http://www.nesacs.org
November 2018 Vol. XCVII, No.3
MonthlyMeeting2018 Norris Award to GerardParkin at Simmons University
Raj RajurReceives2018 HenryA. Hill AwardSeptemberMeetingReportBy Mindy Levine
Photos fromthe GDCh-NSYCCExchangeBy Brian D’Amico
2 The Nucleus November 2018
In 1961,Arthur Obermayer started Mol-eculon Reseach, a contract researchcompany. From 1961 to 1965, heworked with Henry Hill before Henrymoved his company, Riverside Re-search, to Haverhill. Arthur was an avidpromoter of small businesses.
He was very active in NESACSstarting in the late 1950’s. He was a NE-SACS councilor, a trustee, and Chair in1982. In 1996 through Obermayer’sleadership, NESACS was among the firstlocal sections to set up its own website.
I met Dr. Arthur Obermayer for thefirst time in Oct. 2012 when I (alongwith Jennifer Maclachlan and MukundChorgade) organized a Small ChemicalBusiness Symposium at Nova Biomed-ical Corp. This symposium was sched-uled to run from 12 to 5 PM.
This was the NESACS monthlymeeting, which began at 4:30 PM andthe evening meeting, which involved therecognition of 50- and 60-year membersas well as the presentation of the HenryHill Award. Arthur was to receive recog-nition as a 60-year member of the ACS.He wanted to talk at the meeting but wastold that there was no time in theevening program.
I was asked if I could find a placein our symposium for Arthur to speak.Madeleine Jacobs, ACS Executive Di-rector and CEO, graciously agreed togive up her slot to Arthur to talk aboutthe formation of the Small Business In-novative Research (SBIR) Program. Itwas a great addition to our program.Arthur’s speech is printed in the Dec.2012 edition of the Nucleus (http://ne-sacs.org/ pub_nucleus/2012/Dec2012.pdf ).
When I heard his speech, I wasamazed that he had been involved instarting the SBIR program in 1982. Iwas also very surprised that he had beeninvolved in the Bayh-Dole Patent Act afew years later that gave the patent
rights to the SBIR awardees instead ofthe government. This was an incredibleresult. Instead of the Intelectural Prop-erty rights residing in a governmentwarehouse, the private company wouldhave the right to patent and commercial-ize their successful project.
After the symposium, I asked theaudience if anyone was aware ofArthur’s accomplishments with regardto the SBIR. There were representativesfrom banks, venture capital, ACS SCHB,and small businesses at the meeting. Noone in in the audience knew about this.I was aware of a number of companiesthat had successful SBIR’s and I calledand asked them whether anyone knewabout Arthur Obermayer and the SBIR.Again no one was aware of this! We didget Arthur’s remarks published in theDec. 2012 issue of the Nucleus. Ober-mayer received the Henry Hill Award inOct. 2013. http://nesacs.org/pub_nucleus/2013/Oct13.pdf
In July 2015 Arthur and JudithObermayer were inducted into the SBAHall of Fame at a White House Cere-mony (http://www.mvtimes.com/2015/06/24/white-house-honors-chilmark-couple/)
Sadly, in 2016, Arthur passed away.We organized a symposium in honor ofDr. Obermayer and the SBIR Program
at the ACS National Meeting in Bostonin 2018. It was part of the Small Chem-ical Business Div. Program http://ana-lyzersource.blogspot.com/2018/#!.which was held on Aug. 20, 2018.
We had seven speakers and werefortunate to have Dr. Tom Connelly, Ex-ecutive Director and CEO of the ACS,open the program. These presentationshad a considerable amount of informa-tion on the early history to present dayof the SBIR/STTR programs.
During my research, I was amazedto find that the SBIR/STTR program,which had been started in 1982 with a$25,000 NSF award to Obermayer’sMoleculon was funded at 1.7% of theFederal R&D budget in 2018 or $2.3billion dollars. From 1982 to 2018, theFederal Government invested $50 bill-lion dollars in 25,000 awards to smallbusinesses. What a boon to innovationand small business!! We need to domore to publicize Obermayer’s contri-bution to the SBIR program and hope-fully this article is a good start.
I am pleased that Dr. Obermayergave his talk at our symposium becausehe normally did not talk about the in-credible impact of the SBIR/STTR forsmall businesses. He was clearly a cham-pion for small business. We at NESACSare very proud of the Obermayer’s con-tributions to small businesses whichtoday provide 40% of the jobs for scien-tists and engineers. u
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Dr. Arthur Obermayer and the Beginningof the Billion Dollar Small BusinessInnovative Research ProgramBy Jack Driscoll, Chair, Public Relations & Professional Development, NESACS
(l-r): Madeleine Jacobs (ACS), Arthur Ober-mayer (presenter at the symposium and 60-yearmember), Mukund Chorghade and Jack Driscoll(co-organizers of the symposium)
Photo credit: M. Hoffman
The Nucleus November 2018 3
The Nucleus is published monthly, except June and August, by the Northeastern Section of the AmericanChemical Society, Inc. Forms close for advertising on the 1st of the month of the preceding issue. Textmust be received by the editor six weeks before the date of issue.Editor: Michael P. Filosa, Ph.D., 18 Tamarack Road, Medfield, MA 02052 Email:
[email protected]; Tel: 508-843-9070Associate Editors: Myron S. Simon, 60 Seminary Ave. apt 272, Auburndale, MA 02466
Morton Z. Hoffman, 23 Williams Rd., Norton, MA 02766Board of Publications: Ajay Purohit (Chair), Mary Mahaney, Ken Drew, Katherine LeeBusiness Manager: Vacant: contact Michael Filosa at [email protected] Manager: Vacant: contact Michael Filosa at [email protected] Coordinator: Vacant: contact Michael Filosa at [email protected]: Brian D’AmicoProofreaders: Donald O. Rickter, Morton Z. HoffmanWebmaster: Roy Hagen, Email: [email protected] 2018, Northeastern Section of the American Chemical Society, Inc.
The Northeastern Section of the American-Chemical Society, Inc.Office: Anna Singer, 12 Corcoran Road,Burlington, MA 01803(Voice or FAX) (781) 272-1966.e-mail: [email protected] Homepage:http://www.NESACS.orgOfficers 2018ChairMindy Levine35 Cottage StSharon, MA 02067-2130(516) [email protected] ScholteSanofiWaltham, MA(617) [email protected] Past ChairLeland L. Johnson, Jr.EuretosCambridge, MA(617) [email protected] SingerMilliporeSigma400 Summit Drive, Burlington, MA 01803(781-229-7037), [email protected] Saha67 Bow StArlington, MA 02474-2744(978) [email protected] GordonArchivistKen MattesTrusteesPeter C. Meltzer, Dorothy Phillips, Ruth TannerDirectors-at-LargeDavid Harris, June Lum, Michael P. Filosa, John Neumeyer, James U. Piper, Ralph ScannellCouncilors/Alternate CouncilorsTerm Ends 12/31/2018Katherine Lee Chris MoretonCatherine E. Costello Ajay PurohitRuth Tanner June LumKenneth Mattes Malika Jeffries-EL Jackie O’Neil Joshua SacherTerm Ends 12/31/2019Thomas R. Gilbert Ashis SahaMary Jane Shultz Mary A. MahaneyMichael Singer Jerry P. JasinskiLisa Marcaurelle Raj (SB) Rajur Leland L. Johnson, Jr. Matthew M. JacobsenTerm Ends 12/31/2020Michael P. Filosa Morton Z. HoffmanCarol Mulrooney Sonja Strah-PleynetPatricia A. Mabrouk Andrew ScholtetAnna W. Sromek Patrick M. GordonSofia A. Santos All Chairs of standingCommittees, the editor of THE NUCLEUS, and the Trustees of SectionFunds are members of theBoard of Directors. AnyCoun cilor of the American Chemical Societyresiding within the section area is an ex officiomember of the Board of Directors.
ContentsDr. Arthur Obermayer and the Beginning of the Billion Dollar SmallBusiness Innovative Research Program _____________________2By Jack Driscoll, Chair, Public Relations & Professional Development, NESACS
Recipients of the James Flack Norris Award 1951–2018 _______4Monthly Meeting _______________________________________5Presentation of the 2018 James Flack Norris Award for Outstanding Achieve-ment in the Teaching of Chemistry
Raj Rajur Receives the 2018 Henry A. Hill Award _____________6American Chemical Society 256th National Meeting Boston, Massachusetts August 19-23, 2018 _______________________7September 2018 Monthly Meeting________________________10By Mindy Levine, 2018 Chair, Northeastern Section of the American ChemicalSociety
Photos from the 2018 GDCh-NSYCC Exchange - Boston_______12Photos by Brian D'Amico
Medicinal Chemistry Group Hosts Symposium on The Future ofAnti-Infectives ________________________________________14by Mindy Levine
Cover: Professor Gerard Parkin of Columbia University is the 2018 recipientof the James Flack Norris Award for Outstanding Achievement in the Teaching ofChemistry. (Photo courtesy of Professor Parkin).
Editorial Deadlines: January 2019 Issue: November 22, 2018 February 2019 Issue: December 22, 2018
4 The Nucleus November 2018
NESACS Sponsors 2017Platinum $5000+Boston Foundation Esselen AwardSK Life ScienceAmgen, IncJohnson MattheyVertex PharmaceuticalsDavos PharmaBiogenPCI SynthesisNavin Fluorine International Ltd
Gold $3000 up to $5000Merck Research CorpSignal PharmaceuticalsJ-Star ResearchIPG Women ChemistsAbbvie
Silver $1500 up to $3000Mettler ToledoSanofi US ServicesWarp Drive BioPfizerLAVIANAStrem Chemicals
Bronze $500 up to $1500Chemical Computing GroupXtuit PharmaceuticalsCydan Development IncAchillion PharmaceuticalsAlkermesFLAMMASafety Partners IncPiramal Pharma Solutions’Selvita, Inc.OrganixCreaGen Life ScienceEntasis TherapeuticsMorphic TherapeuticInterchim, IncXtal BiostructuresQuartet MedicineAnton Parr USABiotageBioduroNovalix PharmaThermo FisherCresset GroupCustom NMR Services
1951 George Shannon Forbes1953 John Xan1955 Harry Nicholls Holmes1956 Norris Watson Rakestraw1957 Emma Perry Carr & Mary Lura
Sherrill1957 Farrington Daniels1959 Herman Irving Schlesinger1959 Louis Frederick Fieser1960 Louis Plack Hammett1961 Joel Henry Hildebrand1962 Ralph Lloyd Shriner1963 Avery Allen Ashdown1964 James Arthur Campbell &
Lawrence Edward Strong1965 Walter John Moore1966 John Arrend Timm & Edgar
Bright Wilson1967 Edward Lauth Haenisch1968 Samuel Edward Kamerling &
William Campbell Root1969 Joseph Edward Mayer1970 Hubert Newcombe Alyea1971 Charles Lester Bickel1972 Saul Gerald Cohen1973 Eugene George Rochow1974 Grant Hopkins Harnest1975 Leonard Kollender Nash1976 Malcolm Mackenzie Renfrew1977 Anna Jane Harrison1978 Paul Doughty Bartlett & Henry
C. McBay1979 Harry Hall Sisler1980 Robert C. Brasted1981 Fred Basolo1982 William Thomas Lippincott1983 Bassam Z. Shakhashiri1984 Henry A. Bent
1985 Derek A. Davenport1986 Glenn A. Crosby1987 Joseph B. Lambert1988 Dana W. Mayo & Ronald M.
Pike1989 Jerry R. Mohrig1990 Joseph A. Schwarcz1991 John W. Moore1992 Jerry A. Bell1993 Arthur C. Breyer1994 Samuel P. Massie1995 Michael P. Doyle1996 Mary Virginia Orna1997 A. Truman Schwartz1998 Angelica M. Stacy1999 Joseph J. Lagowski2000 Billy Joe Evans2001 Dennis G. Peters2002 Zafra Lerman2003 David N. Harpp2004 Richard N. Zare2005 Morton Z. Hoffman2006 Brian P. Coppola2007 Diane M. Bunce2008 David K. Gosser, Jr.; Jack A.
Kampmeier, Pratihba Varma-Nelson
2009 William F. Polik2010 George M. Bodner2011 Peter Mahaffy2012 Vicente Talanquer2013 Melanie M. Cooper2014 Thomas Greenbowe2015 Frank J. Creegan, Richard S.
Moog, James Spencer2016 Thomas Holme2017 Marcy H. Townes2018 Gerard Parkin u
Recipients of the JamesFlack Norris Award1951–2018
The Nucleus November 2018 5
Monthly MeetingThe 982nd Meeting of the Northeastern Section of theAmerican Chemical SocietyPresentation of the 2018 James Flack Norris Award forOutstanding Achievement in the Teaching of Chemistry Thursday, November 15, 2018Simmons University300 The Fenway, Boston, MA 02115The Linda K. Paresky Conference Center, 3rd Floor of the Main College Build-ingAgenda:4:30 pm NESACS Board Meeting (Room C118, Linda K. Paresky Conference
Center)5:30 pm Social Hour (3rd Floor, Paresky Center)6:30 pm Dinner (3rd Floor, Paresky Center)7:30 pm Presentation of the ACS Award for Volunteer of the Year7:40 pm Presentation of the 2018 James Flack Norris Award for Excellence
in Teaching to Gerard Parkin, Columbia University.Title: Beyond Lewis Theory in the Teaching of Inorganic Chemistry.
Please join us for our November Monthly meeting to honor the 2018 recipientof the James Flack Norris Award. The Award, the first national award for out-standing achievement in the teaching of chemistry, was established in 1950 bythe Northeastern Section of the American Chemical Society to honor the memoryof James Flack Norris, Professor of Chemistry at the Massachusetts Institute ofTechnology, and a teacher of great repute. It is awarded for Outstanding Achieve-ment in the Teaching of Chemistry and pays tribute to outstanding contributionsto the field of chemical education. We will also be honoring Jennifer Maclachanwith the Northeastern Section of the ACS 2018 Volunteer of the Year Award. Thisaward recognizes one individual annually for demonstrating extraordinary out-reach volunteer service within the section.YOU MUST REGISTER IN ADVANCE TO ATTEND THE MEETING:THERE IS NO REGISTRATION FEETO ATTEND THE MEETING; DINNER RESERVATIONS ARE REQUIRED.PUBLIC IS INVITED• For those who would like to join us for dinner, register by noon, Thursday, No-vember 8th, at https://norris-award-2018.eventbrite.com
• Cost: Members, $30; Non-members, $35; Retirees, $20; Students, $10. Dinnerreservations not cancelled 24 hours in advance will NOT be refunded (pleaseselect Meat, Fish or Vegetarian when registering for dinner). Please also indi-cate whether Parking will be required.
• If you wish to join us for this meeting and not eat dinner, please register bynoon, Thursday, November 8th at https://norris-award-2018.eventbrite.comSelect “Seminar only”.
Please note that Parking will not be reimbursed, but is accessible on Avenue LouisPasteur. However, Parking may be limited at this address and other local areaparking garages may need to be used in the Longwood Area. u
Abstract:Beyond Lewis Theory in the Teaching of InorganicChemistryTogether with simple electron countingprocedures (e.g. the octet and 18-elec-tron rules), the concept of the 2-center2-electron (2c–2e) bond, and its repre-sentation as a solid black line betweentwo atoms in so-called “Lewis struc-tures”, have been of immense impor-tance in the development of chemistry.However, despite the significance of theconcept of the 2c–2e bond, its limita-tions as a model are well-known, as il-lustrated by diborane, which features a3-center 2-electron (3c–2e). Althoughthe bonding within such molecules maybe analyzed by application of either mo-lecular orbital theory or more sophisti-cated theoretical methods, they lack theconvenience of simple electron countingprocedures in evaluating the chemical
Biography:Gerard Parkin is a Professor of Chem-istry at Columbia University, where hewas Chair during 1999 – 2002. He hasalso served as Chair of the New YorkSection of the American Chemical So-ciety, Chair of the Inorganic Chemistryand Catalytic Science Section of theNew York Academy of Sciences, Chairof the Organometallic Subdivision ofthe American Chemical Society Divi-sion of Inorganic Chemistry, and Chairof the Gordon Research Conference inOrganometallic Chemistry. He is anelected Fellow of both the AmericanChemical Society and the Royal Societyof Chemistry and is the recipient of a va-riety of international awards, includingthe ACS Award in Pure Chemistry, theACS Award in Organometallic Chem-istry, the RSC Corday Morgan Medal,the RSC Award in OrganometallicChemistry, the RSC Ludwig MondAward, and the RSC Chem Soc RevLecture Award. He is also the recipientof the United States Presidential Awardfor Excellence in Science, Mathematics
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6 The Nucleus November 2018
Raj Rajur received the 2018 Henry A.Hill Award for Outstanding Service tothe Northeastern Section of the Ameri-can Chemical Society (NESACS) at theOctober Meeting. The Hill Award wascreated in 1980 to honor the contribu-tions of Henry A. Hill to NESACS andthe American Chemical Society. HenryA. Hill was the first recipient (posthu-mously) of the award.
Dr. Raj Rajur has been an activeand enthusiastic member of NESACSand a member of the Board of Directorssince 2002. He has been serving as theProgram Chair for the Medicinal Chem-istry section of NESACS since 2002.During his tenure he has made signifi-cant changes to format of the sympo-sium establishing the signature event“Advances in Chemical Sciences Sym-posium Series”, that continues to attractmore than 400 attendees annually. Hehas also regularly represented NESACSat the National ACS meetings and par-ticipated in its governance meetings. Dr.Rajur remains a keen participant in theACS Department of Career Services,mentoring and coaching ACS membersat the national meetings. His vision forMed Chem group remains bringing intop notch science to the symposia and tohelp drive the establishment of a Medic-inal Chemistry prize which would en-able the recognition of an importantlocal medicinal chemist annually at theMay symposium.
Dr. Rajur holds a PhD degree insynthetic organic chemistry and has en-joyed a distinguished career in the aca-demic community and the pharmaceuti-cal industry with a broad range ofexpertise in medicinal chemistry anddrug discovery fields specifically tar-geted towards cancer, diabetes and anti-infective therapeutics. He has authoredmore than 30 papers in peer-reviewedjournals and holds several US patents.Dr. Rajur’s academic career includes ap-pointments at the Southwestern MedicalCenter in Dallas, Boston College,Northeastern University, MassachusettsGeneral Hospital and Harvard MedicalSchool. In the industrial sector, he hasheld scientific and managerial positionsat ArQule and Millipore Corporations.At ArQule, Dr. Rajur supervised collab-orations with Bayer, Pfizer and Amer-sham Pharmacia Biosciences. Dr. Rajuralso significantly contributed to Ar-Qule’s internal drug discovery pro-grams, specifically the ion channel, ki-nase and GPCR programs. Productsco-developed by Dr. Rajur have beenused in drug discovery efforts at VetOn-coRx and Clonetech Laboratories.
Presently, Dr. Rajur heads upCreaGen Inc as CEO, which he launchedin 2003 in order to provide early stagedrug discovery services to biotech, phar-maceutical companies and academic in-stitutes. Since its inception he grewCreaGen from a one-person company toits current 20 people organization. Hehas established more than 50 strategicalliances with pharmaceutical, biotech-nology companies and Federal researchlaboratories.
With over 25 years of experience inbiotechnology management and entre-preneurial ventures involving Drug dis-covery he helped launch CreaGen LifeScience Incubator in 2013, a division ofCreaGen that provides infrastructureand instrumentation to early stage com-panies to conduct their proof of concept.In 2017, the life science incubator wasrebranded as C2I Accelerator to provide
mentoring and seed funding to start-upcompanies. At the C2I accelerator, he isresponsible for venture capitalizationand business development. Dr. Rajur hasalso co-founded a biometric technologycompany “Face pay” which is currentlydeveloping a POC for the technology.Dr. Rajur serves as the reviewer for theACS Journal of Medicinal Chemistry andJournal of Pharmaceutical Sciences, heis on the Board of Directors for Vet On-coRX, Augusta Pharmaceuticals, TMETherapeutics and co-chair for the Mas-sachusetts Biotechnology CROCMOforum. u
Raj Rajur Receives the 2018 Henry A.Hill Award
Q. Exactly, how many awards andscholarships does NESACS sponsor? A) One b) Two c) Many
www.nesacs.org/awards
The Nucleus November 2018 7
Councilor Talking Points: Summary of Governance Issues and ActionsThe following summary is provided to help Councilors reportto their Local Sections and Divisions on key actions of theACS Council meeting held August 22, 2018, and the Board ofDirectors meetings held August 17-19, 2018, at the 2018 ACSfall national meeting in Boston, Massachusetts. Full reportsare posted on the ACS Website as they become available.Actions of the Council Election Results: Elected Committees of Council • By electronic ballot, the Council elected Ella L. Davis,Lissa A. Dulany, Lisa Houston, and Martin D. Rudd forthree-year terms (2019-2021), and Will E. Lynch for a one-year term (2019) on the Council Policy Committee (CPC).
Lawrence J. Berliner 103Michelle V. Buchanan 185Alan B. Cooper 191*Ella L. Davis 196*Lissa A. Dulany 201Lydia E. M. Hines 194*Lisa Houston 231*Will E. Lynch 195*Martin D. Rudd 220Barbara P. Sitzman 163• By electronic ballot, the Council elected Allison Aldridge,Christopher J. Bannochie, Mary K. Engelman, SilviaRonco, and Frankie K. Wood-Black for three-year terms(2019-2021) on the Committee on Nominations and Elec-tions (N&E). *Allison Aldridge 216*Christopher J. Bannochie 228*Mary K. Engelman 222Kenneth P. Fivizzani 162Anne M. Gaffney 187David S. Gottfried 136James M. Landis 189R. Daniel Libby 135*Silvia Ronco 206*Frankie K. Wood-Black 220• By electronic ballot, the Council elected Rodney M. Ben-nett, Jacqueline A. Erickson, Judith M. Iriarte-Gross,Donivan R. Porterfield, and Carolyn Ribes for three-yearterms (2019-2021) on the Committee on Committees(ConC).
*Rodney M. Bennett 189
Richard S. Danchik 92*Jacqueline A. Erickson 217Rick Ewing 176*Judith M. Iriarte-Gross 214Russell W. Johnson 114*Donivan R. Porterfield 206*Carolyn Ribes 328Frank Romano 171Peter Zarras 119Other Council ActionsAmendments to the ACS Bylaws
A recommendation by the Committee on MembershipAffairs that Council approve the Petition on InternationalChemical Sciences Chapters achieved the two-thirds majorityrequired to amend Bylaw XI, Section 3 accordingly (additionsunderlined; deletions struck through):
Affiliations of SOCIETY Local Sections or Divisionsshall become effective upon authorization by their governingbody, approval by their respective Council committees gov-erning Local Sections and Divisions, and by confirmation bythe Council Committee on Constitution and Bylaws acting forthe Council, that the provisions of Section 1 of this Bylaw aremet.
The changes will become effective upon confirmation bythe Board of Directors.
A recommendation by the Committee on MembershipAffairs that Council approve the Petition on InternationalChemical Sciences Chapters achieved the two-thirds majorityrequired to amend Bylaw IX, Section 4 accordingly (additionsunderlined; deletions struck through):
An International Chemical Sciences Chapter shall receiveno allotment of funds from the SOCIETY and shall not be en-titled to elected representation on the Council. A Chapter mayassess its members local Chapter dues to be expended for itsown purposes in harmony with the objects of the SOCIETY.
The changes will become effective upon confirmation bythe Board of Directors.Continuation of CommitteeOn the recommendation of the Committee on Committees,and the concurrence of the Council Policy Committee, Coun-cil approved the continuation of the Committee on ChemicalSafety, subject to concurrence by the Board of Directors.ResolutionsThe Council passed resolutions• in memory of deceased Councilors;
American Chemical Society256th ACS National Meeting
Boston, MassachusettsAugust 19-23, 2018
continued on page 8
8 The Nucleus November 2018
• congratulating ACS Treasurer and Chief Financial OfficerBrian A. Bernstein on the occasion of his retirement afternearly 40 years of service to the Society (34 as ACS Treas-urer); • in gratitude for the officers and members of the Northeast-ern Section, host Section for the 256th National Meeting,the divisional program chairs and symposium organizers,and ACS staff; and• acknowledging Peter K. Dorhout’s service as ACS Presi-dent and presiding officer of the Council.Special DiscussionPresident Dorhout introduced and led a special discussion onwhat role(s) ACS should play in preventing sexual harassmentin the sciences. He highlighted several recent articles, work-shops and studies that have called attention to the issue, no-tably a symposium, “Science of Sexual Harassment”organized during the ACS National Meeting in New Orleans(Spring 2018) by the Women Chemists Committee and Chem-ical & Engineering News; and a National Academies of Sci-ences, Engineering, and Medicine consensus study report:“Sexual Harassment of Women: Climate, Culture, and Con-sequences in Academic Sciences, Engineering, and Medicine”(2018). He directed Council’s attention to existing ACS codesand initiatives to address sexual harassment, and offered itemsfor discussion and possible action:• More signs/information at National Meetings regarding ourpolicies and supporting information• Trained volunteers at national meetings for reporting sexualharassment• A webinar on preventing sexual harassment for local sec-tions or divisions
To further inform the discussion and Councilor input, a briefsurvey was conducted using the audience electronic responsesystem. The results of the survey are listed below. The ACSVolunteer/National Meeting Attendee Conduct Policy was inthe Council Agenda, and can be found online at [http://www.acs.org/content/acs/en/about/governance/councilors.html] Asummary of the discussion and additional information will besent to Councilors at a later time.Have you ever witnessed or experienced sexual harassmentat an ACS meeting or ACS event? (413 responses)Yes 23% (94) No 77% (319)Have you ever witnessed or experienced sexual harassmentat an ACS meeting or ACS event, or in your professionalworkplace or learning environment? (182 women / 223 menresponded)Women MenYes 77% (141) 57% (127)No 23% (41) 43% (96)How familiar are you with the ACS Codes and initiatives forprofessional conduct? (417 responses)
Very Familiar 38% (157)Vaguely Familiar 46% (192)Not Familiar 16% (68)Has your local section or division instituted a sexual harass-ment policy of its own? (419 responses)Yes 3% (12)No 73% (309)Don’t Know 23% (98)Highlights from Committee ReportsNominations and Elections The Committee on Nominations and Elections solicits Coun-cilors’ input of qualified individuals for President-Elect and/orDirectors for future consideration. Suggestions can be sent [email protected].
Ballots for the 2018 fall national election will be distrib-uted October 1-3, with a voting deadline four weeks later, onOctober 31. ACS members eligible to vote and with an emailaddress on file will receive an electronic ballot with the optionto request a paper ballot. Those members with no email ad-dress on file will be sent a paper ballot but with the option tovote electronically. The ACS election vendor, Survey & BallotSystems, will send three email reminders during the votingperiod to those who have not voted as of the reminder date.Budget and FinanceThe Society’s 2018 Probable 1 Projection calls for a Net fromOperations of $31.8 million. This is $1.3 million favorable tothe Approved Budget. Total revenues are projected to be$565.1 million, which is $5.7 million or 1.0% favorable to theBudget. Total expenses are projected at $553.3 million, whichis $4.4 million or 0.8% unfavorable to the Budget.
The Committee considered one 2019 program fundingreauthorization request, and on its recommendation, the Boardsubsequently approved funding the ACS Festival Series forinclusion in the 2019 Proposed Budget and the 2020-2021Forecast Budgets.
The Society is expected to end the year in compliancewith each of the five Board-established financial guidelines.Additional information can be found at www.acs.org, at thebottom of the page, click ‘About ACS’, then ‘Financial’. Boston Meeting AttendanceThe theme of the 256th ACS National Meeting was“Nanoscience, Nanotechnology, and Beyond.” As of Tuesdayevening, August 21, attendance was:Attendees 8294Students 3671Exhibitors 1181Expo only 576Guest 513Total 14,235Membership AffairsAs of August 21, ACS had 149,584 members, which is a de-cline of only eight-tenths of one percent from the over 150,000members in 2017. This year-to-date figure represents an in-crease of over 1,200 members when compared to the last two
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National MeetingContinued from page 7
The Nucleus November 2018 9
years. It was noted that five of last seven months have beenrespectively the best months for membership since at least2014. The current membership count positions ACS for astrong close to the year, and there is cautious optimism thattotal membership will rise for the first time since 2011.Petitions to Amend the Constitution and BylawsNew petitions to amend the Constitution or Bylaws must bereceived by the Executive Director & CEO no later than De-cember 12 to be included in the Council agenda for consider-ation at the spring 2019 meeting in Orlando. Contact theCommittee on Constitution and Bylaws with any questions orrequests for information at [email protected] of the Board of DirectorsThe Board’s Executive SessionAt this meeting, the ACS Board of Directors focused on anumber of key strategic issues and took several related ac-tions.The Board’s Committees The Board of Directors received and discussed reports fromits committees on Corporation Associates, Professional andMember Relations, Executive Compensation, the GoverningBoard for Publishing, and the Society Committee on Budgetand Finance. On the basis of those reports and with regard tothe Board’s strategic vision for the Society:• The Board approved, on the recommendation of the Com-mittee on Professional and Member Relations, the Society’snominees for the 2019 Perkin Medal and the 2019 NationalScience Board Public Service Award.• The Board voted to approve the appointments or reappoint-ments of several editors-in-chief for ACS journals as rec-ommended by the Joint Board-Council Committee onPublications and Editor Selection Committees. Informationabout those appointments will appear in C&EN once the in-dividuals concerned have been notified.• In light of the recent financial performance of the techni-cal-meeting component of our national meetings, the Boardvoted to approve an advance member registration fee ofonly $490 for national meetings held in 2019 (i.e., the cur-rent advance member registration fee escalated to accountfor inflation only); to reauthorize a program funding requestfor the Chemistry Festival program; and in accordance withpast practice, to allocate on a pro-rated basis to qualifiedACS Divisions any net revenues accrued to the Societyfrom the 2020 and future International Chemical Con-gresses of the Pacific Basin Societies (Pacifichem).• The Board liaison to the Committee on Corporation Asso-ciates presented a proposed committee Future State Oper-ating Model and considered options for committee memberterms and appointment processes. The Board expressedsupport for the value of industry to ACS and acknowledgedCorporation Associates as being positioned within the Soci-ety to represent the voice of industry to the Board and ACS.
• The Board’s Society Programs global liaison offered an up-date on efforts to strengthen the global presence of Societyprograms to better serve our international members and theglobal chemistry enterprise. Efforts are underway to clarifyand articulate the current state of international activities,products, and services; to clarify the challenges associatedwith globalization of existing domestic activities; and tooffer recommendations for moving forward. Next steps in-clude interviewing key stakeholders, reviewing past efforts,and exploiting existing market research with a view towarddeveloping a strategic plan, activities, and timelines forBoard consideration.• The Board liaison to the Leadership Advisory Board (LAB)provided an update on initial efforts geared towards the de-velopment of a next-generation ACS Leadership Program.A small task force has been charged with investigating thestate of the art in leadership development, assessing the fu-ture needs of the Society as well as those of individualmembers and their employers, and then proposing, by theend of 2019, a strategic vision for and the specifications ofa next-generation ACS leadership program focused on 2030and beyond. Executive Director and CEO ReportThe Board also received an extensive report from the Execu-tive Director and CEO on issues relating to Passion for Chem-istry and Diversity and Inclusion as core values of the Society,on Membership, ACS financial performance, and upcomingevents and activities. He reported there has been initial successwith several initiatives underway to address and reverse thedecline in membership. His direct reports provided updates tothe Board on the activities of Chemical Abstracts Service(CAS), the ACS Publications Division, and the Office of theSecretary and General Counsel. As part of his report, he alsoinvited the Executive Vice President for Human Resources tobrief the Board on the activities, opportunities and challengesof the Human Resources Division. Other Society Business The Board approved the foundation documents of the newlycreated endowment for the Henry H. Storch Award in EnergyChemistry, which originally was established as a nationalaward in 1964.
As is customary, the Board heard reports from membersof the Presidential Succession on their current and plannedactivities for 2018-2019. Several presidential symposia andevents incorporating and supporting this national meeting’stheme of “Nanoscience, Nanotechnology & Beyond” werehighlighted in those reports.The Board’s Regular SessionThe Board held a well-attended regular session on Sunday,August 19, that featured a presentation by Nobel Laureate SirFraser Stoddart who spoke on transformative research and re-viewed his contributions in supramolecular chemistry and mo-lecular recognition. Also, as a Champion of the program, headvocated for ACS Project SEED on the 50th Anniversary ofthe program. Prior to the presentation, members of the presi-
National MeetingContinued from page 8
photos continued on page 14
10 The Nucleus November 2018
On September 20, 2018, the monthly meeting of the North-eastern Section of the American Chemical Society took place.This meeting was held at Salem State University, in Salem,MA, and one of the goals of the meeting was to be able toview the archives of the Section, currently housed in theSalem State University library. Several members of the NE-SACS board took advantage of this opportunity to view im-portant archives, including notes from the first meeting,brochures and pamphlets from previous Section events, andphotos of key contributors to this important section. Manythanks to Susan Edwards of Salem State University who con-tinues to care for these archives, and to Ken Mattes of the NE-
SACS board for coordinating this important effort.After the tour of the archives and the social hour, the
meeting continued with recognizing 50-, 60-, and 70-yearmembers of the Section. We are particularly honored to haverecognized Dr. Merrill Cohen, a World War II veteran and 70-year member of ACS. Finally, the keynote speaker of theevening, Sam Kean, delivered a highly engaging lecture, inwhich he mentioned several of the books he has authored.Many of the books were available for sale after the lecture.
We are thrilled so many members came out for this meet-ing, and look forward to more exciting monthly meetings andevents! u
September 2018 Monthly MeetingBy Mindy Levine, 2018 Chair, Northeastern Section of the American Chemical Society, Photos by Brian D’Amico.
2018 NESACS Chair, Mindy Levine, introduces Sam Kean, Science writerand the meeting’s keynote speaker.
Sam Kean delivering his keynote address about his book of stories aboutthe periodic table: “The Disappearing Spoon”.
60-year member Alice Joan Adler with NESACS Program Chair AndrewScholte and Mindy Levine.
70-year member Merrill Cohen with NESACS Program Chair AndrewScholte and Mindy Levine.
continued on page 11
The Nucleus November 2018 11
September 2018 Monthly MeetingContinued from page 10
60-year member William Eykamp 60-year member John T. Penniston
50-year member Eugene Barry Wilusz 50-year member Glen Ernest Rodgers
50-year member Anthony P. Wright 50-year member Joseph Eugene Lester
12 The Nucleus November 2018
Photos from the 2018 GDCh-NSYCCExchange - BostonPhotos by Brian D'Amico
Participants in the 18th exchange between the NESACS Younger Chemists Committee (NSYCC) and their German counterpart from the GDCh.
The German visitors and their hosts from NESACS enjoyed a full range of activities including a visit to Cape Cod on Thursday. The trip to the Cape in-cluded a visit to Woods Hole Oceanographic Institute, a clambake at Goodwill Park and a beach outing at Surf Drive Beach. Other activities included aWelcome Dinner on Saturday, A Sunday social mixer with the National YCC at the Back Bay Social Club, A Monday night gathering at Harpoon Brew-ery, a Red Sox game on Wednesday, and a Farewell Dinner and Boston Harbor Cruise on the Odyssey. continued on page 13
The Nucleus November 2018 13
At the Monday gathering at the Harpoon Brewery.
Part of the discussion at the Back Bay Social Club with the National YCC.
Jens Breffke in discussion with our guests prior to the welcome dinner.
The group pays close attention to a presentation on Underwater Roboticsat the Woods Hole Oceanographic Institute.
The Farewell Dinner on the Odyssey.
Enjoying the social hour on the Odyssey prior to the farewell dinner.
2018 GDCH-NSYCC ExchangeContinued from page 12
14 The Nucleus November 2018
Looking for seminars in the Boston area?
Check out the NESACS Calendar
www.nesacs.org/seminars
Updated frequently • Late-breaking news • position postingsBack issues of the Nucleus archived • Career-related Links • Awards and Scholarships
WWW.NESACS.org
The NESACS website
and Engineering Mentoring, the UnitedStates Presidential Faculty FellowshipAward, the Columbia University Presi-dential Award for Outstanding Teaching,and the Lenfest Distinguished ColumbiaFaculty Award.◆
BiographyContinued from page 5
reasonableness of a covalent molecule.Fortunately, approaches for analyzingcomplex covalent molecules in a simpleway are available, and their use in theapplication in the Covalent Bond Clas-sification of molecules will be dis-cussed. ◆
AbstractContinued from page 5
On Thursday September 13, 2018, ap-proximately 70 medicinal chemists (andother chemists interested in medicinalchemistry) gathered together at TakedaPharmaceuticals for a half-day sympo-sium on the topic of “The Future ofAnti-infectives.” This symposium wassponsored by Takeda Pharmaceuticalsand was organized by the MedicinalChemistry Group of the NortheasternSection of the American Chemical So-ciety. The medicinal chemistry group,organized by Dr. Raj Rajur of CreagenBio and Dr. Andrew Scholte of Sanofi,hosts half-day symposia twice a year, inSeptember and in December, at a varietyof pharmaceutical companies through-out the greater Boston area.
The full speaker lineup for the Sep-tember event is shown below:Afternoon speakers:• Kim Lewis, Northeastern University,
Title: Reviving Antibiotic Discoveryfrom Natural Products
• Thomas Durand Reville, Entasis,Title: The rational design and discov-ery of ETX2514, a novel broad-spec-trum β-lactamase inhibitor for thetreatment of Gram-negative infections
• Roger Clark, Macrolide, Title: NovelMacrolides for Gram-Negative Infec-tions
After the afternoon speakers, there wasa break for social hour and dinner, fol-
lowed by the plenary evening lecturepresented by Jacques Dumas ofTetraphase. The title of the talk was“TP-6076: taking chemistry to the nextlevel to beat superbug.”
Overall, the attendees had uni-formly positive things to say about thesymposium, with attendees highlightingthe timeliness of the topic, the relevanceto their careers, and the important net-working opportunities provided throughattending these symposia.
Stay tuned for the next medicinalchemistry symposium, coming in De-cember 2018! ◆
MedicinalChemistryGroup HostsSymposiumon TheFuture ofAnti-Infectivesby Mindy Levine
dential succession and the Executive Di-rector & CEO offered brief reports ontheir activities. The officers providedmore extensive reports on their activitiesand future plans as part of their writtenand oral reports to the Council.SUPPLEMENTAL INFORMA-TION FOR COUNCILORSOfficers:Peter K. Dorhout, President, [email protected] A. Charpentier, President-Elect, [email protected] A. Campbell, Immediate Past President, [email protected] Information for Councilorshttp://www.acs.org/content/acs/en/about/governance/councilors.htmlCouncilor Talking Points is produced bythe ACS Office of the Secretary & Gen-eral CounselPermission is hereby granted to distrib-ute in whole or part. Please direct all comments and ques-tions to: [email protected] ◆
National MeetingContinued from page 9
THE COMMITTEE ONCHEMICAL ABSTRACTS(CCAS) WANTS YOUR
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The Nucleus November 2018 15
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Index of AdvertisersEastern Scientific Co. ......16Micron, Inc. .....................15Organix, Inc. ....................15PCI Synthesis...................15Robertson Microlit Labs..15
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Check the NESACS home pagefor late Calendar additions:http://www.NESACS.orgNote also the Chemistry Department webpages for travel directions and updates.These include:http://www.bc.edu/schools/cas/chemistry/seminars.html
http://www.bu.edu/chemistry/seminars/http://www.brandeis.edu/departments/chemistry/events/index.html
http://chemistry.harvard.edu/calendar/upcoming
http://www.northeastern.edu/cos/chemistry/events-2/
http://chemistry.mit.edu/events/allhttp://chem.tufts.edu/seminars.htmlhttp://engineering.tufts.edu/chbe/newsEvents/seminarSeries/index.asp
http://www.chem.umb.eduhttp://www.umassd.edu/cas/chemistry/http://www.uml.edu/Sciences/chemistry/Seminars-and-Colloquia.aspx
http://www.unh.edu/chemistry/eventshttps://www.wpi.edu/academics/departments/chemistry-biochemistry
November 01Novartis Lecture in Organic ChemistryProf. Shankar Balasubramanian (Cambridge) &Dr. Chris Gampe (Novartis)“The Ends Justify the Means: Tweaking mRNAProperties”MIT, 6-120, 4:00 pmNovember 02 Prof. Tom Baker (University of Ottawa)Boston College, Merkert 130, 4:00 pm
November 05Prof. Eric Hudson (UCLA)Harvard, Pfizer Lecture Hall, 4:15 pmProf. Ursula Jakob (Michigan)MIT, 4-270, 4:00pmProf. Katherine Mirica (Dartmouth)Brandeis, Gerstenzang 121, 3:40 pmProf. Yisong Guo (Carnegie Mellon)Boston Univ., Metcalf 113, 4:00 pmNovember 06 Prof. Neil Garg (UCLA)Boston College, Merkert 130, 4:00 pm Prof. Thomas Mallouk (Penn State)“Managing Electrons and Protons in the Bio-Inspired Production of Fuel from Sunlight”Univ. New Hampshire, Parsons N104, 11:10 amProf. Rob Spitale (UCal-Irvine)Tufts, Pearson P-106, 4:30 pm November 07Prof. John Matson (Virginia Tech)Boston College, Merkert 130, 4:00 pm Prof. Smaranda C. Marinescu (USC)MIT, 4-370, 4:15 pmNovember 12Prof. Raymond Schaak (Penn State)Boston Univ., Metcalf 113, 4:00 pmNovember 13 Prof. Robert Knowles, (Princeton)Boston College, Merkert 130, 4:00 pmNovember 14 Prof. Mohammad Seyedsayamdost, (Princeton)Boston College, Merkert 130, 4:00 pmProf. Brandi Cossairt (Washington)Harvard, Pfizer Lecture Hall, 4:15 pmProf. William Epling (Virginia)Sulfur Oxidation over Automotive CatalystsWPI, Goddard 127, 12:00 noon
November 15 Prof. Bingjun Xu (Delaware)Boston College, Merkert 130, 4:00 pm November 19 Prof. Amie K. Boal (Penn State)“Watching Metalloenzymes at Work”MIT, 4-270, 4:00 pmProf. Lasse Jensen (Penn State)Boston Univ., Metcalf 113, 4:00 pmNovember 20Prof. Wayne Jones (UNH)Univ. New Hampshire, Parsons N104, 11:10 amProf. Sachdev Sidhu (Toronto)Tufts, Pearson, P-106, 4:30 pmNovember 27Prof. Jacob Shelley (RPI)Univ. New Hampshire, Parsons N104, 11:10 amProf. Adriaan Bax (NIH)“Opportunities and challenges of pressure-jumpNMR spectroscopy in the study of proteinfolding”MIT, 6-120, 4:00 pmNovember 28Professor Peng Yin, Harvard UniversityBoston College, Merkert 130, 4:00 pm Prof. Serena DeBeer (Max Planck)Harvard, Pfizer, 4:15 pmProf. Kristi Kiick (Delaware)“Biopolymeric Conjugates in the Production ofResponsive Biomaterials”WPI, Goddard 227, 12:00 noon
Notices for The NucleusCalendar of Seminars should besent to:Michael Filosa, email:[email protected]
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