NIAID Commitment to Influenza Research and
Preparedness
F. Gray Handley
Associate Director for
International Research Affairs
National Institute of Allergy and
Infectious Diseases
National Institutes of Health
January 28-31, 2007
U.S. Department of Health and Human Services
U.S. Department of Health and Human Services
Administration forChildren and Families
(ACF)
Food and DrugAdministration
(FDA)
Health Resourcesand Services
Administration(HRSA)
TheSecretary
Deputy Secretary
Administration onAging(AoA)
Centers for Medicare and
Medicaid Services (CMS)
Indian HealthServices
(IHS)
Centers for Disease Controland Prevention
(CDC)
Substance Abuse andMental Health Services
Administration(SAMHSA)
Program SupportCenter(PSC)
Agency for ToxicSubstances andDisease Registry
(ATSDR)
Agency for Health Care Policy
and Research(AHCPR)
National Institutesof Health
(NIH)
Office of the Director
National Instituteo Alcohol Abuseand Alcoholism
National Instituteof Arthritis andMusculoskeletal
and Skin Diseases
National CancerInstitute
National Instituteof Diabetes andDigestive and
Kidney Diseases
National Instituteof Dental andCraniofacial
Research
National Instituteon Drug Abuse
National Instituteof Environmental Health Sciences
National Instituteon Aging
National Instituteof Child Health
and HumanDevelopment
National Institute onDeafness and Other
CommunicationDisorders
National EyeInstitute
National HumanGenome Research
Institute
National Heart,Lung, and Blood
Institute
National Instituteof Mental Health
National Instituteof NeurologicalDisorders and
Stroke
National Instituteof General
Medical Sciences
National Instituteof Nursing Research
National Libraryof Medicine
Center for InformationTechnology
Center for Scientific Review
National Centerfor Complementary
and AlternativeMedicine
National Instituteof Allergy and
Infectious Diseases
National Centerfor ResearchResources
Clinical Center
National Center on Minority Health andHealth Disparities
National Institute of Biomedical Imagingand Bioengineering
FogartyInternational
Center
National Institutes of Health
NIAID Basic Research on Influenza
Viral replication and evolution Host-virus interactions Mechanisms and sites that stimulate immune
response Immune correlates of protection related to
seasonal influenza vaccination Modeling the dynamics of influenza
transmission in large human populations Sequence analysis of the 1918 pandemic
virus and its impact on human immune response
http://www.niaid.nih.gov/dmid/genomes/mscs/influenza.htm
NIAID Influenza Reagent Repository Managed by BEI Resources Makes reagents available to all registered
researchers (including international) at no charge (shipping and handling fees only)
Influenza reagents currently available: Purified H and N proteins Poly and monoclonal antibodies Influenza virus isolates Peptide arrays designed for epitope mapping Antiserum including human serum from H5
vaccinees
Register at: www.beiresources.gov
H5 Influenza Plans Underway in SE AsiaH5 Influenza Plans Underway in SE Asia
Increase training for investigators in SE Asia in areas related to clinical research and data management
Support seroprevalence H5N1 studies in China and Vietnam through NIAID’s CIPRA program and in collaboration with AFRIMS.
Develop research studies to examine cross-reactivity of H5N1 strains and molecular characterization of strains.
Funding in FY06: $18 Million.
Increase training for investigators in SE Asia in areas related to clinical research and data management
Support seroprevalence H5N1 studies in China and Vietnam through NIAID’s CIPRA program and in collaboration with AFRIMS.
Develop research studies to examine cross-reactivity of H5N1 strains and molecular characterization of strains.
Funding in FY06: $18 Million.
Opportunities for Expanded Research Cooperation
Global networks focused on basic, translational, therapeutic, vaccine research
Viral characterization and ecology studies (human and animal)
Training in all areas Seroprevalence studies Cooperative sequencing of strains Bioinformatics to facilitate access to
sequence data and analysis tools globally and equitably
Key Funding Links
Collaborative projects involving investigators and institutions from international sites and the U.S. are particularly encouraged.
NIAID has a long-standing interest in and commitment to global health and international research.
Topics of interest for this program are limited to research on infectious diseases, including emerging infections that are of the greatest public health significance within the overseas country (e.g. tuberculosis; malaria; HIV/AIDS; sexually transmitted diseases; diarrheal, respiratory, and enteric diseases; viral hemorrhagic fevers; viral encephalitides; parasitic diseases; and vector-borne diseases).
Development of immunological, microbiological, biostatistical, epidemiological, and clinical research capacity is encouraged. Studies may be proposed on any aspect of infectious diseases (except clinical trials), including but not limited to: the epidemiology, pathogenesis, immunopathogenesis of infectious diseases; epidemiologic studies to define the incidence, clinical presentations, and outcomes of diseases; identification of resistance patterns; characterization of susceptible cohorts for a particular pathogen; pilot and feasibility studies in preparation for larger studies.
http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-06-041.html http://grants.nih.gov/grants/guide/pa-files/PA-06-180.html
For further information contact Karen Lacourciere: [email protected]
