébastien has spoken at more

than ten industry conferences worldwide in the last two years.

Sébastien graduated from Grenoble Institute of Technology (Grenoble INP - Grenoble, France) with a master’s degree in

Biomedical Technologies. He then completed his curriculum with a master’s degree in Innovation and Technology Management

from the same institute.

Email: [email protected]

Asma Siari

As a Technology & Market Analyst in the Medical Technologies (MedTech) business unit at Yole Développement (Yole), Asma Siariis involved in the development of technology & market reports as well as custom consulting projects. After a Master’s degree inBiotechnologies, Diagnostic Therapeutics & Management, Asma worked as a Research Assistant at the Moores Cancer Center(San Diego, CA). She is a coauthor in two scientific publications published in the Molecular Cancer Research Journal. Whileworking at Yole, Asma graduated with an Advanced Master’s degree in International Strategy & Marketing BtoB (EMLyon BusinessSchool, France).

Email: [email protected]

Next-Generation Sequencing & DNA Synthesis

Page 3: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

3| Sample | www.yole.fr | ©2019

454 Life Sciences (Roche), AGC (Asahi Glass Co.), Agilent Technologies, Advanced Liquid Logic (ALL) (Illumina), AppliedBiosystems (Thermo Fisher), Apton Biosystems, Armonica Technologies, Atum, Base4 Innovation, BGI (Beijing GenomicsInstitute), Bio Basic, Biocat, Bioneer, Bio-Rad Laboratories, Broad Institute of MIT and Harvard, Caerus Molecular Diagnostics,Catalog, Centrillion Technologies, Complete Genomics (BGI), Corning, Cygnus Biosciences, Depixus, Desktop Genetics, DirectGenomics, DNA Electronics, DNA Script, Dover Motion (Danaher), Electronic Biosciences, Electron Optica, Electroseq, Eurofins,Eve Biomedical, Evonetix, Gen9 Bio (Gingko Bioworks), Genapsys, GeneArt, GeneOracle, Geneseque, Genewiz (BrooksAutomation), Genia Technologies (Roche), Genome Surveilllance, GenScript, Gingko Bioworks, GnuBio (Bio-Rad), Grail, HalcyonMolecular, Harvard University, Helicos Biosciences, Helixworks, Heraeus, Hoya, IDT (Integrated DNA Technologies), Illumina, IMTAG, IMT MEMS, iNanoBio, inSilixa, Intelligent Biosystems (IBS) (Qiagen), Invenios, Ion Torrent (Life technologies) (ThermoFisher), Iridia, Jilin Zixin Pharma, Kilobaser, LabGenius, LaserGen (Agilent), Lightspeed Genomics (BioSearch Technologies), LittleThings Factory, MGI (BGI), Micralyne, Micronit, Mir Enterprises, Molecular Assemblies, Nabsys, NanoString Technologies,NobleGen, NorthShore Bio, Novati (Skorpios Technologies), NuGen, Ohara Corporation, Omniome, Origene, Oxford NanoporeTechnologies (ONT), Pacific Biosciences, Plan Optik, Personal Genomics, Powerchip Technologies, Quantapore, Qiagen,QuantuMDx, QuantumSi, Roche, Roswell Biotechnologies, Schott AG, SeqLL, Silex Microsystems, SingularBio, Singular Genomics,Solametrix, Solexa (Illumina), Stratos Genomics, Synthomics, Thermo Fisher Scientific, TSMC (Taiwan SemiconductorManufacturing Company), Twist Bioscience, Two Pore Guys, Universal Sequencing Technology Corporation, University of Alabama,Wellcome Trust Sanger Institute, Xgenomes, ZS Genetics, and more.

COMPANIES CITED IN THIS REPORT

Next-Generation Sequencing & DNA Synthesis

Orange font = not active anymore

Green font = acquired by ()

210+ slides of market and technology analysis

Information gathered through direct discussions with players all along the supply chain

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4| Sample | www.yole.fr | ©2019

REPORT OBJECTIVES

• Give an overview of the Next-Generation Sequencing and Next-Generation DNA Synthesis market and technologylandscapes, understand who the established and upcoming players are, what their technologies are along with advantages anddrawbacks, and how it will evolve in the next few years

• Understand how and why semiconductor technologies are leveraged in these fields, enabling improvements in cost, size,speed, production scale-up, reproducibility, etc.

• Identify where the opportunities are for the different players all along the supply chain, from materials suppliers andMEMS/microfluidic foundries to sequencing technology developers.

• Provide market data and forecasts along with market shares (installed base of sequencers, number of flowcells, number of 8”equivalent wafers, consumables market in $, fab market in $, raw material market in $)

• Understand the different technologies at the consumable (flow cell) level, in terms of microstructures, materials,manufacturing processes, etc.

Next-Generation Sequencing & DNA Synthesis

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5| Sample | www.yole.fr | ©2019

REPORT METHODOLOGY

Market forecast methodology

Next-Generation Sequencing & DNA Synthesis

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REPORT METHODOLOGY

Technology analysis methodology Information collection

Next-Generation Sequencing & DNA Synthesis

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TABLE OF CONTENT (1/3)

Executive Summary p.14

DNA sequencing part1) Context p.56

DNA Structure and DNA sequencing

History of DNA sequencing

Cost of sequencing

Microstructures and the use of semiconductor technologies

Clonal vs. Single-molecule sequencing

Limitations of short reads

Genome assembly

A myriad of technologies in development

Geographical location of sequencing companies

2) Market forecasts p.70

Installed base of sequencers

Flow cells market (units)

Flow cells market (8” equivalent wafers)

Sequencing consumables market ($M)

Sequencing consumables fab market ($M)

Sequencing consumables raw material market ($M)

Conclusions

3) Market trends p.83

Applications of NGS

Evolution of sequencing revenue per application

Applications driving the use of NGS

Leveraging semiconductor technologies

The value will switch from the optics to the chip

Clonal vs. Single molecule technologies – A difficult road to market

Consumables and sample prep

Penetration of the clinical market

Why has Illumina won the sequencing race so far?

Why will Illumina be challenged at some point?

Competition on price

Advices to newcomers

Next-Generation Sequencing & DNA Synthesis

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TABLE OF CONTENT (2/3)

4) Market shares and supply chain p.104

Installed base of sequencers

Number of flow cells per player

Number of flow cells per material

Potential sequencing output per player

Sequencing consumables revenue per player

Sequencing consumables revenue per flow cell material

8” equivalent wafers, per flow cell material

Flow cell fab market, per flow cell material

Flow cell raw material market, per flow cell material

Comments and conclusion

Supply chain analysis:

o DNA sequencing flow cell manufacturing

o Glass substrates providers

o Conclusion

5)Technology trends p.124

Methods for DNA sequencing

Clonal amplification vs. single molecule technologies

Sample prep

Drivers for technology development: an endless race

Clonal vs. Single molecule technologies – which ones are solid-state?

Which are the substrates used?

Detection methods

Use of semiconductor substrates

Size of the chips

Flow cell cost and price breakdown

Quality scores in sequencing

Performances comparison of sequencing technologies

Technology focus: Illumina, Oxford Nanopore, Pacific Biosciences, IonTorrent

Conclusion

6) Company profiles (50+ company profiles of companiesdeveloping sequencing technologies) p.161

Next-Generation Sequencing & DNA Synthesis

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TABLE OF CONTENT (3/3)

DNA synthesis part p.193

Definition

Rapid growth in base pairs

A massive divergence in capacity

HISTORY of DNA writing

What can be synthetized?

How DNA can be Synthetized?

Current DNA synthesis methods

Geographical location of DNA synthesis companies

Mergers and acquisitions

Market data and forecasts

Writing synthetic DNA on silicon chips

Company profiles

Applications for DNA synthesis

New type of DNA suppliers

Market opportunities and current developments

Adoption of silicon chips-based DNA Synthesis technology

Conclusion

Conclusion of the report p.215

Next-Generation Sequencing & DNA Synthesis

Page 11: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

11| Sample | www.yole.fr | ©2019

INTRODUCTION

History of DNA sequencing – Main players’ first commercial products and M&A

Applied Biosystems SOLiD

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019

Solexa GA

454 GS 20

Church Lab / Danaher

Motion Polonator

Helicos Genetic Analyzer

Ion PGM

?IBS MAX-Seq Qiagen GeneReader

PacBio RS

Direct Genomics

Genocare

Oxford Nanopore MinION

BGI BGISEQ-500

Illumina GA IIx

454 GS FLX

Who’s next?

Next-Generation Sequencing & DNA Synthesis

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12| Sample | www.yole.fr | ©2019

INTRODUCTION

Microstructures and the use of semiconductor technologies

Most sequencing technologies are using, to some extent, microstructures. Beads, wells, membranes, patterned surfaces, nanoporesare examples of microstructures which can be found in sequencing consumables.

Sequencing consumables from several sequencing systems leverage semiconductor technologies to manufacture thesemicrostructures in a reproducible and scalable manner. While glass is often used when optical detection is the method of choice,the advent of electrical detection methods has led to the increased use of CMOS substrates.

Ion Torrent 316 chip (CMOS)Illumina HiSeq flow cell (glass)

Next-Generation Sequencing & DNA Synthesis

Page 13: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

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CONTENT OF THE REPORT

Introduction and context

Next-Generation Sequencing & DNA Synthesis

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CONTENT OF THE REPORT

Market forecasts

Next-Generation Sequencing & DNA Synthesis

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CONTENT OF THE REPORT

Market trends

Next-Generation Sequencing & DNA Synthesis

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16| Sample | www.yole.fr | ©2019

CONTENT OF THE REPORT

Market shares and supply chain analysis

Next-Generation Sequencing & DNA Synthesis

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17| Sample | www.yole.fr | ©2019

CONTENT OF THE REPORT

Technology trends (1/2)

Next-Generation Sequencing & DNA Synthesis

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CONTENT OF THE REPORT

Technology trends (2/2)

Next-Generation Sequencing & DNA Synthesis

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CONTENT OF THE REPORT

Company profiles

Next-Generation Sequencing & DNA Synthesis

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CONTENT OF THE REPORT

DNA synthesis dedicated part

Next-Generation Sequencing & DNA Synthesis

Page 21: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

21| Sample | www.yole.fr | ©2019

YOLE GROUP OF COMPANIES RELATED REPORTS

Next-Generation Sequencing & DNA Synthesis

Page 22: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts to permit it. Research is progressing and enabling a better understanding of the genetic content of life. Sequencing therefore holds a bright future in clinical applications, enabling clinical decisions on the basis of sequencing information. Increasing adoption paves the way for personalized medicine, helping to better understand cancers and rare genetic diseases. Sequencing even has potential for non-invasive early cancer detection with liquid biopsies. It is also increasingly used in other applications, such as forensics, agricultural sciences and drug development. Furthermore, the possibility of encoding vast amounts of information in DNA could replace our current data storage solutions, offering an insanely space efficient storage at low cost in the future.

The sequencing market is dominated by a handful of players, all with their own sequencing technology, and associated advantages and drawbacks. However, Illumina currently holds more than 80% of the sequencing market, leaving only crumbs to its competitors. Nevertheless, newcomers such as China’s BGI and the UK’s Oxford Nanopore have the potential to change this along with other technologies in development, some of which might reach the market as soon as 2019. In total, Yole Developpement’s (Yole) analysts identified more than 50 companies developing sequencing

technologies. In the report, Yole's analysts provide our analysis of how the sequencing landscape will evolve in the coming years and how these new technologies could change the game. Cost, throughput, read length, accuracy, speed, portability, ease of interpretation are criteria on which there is room for improvement, and Illumina might win some but not all of these races.

One thing remains clear: we are still in the early days of sequencing and tremendous growth is expected as the use of sequencing spreads. This is why Yole’s analysts expect that the fleet of sequencing instruments will more than double by 2024, from almost 30,000 sequencers today. As a consequence of the razor/razor-blade business model of sequencing consumables, the number of sequencing flow cells, the disposable chips used to perform and sometimes detect the sequencing reaction, is poised to grow at a 21% Compound Annual Growth Rate (CAGR), from 1.28 million units in 2018 to 4.19 million units in 2024. But this is only a first step: the $1,000 genome was achieved years ago, and we’re now heading towards the $100 genome. The continuous improvement of sequencing technologies will someday lead to a much more affordable and practical sequencing, the $10 genome or even below. At this point, it is not millions of flow cells per year but hundreds of millions that one needs to consider, representing an immense opportunity for the entire semiconductor supply chain.

NEXT GENERATION SEQUENCING & DNA SYNTHESIS: TECHNOLOGY, CONSUMABLES MANUFACTURING AND MARKET TRENDS 2019 Market & Technology Report - April 2019With the sequencer installed base doubling, the sequencing consumables market will reach $7.8B by 2024.

REPORT KEY FEATURES • History of DNA sequencing• Use of semiconductor technologies

in sequencing• Market data, forecasts and market

shares including installed base of sequencers, number of flow cells, number of 8” equivalent wafers, consumables market in $, fab market in $ and raw material market in $

• Market analysis: applications, drivers, competitive landscape, etc.

• Supply chain analysis• Technology analysis: description,

segmentation and comparison of sequencing technologies available and in development. Sample preparation, detection methods, focus on semiconductor-based consumables

• Company profiles: 50+ companies developing sequencing technologies

• Dedicated part for DNA synthesis technologies, applications and market trends with a focus on semiconductor technologies

REPORT OBJECTIVES• Give an overview of the Next-

Generation Sequencing and Next-Generation DNA synthesis market and technology landscapes, understand who the established and upcoming players are, what their technologies are along with their advantages and drawbacks, and how they will evolve in the next few years

• Understand how and why semiconductor technologies are leveraged in these fields, enabling improvements areas such as cost, size, speed, production scale-up and reproducibility

• Describe the supply chain• Identify where the opportunities are

for the different players all along the supply chain, from materials suppliers and MEMS/microfluidic foundries to sequencing technology developers

• Provide detailed market data and forecasts along with market shares

• Understand the different technologies at the consumable flow cell level, in terms of microstructures, materials and manufacturing processes (Yole Développement, April 2019)

Sequencing market forecasts of flow cells shipped

SEQUENCING IS A VERY DYNAMIC MARKET AND HAS APPLICATIONS IN MANY FIELDS, HOWEVER IT IS ONLY THE BEGINNING OF THE STORY

0

1

2

3

4

5

2017 2018 2019 2020 2021 2022 2023 2024

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Pacific Biosciences

BGI

Thermo Fisher Scientific

Oxford Nanopore

Illumina

CAGR 2019-2024= +21%

Page 23: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

NEXT GENERATION SEQUENCING & DNA SYNTHESIS – TECHNOLOGY, CONSUMABLES MANUFACTURING AND MARKET TRENDS 2019

THE TIME FOR NEW DNA SYNTHESIS TECHNOLOGIES BASED ON SEMICONDUCTOR CHIPS HAS ARRIVED

Gene synthesis technology has revolutionized both the understanding of DNA functions and the ability to manipulate DNA for experimental, medical, and industrial purposes. Until recently, DNA was synthesized using enzymatic and chemical processes. These methods include random errors, making the DNA useless, and finding error-free DNA is a time-

consuming mission requiring further analysis and sequencing.

Semiconductor chips are allowing important advancements in the field of genomic research by enabling the synthesis of thousands of genes in parallel. This is revolutionizing the way DNA synthesis is performed, enabling faster and more efficient synthesis. Such technology leverages semiconductor processing techniques to greatly increase throughput and has the potential to make oligonucleotide synthesis cost 1000 times lower. On the other hand, the throughput can be increased even further by scaling down the chips’ feature size. In this context, Yole’s analysts estimate that the global market of semiconductor chips used for DNA synthesis will reach $213.2M in 2024 with a CAGR of 40% over the period 2018-2024.

A wide range of applications such as drug discovery, agriculture and data storage will increasingly rely upon gene synthesis to solve problems related to healthcare, food supplies and storage modalities respectively. In the report, Yole’s analysts explore the possibilities envisioned thanks to emerging semiconductor-based DNA synthesis technologies, identify the key players leading the market, highlight the new needs for each application and discuss the technology’s evolution.

Sequencing flow cells market shares per material (in units)

(Yole Développement, April 2019)

Glass flow cells

Silicon flow cells

72%(0.92 million

units)

1.28 million flow cells2018

2024

*CAGR2018-2024= +21%

*CAGR: Compound Annual Growth Rate

52%(2.17 million units)

4.18 million flow cells

28%(0.36 million

units)

48%(2.01 million units)

CHEAPER, BETTER, FASTER, LONGER SEQUENCING READS: SEMICONDUCTOR TECHNOLOGIES HAVE A KEY ROLE TO PLAY IN DRIVING THIS ENDLESS RACE

Most sequencing technologies are using, to some extent, microstructures. Beads, wells, membranes, patterned surfaces and nanopores are all examples of microstructures that can be found in sequencing consumables. Sequencing consumables from most players leverage semiconductor technologies to manufacture these microstructures in a reproducible and scalable manner. The key to scaling sequencing power is always increasing flow cells’ density to generate more data on the same surface area. It is no coincidence that the cost of sequencing has dropped much faster than Moore’s law over the past 15 years.

While glass is often used when optical detection is the method of choice, the advent of electrical detection methods has led to the increased use of silicon and CMOS substrates. Silicon, especially CMOS, is the material of choice for the flow cells used by most technologies currently in development. The expected market introduction of several of these technologies in the next few years will boost the associated number of wafers. Sequencing companies need, or will need, to mass-manufacture these flow cells, creating opportunities at all the levels of the semiconductor supply chain. Indeed, most sequencing players have made the choice to outsource this production to specialized players. However, some start-ups struggle in the development phase because foundries seem not to realize the potential volumes sequencing flow cells could represent in the future. Consequently it is difficult for them to get access to the equipment and processes they need. In this report, Yole analyzes the supply chain and also focuses on several leading and emerging flow cell technologies from key and upcoming players including the type of microstructures, process flow, and evolution over time. Yole's analysts also talk about the limitation of optical detection technologies leading to ever larger glass flow cells, which represents a significant opportunity for glass players as well.

History of DNA writing

(Yole Développement, April 2019)

1970 1975 1980 1985 1990 1995 2000 2005 2010 2015

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commercial gene synthesis

2020

The next generation of DNA synthesis

Up to ~ 1M Oligos/Chip

Courtesy of Fisher Scientific

Page 24: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

MARKET & TECHNOLOGY REPORT

COMPANIES CITED IN THE REPORT (non exhaustive list)

AGC [Asahi Glass Co.], Agilent Technologies, Advanced Liquid Logic (Illumina), Apton Biosystems, Armonica Technologies, Atum, Base4 Innovation, BGI [Beijing Genomics Institute], Bio Basic, Biocat, Bioneer, Bio-Rad Laboratories, Biosearch Technologies, Caerus Molecular Diagnostics, Catalog, Centrillion Technologies, Complete Genomics (BGI), Corning, Cygnus Biosciences, Depixus, Desktop Genetics, Direct Genomics, DNA Electronics, DNA Script, Electronic Biosciences, Electron Optica, Electroseq, Eurofins, Eve Biomedical, Evonetix, Gen9 Bio (Gingko Bioworks), Genapsys, GeneArt, GeneOracle, Geneseque, Genewiz (Brooks Automation), Genia Technologies, Genome Surveilllance, GenScript, Gingko Bioworks, GnuBio (Bio-Rad), Grail, Helixworks, Heraeus, Hoya, Integrated DNA Technologies (Danaher), Illumina, IMT AG, IMT MEMS, iNanoBio, inSilixa, Intelligent Biosystems (Qiagen), Invenios, Ion Torrent (Thermo Fisher), Iridia, Jilin Zixin Pharma, Kilobaser, LabGenius, LaserGen (Agilent), Lightspeed Genomics, Little Things Factory, MGI (BGI), Micralyne, Micronit, Mir Enterprises, Molecular Assemblies, Nabsys, NanoString Technologies, NorthShore Bio, Novati (Skorpios Technologies), Ohara Corporation, Omniome, Origene, Oxford Nanopore Technologies [ONT], Pacific Biosciences (Illumina), Plan Optik, Personal Genomics, Powerchip Technologies, Quantapore, Qiagen, QuantuMDx, QuantumSi, Roche, Roswell Biotechnologies, Schott AG, SeqLL, Silex Microsystems, SingularBio, Singular Genomics, Solexa (Illumina), Stratos Genomics, Synthomics, Thermo Fisher Scientific, TSMC [Taiwan Semiconductor Manufacturing Company], Twist Bioscience, Two Pore Guys, Universal Sequencing Technology Corporation, Xgenomes, ZS Genetics, and more.

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Find all our reports on www.i-micronews.com

Sébastien Clerc works as a Technology & Market Analyst, Microfluidics & Medical Technologies at Yole Développement (Yole). As part of the Life Sciences & Healthcare division, Sébastien has authored a collection of market and technology reports dedicated to topics such as microfluidics, point-of-care, MEMS for healthcare applications and connected medical devices. In parallel, he is daily involved in custom projects such as strategic marketing, technology scouting and technology evaluation to help academic and industrial players in their innovation processes. Thanks to his technology & market expertise, Sébastien has spoken in more than 10 industry conferences worldwide over the last 2 years. Sébastien Clerc graduated from Grenoble Institute of Technology (Grenoble INP - Grenoble, France) with a Master’s degree in Biomedical Technologies. He then completed his cursus with a Master’s degree in Innovation and Technology Management in the same institute.

AUTHORS

TABLE OF CONTENTS (complete content on i-Micronews.com)Executive summary 14

DNA SEQUENCING PART 55

Context 56

Market forecasts 70

> Installed base of sequencers> Flow cell market (units and 8” equivalent wafers)> Sequencing consumable market ($M)> Sequencing consumable fab market ($M)> Sequencing consumable raw material market ($M)

Market trends 83

> Applications of NGS> Evolution of sequencing revenue by application> Applications driving the use of NGS> Leveraging semiconductor technologies> The value will switch from the optics to the chip> Clonal vs. single molecule technologies – A difficult

road to market> Consumables and sample preparation> Penetration of the clinical market> Why has Illumina won the sequencing race so far?> Why will Illumina be challenged at some point?> Competition on price> Advice to newcomers

Market shares and supply chain 104

> Installed base of sequencers> Number of flow cells per player and per material> Potential sequencing output per player> Sequencing consumable revenue per player and per

flow cell material> 8” equivalent wafers, per flow cell material> Flow cell fab market, per flow cell material> Flow cell raw material market, per flow cell material> Comments and conclusion> Supply chain analysis:

- DNA sequencing flow cell manufacturing- Glass substrate providers

Technology trends 124

> Methods for DNA sequencing> Clonal amplification vs. single molecule technologies> Sample preparation> Drivers for technology development: an endless race> Clonal vs. single molecule technologies – which ones

are solid-state?> Which substrates are used?> Detection methods> Use of semiconductor substrates> Size of the chips> Flow cell cost and price breakdown> Quality scores in sequencing> Performances comparison of sequencing technologies> Technology focus: Illumina, Oxford Nanopore, Pacific > Biosciences, Ion Torrent> Conclusion

Profiles of over 50 companies developing sequencing technologies 161

DNA SYNTHESIS PART 193

> Definition > Rapid growth in base pairs> A massive divergence in capacity> History of DNA writing> What can be synthesized?> How can DNA be synthesized?> Current DNA synthesis methods> Geographical location of DNA synthesis companies> Mergers and acquisitions> Market data and forecasts > Writing synthetic DNA on silicon chips> Company profiles> Applications for DNA synthesis> New types of DNA suppliers> Market opportunities and current developments> Adoption of silicon chip-based DNA synthesis technology

Conclusion of the report 215

As a Technology & Market Analyst, Biotechnologies & Molecular Innovations, Medical Technologies in the Life Sciences & Healthcare division at Yole Développement (Yole), Asma Siari is involved in the development of technology & market reports as well as the production of custom consulting projects. After a Master’s degree in Biotechnologies, Diagnostic Therapeutics & Management, Asma served as Research Assistant at the Moores Cancer Center (San Diego, CA). She is a coauthor in three scientific publications published in the Molecular Cancer Research Journal. Asma Siari graduated with an Advanced Master’s degree in International Strategy & Marketing BtoB from EM Lyon Business School (France).

Page 25: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

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+ 49 15 123 544 182 – [email protected]• Japan & Rest of Asia - Takashi Onozawa:

+81-80-4371-4887 – [email protected]• Greater China - Mavis Wang:

+886 979 336 809 – [email protected]• Specific inquiries: +33 472 830 180 – [email protected]

(1) Our Terms and Conditions of Sale are available at www.yole.fr/Terms_and_Conditions_of_Sale.aspx The present document is valid 24 months after its publishing date: April 11, 2019

/

ABOUT YOLE DEVELOPPEMENT

BILL TO

Name (Mr/Ms/Dr/Pr):

Job Title:

Company:

Address:

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Date:

PRODUCT ORDER - Ref YD19013Please enter my order for above named report: One user license*: Euro 5,990 Multi user license: Euro 6,490- The report will be ready for delivery from April 19, 2019- For price in dollars, please use the day’s exchange rate. All reports are

delivered electronically at payment reception. For French customers, add 20% for VAT

I hereby accept Yole Développement’s Terms and Conditions of Sale(1)

Signature:

*One user license means only one person at the company can use the report.

Founded in 1998, Yole Développement has grown to become a group of companies providing marketing, technology and strategy consulting, media and corporate finance services, reverse engineering and reverse costing services and well as IP and patent analysis. With a strong focus on emerging applications using silicon and/or micro manufacturing, the Yole group of companies has expanded to include more than 80 collaborators worldwide covering MEMS and Image Sensors, Compound Semiconductors, RF Electronics, Solid-State Lighting, Displays, Software, Optoelectronics, Microfluidics & Medical, Advanced Packaging, Manufacturing, Nanomaterials, Power Electronics and Batteries & Energy Management.The “More than Moore” market research, technology and strategy consulting company Yole Développement, along with its partners System Plus Consulting, PISEO and KnowMade, support industrial companies, investors and R&D organizations worldwide to help them understand markets and follow technology trends to grow their business.

CONSULTING AND ANALYSIS• Market data & research, marketing analysis• Technology analysis• Strategy consulting• Reverse engineering & costing• Patent analysis• Design and characterization of innovative optical systems• Financial services (due diligence, M&A with our partner)More information on www.yole.fr

MEDIA & EVENTS• i-Micronews.com website & related @Micronews e-newsletter• Communication & webcast services• Events: TechDays, forums…More information on www.i-Micronews.com

REPORTS• Market & technology reports• Patent investigation and patent infringement risk analysis• Structure, process and cost analysis• Cost simulation toolMore information on www.i-micronews.com/reports

CONTACTSFor more information about :• Consulting & Financial Services: Jean-Christophe Eloy ([email protected])• Reports: David Jourdan ([email protected]) Yole Group of Companies• Press Relations & Corporate Communication: Sandrine Leroy ([email protected])

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© 2019

Yole Développement

From Technologies to Market

Source: Wikimedia Commons

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2©2019 | www.yole.fr | About Yole Développement

YOLE DEVELOPPEMENT – FIELDS OF EXPERTISE

Life Sciences

& Healthcare o Microfluidics

o BioMEMS & Medical Microsystems

o Inkjet and accurate dispensing

o Solid-State Medical Imaging & BioPhotonics

o BioTechnologies

Power

& Wireless

o RF Devices & Technologies

o Compound Semiconductors & Emerging Materials

o Power Electronics

o Batteries & Energy Management

Semiconductor

& Software o Package,Assembly & Substrates

o Semiconductor Manufacturing

o Memory

o Software & Computing

Photonics,

Sensing & Display

o Solid-State Lighting

o Display

o MEMS, Sensors & Actuators

o Imaging

o Photonics & Optoelectronics

Semiconductor

& Software

Power & Wireless

Photonics,

Sensing

& Display

Life

Sciences &

Healthcare

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3©2019 | www.yole.fr | About Yole Développement

4 BUSINESS MODELS

o Consulting and Analysis

• Market data & research,

marketing analysis

• Technology analysis

• Strategy consulting

• Reverse engineering & costing

• Patent analysis

• Design and characterization

of innovative optical systems

• Financial services (due

diligence, M&A with our

partner)

www.yole.fr

o Syndicated reports

• Market & technology reports

• Patent investigation and patent

infringement risk analysis

• Teardowns & reverse costing

analysis

• Cost simulation tool

www.i-Micronews.com/reports o Media

• i-Micronews.com website

• @Micronews e-newsletter

• Communication & webcast

services

• Events: TechDays, forums,…

www.i-Micronews.com

o Monitors

• Monthly and/or Quarterly

update

• Excel database covering supply,

demand, and technology

• Price, market, demand and

production forecasts

• Supplier market shares

www.i-Micronews.com/reports

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4©2019 | www.yole.fr | About Yole Développement

6 COMPANIES TO SERVE YOUR BUSINESS

Due diligence

www.yole.fr

Manufacturing costs analysis

Teardown and reverse engineering

Cost simulation tools

www.systemplus.fr

Market, technology and strategy

consulting

www.yole.fr

IP analysis

Patent assessment

www.knowmade.fr

Innovation and business maker

www.bmorpho.com

Design and characterization of

innovative optical systems

www.piseo.fr

Yole Group of Companies

Page 30: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

5©2019 | www.yole.fr | About Yole Développement

OUR GLOBAL ACTIVITY

30%of our business

40%of our business 30%

of our business

Greater

China office

Yole Japan

HQ in Lyon

Nantes

Paris

Nice

Vénissieux

Europe office

Frankfurt

Hsinchu

Tokyo

Yole Inc.

Phoenix

Yole Korea

Seoul

Palo Alto

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6©2019 | www.yole.fr | About Yole Développement

ANALYSIS SERVICES - CONTENT COMPARISON

Technology

and Market

Report

Leadership

Meeting

Q&A

Service

Depth of the analysis

Bre

adth

of th

e a

nal

ysis

Meet the

Analyst

Custom

Analysis

High

High

Low

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7©2019 | www.yole.fr | About Yole Développement

SERVING THE ENTIRE SUPPLY CHAIN

Our analysts provide market analysis,

technology evaluation,

and business plans along the entire

supply chain

Integrators, end-

users and software

developers

Device manufacturers

Suppliers: material, equipment,

OSAT, foundries…

Financial investors, R&D centers

Page 33: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

8©2019 | www.yole.fr | About Yole Développement

SERVING MULTIPLE INDUSTRIAL FIELDS

We workacross

multiples industries to understand

the impact of More-than-

Moore technologies from deviceto system

From A to Z…

Transportation

makers

Mobile phone

and

consumer

electronics

Automotive

Medical

systems

Industrial

and defense

Energy

management

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9©2019 | www.yole.fr | About Yole Développement

o Over the course of more than 20 years, Yole Développement has grown to become a group of companies. Together with System Plus Consulting and KnowMade, we now

provide marketing, technology and strategy consulting, media and corporate finance services, reverse costing, structure, process and cost analysis services and well as

intellectual property (IP) and patent analysis. Together, our group of companies is collaborating ever closer and therefore will offer, in 2019, a collection of over 125 reports

and 10 new monitors. Combining respective expertise and methodologies from the three companies, they cover:

o If you are looking for:

• An analysis of your product market and technology

• A review of how your competitors are evolving

• An understanding of your manufacturing and production costs

• An understanding of your industry’s technology roadmap and related IPs

• A clear view supply chain evolution

Our reports and monitors are for you!

o Our team of over 70 analysts, including PhD and MBA qualified industry veterans from Yole Développement, System Plus Consulting and KnowMade, collect information,identify trends, challenges, emerging markets, and competitive environments. They turn that information into results and give you a complete picture of your industry’slandscape. In the past 20 years, we have worked on more than 2,000 projects, interacting with technology professionals and high-level opinion makers from the mainplayers of their industries and realized more than 5,000 interviews per year.

WHAT TO EXPECT IN 2019?In 2019 we will extend our offering with a new ‘monitor’ product which provides more updates on your industry during the year. The Yole Group of Companies is also buildingon and expanding its investigations of the memory industry. Moreover, in parallel, the Yole Group reaffirms its commitment to a new collection of reports mixing software andhardware and is increasing its involvement in displays, radio-frequency (RF) technology, advanced substrates, batteries and compound semiconductors. Discover our 2019program right now, and ensure you get a true vision of the industry. Stay tuned!

REPORTS COLLECTION

www.i-Micronews.com

• MEMS & Sensors

• RF devices & technologies

• Medical technologies

• Semiconductor Manufacturing

• Advanced packaging

• Memory

• Batteries and energy management

• Power electronics

• Compound semiconductors

• Solid state lighting

• Displays

• Software

• Imaging

• Photonics

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10©2019 | www.yole.fr | About Yole Développement

OUR 2019 REPORTS COLLECTION (1/4)

18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

Market –Technology – Strategy – by Yole DéveloppementYole Développement (Yole) offers market reports including quantitative market forecasts,

technology trends, company strategy evaluation and indepth application analyses. Yole will

publish more than 55 reports in 2019, with our partner PISEO contributing to some of

the lighting reports.

Reverse Costing® – Structure, Process and Cost Analysis – by

System Plus ConsultingThe Reverse Costing® report developed by System Plus Consulting provides full

teardowns, including detailed photos, precise measurements, material analyses,

manufacturing process flows, supply chain evaluations, manufacturing cost analyses and

selling price estimations. The reports listed below are comparisons of several analyzed

components from System Plus Consulting. More reports are however available, and over

60 reports will be released in 2019.The complete list is available at www.systemplus.fr.

Patent Reports – by KnowMadeMore than describing the status of the IP situation, these analyses provide a missing link

between patented technologies and market, technological and business trends. They offer

an understanding of the competitive landscape and technology developments from a

patent perspective. They include key insights into key IP players, key patents and future

technology trends. For 2019 KnowMade will release over 15 reports.

The markets targeted are :

• Mobile & Consumer

• Automotive & Transportation

• Medical

• Industrial

• Telecom & Infrastructure

• Defense & Aerospace

• Linked reports are dealing with the same topic to provide

• a more detailed analysis.

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11©2019 | www.yole.fr | About Yole Développement

OUR 2019 REPORTS COLLECTION (1/5)18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

MEMS & SENSORS

o MARKET AND TECHNOLOGY REPORT

• Status of the MEMS Industry 2019 - Update

• Status of the Audio Industry 2019 - New

• Uncooled Infrared Imagers and Detectors 2019 – Update

• Consumer Biometrics:Technologies and Market Trends 2018

• MEMS Pressure Sensor Market and Technologies 2018

• Gas & Particle Sensors 2018

o STRUCTURE, PROCESS & COST REPORT

• MEMS & Sensors Comparison 2019

• MEMS Pressure Sensor Comparison 2018

• Particle Sensors Comparison 2019

• Miniaturized Gas Sensors Comparison 2018

o PATENT REPORT

• MEMS Foundry Business Portfolio 2019 - New

• Miniaturized Gas Sensors 2019 - New

PHOTONIC AND OPTOELECTRONICS

o MARKET ANDTECHNOLOGY REPORT

• Photonic Integrated Circuit 2019 - New

• LiDARs for Automotive and Industrial Applications 2019 - Update

• Silicon Photonics 2018

o PATENT REPORT

• Silicon Photonics for Data Centers: Optical Transceiver 2019 - New

• LiDAR for Automotive 2018

RF DEVICES AND TECHNOLOGIES

o MARKET ANDTECHNOLOGY REPORT

• RF GaN Market: Applications, Players, Technology,

and Substrates 2019 - Update

• 5G’s Impact on RF Front-End Module and Connectivity

for Cell Phones 2019 – Update

• 5G Impact on Wireless Infrastructure 2019

• Radar and Wireless for Automotive: Market and Technology

Trends 2019 - Update

• Advanced RF Antenna Market & Technology 2019 - New

• RF Standards and Technologies for Connected Objects 2018

o STRUCTURE, PROCESS & COST REPORT

• RF Front-End Module Comparison 2019 - Update

• Automotive Radar RF Chipset Comparison 2018

o PATENT REPORT

• Antenna for 5G Wireless Communications 2019 - New

• RF Front End Modules for Cellphones 2018

• RF Filter for 5G Wireless Communications: Materials and Technologies 2019

• RF GaN : Materials, Devices and Modules 2018

Update : 2018 version still available

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12©2019 | www.yole.fr | About Yole Développement

OUR 2019 REPORTS COLLECTION (2/5)18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

IMAGING

o MARKET AND TECHNOLOGY REPORT

• Status of the CIS Industry 2019: Technology

and Foundry Business - Update

• Imaging for Automotive 2019 - Update

• Neuromorphic Technologies for Sensing 2019 - Update

• Status of the CCM and WLO Industry 2019 – Update

• 3D Imaging & Sensing 2018

• MachineVision for Industry and Automation 2018

• Sensors for Robotic Vehicles 2018

o STRUCTURE, PROCESS & COST REPORT

• Compact Camera Modules Comparison 2019

• CMOS Image Sensors Comparison 2019

o PATENT REPORT

• Facial & Gesture Recognition Technlogies in Mobile Devices 2019 - New

• Apple iPhone X Proximity Sensor & Flood Illuminator 2018

MEDICAL IMAGING AND BIOPHOTONICS

o MARKET ANDTECHNOLOGY REPORT

• X-Ray Detectors for Medical, Industrial

and Security Applications 2019- New

• Microscopy Life Science Cameras: Market and Technology Analysis 2019

• Ultrasound technologies for Medical, Industrial

and Consumer Applications 2018

o PATENT REPORT

• Optical Coherence Tomography Medical Imaging 2018

MICROFLUIDICS

o MARKET ANDTECHNOLOGY REPORT

• Status of the Microfluidics Industry 2019 - Update

• Next Generation Sequencing & DNA Synthesis - Technology,

Consumables Manufacturing and Market Trends 2019 - New

• Organ-on-a-Chip Market & Technology Landscape 2019 - Update

• Point-of-Need Testing Application of Microfluidic Technologies 2018

• Liquid Biopsy: from Isolation to Downstream Applications 2018

• Chinese Microfluidics Industry 2018

o PATENT REPORT

• Microfluidic Manufacturing Technologies 2019 – New

INKJET AND ACCURATE DISPENSING

o MARKET ANDTECHNOLOGY REPORT

• Inkjet Printheads - Dispensing Technologies

& Market Landscape 2019 - Update

• Emerging Printing Technologies

for Microsystem Manufacturing 2019 - New

• Piezoelectric Materials from Bulk to Thin Film 2019 - New

• Inkjet Functional and Additive Manufacturing for Electronics 2018

o STRUCTURE, PROCESS & COST REPORT

• Piezoelectric Materials from Bulk to Thin Film Comparison 2019

Update : 2018 version still available

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13©2019 | www.yole.fr | About Yole Développement

OUR 2019 REPORTS COLLECTION (3/5)18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

BIOTECHNOLOGIES

o MARKET AND TECHNOLOGY REPORT

• CRISPR-Cas9 Technology: From Lab to Industries 2018

o PATENT REPORT

• Personalized Medicine 2019 – New

BIOMEMS & MEDICAL MICROSYSTEMS

o MARKET ANDTECHNOLOGY REPORT

• Medical Wearables: Market & Technology Analysis 2019 - New

• Neurotechnologies and Brain Computer Interface 2018

• BioMEMS & Non-Invasive Sensors: Microsystems for Life Sciences

& Healthcare 2018

o PATENT REPORT

• 3D Cell Printing 2019 - New

• Circulating Tumor Cells Isolation 2019 - New

• Nanopore Sequencing 2019 - New

SOFTWARE AND COMPUTING

o MARKET ANDTECHNOLOGY REPORT

• Artificial Intelligence Computing For Automotive 2019 - New

• Hardware and Software for Artificial Intelligence (AI)

in Consumer Applications 2019 - Update

• From Image Processing to Deep Learning 2019 - Update

• xPU (Processing Units) for Cryptocurrency, Blockchain, HPC

and Gaming 2019 – New

MEMORY

o MARKET AND TECHNOLOGY REPORT

• Status of the Memory Business 2019 - New

• MRAM Technology and Business 2019 - New

• Emerging NonVolatile Memory 2018

o STRUCTURE, PROCESS & COST REPORT

• Memory Comparison 2019

o PATENT REPORT

• Magnetoresistive Random-Access Memory (MRAM) 2019 - New

• 3D Non-Volatile Memory 2018

ADVANCED PACKAGING

o MARKET ANDTECHNOLOGY REPORT

• Fan Out Packaging Technologies and Market Trends 2019 - Update

• 3D TSV Integration and Monolithic Business Update 2019 - Update

• Advanced RF SiP for Cellphones 2019 - Update

• Status of Advanced Packaging 2019 - Update

• Status of Advanced Substrates 2019 - Update

• Panel Level Packaging Trends 2019 - Update

• System in Package (SiP) Technology and Market Trends 2019 - New

• Trends in Automotive Packaging 2018

• Thin-Film Integrated Passive Devices 2018

o STRUCTURE, PROCESS & COST REPORT

• Advanced RF SiP for Cellphones Comparison 2019

Update : 2018 version still available

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14©2019 | www.yole.fr | About Yole Développement

OUR 2019 REPORTS COLLECTION (4/5)18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

SEMICONDUCTOR MANUFACTURING

o MARKET ANDTECHNOLOGY REPORT

• Nano Imprint Lithography 2019 - New

• Equipment and Materials for Fan Out Packaging 2019 - Update

• Equipment for More than Moore: Thin Film Deposition

& Etching 2019 - New

• Wafer Starts for More Than Moore Applications 2018

• Polymeric Materials at Wafer-Level

for Advanced Packaging 2018

• Bonding and Lithography Equipment Market

for More than Moore Devices 2018

o STRUCTURE, PROCESS & COST REPORT

• Wafer Bonding Comparison 2018

o PATENT REPORT

• Hybrid Bonding for 3D Stack 2019 – New

SOLID STATE LIGHTING

o MARKET ANDTECHNOLOGY REPORT

• Status of the Solid State Light Source Industry 2019 - New

• Edge Emitting Lasers (EELS) 2019 - New

• Light Shaping Technologies 2019 - New

• Automotive Advanced Front Lighting Systems 2019 - New

• VCSELs - Technology, Industry and Market Trends 2019 - Update

• IR LEDs and Laser Diodes – Technology, Applications,

and Industry Trends 2018

• Automotive Lighting 2018: Technology, Industry and Market Trends

• UV LEDs - Technology, Manufacturing and Application Trends 2018

• LiFi: Technology, Industry and Market Trends 2018

o STRUCTURE, PROCESS & COST REPORT

• VCSEL Comparison 2019

o PATENT REPORT

• VCSELs 2018

DISPLAY

o MARKET ANDTECHNOLOGY REPORT

• Next Generation 3D Display 2019 - New

• Next Generation Human Machine Interaction (HMI)in Displays 2019 - New

• Micro-and Mini-LED Displays 2019 - Update

• Technologies And Markets for Next Generation Televisions

• Displays & Optical Vision Systems for VR, AR & MR 2018

o PATENT REPORT

• MicroLED Displays : Intellectual Property Landscape 2018

Update : 2018 version still available

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15©2019 | www.yole.fr | About Yole Développement

OUR 2019 REPORTS COLLECTION (5/5)18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

POWER ELECTRONICS

o MARKET ANDTECHNOLOGY REPORT

• Power SiC: Materials, Devices and Applications 2019 - Update

• Power Electronics for EV/HEV and e-mobility:

Market, Innovations and Trends 2019 - Update

• Status of the Power Electronics Industry 2019 - Update

• Discrete Power Packaging : Material Market

and Technology Trends 2019 - New

• Status of the Power ICs Industry 2019 - Update

• Status of the Passive Components for the Power Electronics

Industry 2019 - Update

• Status of the Inverter Industry 2019 - Update

• Status of the Power Module Packaging Industry 2019 - Update

• Wireless Charging Market Expectations

and Technology Trends 2018

• Power GaN 2018: Epitaxy, Devices, Applications

and Technology Trends

o STRUCTURE, PROCESS & COST REPORT

• Automotive Power Module Packaging Comparison 2018

• GaN-on-Silicon Transistor Comparison 2019

• SiC Transistor Comparison 2019

o PATENT REPORT

• Power SiC : Materials, Devices and Modules 2019 - New

• Power GaN : Materials, Devices and Modules 2019 – Update

BATTERY & ENERGY MANAGEMENT

o MARKET ANDTECHNOLOGY REPORT

• Status of the Rechargeable Li-ion Battery Industry 2019 - New

• Li-ion Battery Packs for Automotive and Stationary Storage

Applications 2019 - Update

o PATENT REPORT

• Battery Energy Density Increase: Materials

and Emerging Technologies 2019 - New

• Solid-State Batteries 2019 - New

• Status of the Battery Patents 2018

COMPOUND SEMI.

o MARKET ANDTECHNOLOGY REPORT

• Emerging Compound Semiconductor

Market & Technology Trends 2019 - New

• Status of the Compound Semiconductor Industry 2019 - New

• InP Materials, Devices and Applications 2019 - New

• GaAs Wafer and Epiwafer Market: RF, Photonics,

LED and PV Applications 2018

o PATENT REPORT

• GaN-on-Silicon Substrate: Materials, Devices

and Applications 2019 - Update

Update : 2018 version still available

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16©2019 | www.yole.fr | About Yole Développement

OUR 2019 MONITORS COLLECTION (1/2)

Get the most updated overview of your market to monitor your strategy

Yole Développement, System Plus Consulting and KnowMade, all part of the Yole Group of Companies, are launching a collection of 10 monitors in 2019. The monitors aim to

provide updated market, technology and patent data as well dedicated quarterly analyses of the evolution in your industry over the previous 12 months. Furthermore, you can

benefit from direct access to the analyst for an on-demand Q&A and discussion session regarding trend analyses, forecasts and breaking news.

Topics covered will be compact camera modules (CCMs), advanced packaging, compound semiconductors, microfluidics, batteries, RF and memory.

MARKET MONITOR byYole Développement

A FULL PACKAGE:The monitors will provide the evolution of the market in units, wafer area and revenues.They will also offer insights into what is driving the business and a close look at what ishappening will also be covered in it.

The following deliverables will be included in the monitors:

• An Excel database with all historical and forecast data

• A PDF slide deck with graphs and comments/analyses covering the expected

evolutions

o ADVANCED PACKAGING – NEWThis monitor will provide the evolution of the advanced packaging platforms. It willcover Fan-Out Wafer Level Packaging (WLP), Fan-Out Panel Level Packaging (PLP),Wafer-Level Chip Scale Packaging (WLCSP), Flip Chip packaging platforms, and 2.5Dand 3D Through Silicon Via (TSV) integration. Frequency: Quarterly, starting from Q32019

o COMPOUND SEMI. – NEWThis monitor will describe how the compound semiconductor industry is evolving. Itwill offer a close look at GaAs, InP, SiC, GaN and other compounds of interestproviding wafer volumes, revenues, application breakdowns and momentum.Frequency: Quarterly, starting from Q3 2019

o CAMERA MODULE – NEWThis monitor will provide the evolution of the imaging industry, with a close look atimage sensor, camera module, lens and VCM. Volumes, revenues and momentum ofcompanies like Sony, Samsung, Omnivision and OnSemi will thus be analysed.Frequency: Quarterly, starting from Q3 2019

o MEMORY – UPDATEFor the memory industry you can have access to a quaterly monitor, as well as anadditional service, a monthly pricing. Both services can be bought seprately:

• DRAM Service: Including a quarterly monitor and monthly pricing.

• NAND Service: Including a quarterly monitor and monthly pricing.

REVERSETECHNOLOGY MONITOR by System Plus Consulting

o SMARTPHONES – NEWTo stay updated on the latest components, packaging and silicon chip choices of the smartphone makers, System Plus Consulting has created its first Smartphone ReverseTechnology monitor. This year, get access to the packaging and silicon content database of at least 20 different flagship smartphones – more than five per quarter. Starting at thebeginning of 2019, the monitor will include an Excel database report for each phone and a quarterly comparison.

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17©2019 | www.yole.fr | About Yole Développement

OUR 2019 MONITORS COLLECTION (2/2)

Get the most updated overview of your market to monitor your strategy

PATENT MONITOR by KnowMade

A FULL PACKAGE:Starting at the beginning of the year, the KnowMade monitors include the following deliverables:

• An Excel file including the monthly IP database of:

• New patent applications

• Newly granted patents

• Expired or abandoned patents

• Transfer of IP rights through re-assignment and licensing

• Patent litigation and opposition

• Quarterly report including a PDF slide deck with the key facts & figures of thequarter: IP trends over the three last months, with a close look to key IP players andkey patented technologies.

o GaN for Power & RF ElectronicsWafers and epiwafers, GaN-on-SiC, silicon, sapphire or diamond, semiconductordevices such as transistors, and diodes, devices and applications including converters,rectifiers, switches, amplifiers, filters, and Monolothic Microwave Integrated Circuits(MMICs), packaging, modules and systems.

o GaN for Optoelectronics & PhotonicsWafers and epiwafers, GaN-on-sapphire, SiC or silicon; semiconductor devices suchas LEDs and lasers; and applications including lighting, display, visible communication,photonics, packaging, modules and systems.

o Li-ion BatteriesAnodes made of lithium metal, silicon, and lithium titanate (LTO); cathodes made ofLithium Iron Phosphate (LFP), Nickel-Manganese-Cobalt (NMC), Lithium NickelCobalt Aluminium Oxide (NCA), Lithium Nickel Metal Dioxide (LiNiMO2), LithiumMetal Phosphate (LiMPO4), and Lithium Metal Tetroxide (LiMO4); electrolytesincluding liquid, polymer/gel, and solid inorganics; ceramic and other separators;battery cells including thin film/microbattery, flexible, cylindrical and prismatic; andbattery packs and systems.

o Post Li-ion BatteriesBattery technologies including redox-flow batteries, sodium-ion, lithiumsulfur, lithium-air, and magnesium-ion, and their supply chains, including electrodes, electrolytes,battery cells and battery packs/systems.

o Solid-State BatteriesSupply chain including electrodes, battery cells, battery packs/systems andelectrolytes, including polymer, inorganic and inorganic/polymer, inorganic materials,including argyrodites, LIthium Super Ionic CONductor, (LISICONs), Thio-LISICONs,sulfide glasses, oxide glasses, perovskites, anti-perovskites and garnets.

o RF Acoustic Wave FiltersIncluding Surface Acoustic Wave (SAW), Temperature Compensated (TC)- SAW, BulkAcoustic Wave- Free-standing Bulk Acoustic Resonator (BAWFBAR), BAW-Solidly-Mounted Resonator (BAW-SMR), and Packaging.

o RF Power AmplifiersIncluding Low Noise Amplifiers, Doherty Amplifiers, Packaging, and Millimeter-Wavetechnology.

o RF Front-End Modules

o MicrofluidicsFrom components to chips and systems, including all applications.

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18©2019 | www.yole.fr | About Yole Développement

MICRONEWS MEDIA

o About Micronews Media

To meet the growing demand for market,

technological and business information,

Micronews Media integrates several tools able

to reach each individual contact within its

network.We will ensure you benefit from this.

ONLINE ONSITE INPERSON

@Micronews e-newsletter

i-Micronews.com

i-Micronewsjp.com

FreeFullPDF.com

Events Webcasts

Unique, cost-effective ways

to reach global audiences.

Online display advertising

campaigns are great strategies

for improving your

product/brand visibility. They

are also an efficient way to

adapt with the demands of the

times and to evolve an effective

marketing plan and strategy.

Brand visibility, networking

opportunities

Today's technology makes it

easy for us to communicate

regularly, quickly, and

inexpensively – but when

understanding each other is

critical, there is no substitute

for meeting in-person. Events

are the best way to exchange

ideas with your customers,

partners, prospects while

increasing your brand/product

visibility.

Targeted audience

involvement equals clear,

concise perception of your

company’s message.

Webcasts are a smart,

innovative way of

communicating to a wider

targeted audience. Webcasts

create very useful, dynamic

reference material for

attendees and also for

absentees, thanks to the

recording technology.

Benefit from the i-Micronews.com

traffic generated by the 11,200+

monthly unique visitors, the

10,500+ weekly readers of

@Micronews e-newsletter

Several key events planned for

2018 on different topics to

attract 120 attendees on average

Gain new leads for your business

from an average of 340

registrants per webcast

Contact: Camille Veyrier ([email protected]), Marketing & Communication Director

Page 44: Next-Generation Sequencing & DNA Synthesis · DNA sequencing has many applications in healthcare and life sciences and it is increasingly used in myriad areas as cost reduction starts

19©2019 | www.yole.fr | About Yole Développement

CONTACT INFORMATION

o CONSULTING AND SPECIFIC ANALYSIS, REPORT BUSINESS

• North America:

• Steve LaFerriere, Senior Sales Director for Western US & Canada

Email: [email protected] – + 1 310 600-8267

• Chris Youman, Senior Sales Director for Eastern US & Canada

Email: [email protected] – +1 919 607 9839

• Japan & Rest of Asia:

• Takashi Onozawa, General Manager, Asia Business Development

(India & ROA)

Email: [email protected] - +81 34405-9204

• Miho Othake, Account Manager (Japan)

Email: [email protected] - +81 3 4405 9204

• Itsuyo Oshiba, Account Manager (Japan & Singapore)

Email: [email protected] - +81-80-3577-3042

• Korea: Peter Ok, Business Development Director

Email: [email protected] - +82 10 4089 0233

• Greater China: Mavis Wang, Director of Greater China Business

Development

Email: [email protected] - +886 979 336 809

• Europe: Lizzie Levenez, EMEA Business Development Manager

Email: [email protected] - +49 15 123 544 182

• RoW: Jean-Christophe Eloy, CEO & President, Yole Développement

Email [email protected] - +33 4 72 83 01 80

o FINANCIAL SERVICES (in partnership with Woodside Capital

Partners)

• Jean-Christophe Eloy, CEO & President

Email: [email protected] - +33 4 72 83 01 80

• Ivan Donaldson, VP of Financial Market Development

Email: [email protected] - +1 208 850 3914

o CUSTOM PROJECT SERVICES

• Jérome Azémar, Technical Project Development Director

Email: [email protected] - +33 6 27 68 69 33

o GENERAL

• Camille Veyrier, Director, Marketing & Communication

Email: [email protected] - +33 472 83 01 01

• Sandrine Leroy, Director, Public Relations

Email: [email protected] - +33 4 72 83 01 89 / +33 6 33 11 61 55

• Email: [email protected] - +33 4 72 83 01 80

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