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NovaMin
A “high-tech” active ingredient used in the
most innovative professional dental products. Material Description
NovaMin is a breakthrough remineralization technology.
A tasteless white powder form.
NovaMin amplifies the natural
protective and repair mechanisms
for teeth and gums.
Extensively proven in clinical and
scientific studies at leading dental
schools around the world.
Technical Breakdown
Comprised of calcium, sodium, phosphorous and silica, all natural elements found in the body
Chemical name is Calcium Sodium Phosphosilicate
NovaMin is recognized as the only man made ingredient that directly leads to the formation of new tooth mineral (HCA)
What is NovaMin®?
What Does NovaMin® Do?
Reduces SensitivityOccludes dentin tubules: forms a protective biomimetic HCA layer.
Improves Gingival Health Antimicrobial properties & Anti-inflammatory properties reduce gingivitis.
Repairs Surface LesionsForms biomimetic HCA on tooth dentin and enamel surface lesions
The NovaMin® Solution
Hard Tissue Benefits
The NovaMin® Solution
Soft Tissue Benefits
NovaMin is also called “calcium sodium phosphosilicate”.
It is made from elements naturally found in healthy
teeth and bones: Calcium ( ), Phosphorus
( ), Sodium ( ) and Silicon ( )
NovaMin: How it Starts
pH
8.0-8.5
NovaMin reacts with saliva. Na+ ions
release, elevating pH into the range essential for
HCA formation.
Step 1: pH Elevation
+H2O
Ca2+ and P5+ ions are released, saturating
saliva with the ions needed
for remineralizati
on.
Ca2+ P5+
Step 2: Mineral Release
Na+ and Ca2+ ions overwhelm bacterial
cells’ ability to regulate their water content, leading to lysis (cell death) of harmful bacteria in
the mouth.F. Nucleatum
S. Mutans
-99.99%
-99.999%
S. Sanguis
-99.99999%
A.Naeslundii
-99.999%
Step 3: Bacterial Kill
Demineralized lesions attract
Ca2+ and P5+ ions, where they build new HCA crystal to remineralize the defect from the bottom up.
Step 4: Crystal Building
Enamel Crystal Prism
Tooth
Min
era
l Str
uct
ure
- H
ydro
xy-c
arb
onate
Apati
te (
“HC
A”)
Enamel Crystal Prism
Tooth
Min
era
l Str
uct
ure
- H
ydro
xy-c
arb
onate
Apati
te (
“HC
A”)
NovaMin particles adhere to tooth
surfaces for up to 7 days, continuing to release Na+, Ca2+,
and P5+ ions to maintain elevated
pH at the tooth surface and foster remineralization
over time.
Step 5: Time Release
Bef
ore
Tre
atm
ent
Surface Lesion In-vitro
Surface Abrasion In-Situ
Exposed Dentin In-vitro
Remineralization of Dentin & EnamelIn-vitro Study – In-Situ Models
Aft
er T
reat
men
t
NovaMin Product Focuses
• Sensitivity:Faster & better results
Addresses symptom, not cause.
• Gingivitis: Faster results
Less controversial ingredient
• Root Caries/Remineralization:Adult caries predominantly related to hyposalivation.
NovaMin directly addresses this etiology.
NovaMin & SensitivityNovaMin Therapy Paste Results
Clinical Results Vs. Placebo
Averaged Across Methods
01
23
45
67
8
Baseline 1 week 2 weeks 3 weeks 4 weeks
VA
S S
core
NovaMin
Control
p<0.001
NovaMin & SensitivityNovaMin Therapy Paste ResultsClinical Results Vs. Other Actives
NovaMin Vs. Potassium Nitrate
0.0
2.0
4.0
6.0
8.0
0 2 4 12
Weeks
VA
S W
ater Potassium Nitrate
Stannous Fluoride
NovaMin
p<0.05
Product Tested Code
7.5% NM/1100 ppm MFP 1
7.5% NM 2
Company CR 5000 ppm NaF 3
Company CG 1.1 ppm MFP 4
0% NM/O ppm F 5
NovaMin vs. Fluoride Remineralization of Dentin
NTI-UCSF In-vitro Study – Dentin Remin/Demin Model
0
200
400
600
800
1000
1200
1400
1 2 3 4 5
Product Code Tested
Del
ta Z
Log Reduction in Microbial CFU's - 2 Minute Exposure to 1:3 Dilution
-9
-8
-7
-6
-5
-4
-3
-2
-1
0S mutans S sanguis F nucleatum A naeslundii
Bacterial Species
Lo
g R
ed
uc
tio
n in
Via
bili
ty
NovaMin Non Aqueous Toothpaste
NovaMin Powder
Colgate Red Box Toothpaste
NovaMin and GingivitisAnti-Microbial Properties
Summary of Gingival Index Findings
0
0.2
0.4
0.6
0.8
1
1.2
1.4
baseline 6 week
Time Period
GB
I NovaMin
Placebo-59%
p<0.01
NovaMin and GingivitisPilot Clinical Study – Gingival Bleeding Index
Summary of Plaque Index Findings
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
1.8
baseline 6 week
Time Period
PL
I NovaMin
Placebo
p<0.025
NovaMin and GingivitisPilot Clinical Study – Plaque Index
NovaMin Dentifrice + F Treated Sample
Fluoride Dentifrice Treated Sample
Demineralized Untreated Sample
Sound Enamel
Surface Lesion ~ 100µm
NovaMin/Fluoride Enamel
Remineralization In-vitro Study – Remin/Demin Model
Sound Enamel Sound Enamel
Lesion Area
0
10
20
30
40
Demin F paste F + NovaMin
Treatment Group
Lesi
on A
rea
(sq.
m
icro
ns x
1000
)
-30% -45%
p<0.001
NovaMin/Fluoride Enamel Remineralization
In-vitro Study – Remin/Demin Model