N.O.E. lesson 3 module 2

The Nuclear Overhauser Effect

Prof. Claudio Santi

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E.

Introduction

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Introduction “steady-state”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Introduction “steady-state”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Introduction “steady-state”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Introduction “stady-state”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Introduction “stady-state”

Influence of magnetic field

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Introduction “stady-state”

Influence of external relaxation sources

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Introduction “stady-state”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Introduction “stady-state”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Introduction “stady-state”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Introduction “stady-state”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Introduction “NOE-diff”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Example “NOE-diff”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Example “stady-state”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Example “stady-state”

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Example “stady-state”Geometry of trisobstituted olefines

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Example “stady-state”Geometry of heterocycles

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Example “stady-state”When the coupling costants are not determinant

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Example “stady-state”Sometimes it is not usefull

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Example “stady-state”Attribution of the faces in cyclic compounds

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Example “stady-state”Attribution of the faces in cyclic compounds

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Example “stady-state”Assignment of similar groups

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Example “stady-state”Conformational analysis

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Transient NOE

s

I

s

II

II

ss

s

I

NOE

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. Transient NOE and Distances

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. NOESY

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. NOESY

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. ROESY

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. ROESY

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. ROESY

Additional slidesnot for the presentation

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E.

ADDITIONAL

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E.

ADDITIONAL

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E.

ADDITIONAL

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E.

ADDITIONAL

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E.

ADDITIONAL

Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia

N.O.E. ADDITIONAL