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Yi- 1 Globa Univ U Intro mous 13 C m T 2 of To in new gain Meth spec reado repea and m and s was 6 liver, was s afte clinic imag estim weig Resu most 1). T 2 previ value altho The T show challe brain was o bicar in glio gliom Warb had a appro Conc T 2 m inject echo phys Ackn Refe Biom B. Ch Phys Non-CP -Fen Yen 1 , Sonal J al ASL, GE Health versity, Stanford, C University, Stanfor oduction P se model of p metabolites m the non-reco ncrease the di MR pulse seq signal-to-nois hod T trally selectiv outs. The seq ated with freq maximum B 1 slew rate 150 60 ms and 32 TRAMP and injected into n er the start of cal MR scann es pixel-by-p mated by com hted by an ex ults La t metabolites 2 of healthy ra ous single-vo es were obse ough it appear T 2 fitting error wn). This sequ enging metab n (Fig. 2). From obtained with rbonate signa oma. On the ma than the co burg Effect. C an SNR gain oximately 3 fo clusion T apping of mu tion. It also ha oes. Further st ical basis for nowledgeme erence: 1) Y-F med, 2010; 23 hronik, et al. M s. 1985; 12(2) PMG Echo-Tr Josan 2,3 , Lasitha Se May hcare, Menlo Park CA, United States, rd, CA, United Sta revious studie prostatic aden may be a prom overable 13 C m iagnostic valu quence for hig se ratio (SNR he pulse sequ e, spatially no quence was u quency offsets 0.2 Gauss fo 0mT/m/ms) bu 2 echoes wer rat glioma m normal rats, 0 injection. All er (Signa™, G ixel with a mo paring the SN xponential dec arge 13 C sign and the quali at liver was co oxel results [1 rved from TR red homogen rs were appro uence was als bolites, such a m a thin slice hin the contral al was expecte contrary, lact ontralateral si Compared to t of approxima old. his work repo ltiple hyperpo as a large SN tudies are ne the T 2 variati ent: NIH grant F. Yen, et al., (4):414-23. 3 Magma 2000 ):232–233. rain Sequence enadheera 4 , Jae M yer 2,3 , Lawrence Re , CA, United State 4 Dept. of Radiatio ates, 6 Dept. of Neu es showed lo nocarcinoma ( mising metric f metabolite sig ue of 13 C meta gh-resolution R) by averagin uence was co on-selective 1 used to acquir s to acquire o r all RF pulse ut by using a h e acquired. T odels, followi 0.3 mL of 80 m experiments GE Healthcar ono-exponent NR of the first cay using the als were obse ty of fit was g onsistent with ]. Heterogene RAMP tumor ( eous on proto oximately ±20 so used to im as 13 C bicarbo of 2.75 mm, lateral side, w ed to be large ate signal wa de, in agreem he first echo, ately 2.5 fold a orts a novel se olarized 13 C m NR advantage eded to unde on in maligna ts RR09784, A Proceedings ) P. Le Roux. ; 10(2):131-14 e for T 2 Mapp o Park 3,5 , Atsushi echt 6 , Lei Xing 4 , D es, 2 Neuroscience P on Oncology, Stan rology and Neuro Healthcar ng transverse (TRAMP) [1] a for cancer dia gnal was limite abolite T 2 , it is T 2 mapping o ng the echo-tr omposed of a 180° refocusin re image of on other 13 C meta es. Minimum s high-performa The scan time ng IACUC ap mM into TRAM were perform re, Waukesha tial decay cur t spin-echo to e lactate T 2 . erved for good (Fig. h the eous T 2 Fig. 1), on image. 00 ms (not age SNR- onate in SNR of 6:1 where er than that as larger in ment with linear sum o and weighted equence for h metabolites in e when summ erstand physio ant tumors vs AA13521-INIA s of the 16 th IS . J Magn Res 46. 6) K. Derb ing and Large Takahashi 1 , Taich Daniel Spielman 3 , R Program, SRI Inte nford University, S logical Sciences, S re, Palaiseau, Fra e relaxation ti and hepatoce agnosis using ed to a single s useful to ma of multiple 13 C ain signals. a 90° spectral- ng RF pulses ne slice from abolites of the slice thicknes ance gradient was 2 s per pproved proto MP mice and med by using a a, WI). T 2 map rve after noise o both a linear ver 32 echoe sum high-resolutio a single med over all ological or . normal tissu A, AA05965, SMRM, Toron on 2002; 155 by, et al. J Ma e SNR Gain in hang Jang 6 , Milton Ralph Hurd 1 , and P ernational, Menlo P Stanford, CA, Unit Stanford Universit ance imes (T 2 ) of 13 ellular carcino hyperpolariz e voxel per inj ap T 2 with goo C metabolites -spatial excita s with non-CP one 13 C meta e same slice. ss was 15 mm t insert [5], 2 metabolite. In ocols. 3 mL of 3 mL of 125 a custom-bui ps were obtai e corrections r sum of 32 ec es n ues. EB009070, A nto, Canada, 2 5:278. 4) P. Le agn Reson 19 Figure [1- 13 C] with is Fi an pr m in is n Hyperpolari n Merchant 6 , Priti B Patrick Le Roux 7 Park, CA, United ted States, 5 Dept. o ty, Stanford, CA, U 3 C labeled me oma tumors [2 zed 13 C MR. T ection and la od spatial res s. The same s ation RF puls PMG [3,4] pha abolite at a tim The spectral m when using mm was achi n vivo data we f 80 mM hype mM into gliom lt 1 H/ 13 C quad ined by fitting were made [7 choes and to AA018681, an 2008; p.1747 e Roux, et al. 990; 86:645. e 2: Good signa ]lactate on a ra otropic resolut igure 1: Color nd [1- 13 C]pyruv roton 3DSPGR mouse. Slice thi-plane resolutiillustrated on t ized 13 C Imag Balchandani 3 , Jam States, 3 Dept. of R of Electrical Engin United States, 7 Glo etabolites in a 2], suggesting The technique rge voxel size solution. Here sequence was e, followed by ase schemes me, which wa selectivity wa clinical gradie ieved. The ec ere acquired erpolarized [1 ma rats. Scan drature coil [6 the echo-tra 7]. SNR gain the sum of 3 nd DOD-PCRP . 2) Y-F. Yen . ESMRMB 20 7) R.M. Henk al of 13 C-bicarb at glioma mode ion of 2.75 mm maps of [1- 13 C vate T 2 (ms) ov R image of a TR ckness was 2 on 1.5 mm. Qu the left. ing mes Tropp 1 , Dirk Radiology, Stanford neering, Stanford obal ASL, GE a transgenic g that T 2 of e to measure e (1.6 cc) [2]. e we report a s also used to y a train of and EPI as then as ±80 Hz ents (40mT/m cho spacing on normal rat - 13 C]pyruvate ns started 24 6] on a 3T in magnitude was 2 echoes PC094387. , et al., NMR 009; p.114. 5 kelman. Med. bonate and el acquired m. C]lactate verlaid on RAMP mm and uality of fit d o m t e ) 4295 Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)
