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NIRF Weissleder et al., Nature Cancer Rev 2002 2(1):11-8 Wavelength [nm] Absorption coefficient (cm -1 )
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NIRF
Weissleder et al., Nature Cancer Rev 2002 2(1):11-8
Wavelength [nm]
Abs
orpt
ion
coef
ficie
nt (
cm-1)
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Proteasen sensitive KM
Weissleder et al., Nature Biotech; 1999;17:375-378
a
CY
PL
MPEG COATING
Enzym
Kein Signal Signal
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MMP-Probe
Bremer et al. Nat Med (2001) 7 (6) 743-8
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Enyzmatische Aktivierung
0
250
500
0 300 600 900 15001200
Zeit [min]
MMP-2 Probe
Kontroll-Probe
Flu
ore
szen
s [A
U]
![Page 5: NIRF Weissleder et al., Nature Cancer Rev 2002 2(1):11-8 Wavelength [nm] Absorption coefficient (cm -1 )](https://reader035.documents.pub/reader035/viewer/2022070310/55204d8149795902118d480e/html5/thumbnails/5.jpg)
ZellexperimenteGenexpression: rt-PCR
BT20 HT1080 MW-Standard
- +
Bremer et al. Radiology 221 (2), 523-9 (2001)
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In-vivo Experimente
MMP-2 + MMP-2 -Lichtbild
NIRF-Bild
MMP-2 + MMP-2 -
Bremer et al. Radiology 221 (2), 523-9 (2001)
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Inhibition der Probenaktivierung
AG3340
0
50
100
150p
rob
e ac
t. [
%]
AG3340 [M]
Flu
ore
szen
san
stie
g [
%]
10-12 10-10 10-8 10-6 10-4
Bremer et al. Nat Med (2001) 7 (6) 743-8
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MMP-Hemmung
Kontrolle AG3340
Bremer et al. Nat Med (2001) 7 (6) 743-8
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Fluorescence mediated Tomography
Ntziachristos et al; Nat Med 2002
![Untitled-1 [newmancollege.ac.in]newmancollege.ac.in/wp-content/uploads/2018/01/NIRF-REPORT-1-m… · 12/8/2017 All Report-MHRD, National Institutional Ranking Framework (NIRF) Median](https://static.documents.pub/doc/80x56/5f0602a57e708231d415d7c8/untitled-1-1282017-all-report-mhrd-national-institutional-ranking-framework.jpg)
