NOTlCE OF MAILING CHANGE 0 Check here if you wish to discontinue receiving this publication 0 Check here if your address has changed and you wish to con- tinue receiving this publication. Make corrections below and mail this page to: NIH Guide Printing & Reproduction Branch National Institutes of Health Room B4BNO8, Building 31 Bethesda, Maryland 20892 First Class Mail Postages & Fees Paid PHS/NIH/OD . -“7 US. DEPARTMENT OF H W AND HUMAN SERVICES OFFICIALBL’SINESS Penaltv for Private be, 6300 The NIH Guide announces scientific initiativesand provides policy and administrative information to indivi. duals and organizationswho need to be kept informed of opportunities. requirements. and changes in extra- mural proppms administered by the National Insritutes of Health. Vol. 18, No. 28 August 18, 1989
Transcript
NOTlCE OFMAILING CHANGE 0 Check here if you wish t o
discontinue receiving this publication
0Check here if your address has changed and you wish to continue receiving this publication. Make corrections below and mail this page to:
NIH Guide Printing & Reproduction Branch National Institutes of Health Room B4BNO8, Building 31 Bethesda, Maryland 20892
First Class Mail Postages & Fees Paid
PHS/NIH/OD
.-“7
US. DEPARTMENT OF H W AND HUMAN SERVICES
OFFICIALBL’SINESS Penaltv for Private b e , 6300
The NIH Guide announces scientific initiativesand provides policy and administrative information to indivi. duals and organizationswho need to be kept informed o f opportunities. requirements. and changes in extra-mural proppms administered by the National Insritutes of Health.
Vol. 18, No. 28 A u g u s t 18, 1989
Vol. 18, NO. 28, August 18, 1989
NOTICES
DRG'S GRANTS INQUIRIES ON-LINE SYSTEM ....................................... 1 _1
Division of Research GrantsIndex: DIVISION OF RESEARCH GRANTS
PITTSBURGH SUPERCOMPUTING CENTER BIOMEDICAL WORKSHOP ONSUPERCOMPUTING TECHNIQUES ................................................... 2Division of Research Resources Index: RESEARCH RESOURCES
REVISIONS IN THE SALARY SCHEDULE FOR ADAMHA RESEARCH CAREER AWARDS .......... 2Alcohol, Drug Abuse, and Mental Health Administration Index: ALCOHOL, DRUG ABUSE, MENTAL HEALTH
CLARIFICATION OF THE ANIMAL FACILITIES IMPROVEMENT PROGRAM .................. 3 Division of Research Resources Index: RESEARCH RESOURCES
PATED ANNOUNCEMENTS (RFPs AND RFAs)
TECHNICAL, ANALYTICAL, AND DOCUMENTATION SUPPORT SERVICES FOR THENATIONAL HEART, BLOOD VESSEL, LUNG, AND BLOOD DISEASES AND BLOODRESOURCES PROGRAM (RFP) ..................................................... 3National Heart, Lung, and Blood Institute Index: HEART, LUNG, BLOOD
INTERVENTION RESEARCH IN HISPANIC POPULATIONS (RFA) ......................... 4National Cancer Institute Index: CANCER
-'
ONGOING PROGRAM ANNOUNCEMENTS
RESEARCH ON URINARY INCONTINENCE AND OTHER URINARY DYSFUNCTION IN OLDER PERSONS ............................................................... 5 National Institute on AgingIndex: AGING
SMALL GRANTS TO FACILITATE USE OF NEW TECHNIQUES BY RESEARCHERS INDIABETES, ENDOCRINOLOGY AND METABOLISM ...................................... 7 National Institute of Diabetes and Digestive and Kidney DiseasesIndex: DIABETES, DIGESTIVE DISEASES, KIDNEY DISEASES
SOCIAL SUPPORT AND CARDIOVASCULAR DISEASE ................................... 10 National Heart, Lung, and Blood InstituteIndex: HEART, LUNG, BLOOD
BEHAVIORAL, ETIOLOGIC AND PHYSIOLOGIC ASPECTS OF STUTTERING . . . . . . . . . . . . . . . . . 1 1 National Institute on Deafness and Other Communication Disorders Index: DEAFNESS, COMMUNICATION DISORDERS
ERRATA
"OTHER SUPPORT" IN PHS GRANT APPLICATIONSPHS GRANT APPLICATION FORM 398 - REMINDERSPHS 398 MISCONDUCT IN SCIENCE ASSURANCE INCLUSION OF MINORITIES IN STUDY POPULATIONS INCLUSION OF WOMEN IN STUDY POPULATIONS ..................................... 13Alcohol, Drug Abuse, and Mental Health Administration UIL
Index: ALCOHOL, DRUG ABUSE, MENTAL HEALTH
PJOTICES
Id
d
PRG'S GRANTS INQUIRIES ON-LINE SYSTEY
P.T. 16; K.W. 1004008, 1014006
Divis ion o f Research Grants
N I H ' s Div is ion o f Research Grants ( D R G ) now has an on- l ine system--GrantsI n q u i r i e s On-line--that provides f o r access ing e l e c t r o n i c a l l y those N I H and Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion extramural programguide l ines t h a t are a v a i l a b l e i n p r i n t e d form from D R G ' s Office o f Grants I n q u i r i e s ( O G I ) . The system f i l e is now a v a i l a b l e t o t h e s c i e n t i f i c communitythrough t h e BITNET node. A s of August 1, 1989, t h e fol lowing d a t a sets are a v a i l a b l e on t h e f i l e :
Index f o r g r a n t s 1nqui r ies .Onl ine CPDSl
Combined F i l e s , Revised August 1, 1989 CCOMBFILEl
The C l i n i c a l I n v e s t i g a t o r Awards (K08)-Guidelines and SupplementalI n s t r u c t i o n s , A p r i l 1988 CCIAI
Guide l ines f o r E s t a b l i s h i n g and Operating Consortium Grants , January 1989,C CONSORT1
Nat iona l Research Se rv ice Awards f o r Ind iv idua l Fellows (F32) Guidel ines ,Revised May 1, 1989 CF321
Nat iona l Research Se rv ice Awards f o r Senior Fellows (F33) Guidel ines , Revised A p r i l 15, 1989 IF331
Nat iona l Research Se rv ice Awards f o r I n s t i t u t i o n a l Grants (T32l-Guidelines and I n s t r u c t i o n s , Revised A p r i l 1 , 1989 CT321
The Physician S c i e n t i s t Awards, Ind iv idua l (K11) and Program (Kl2l-Guidelinesand Supplemental I n s t r u c t i o n s t o PHS 398, Revised A p r i l 15, 1988 CPSAI
The Research Career Development Award (KO4)-Guidelines and I n s t r u c t i o n s ,Revised A p r i l 1989 CK041
Support o f S c i e n t i f i c Meeting~-Meetings(Rl3)-Special Information and I n s t r u c t i o n s , Revised August 1988 CR131
Small Grants Program (RO3)-Guidelines and P a r t i c i p a t i n g N I H I n s t i t u t e s ,Revised August 1988 CR031
BITNET E l e c t r o n i c Trans fe r
To p a r t i c i p a t e i n t h e BITNET e l e c t r o n i c t r a n s f e r system, i n d i v i d u a l s are asked t o provide t h e name, t i t l e , te lephone number, and BITNET address t o t h e P r o j e c t D i rec to r below. I n i t i a l l y , r eques to r s w i l l be s e n t t h e O G I ONLINE combined f i l e . O G I ONLINE w i l l be updated r e g u l a r l y a t l eas t once a month. Those wi th BITNET addres ses w i l l au tomat ica l ly be s e n t an updated ve r s ion a t t h e t i m e o f update .
Ques t ions may be d i r e c t e d t o :
Ms. Sue Meadows P r o j e c t D i rec to r BITNET Node Address: NXMaNIHCU
Office o f Grants I n q u i r i e sDivis ion o f Research Grants Westwood Building, Room 449 Nat ional I n s t i t u t e s o f Heal th Bethesda, Maryland 20892 Telephone: (301) 496-7441
Vol. 18, No. 28, August 18, 1989 - Page 1
PITTSBURGH SUPERCOMPUTING CENTER BIOMEDICAL WORKSHOP ON SUPERCOMPUTIN G TECHNIQUES
P.T. 42; K.W. 1004000, 0780018 Divis ion o f Research Resources
"rnlThe P i t t s b u r g h Supercomputing Center (PSC) is conduct ing a five-day workshop on supercomputing techniques f o r biomedical r e s e a r c h e r s December 4-8, 1989. This workshop is funded by a g ran t from t h e Div is ion of Research Resources' Biomedical Research Technology (BRT) Program o f t h e Nat iona l I n s t i t u t e s o f Health ( N I H ) . The workshop is aimed a t experienced FORTRAN programmers, bu t p r i o r supercomputing exper ience is not necessary . The t o p i c s inc lude an i n t r o d u c t i o n t o VMS (half-day, o p t i o n a l ) , t h e Cray-Vax i n t e r f a c e , t h e UNICOS opera t ing system, opt imiza t ion techniques , an overview o f a v a i l a b l e biomedical sof tware and a d e s c r i p t i o n o f access pa ths t o t h e PSC.
Travel , meals, and h o t e l accommodations are covered f o r U.S. academic p a r t i c i p a n t s under t h e g r a n t . Enrollment is l i m i t e d t o 20 p a r t i c i p a n t s . THE DEADLINE FOR SUBMISSION OF APPLICATIONS IS OCTOBER 13, 1989.
For a p p l i c a t i o n forms and f u r t h e r information, c a l l o r write t o :
Cherolyn A. Brooks User Se rv ices P i t t s b u r g h Supercomputing Center 4400 F i f t h Avenue Pi t t sbu rgh , Pennsylvania 15213 Telephone: (412) 268-5206, o r 1-800-222-9310 (Pennsylvania)
1-800-221-1641 ( o u t s i d e Pennsylvania)
JEVISIONS I N THE SALARY SCHEDULE FOR ADAMHA RESEARCH CAREER AWARDS
P.T. 34; K.W. 1014006
Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion National I n s t i t u t e on Alcohol Abuse and Alcoholism Nat iona l I n s t i t u t e on Drug Abuse Nat iona l I n s t i t u t e o f Mental Heal th
Beginning wi th awards made from F i s c a l Year 1990 funds ( i . e . , awards made af ter October 1, 19891, t h e Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion (ADAMHA) w i l l raise t h e s a l a r y l i m i t on a l l r e sea rch career awards. Th i s w i l l inc lude competing and noncompeting awards f o r t h e fo l lowing funding mechanisms:
Research S c i e n t i s t Development Award, Level I n KO1 Research S c i e n t i s t Development Award, Level I1 KO2 Research S c i e n t i s t Award KO5 NIMH Academic Awards NIMH C l i n i c a l I n v e s t i g a t o r AwardX NIMH Phys ic ian S c i e n t i s t Awardn S c i e n t i s t Development Award f o r C l i n i c i a n s S c i e n t i s t Development Award
KO7 KO8 K11 K20 K21
Under t h e new po l i cy , ADAMHA w i l l provide an amount equal t o 100 percent of t h e cand ida te ' s base i n s t i t u t i o n a l s a l a r y up t o a maximum of $ 4 5 , 0 0 0 , o r f o r base i n s t i t u t i o n a l s a l a r i e s h igher t han $60,000, ADAMHA w 11 provide an amount equal t o 75 percent o f t h e cand ida te ' s base i n s t i t u t i o n a l s a l a r y up t o a maximum o f $75,000. Based on t h i s po l i cy , ADAMHA'S c o n t r i b u t i o n t o t h e s a l a r y w i l l be c a l c u l a t e d us ing t h e fo l lowing t a b l e :
Base I n s t i t u t i o n a l S a l a r y ADAMHA Contr ibut ion Adjusted f o r Percent Time Dedicated t o t h e Grant
Up t o $45,000 100 percent o f t h e I n s t i t u t i o n a l S a l a r y
$45,001-$60r000 $45,000
$60,001 and above 75 percent o f t h e I n s t i t u t i o n a l S a l a r y up t o a Maximum of $75,000
Vol. 18, No. 28, August 18, 1989 - Page 2
The c a l c u l a t i o n o f t h e ADAMHA'S c o n t r i b u t i o n inc ludes an adjustment o f t h e base i n s t i t u t i o n a l s a l a r y t o incorpora te t h e percentage t i m e t h e candida te proposes t o devote t o t h e g r a n t .
X No new K01, K O 8 o r K11 awards w i l l be made af ter F i s c a l Year 1989.
Id CLARIFICATION OF THE ANIMAL FACILITIES IMPROVEMENT PROGRAM
RFA 89-RR-02 - DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
RFA 89-RR-03 - ANIMAL FACILITY IMPROVEMENTS FOR SMALL RESEARCH PROGRAMS
P.T. 34; K . W . 1002002, 0201011
Divis ion o f Research Resources
The Div is ion o f Research Resources has r e c e n t l y announced two compet i t ive g ran t programs t o assist i n s t i t u t i o n s i n upgrading t h e i r r e sea rch animal f a c i l i t i e s . The first program, "Developing and Improving I n s t i t u t i o n a l Animal Resources", RFA 89-RR-02, was announced i n t h e A p r i l 28, 1989 i s s u e of t h e N I H Guide f o r Grants and Cont rac ts , Vol. 18, No. 15, and is intended f o r , bu t is no t r e s t r i c t e d t o , t h o s e i n s t i t u t i o n s t h a t r ece ive more than $500,000 of Publ ic Heal th Se rv ice funds annual ly f o r an imal - re la ted r e sea rch . The t o t a l award must be matched ( d o l l a r - f o r - d o l l a r ) by non-federal funds.
The second program, RFA 89-RR-03, "Animal F a c i l i t y Improvements f o r Small Research Programs", w a s announced i n t h e J u l y 7, 1989 i s s u e of t h e N I H Guide f o r Grants and Cont rac ts , Vol. 18, No. 23, and is intended f o r t h o s e i n s t i t u t i o n s t h a t r ece ive less than $500,000 o f Publ ic Heal th Se rv ice funds annual ly f o r an imal - re la ted r e sea rch . No matching funds are r equ i r ed . An i n s t i t u t i o n t h a t i s e l i g i b l e f o r t h e second program is a l s o e l i g i b l e f o r t h e first program bu t can only apply t o one program, not bo th .
It is c u r r e n t l y a n t i c i p a t e d t h a t $9.931 mi l l i on w i l l be a v a i l a b l e f o r t h e program announced under RFA 89-RR-02 (not $10.931 m i l l i o n as previous lyannounced), and $1 m i l l i o n w i l l be a v a i l a b l e f o r t h e program announced under RFA 89-RR-03. The t r a d i t i o n a l 3-year f a c i l i t y improvement program is no longer a c t i v e .
'd Details o f each program can be obta ined by con tac t ing :
D i rec to r Laboratory Animal ScSences ProgramDivis ion o f Research Resources 5333 Westbard Avenue, Room 853 Bethesda, Maryland 20892 Telephone: (301) 496-5175
PATED ANN0UNCEMENTS (RFPs AND R F W
TECHNICAL, ANALYTICAL, AND DOCUMENTATION SUPPORT SERVICES FOR THE NATIONqLHEART, BLOOD VESSEL, LUNG, AND BLOOD DISEASES AND BLOOD RESOURCES PROGRAH RFP AVAILABLE: RFP-NHLBI-HO-89-11
P.T. 34; K.W. 0780000
Nat ional Heart, Lung, and Blood I n s t i t u t e
The Nat ional Heart, Lung, and Blood I n s t i t u t e ( N H L B I ) w i l l make a v a i l a b l e t o i n t e r e s t e d c o n t r a c t o r s a r eques t f o r proposa ls t o suppor t a c t i v i t i e s f o r t h e Nat ional Heart, Blood Vessel, Lung, and Blood Diseases and Blood Resources Program (P.L. 99-158). I n adminis te r ing t h e Program, NHLBI suppor t s a v a r i e t yof t a s k fo rces , conferences, and workshops and p repa res numerous r e p o r t s and t e c h n i c a l documents. Se rv ices are r equ i r ed t o : ( 1 ) provide t e c h n i c a l support t o s c i e n t i f i c working groups; ( 2 ) provide documentation support inc ludingprepa ra t ion of t e c h n i c a l r e p o r t s ; p repare v i s u a l e x h i b i t s such as b r i e f i n gmaterials; and e d i t o r i a l support f o r many d ive r se , t e c h n i c a l r e p o r t s ; and (3)provide a n a l y t i c support inc luding q u a l i t a t i v e and q u a n t i t a t i v e d a t a c o l l e c t i o n and appropr i a t e s y n t h e s i s . Documentation s e r v i c e s are r equ i r ed t o assist i n t h e p repa ra t ion of t h e NHLBI Fact Book, t h e Annual R e o r t o f t h e Di rec to r , t h e semi-annual Program and F i s c a l Reviews of t h e NHLE Advisory
d Council , and a v a r i e t y o f special-purpose s c i e n t i f i c r e p o r t s . Addi t iona l ly ,s c i e n t i f i c meeting, workshop, and a n a l y t i c and documentation services are r equ i r ed i n suppor t o f va r ious a c t i v i t i e s and p r o j e c t s undertaken by t h e
Vol. 18, No. 28, August 18, 1989 - Page 3
Div i s ions of t h e I n s t i t u t e and t h e Off ice o f t h e Di rec to r , inc luding f o r example, updates of t h e Nat ional Program Plan and support f o r t h e Off ice o f Prevent ion, Education, and Control (OPEC) and t h e Office of Program Planningand Evaluat ion (OPPE). The support f o r a l l t a s k s dur ing t h e f i v e - ( 5 ) yearc o n t r a c t pe r iod w i l l r e q u i r e approximately 12 person years pe r yea r . The p r o j e c t s ta f f o f t h e success fu l o f f e r o r (and subcon t rac to r s i f any) must be a v a i l a b l e t o meet wi th program s t a f f a t t h e Nat ional I n s t i t u t e s o f Heal th , i n Bethesda, wi th as l i t t l e a s two (2) hours advance n o t i c e . Such meetings on any given day may involve one o r more members o f t h e o f f e r o r l s team and cannot be scheduled i n advance. When otherwise poss ib l e , meetings w i l l be scheduled i n advance. The success fu l o f f e r o r must be f u l l y a b l e t o meet t h i s requirement w i th in 30 days of c o n t r a c t award.
Th i s is not a Request f o r Proposa ls . RFP NHLBI-HO-89-11 w i l l be r e l eased on o r about August 25, 1989, with proposa ls due on o r about September 27, 1989. One ( 1 ) award is a n t i c i p a t e d by t h e Government. Your w r i t t e n reques t should inc lude t h r e e (3) l a b e l s , se l f -addressed wi th your mai l ing address , and must c i t e RFP No. NHLBI-HO-89-11.
Requests f o r cop ie s o f t h e RFP should be s e n t t o t h e
Kristee M . Ryman, Contract S p e c i a l i s t HLVD Cont rac ts Sec t ion , Cont rac ts Operat ions Branch,Nat iona l Heart , Lung, and Blood I n s t i t u t e Federa l Bui lding, Room 4C04 National I n s t i t u t e s o f Heal th Bethesda, Maryland 20892
INTERVENTION RESEARCH I N HISPANIC POPULATIONS
RFA AVAILABLE: 89-CA-15
P . T . 3 4 , FD; K.W. 0715035, 0745027, 0795003, 0745000
Nat iona l Cancer I n s t i t u t e
Letter o f I n t e n t Receipt Date: September 1 , 1989 Appl ica t ion Receipt Date: December 1 , 1989
fo l lowing address :
DEA
The Spec ia l Popula t ions S t u d i e s Branch o f t h e Div is ion of Cancer Prevent ion and Control (DCPC), Nat iona l Cancer I n s t i t u t e ( N C I ) , announces t h e a v a i l a b i l i t y o f a Request f o r Appl ica t ions (RFA) i n v i t i n g CooperativeAgreement a p p l i c a t i o n s f o r i n v e s t i g a t o r s t o p a r t i c i p a t e , wi th t h e a s s i s t a n c e o f t h e N C I , i n s t u d i e s t o determine t h e e f f e c t i v e n e s s o f cancer prevent ion and c o n t r o l i n t e r v e n t i o n s t r a t e g i e s i n Hispanic popula t ions .
The s u b j e c t s f o r t h e s t u d i e s w i l l be Mexican Americans, Puer to Ricans, Cuban Americans o r Central /South Americans r e s i d i n g i n t h e United S t a t e s . The r e sea rch w i l l involve s t u d i e s which address : 1 ) t h e e f f i c a c y and e f f e c t i v e n e s s o f e x i s t i n g cancer prevent ion and c o n t r o l i n t e r v e n t i o n s t r a t e g i e s ; or 2 ) t h e development of new i n t e r v e n t i o n s t r a t e g i e s . The rangeof r e sea rch is no t l i m i t e d t o any p a r t i c u l a r a spec t o f cancer prevent ion and c o n t r o l bu t must be m u l t i d i s c i p l i n a r y and may inc lude , f o r example:
o methods f o r circumventing b a r r i e r s t o h e a l t h system u t i l i z a t i o n , o s t r a t e g i e s t o inc rease e a r l y d e t e c t i o n o f cancer , and/or o prevent ion s t r a t e g i e s inc luding smoking c e s s a t i o n and d i e t a r y
modif ica t ion .
The i n t e r v e n t i o n r e sea rch w i l l advance through two s t a g e s : A Methods Development o r S t r a t e g i e s Modif icat ion, i . e . , Developmental s t age , S tage One (Cancer Control Phase I1 Research S t u d i e s ) followed by an In t e rven t ion Implementation and Evaluat ion s t a g e , S tage Two (Cancer Control Phase I11 Research S t u d i e s ) . I n v e s t i g a t o r s submi t t ing evidence o f i n t e r v e n t i o n m e t h o d d s t r a t e g i e s a l r eady p i l o t t e s t e d i n Hispanic communities may op t f o r s t u d i e s focus ing s o l e l y on t h e I n t e r v e n t i o n Implementation/Evaluation s t a g e .
I n t e r v e n t i o n Research i n Hispanics i s t o be cha rac t e r i zed by methods which w i l l circumvent o r reduce b a r r i e r s t o cancer prevent ion and c o n t r o l programsand s e r v i c e s ; and, as i n t h e case of smoking prevent ion and c e s s a t i o n o r d i e t a r y change, by methods which are used t o modify e x i s t i n g behavior o r prevent t h e development of caqtcer r i s k behaviors . Barriers inc lude but are no t l i m i t e d t o : ( 1 ) BehavioraWCultural Barriers, i . e . , language d i f f e r e n c e s ,soc ia l -psychologica l cons ide ra t ions , p a r t i c u l a r c u l t u r a l b e l i e f s which mayaffect access ing cancer c o n t r o l s e r v i c e s , l a c k o f knowledge and understandingof cancer prevent ion and c o n t r o l oppor tun i t i e s ; and (2) Health System/S t r u c t u r a l Barriers, i . e . , a v a i l a b i l i t y of cancer c o n t r o l s e r v i c e s , f i n a n c i a l
Vol. 18, No. 28, August 18, 1989 - Page 4
.,.
4
l i m i t a t i o n s , t r a n s p o r t a t i o n b a r r i e r s and l i m i t e d b i - l i n g u a l / c u l t u r a l h e a l t h care p rov ide r s . Smoking prevent ion and c e s s a t i o n as w e l l as d i e t a r y change programs are a l s o appropr i a t e i n t e r v e n t i o n areas which may be cons idered .
The a s s i s t a n c e mechanism used t o support t h e s e s t u d i e s w i l l be t h e coopera t ive agreement, which is similar t o t h e t r a d i t i o n a l N I H r e sea rch g r a n t . It d i f f e r s from a r e sea rch g ran t i n t h e ex ten t and n a t u r e of N C I s t a f f involvement wi th i n v e s t i g a t o r s . Two elements are c r i t i c a l f o r ob ta in ing support f o r a s tudy:Respondents must demonstrate t h e a b i l i t y t o : 1 ) access and ob ta in t h e p a r t i c i p a t i o n o f t h e Hispanic popula t ion i n which t h e cancer i n t e r v e n t i o n s tudy w i l l be conducted, and 2 ) develop and eva lua te a c u l t u r a l l y compatiblei n t e r v e n t i o n i n t h e target popula t ion . I n t e r e s t e d i n s t i t u t i o n s may reques tcop ie s o f t h e RFA. Note t h a t awards w i l l no t be made t o f o r e i g n i n s t i t u t i o n s . It is a n t i c i p a t e d t h a t f i v e t o s i x awards w i l l be made.
Requests f o r cop ie s o f t h e RFA should be addressed t o r
Elva Ruiz Spec ia l Populat ions S t u d i e s Branch Divis ion o f Cancer Prevent ion and Control National Cancer I n s t i t u t e Executive P laza North, Room 240 9000 Rockvi l le Pike Bethesda, Maryland 20897 Telephone: ( 3 0 1 ) 496-8589
ONGOI N G PROGRAM ANNOUNCEMENTS
RESEARCH ON URINARY INCONTINENCE AND OTHER URINARY DYSFUNCTION I N OLDER PERSONS
The Nat ional I n s t i t u t e on Aging ( N I A ) announces a cont inuing i n t e r e s t i n suppor t o f r e sea rch on u r i n a r y incont inence and o t h e r u r i n a r y dysfunct ion i n o l d e r persons.
BACKGROUND
Urinary incont inence , t h e involuntary l o s s o f u r i n e so severe as t o have s o c i a l and/or hygienic consequences, is a major c l i n i c a l problem and a s i g n i f i c a n t cause o f d i s a b i l i t y and dependency. Urinary incont inence affects a l l age groups and is p a r t i c u l a r l y common i n o l d e r persons. A t l eas t 10 m i l l i o n a d u l t Americans s u f f e r from u r ina ry incont inence, inc ludingapproximately 15 t o 30 percent o f community-dwelling o l d e r people and a t l eas t one-half of a l l nurs ing home r e s i d e n t s . The monetary c o s t s o f managingur inary incont inence are conse rva t ive ly estimated a t $10 .3 b i l l i o n annual ly ,and t h e psychosocial burden o f u r i n a r y incont inence is g r e a t .
Urinary incont inence is a symptom r a t h e r t han a d i s e a s e . I t appears i n a l i m i t e d number o f c l i n i c a l p a t t e r n s , each having s e v e r a l p o s s i b l e causes . I n some cases, t h e d i s o r d e r is t r a n s i e n t , secondary t o an e a s i l y reversed cause such as a medication or an acu te i l l n e s s l i k e u r i n a r y t r a c t i n f e c t i o n . Many cases are chronic , however, l a s t i n g i n d e f i n i t e l y u n l e s s proper ly diagnosed and t r e a t e d .
An N I H Consensus Development Conference e n t i t l e d "Urinary Incont inence i n Adults" was he ld October 3-5 , 1988. This conference was sponsored by t h e Nat ional I n s t i t u t e on Aging and t h e Office of Medical Appl ica t ions o f Research o f t h e Nat ional I n s t i t u t e s o f Health, i n conjunct ion with t h e Nat ional I n s t i t u t e o f Diabetes and Diges t ive and Kidney Diseases, t h e Nat ional Center f o r Nursing Research, t h e Nat ional I n s t i t u t e o f Neurological and Communicative Disorder and S t roke and t h e Veterans Adminis t ra t ion.
The Consensus Development Conference provided an overview of c u r r e n t knowledge on t h e e t io logy , pathophysiology, sequelae, and management of t h i s p reva len tc l in i ca l problem. Although information on incont inence is inc reas ing , t h e f i e l d has long been neglec ted , and numerous gaps e x i s t i n our knowledge.While many c o n t r o v e r s i e s were addressed, numerous ques t ions were i d e n t i f i e d t h a t await answers and t h u s serve as t h e focus f o r f u t u r e r e sea rch d i r e c t i o n s . These i s s u e s w i l l r e q u i r e t h e c o l l a b o r a t i v e input o f i n v e s t i g a t o r s from t h e spectrum of r e l e v a n t d i s c i p l i n e s and t h e r igo rous a p p l i c a t i o n o f appropr i a t e
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v
r e sea rch p r i n c i p l e s . The Conference concluded with t h e conferees ' i s suance o f a s ta tement i d e n t i f y i n g needs �or f u t u r e r e sea rch .
RESEARCH GOALS AND SCOPE
The fo l lowing l i s t of f u t u r e d i r e c t i o n s f o r needed r e sea rch were i d e n t i f i e d byt h e Consensus Development Conference on Urinary Incont inence i n Adults .
o Basic r e sea rch on t h e mechanisms underlying t h e e t i o l o g y , exacerba t ion , and response t o t rea tment of s p e c i f i c forms o f u r i n a r y incont inence and urgency.
o Epidemiologic s t u d i e s with emphasis on e l u c i d a t i o n o f r i s k f a c t o r s f o r development of u r i n a r y incont inence, i ts occurrence i n s p e c i f i c popula t ions( p a r t i c u l a r l y males and nonwhites) , and t h e n a t u r a l h i s t o r y o f t h e va r ious c l i n i c a l and physiologic: subtypes .
o S t u d i e s of s t r a t e g i e s t o prevent u r i n a r y incont inence .
o Randomized c l i n i c a l t r i a l s , inc luding l o n g i t u d i n a l s t u d i e s i n wel l - spec i f iedpopula t ions , of a lgor i thms f o r t h e sys temat ic assessment of p a t i e n t s wi th incont inence and of s p e c i f i c behaviora l , pharmacologic, and s u r g i c a lt r ea tmen t , e i t h e r a lone o r i n combination.
o Development of new t h e r a p i e s , inc luding pharmacologic agen t s wi th g r e a t e rs p e c i f i c i t y f o r t h e u r i n a r y t r ac t and new behaviora l and s u r g i c a l s t r a t e g i e sand o t h e r innovat ive techniques, inc luding e l e c t r i c a l s t i m u l a t i o n .
The above noted t o p i c s f o r r e sea rch on u r i n a r y incont inence are a l s o a p p l i c a b l e t o o t h e r common d i s o r d e r s of u r i n a r y dysfunct ion inc luding urgency,frequency and r e t e n t i o n . Appl ica t ions address ing t h e s e problems a r e a l s o sought .
The s p e c i f i c r e sea rch a r e a s l i s t e d above are not intended t o l i m i t t h e s e l e c t i o n of t o p i c s �or i n v e s t i g a t i o n i n any r e sea rch area r e l a t e d t o u r i n a r yt r a c t dysfunct ion i n o l d e r persons . The N I A is i n t e r e s t e d i n a l l innovat ive r e sea rch on t h e epidemiology, e t i o l o g y , prevent ion , pathophysiology, d i agnos i sand t rea tment o f t h i s problem.
APPLICATION AND REVIEW PROCEDURES
The primary mechanisms f o r support o f t h i s program area
o Research g ran t (R011
o Program P r o j e c t Award (PO11
o F i r s t Independent Research Support and T r a n s i t i o n (FIRST)Award (R29)
o Career awards, which inc lude : Academic Award (KO81C l i n i c a l I n v e s t i g a t o r Award (KO81
o Tra in ing g r a n t s (T32)
o Fel lowships (F32, F3J )
Appl ica t ions f o r ROls, R29s, F32s and F33s w i l l be reviewed f o r s c i e n t i f i c and t e c h n i c a l merit by an appropr i a t e s tudy s e c t i o n i n t h e N I H Div is ion o f Research Grants . A l l o t h e r a p p l i c a t i o n s w i l l be reviewed by an appropr i a t eI n s t i t u t e review committee. Secondary review w i l l be performed by an appropr i a t e Nat ional Advisory Council .
There are no s e t - a s i d e funds f o r t h e s e a p p l i c a t i o n s . Appl ica t ions compete on t h e b a s i s o f s c i e n t i f i c merit wi th a l l o t h e r a p p l i c a t i o n s . The review c r i t e r i a are t h o s e f o r r e sea rch p r o j e c t , program p r o j e c t , career development,t r a i n i n g , and f e l lowsh ip a p p l i c a t i o n s .
The N I H u rges a p p l i c a n t s f o r g r a n t s t o inc lude members o f minor i ty groups and women i n t h e s tudy popula t ions f o r r e sea rch . I n those in s t ances i n which t h i s is no t f e a s i b l e o r appropr i a t e an explana t ion should be provided.
Researchers cons ider ing an a p p l i c a t i o n i n response t o t h i s announcement a r e welcome t o d i s c u s s t h e i r p r o j e c t , and t h e range of g ran t mechanisms a v a i l a b l e ,wi th N I A s t a f f i n advance of formal submission. This can be done e i t h e rthrough a te lephone conversa t ion o r a b r i e f l e t te r g iv ing t h e d e s c r i p t i v e w w
t i t l e of t h e proposed p r o j e c t and i d e n t i f y i n g t h e p r i n c i p a l i n v e s t i g a t o r and,when known, o t h e r key p a r t i c i p a n t s .
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Appl icants should use t h e r egu la r r e sea rch p r o j e c t g ran t a p p l i c a t i o n form (PHS398, r ev . 10188) or i nd iv idua l NRSA gran t a p p l i c a t i o n form (PHS 419-1, r e v . 7 / 8 8 ) f o r fe l lowships , a v a i l a b l e a t t h e a p p l i c a n t ' s i n s t i t u t i o n or from:
Of f i ce o f Grants I n q u i r i e sDivis ion o f Research Grants Westwood Building, Room 449
-+' National I n s t i t u t e s o f Heal th Bethesda, Maryland 20892 Telephoner ( 3 0 1 ) 496-7441
To exped i t e t h e a p p l i c a t i o n ' s r o u t i n g wi th in N I H , p l ease check t h e box on t h e face shee t o f t h e a p p l i c a t i o n i n d i c a t i n g t h a t your proposal is i n response t o t h i s announcement and p r i n t (next t o t h e checked box) "NIA Research on Urinary Incont inence e t c . , P.A."
Mail t h e completed a p p l i c a t i o n (with 6 cop ies ) t o :
Appl ica t ion Receipt Office Divis ion o f Research Grants National I n s t i t u t e s o f Heal th Westwood Building, Room 240 Bethesda, Maryland 20892XW
Receipt d a t e s f o r Research Grant, Program P r o j e c t Grant, Career Award and F i r s t Award a p p l i c a t i o n s are February 1, June 1 , and October 1; t hose f o r Train ing ,Grant and Fellowship a p p l i c a t i o n s are January 10, May 10, and September 1 0 .
Correspondence and i n q u i r i e s should be d i r e c t e d t o :
Stan ley L . S l a t e r , M.D. Direc to r , G e r i a t r i c Research and Tra in ing ProgramGeriatrics Branch Nat iona l I n s t i t u t e on AgingNational I n s t i t u t e s of Health Bui ld ing 3 1 , Room 5C27 Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-6761
SMALL GRANTS TO FACILITATE USE OF NEW TECHNIQUES BY RESEARCHERS IN DIABETES,ENDOCRINOLOGY AND METABOLISM
Nat iona l I n s t i t u t e of Diabetes and Diges t ive and Kidney Diseases
INTRODUCTION
The Div is ion of Diabetes , Endocrinology and Metabolic Diseases (DDEM) suppor t sresearch and t r a i n i n g re la ted t o d i a b e t e s m e l l i t u s and i t s complicat ions, t o endocrinology and t o a v a r i e t y of g e n e t i c metabol ic d i s e a s e s , inc luding c y s t i cf i b r o s i s . Within each of t h e s e a r e a s ? t h e p u r s u i t of r e sea rch i n t o t h e mechanisms of var ious r egu la to ry func t ions and d i s e a s e pathophysiology o f t e n r e q u i r e s t h e a b i l i t y t o use new techniques of s t r u c t u r a l , molecular and c e l l u l a r biology, gene t i c s , biophysics , v i ro logy? immunology, and physiology.The DDEM encourages P r i n c i p a l I n v e s t i g a t o r s (PIS) supported by t h e Diabetes Research Programs, t h e Endocrinology Research Program, t h e Metabolic Diseases Research Program and t h e Cys t ic F i b r o s i s Program, or under s p e c i a lcircumstances a member of t h e PI 'S r e sea rch team, t o o b t a i n first hand experience with new techniques as a V i s i t i n g Researcher i n t h e l a b o r a t o r y of an exper t Host. The new techniques should be an i n t e g r a l p a r t of an o r i g i n a lp i l o t r e sea rch p r o j e c t conceived by t h e V i s i t i n g Researcher i n c o l l a b o r a t i o n with t h e Host. The proposed r e sea rch p r o j e c t should r e s u l t i n novel pre l iminary d a t a which could s t r eng then a subsequent a p p l i c a t i o n f o r r e g u l a rg ran t suppor t .
OBJECTIVES AND SCOPE
The o v e r a l l goa l o f t h i s program announcement is t o f a c i l i t a t e inco rpora t ionof r e l e v a n t new techniques i n t o r e sea rch p r o j e c t s supported by DDEM. Prospec t ive V i s i t i n g Researchers i n d i abe te s , endocrinology and metabolism are encouraged t o i d e n t i f y Hosts i n o rde r t o prepare and submit a small g ran ta p p l i c a t i o n . The a p p l i c a t i o n must be submit ted by t h e V i s i t i n g Researcher and 'Ih i s l h e r I n s t i t u t i o n . The proposed o r i g i n a l r e sea rch p r o j e c t , t o be performed
i n t h e Host ' s l abo ra to ry , need not be d i r e c t l y r e l a t e d t o d i a b e t e s ,endocrinology or metabolism. However, t h e techniques u t i l i z e d while
Vol. 1 8 , No. 28, August 18, 1989 - Page 7
performing t h e r e sea rch p r o j e c t must be d i r e c t l y app l i cab le t o t h e V i s i t i n gResearcher 's f u t u r e work i n t h e s e a r e a s .
Some examples o f new techniques are: recombinant DNA; gene mapping andlor sequencing; product ion o f t r ansgen ic c e l l l i n e s and organisms inc lud ing vec to r cons t ruc t ion , t r a n s f e c t i o n and i n f e c t i o n ; hybridoma product ion; i d e n t i f i c a t i o n of gene products ; c e l l s o r t i n g and t r a f f i c k i n g ; s i g n a l t r ansduc t ion inc ludingpatch clamping; p e p t i d e l p r o t e i n c r y s t a l l o g r a p h i c a n a l y s i s ; p e p t i d e l p r o t e i nmodeling and molecular dynamics s imula t ions ; 2D-nuclear magnetic resonance o f p e p t i d e s l p r o t e i n s ; i n v i t r o and i n vivo magnetic resonance spectroscopy o r magnetic resonance imaging and o t h e r b iophys ica l o r s p e c i a l i z e d techniquesu s e f u l i n d i a b e t e s , endocrinology and metabolism re sea rch .
ELIGIBILITY REQUIREMENTS
The proposed V i s i t i n g Researcher must be P r i n c i p a l I n v e s t i g a t o r on a t l e a s t one DDEM-supported r e sea rch p r o j e c t g ran t (Rol l o r P r i n c i p a l I n v e s t i g a t o r on a program p r o j e c t g ran t ( P o l ) , o r r e sea rch center g ran t ( P 5 0 ) . Under s p e c i a lcircumstances t h e p r i n c i p a l i n v e s t i g a t o r may sponsor a q u a l i f i e d member of h i s l h e r team, provided t h e member r e t u r n s t o t h e Sponsor 's l abo ra to ry and a p p l i e s t h e acqui red techniques f o r a t l eas t one yea r . I n t h i s case, t h e Sponsor w i l l s e r v e as t h e P r i n c i p a l I n v e s t i g a t o r on t h e p r o j e c t .
The Host i n s t i t u t i o n must be d i f f e r e n t from t h e V i s i t i n g Researcher ' s . Under compelling circumstances an exemption from t h i s requirement may be considered,but i n such cases p r i o r w r i t t e n approval must be obta ined from t h e appropr i a t e program d i r e c t o r before t h e a p p l i c a t i o n is submit ted.
A l l a p p l i c a n t s must have rece ived a Ph.D., M . D . , o r equ iva len t degree from an a c c r e d i t e d domestic o r f o r e i g n i n s t i t u t i o n , and must have had a t l eas t seven subsequent y e a r s of r e l e v a n t r e sea rch o r p r o f e s s i o n a l exper ience .Demonstrated r e sea rch a b i l i t y must be evidenced by p u b l i c a t i o n s and former o r c u r r e n t g r a n t s from N I H , NSF o r r e sea rch foundat ions . The Host must be an e s t a b l i s h e d r e sea rche r wi th recognized e x p e r t i s e i n t h e area o f t h e p i l o tr e sea rch p r o j e c t proposed.
A l l Hosts, V i s i t i n g Researchers , o r sponsored V i s i t i n g Researchers must be c i t i z e n s o r nonc i t i zen n a t i o n a l s o f t h e United S t a t e s , o r have been l awfu l lyadmit ted t o t h e United S t a t e s f o r permanent r e s idence .
PURPOSE AND TERMS OF THE AWARD
Th i s non-renewable award provides a maximum of $12,500 t o $25,000 f o r a 3-6 months pe r iod i n a Host l abora to ry with pe r iods less than s i x months beingpro ra t ed . The funds are t o be used f o r sa lar ies , supply needs i n t h e Host ' s l a b o r a t o r y , and t r a v e l and subs i s t ence funds f o r t h e V i s i t i n g Researcher . A maximum of $2,500 t o 5 , 0 0 0 f o r 3 t o 6 months r e s p e c t i v e l y is allowed f o r s a l a r i e s of t e c h n i c a l personnel i n t h e Host l a b o r a t o r y . A subcont rac t agreement wi th t h e Host i n s t i t u t i o n w i l l be necessary i f funds are t o be provided t o t h e Hos t ' s i n s t i t u t i o n . The proposed a c t i v i t y must be fu l l - t ime and must inc lude t h e conduct of r e sea rch wi th superv is ion provided by t h e Host, o r by t h e Host i n a s s o c i a t i o n wi th an expe r t member o f t h e Hos t ' s l a b o r a t o r y . A minimum f u l l - t i m e commitment of 3 months is requ i r ed . The a c t i v i t y should be scheduled wi th in t h e 12 month pe r iod fo l lowing t h e d a t e o f t h e award. The s e t t i n g may be a U.S. nonpro f i t p r i v a t e o r p u b l i c i n s t i t u t i o n ,inc luding a Federa l l a b o r a t o r y . Funding of mer i to r ious a p p l i c a t i o n s submit ted i n response t o t h i s program announcement is cont ingent on t h e a c t u a l a v a i l a b i l i t y o f funds.
APPLICATION AND REVIEW PROCEDURES
An a n t i c i p a t e d schedule f o r review and award is d e t a i l e d below:
Appl ica t ionReceipt Date
June 1 October 1 Feb 1
N I D D K I n i t i a l Review Committee
Earliest Award Date
September - October December 1 February A p r i l 1 June September 1
The above t h r e e , y e a r l y r e c e i p t d a t e s w i l l be s t r i c t l y enforced .
Upon r e c e i p t , a p p l i c a t i o n s w i l l be reviewed ( i n i t i a l l y ) by t h e Div is ion of Research Grants (DRG) f o r completeness. Incomplete a p p l i c a t i o n s w i l l be r e tu rned t o t h e a p p l i c a n t without f u r t h e r cons ide ra t ion . Appl ica t ions w i l l t hen be reviewed by a s t and ing N I D D K review committee, based on t h e fo l lowingcr i te r ia :
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1 . Is it l i k e l y t h a t p re l iminary d a t a w i l l r e s u l t t h a t could s t r eng thent h e P I ' S r e sea rch program andlor are t h e techniques being l ea rned l i k e l y t o f u r t h e r t h e P I ' S r e sea rch i n t e r e s t s ?
2 . W i l l t h e V i s i t i n g Researcher ga in hands-on experience i n techniques no t e a s i l y a v a i l a b l e t o himyher a t h i d h e r own i n s t i t u t i o n ?
'I.' 3 . A r e t echniques proposed i n t h e r e sea rch p r o j e c t r e l e v a n t t o t h e V i s i t i n g Researcher 's f u t u r e s t u d i e s i n d i abe te s , endocrinology, o r metabolism?
4 . Is t h e Host ' s l a b o r a t o r y and s ta f f involved i n t h i s p r o j e c tappropr i a t e �or t h e proposed work?
5 . Is t h e experimental des ign adequate and appropr i a t e?
The review group w i l l a l s o c r i t i c a l l y examine t h e submit ted budget and w i l l recommend an appropr i a t e budget f o r each approved a p p l i c a t i o n .
On l i n e 2 of t h e a p p l i c a t i o n face page, check YES and i n s e r t t h e t i t l e o f t h i s Program Announcement "Small Grants t o F a c i l i t a t e U s e o f N e w Techniques byResearchers i n Diabetes , Endocrinology and Metabolism."
Appl icants should submit a s igned, t ypewr i t t en o r i g i n a l of t h e a p p l i c a t i o n ,inc luding t h e Checkl i s t , and fou r ( 4 ) signed, exac t photocopies , i n one package t o t h e Div is ion of Research Grants a t t h e address below. The photocopies must be c lear and s i n g l e s ided .
Appl ica t ion Receipt Office Divis ion o f Research Grants Nat ional I n s t i t u t e s of Health Westwood Building,,Room 240 Bethesda, Maryland 20892XX
A t t h e time o f submission, two a d d i t i o n a l cop ie s o f t h e a p p l i c a t i o n should be s e n t t o :
Review Branch Nat ional I n s t i t u t e o f Diabe tes and Diges t ive
A F i n a l Progress Report , an Invent ion Statement and a F inanc ia l S t a t u s Report must be submit ted wi th in n i n e t y days a f t e r t h e t e rmina t ion o f t h e award. This f i n a l r e p o r t i n g requirement is t h e same as t h a t f o r o t h e r t ypes of r e sea rch g r a n t s and is i n accord wi th 42 CFR 52 and 45 CFR 7 4 .
CONSULTATION WITH PROGRAM STAFF
Prospec t ive a p p l i c a n t s are encouraged t o d i s c u s s t h e i r i d e a s with programs ta f f (see below) t o determine whether t hey f i t t h e d e f i n i t i o n s and gu ide l ines of t h i s announcement. Appl ica t ions which, i n t h e opinion o f s t a f f , do not meet t h e s e o b j e c t i v e s , scope and e l i g i b i l i t y c r i t e r i a w i l l be r e tu rned without review.
Although t h e abbrevia ted a p p l i c a t i o n must be prepared and submit ted on form PHS 398 ( r e v i s e d 1 0 / 8 8 ) , t h e format o f t h e a p p l i c a t i o n is d i f f e r e n t from t h a t used f o r r e g u l a r r e sea rch p r o j e c t g r a n t s . The COMPLETE PROGRAM ANNOUNCEMENT and SPECIAL INSTRUCTIONS FOR prepa ra t ion o f t h e a p p l i c a t i o n are a v a i l a b l e and MUST BE consul ted by t h e app l i can t before prepar ing an a p p l i c a t i o n . Programstaff l i s t e d below should be contac ted with ques t ions o r r eques t s :
For Endocrinology, Metabolism For Diabetes : and Cys t i c F i b r o s i s :
Robert Katz, Ph.D. Joan T. Harmon, Ph.D. Deputy Chief, Endocrinology Director, Diabetes Research Programand Metabolic Diseases DDEM, N I D D K Programs Branch, DDEM, N I D D K Westwood Building, Room 622 Westwood Building, Room 607A N I H , Bethesda, Maryland 20892
a c o n s i s t e n t 15 yea r s a number o f population-based s t u d i e s have demonstrated Over t h e p a s t r e l a t i o n s h i p between inadequate s o c i a l r e l a t i o n s h i p s or support -111
and emotional s ta tes ( e . g . , anx ie ty , dep res s ion ) , and prevalence o f ca rd iovascu la r (CV) r i s k f a c t o r s , morbidi ty , a l l - cause m o r t a l i t y , and m o r t a l i t y from ca rd iovascu la r d i s e a s e ( C V D ) . Data on t h e a s s o c i a t i o n between s o c i a l support and h e a l t h come from a d i v e r s e set o f i n t e r n a t i o n a l i n v e s t i g a t i o n s . I n t h e Alameda County Study low s o c i a l support w a s p rospec t ive ly r e l a t e d t o a l l - cause m o r t a l i t y and t h i s r e l a t i o n s h i p was maintained af ter c o n t r o l l i n g f o r socioeconomic s t a t u s , i n i t i a l h e a l t h s t a t u s ,and s tandard r i s k f a c t o r s ( e . g . , smoking, o b e s i t y , a l coho l consumption).Furthermore, low support p red ic t ed s p e c i f i c causes o f dea th , inc ludingischemic h e a r t d i s e a s e and cancer . I n a p rospec t ive Tecumseh, Michigan s tudy , a s imilar r e l a t i o n s h i p between s o c i a l support and m o r t a l i t y was found f o r men. Re la t ionsh ips between support and m o r t a l i t y were found i n t h e Evans County,Georgia, s tudy for white men, bu t no t f o r women or b lack men. I n a p r e d i c t i v es tudy conducted on o l d e r men and women i n Durham, North Caro l ina , a v a i l a b i l i t yo f suppor t , frequency o f c o n t a c t s with network members, and pe rcep t ions o f suppor t were a l l r e l a t e d t o m o r t a l i t y a f t e r c o n t r o l l i n g f o r socioeconomic s t a t u s , phys i ca l h e a l t h , stress, and smoking.
Outside t h e United S t a t e s , popula t ion s t u d i e s have r e p l i c a t e d t h i s s o c i a l support and m o r t a l i t y r e l a t i o n s h i p . I n a s tudy o f men i n Gothenburg, Sweden,s o c i a l p a r t i c i p a t i o n w a s nega t ive ly r e l a t e d t o m o r t a l i t y . Th i s r e l a t i o n s h i p w a s maintained after c o n t r o l l i n g f o r age and ca rd iovascu la r r i s k f a c t o r s . S imi l a r ly , a p o s i t i v e effect o f s o c i a l c o n t a c t s and s o c i a l i n t e r a c t i o n s on s u r v i v a l was found f o r a random sample o f t h e Swedish popula t ion aged 29 t o 7 4 . I n t h e F innish North Karelia s tudy, s o c i a l support w a s a s soc ia t ed wi th t o t a l and ca rd iovascu la r m o r t a l i t y i n men.
I n a prospec t ive s tudy of male su rv ivo r s of myocardial i n f a r c t i o n ( M I ) , it w a s found t h a t low suppor t coupled with psychologica l s t r a i n p red ic t ed post-MIm o r t a l i t y a f te r c o n t r o l l i n g f o r medical s t a t u s and t r a d i t i o n a l CVD r i s k f a c t o r s . Recent s t u d i e s have a l s o demonstrated a r e l a t i o n s h i p between s o c i a l support and h e a l t h behaviors . For example, people with adequate support maybe more l i k e l y t o comply wi th medical regimens, and may be more success fu l a t a l t e r i n g r i s k behaviors ( e . g . , smoking c e s s a t i o n ) . Some d a t a a l s o demonstrate ** a p o s s i b l e r o l e f o r p o s i t i v e s o c i a l r e l a t i o n s and heal th-seeking behaviors , short- term recovery ,,from ca rd iovascu la r events , and long-term adjustment t o CVD. For example, access t o suppor t ive o t h e r s has been i d e n t i f i e d as a component i n f a c i l i t a t i n g recovery from bypass surgery .
Support may a l s o b u f f e r t h e effect o f stress on h e a l t h . A s tudy conducted i n t h e Nether lands, f o r example, found t h a t s t r e s s e d employees wi th s o c i a l support had lower blood p res su re than s t r e s s e d employees without suppor t . A Swedish s tudy o f work cond i t ions , p a r t i c u l a r l y degree of c o n t r o l over t h e work day, pe rcep t ions o f autonomy, and sources of s o c i a l suppor t , revea led t h a t t h e h ighes t rates of ca rd iovascu la r d i s e a s e occurred i n persons who perce ived h igh stress i n t h e i r jobs , had a low a b i l i t y t o c o n t r o l t h e i r working environment, and had low s o c i a l suppor t .
To summarize, population-based s t u d i e s have c o n s i s t e n t l y demonstrated a r e l a t i o n s h i p between s o c i a l support and CVD-related h e a l t h and well-being. This a s s o c i a t i o n is p a r t i c u l a r l y robus t when one cons ide r s t h a t t h e empi r i ca l i n v e s t i g a t i o n s have been notab ly d i v e r s e with marked v a r i a t i o n s i n s o c i o c u l t u r a l con tex t s , measures o f s o c i a l support , s tudy endpoints , and confounding v a r i a b l e s . Unfortvnately, very l i t t l e is known beyond t h e s e broad a s s o c i a t i o n s between s o c i a l support and CVD. More s p e c i f i c a l l y , s t u d i e s t o d a t e have no t been designed t o address t h e mechanisms and processes t h a t may account f o r t h e s e broad a s s o c i a t i o n s between s o c i a l support and CVD-related h e a l t h . U n t i l a clearer understanding o f t h e s e processes is achieved, i n t e r v e n t i o n s designed t o a l l e v i a t e t h e nega t ive h e a l t h effects of inadequate s o c i a l suppor t are no t f e a s i b l e .
The purpose o f t h i s announcement is t o s t i m u l a t e r e sea rch designed t o i n v e s t i g a t e t h e processes through which s o c i a l support may in f luence t h e onse t , s e v e r i t y , p rogress ion or adjustment t o ca rd iovascu la r d i s e a s e . Appl icants are encourage t o inc lude wi th in t h e i r p roposa ls t h e fo l lowing elements: a c l e a r l y s p e c i f i e d model of t h e processes through which support i n f luences CVD, r e l i a b l e and v a l i d measures o f s o c i a l support and r e l a t e d c o n s t r u c t s t h a t are appropr i a t e t o t h e model being t e s t e d , a c l e a r concep tua l i za t ion o f t h e form of support r e l evan t t o t h e model i n v e s t i g a t e d and endpoin ts assessed , r e l i a b l e and v a l i d assessments of t h e f a c t o r s t h a t may
Vol. 18, No. 28, August 18, 1989 - Page 10
re la te t o s o c i a l support o r t o t h e outcome measures used ( e . g . , o t h e r r i s k f a c t o r s f o r CVD), and s o p h i s t i c a t e d assessment o f outcomes and mediatingv a r i a b l e s . S tud ie s us ing m u l t i l e v e l assessment approaches ( e . g . , behaviora l and biochemical) are encouraged. Endpoints might inc lude angina, d i s e a s e progress ion , recovery ra tes , r e t u r n t o normal func t ion ing ( e . g . , multi-domain q u a l i t y of l i f e assessments ) , changes i n r i s k f a c t o r behaviors , medication and
d regimen adherence, and r e h o s p i t a l i z a t i o n . Mul t ip le outcome measures are p a r t i c u l a r l y va luable .
The complexity o f t h e i s s u e s r e l a t e d t o s o c i a l support and CVD n e c e s s i t a t e t h e use o f an i n t e r d i s c i p l i n a r y r e sea rch team, wi th demonstrated e x p e r t i s e i n t h e biomedical and behaviora l s c i ences r equ i r ed . I n add i t ion , depending on t h e s p e c i f i c ques t ions addressed and popula t ion examined, t h e i n v e s t i g a t i v e team may inc lude i n d i v i d u a l s with e x p e r t i s e i n areas such as hea l th , developmental,s o c i a l and biopsychology; n u t r i t i o n ; behaviora l epidemiology; prevent ivecard io logy , card io logy , c a r d i a c surgery, and r e h a b i l i t a t i o n card io logy;b i o s t a t i s t i c s and psychometrics; and nurs ing .
It is a n t i c i p a t e d t h a t success fu l respondents t o t h i s announcement may be i n v i t e d t o meet annual ly t o d i s c u s s r e sea rch des igns , develop comparable measures, compare r e s u l t s , and cons ider t h e imp l i ca t ions o f t h e r e s u l t s f o r f u t u r e in te rvent ion-based i n v e s t i g a t i o n s .
Appl ica t ion Submission and Review
Appl ica t ion r e c e i p t d a t e s f o r new a p p l i c a t i o n s are t h e r e g u l a r a p p l i c a t i o nr e c e i p t d a t e s o f February 1 , June 1 , and October 1 . The f irst accep tab ler e c e i p t d a t e w i l l be February 1, 1990. The ear l ies t p o s s i b l e award d a t e i s approximately t e n months a f t e r t h e r e c e i p t d a t e . Appl ica t ions should use t h e r e g u l a r r e sea rch g ran t a p p l i c a t i o n PHS Form 398 ( r e v i s e d 10/88), which is a v a i l a b l e a t most i n s t i t u t i o n a l bus iness o f f i c e s or from t h e Div is ion o f Research Grants (DRG) , N I H .
To i d e n t i f y responses t o t h i s announcement, check "yes" and put "Socia l Support and Cardiovascular Disease" under i t e m 2 of page 1 of t h o s e g r a n ta p p l i c a t i o n s r e l a t i n g t o t h e t o p i c s i d e n t i f i e d he re in . The completeda p p l i c a t i o n and s i x exac t copies should be mailed t o :
Div is ion of Research Grants Nat ional I n s t i t u t e s o f Heal th
The DRG w i l l a s s i g n a p p l i c a t i o n s f o r review according t o t h e N I H p rocess f o r r e g u l a r r e sea rch g ran t a p p l i c a t i o n s . Addi t iona l information may be obta ined by con tac t ing :
S a l l y A. Shumaker, Ph.D. Behavioral Medicine Branch Divis ion of Epidemiology and C l i n i c a l Appl ica t ions National Heart, Lung, & Blood I n s t i t u t e Federa l Bui lding, Room 216 7550 Wisconsin Avenue Bethesda, Maryland 20892 Telephone: (301) 496-9380
XThis program is descr ibed i n t h e c a t a l o g o f Federa l Domestic Ass is tance No. 13.837, Heart and Vascular Disease Research. Awards w i l l be made under t h e a u t h o r i t y o f t h e Publ ic Heal th Se rv ice A c t , Sec t ion 301 (42 USC 241) and adminis tered under PHS g ran t p o l i c i e s and Federal Regulat ions, most s p e c i f i c a l l y 42 CFR P a r t 52 and 45 CFR p a r t 74. This program is no t s u b j e c t t o t h e intergovernmental review requirements o f Execut ive Order 12372, o r t o Health Systems Agency Review.
BEHAVIORAL, ETIOLO G I C AND PHYSIOLOGIC ASPECTS OF STUTTERINF
National I n s t i t u t e on Deafness and Other Communication Disorders
The Div is ion o f Communication Sciences and Disorders (DCSD) o f t h e Nat ional I n s t i t u t e on Deafness and Other Communication Disorders ( N I D C D ) encourages t h e submission of i nd iv idua l r e sea rch p r o j e c t g r a n t s t o i n v e s t i g a t e s t u t t e r i n g .
-alB/
Vol. 18, No. 28, August 18, 1989 - Page 1 1
I
I . BACKGROUND
S t u t t e r i n g , a speech d i s o r d e r which t y p i c a l l y begins during t h e preschool yea r s , is cha rac t e r i zed by t h e r e p e t i t i o n and pro longat ion of speech sounds. Many i n d i v i d u a l s who begin t o s t u t t e r dur ing childhood experience spontaneousremission of t h e i r symptoms by adolescence. More information is needed concerning t h e causes o f t h i s d i s o r d e r and t h e reasons f o r spontaneous
-LILlfl recovery. Because t h e r e i s a l a c k o f unanimity concerning t h e d e f i n i t i o n of t h i s d i s o r d e r , d i agnos t i c c r i t e r i a are needed f o r t h e i d e n t i f i c a t i o n o f both c h i l d and a d u l t s t u t t e r e r s . Experimental i n v e s t i g a t i o n s t h a t expand our knowledge of s t u t t e r i n g i n t h e s e a r e a s w i l l l e a d t o improved t rea tment methods.
11. RESEARCH GOALS AND SCOPE
The N I D C D encourages i n v e s t i g a t i o n s i n t o t h e e t i o l o g y , i d e n t i f i c a t i o n ,development, and t rea tment o f s t u t t e r i n g . I n v e s t i g a t o r s are encouraged t o develop s i n g l e - i n v e s t i g a t o r o r i n t e r d i s c i p l i n a r y s t u d i e s i n t h e fol lowing areas, which are not exc lus ive :
o Et io logy: Fac to r s c o n t r i b u t i n g t o t h e development of s t u t t e r i n g ;i d e n t i f i c a t i o n o f famil ia l c h a r a c t e r i s t i c s a s s o c i a t e d with s t u t t e r i n g .S t u d i e s may u t i l i z e high-densi ty des igns (families with s t u t t e r i n g a d u l t s and young c h i l d r e n a t r i s k f o r developing s t u t t e r i n g ) , wi th assessment o f phenotype i n each fami ly .
o I d e n t i f i c a t i o n : Objec t ive c r i t e r i a o r i d e n t i f i c a t i o n measures appropr i a t ef o r t h e s p e c i f i c a t i o n of speech s i m i l a r i t i e s and d i f f e r e n c e s between s t u t t e r e r s and n o n - s t u t t e r e r s .
o Pathophysiology of s t u t t e r i n g : determine t h e phys io log ica l d i f f e r e n c e s between s t u t t e r e r s and normal speakers and t h e r e l a t i o n s h i p between phys io log ica l d i f f e r e n c e s and speech c h a r a c t e r i s t i c s .
o Development o f s t u t t e r i n g : The r e l a t i o n s h i p between speech and languagedevelopment and t h e onse t o f s t u t t e r i n g ; c h a r a c t e r i s t i c s o f childhood s t u t t e r e r s who recover v s t h o s e whose symptoms p e r s i s t ; c h a r a c t e r i s t i c s o f speech of "recovered s t u t t e r e r s " ; f a c t o r s which c o n t r i b u t e t o r e l a p s e ; t h e c h a r a c t e r i s t i c s o f f l u e n t speech development; t h e d i f f e r e n t i a t i n g of normal dysf luency from mild s t u t t e r i n g .
.(rlo Treatment: Procedures appropr i a t e f o r a s s e s s i n g s t u t t e r i n g pre- and pos t - t rea tment ; t h e r e l a t i o n s h i p between c h a r a c t e r i s t i c s p re sen t a t onse t o f t rea tment t o t rea tment outcome. S t u d i e s may address t h e eva lua t ion o f s p e c i f i c t r ea tmen t s , e a r l y in t e rven t ion , changes i n s t u t t e r i n g dur ingt rea tment , and maintenance o f f luency fo l lowing t r ea tmen t .
111. Mechanisms o f Support
The suppor t mechanism f o r g r a n t s i n t h i s area w i l l be t h e ind iv idua l r e sea rch g ran t (Rol l and t h e FIRST award (R29). Under t h e s e mechanisms, t h e p r i n c i p a li n v e s t i g a t o r and any p a r t i c i p a t i n g i n v e s t i g a t o r s w i l l p lan , d i r e c t , and perform t h e r e sea rch .
APPLICATION AND REVIEW PROCEDURES
Appl ica t ions must be prepared on form PHS 398 (Rev. 10188) us ing t h e i n s t r u c t i o n s included i n t h e a p p l i c a t i o n k i t . These k i t s are a v a i l a b l e from t h e address c i t e d below o r from t h e Div is ion of Research Grants, Nat ional I n s t i t u t e s of Health, Westwood Building, Room 449, Bethesda, MD 20892.
Receipt d a t e s f o r new re sea rch p r o j e c t g ran t and FIRST award a p p l i c a t i o n s are February 1, June 1, and October 1 .
On page 1 of form PHS 398, check "yes" i n i t e m 2 and type : " N I D C D Announcement: Behavioral , E t i o l o g i c , and Phys io logic Aspects o f S t u t t e r i n g . "Use t h e mai l ing l a b e l provided i n t h e a p p l i c a t i o n k i t and m a i l t h e s i ned o r i g i n a l and s i x exac t cop ie s t o t h e Div is ion o f Research Grants (DRGY.
Research p r o j e c t g ran t and FIRST award a p p l i c a t i o n s w i l l be reviewed f o r s c i e n t i f i c and t e c h n i c a l merit by an appropr i a t e s tudy s e c t i o n i n t h e Div is ion of Research Grants . Secondary review w i l l be by t h e Nat ional I n s t i t u t e on Deafness and Other Communication Disorders Nat iona l Advisory Council Appl ica t ions judged t o be wi th in t h e purview o f o t h e r I n s t i t u t e s o f N I H w i l l be ass igned accord ingly . *
Vol. 18, No. 28, August 18, 1989 - Page 12
For f u r t h e r information, p o t e n t i a l a p p l i c a n t s are encouraged t o ca l l o r w r i t e t o :
J u d i t h A . Cooper, Ph.D. Divis ion o f Communication Sciences and Disorders National I n s t i t u t e on Deafness and Other Communication Disorders
This program is descr ibed i n t h e Catalog o f Federa l Domestic Ass is tance No. 1 3 . 8 5 4 , Bio log ica l Basis Research i n t h e Neurosciences and Communicative Sc iences , and No. 13.853, C l i n i c a l Basis Research i n t h e Neurosciences and Communicative Sc iences . Awards w i l l be made under t h e a u t h o r i t y of t h e Publ ic Heal th Se rv ice A c t , Sec t ion 301 ( 4 2 USC241) and adminis tered under PHS g ran tp o l i c i e s and Federa l Regulat ions 42 CFR P a r t 52 and 45 CFR P a r t 7 4 . This program is not s u b j e c t t o review by a Heal th Systems Agency.
ERRATA
"OTHER SUPPORT" I N PHS GRANT APPLICATIONS
P.T. 3 4 ; K . W . 1014002, 1014006
Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion
The Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion (ADAMHA) was i n a d v e r t e n t l y omit ted from t h e n o t i c e when it was publ ished i n t h e N I H Guide f o r Grants and Cont rac ts , Vol. 1 8 , No. 2 0 , Page 2 , June 9 , 1989. This n o t i c e a l s o a p p l i e s t o a l l a p p l i c a n t s f o r g ran t support from ADAMHA.
PHS GRANT APPLICATION FORM 398 -- REMINDERS
P.T. 3 4 ; K . W . 0710030, 1014002
Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion **..J The Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion (ADAMHA) w a s
i nadve r t en t ly omi t ted from t h e n o t i c e when it was publ ished i n t h e N I H Guide f o r Grants and Cont rac ts , Vol. 1 8 , No. 2 0 , Page 3 , June 9 , 1989. These reminders regard ing Form 398 a l s o apply t o a p p l i c a t i o n s f o r support from ADAMHA.
PHS 398 MISCONDUCT I N SCIENCE ASSURANCE
P.T. 34; K . W . 0710030, 1014002
Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion
The Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion was i n a d v e r t e n t l yomit ted from t h e n o t i c e when it was publ ished i n t h e N I H Guide f o r Grants and Cont rac ts , Vol. 18, No. 2 0 , Page 3 , June 9 , 1989.
INCLUSION OF MINORITIES I N STUDY POPULATIONS
P.T. 3 4 , FFi K . W . 1014002, 0710030
INCLUSION OF WOMEN I N STUDY POPULATIONS
P.T. 3 4 , 11; K . W . 0770000, 1014002
Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion
The con tac t o f f i c e s f o r f u r t h e r c l a r i f i c a t i o n o r d i scuss ion o f t h e s e i s s u e s were l i s t e d i n c o r r e c t l y i n t h e n o t i c e when it was publ i shed i n t h e N I H Guide f o r Grants and Cont rac ts , Vol. 1 8 , No. 2 1 , Pages 1-4, June 16, 1989. The c o r r e c t c o n t a c t s are l i s t e d below:
Vol. 1 8 , No. 2 8 , August 18, 1989 - Page 13
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
ZZTHE MAILING ADDRESS GIVEN FOR SENDING APPLICATIONS TO THE DIVISION OF RESEARCH GRANTS OR CONTACTING PROGRAM STAFF IN THE WESTWOOD BUILDING IS THE CENTRAL MAILING ADDRESS FOR THE NATIONAL INSTITUTES OF HEALTH. APPLICANTS WHOUSE EXPRESS MAIL OR A COURIER SERVICE ARE ADVISED TO FOLLOW THE CARRIER'S REQUIREMENTS FOR SHOWING A STREET ADDRESS. THE ADDRESS FOR THE WESTWOOD BUILDING IS: 5333 Westbard Avenue Bethesda, Maryland 20816
Y
* U. 5. COVE R N E N T PRINTING OFF I C E : l 9 8 9 - ~ 4 1 - 2 1 5 10[1009
