NRI Annual Report 2011-12

NRI 11-12 Annual Report 1

2011-2012 Annual Report

http://www.nri.ucsb.edu




Table of Contents

Mission Statement......................................................3Directors’ Statement.................................................4Organization Chart.....................................................5Other Projects + Activities...................................6Center Research Reports................................7-8Awards Administered........................................9-17Space..........................................................................18-21Publications..........................................................22-29Statistical Summary................................................30Budget Summary.............................................31-32Advisory Committee..............................................33Administrative + Technical Staff...................33Principal Investigators..........................................34Students..........................................................................35Special Thanks...........................................................36


Mission Statement

The mission of the Neuroscience Research Institute is to foster knowledge and understanding of the nervous system by serving as a center for scientific research breakthroughs. The NRI is a group of investigators whose collective goal is to create an intellectual atmosphere conducive to exploration at the frontiers of human knowledge where disciplinary boundaries disappear. Investigators in the NRI recognize that the interests of neuroscience extend broadly from repair and prevention of human disease to the principles that underlie the earliest nervous systems, from the human mind to the single molecular building blocks of the brain.


Directors’ Statement The Neuroscience Research Institute continues to focus its energy on interdisciplinary basic biological research and serving as a clearinghouse for all members of the campus community interested in neuroscience. In addition to serving faculty from seven different academic departments, we recently established a list of thirty additional UCSB “NRI Affiliates” with neuroscience interests in order to highlight their work and to integrate our many intellectual and research efforts. In addition, plans were set in motion to strengthen our working research relationship with physicians at Cottage Hospital as a means to coordinate resources and to better serve the local community.

NRI continues to make great progress toward understanding the development, maintenance, function, degeneration/regeneration and evolution of the nervous system, despite the many fiscal obstacles inherent in the current economic situation. Our work helps define many of the cutting edges throughout the broad discipline of neuroscience, running the gamut from molecular and cellular neuroscience to behavioral and cognitive neuroscience and beyond. Our three Centers (Alzheimer’s Disease Research Center, Center for Stem Cell Biology and Engineering. and Center for the Study of Macular Degeneration) are all active and growing. In addition to our broad-based and superb basic research, NRI investigators are also involved in, or planning, major clinical trials for devastating neurodegenerative conditions such as Alzheimer’s disease and blindness. More details on this work are available on our newly designed NRI webpage and within this Annual Report.

Among the infrastructure highlights for this past year are: (i) the acquisition of a new state-of-the-art Spectral Laser Scanning Microscope funded by the NIH for our communal NRI/MCDB Microscopy Facility and (ii) we are in the process of acquiring for 10 years approximately 11,000 square feet of newly renovated research space dedicated specifically to the Center for Stem Cell Biology and Engineering and (iii) we have just launched our new media-focused NRI website along with Twitter and Facebook accounts to engage colleagues and collaborators online. Additionally, our DNA/RNA library sequencing facility continues to provide the most sophisticated technology available today to all interested UCSB research personnel.

Finally, all that we do in NRI is possible only because of the outstanding people that are the heart of the unit. Our faculty, staff and students are superb and their efforts are facilitated, and indeed made possible, by our exceptional and extremely dedicated administrative and technical staffs. Despite all the trials and tribulations imposed by the ongoing fiscal crisis, NRI personnel continue to excel in our collective efforts to better understand the nervous system.

Stuart C. FeinsteinCo-Director

Kenneth S. Kosik Co-Director



Organization Chart


Other Projects + Activities

ACADEMIC PROJECTS

October 2011 Losing Control Film ScreeningNovember 2011 NRI Symposium Gus Gurley Lecture - Gary Banker, OHSUJanuary 2012 Microscopy WorkshopApril 2012 Alzheimer’s Association Symposium

RESEARCH EXPERIENCES FOR GRADUATE STUDENTS

Clegg Lab Stem Cells, BlindnessJohnson Lab Macular DegenerationJordan/Wilson Lab Microtubule Polymerization Kosik Lab Alzheimer’s Genetics, MicroRNAsMa Lab Membrane Trafficking, AGS3 and Addiction Reese Lab Retinal NeurobiologyRothman Lab Development, TumorigenesisSmith Lab Sea Squirt DevelopmentWeimbs Lab Polycystic Kidney Disease

RESEARCH EXPERIENCES FOR UNDERGRADUATES

Clegg Lab Stem Cells, BlindnessFeinstein Lab Tau in Alzheimer’sFisher Lab Retinal Detachment Grafton Lab Cognitive Control of ActionJordan/Wilson Lab Microtubule PolymerizationKosik Lab Alzheimer’s Genetics, MicroRNAsParsons Lab Acetylcholine NeurotransmitterReese Lab Retinal NeurobiologyWeimbs Lab Polycystic Kidney Disease


ALZHEIMER’S DISEASE RESEARCH CENTER

Investigations in the ADRC focus upon the normal and pathological action of the microtubule associated protein, tau, as well as mechanisms of neuronal plasticity and its impairment in neurodegeneration. In 2011 co-director Stu Feinstein discovered a new direction in Alzheimer’s research when his lab found that tau completely fragmented, rather than phosphorylated, when neuronal cells were exposed to amyloid beta. In early 2012 it was announced that Ken Kosik and researchers with the Banner Alzheimer’s Institute will begin clinical trials for Genentech’s preventive Alzheimer’s therapy in 2013.

CENTER FOR STEM CELL BIOLOGY & ENGINEERING

The mission of the UCSB Center in Stem Cell Biology and Engineering is to foster an interdisciplinary program of stem cell research and teaching to develop new technologies in the emerging field of regenerative medicine. To accomplish this, the center supports collaboration and exchange of ideas among a wide range of disciplines, with research divided into three general areas: Molecular mechanisms of stem cell pluripotency, proliferation and differentiation; Biotechnology and Bioengineering of stem cell growth, differentiation, sorting and delivery; and Regenerative Medicine to translate discoveries to the clinic.

Training

Funded by a grant of $1.3 million in 2005 from the California Institute for Regenerative Medicine (CIRM), a stem cell training program has been developed

to support graduate and postdoctoral fellows engaged in a variety of stem cell projects.

Facilities

The UCSB Laboratory for Stem Cell Biology and Engineering was established free of federal funding to allow research on all stem cell lines. Renovation of this facility, funded by a $2.2 million grant from CIRM, is currently underway.

Center Research Reports

http://www.nri.ucsb.edu/adrc

http://www.ia.ucsb.edu/pa/display.aspx%3Fpkey%3D2504



http://www.stemcell.ucsb.edu/


CENTER FOR THE STUDY OF MACULAR DEGENERATION

The Center for the Study of Macular Degeneration (CSMD) is a dedicated biomedical research unit and part of the Neuroscience Research Institute (NRI) at the University of California, Santa Barbara (UCSB). The mission of the CSMD is to advance basic biomedical research into the cellular, molecular, and genetic factors that contribute to the human ocular diseases that are known as macular degeneration. In pursuing its mission, the CSMD seeks to stimulate interactions between basic and clinical scientists, contribute to the training of students and postdoctoral fellows, and lay the groundwork for the development of new diagnostic and therapeutic approaches to treat macular degeneration.

A study led by CSMD scientists identified genes whose expression levels can identify people with AMD, as well as genes that distinguish clinical AMD subtypes. The findings, which appeared in BioMed Central’s journal Genome Medicine in February 2012, could offer new candidate targets for the development of AMD diagnostics and therapies. The CSMD also appointed a new director, Pete Coffey, former director of the London Project to Cure Blindness.

Center Research Reports

http://www.csmd.ucsb.edu




Awards Administered

UNIVERSITY OF SOUTHERN CALIFORNIA

Dennis Clegg 4/1/11-3/31/13 $739,565Stem Cell Based Treatment Strategy for Age-Related Macular Degeneration (AMD)

We established The California Project to Cure Blindness, a “Disease Team” of investigators from USC, Caltech, City of Hope, University College London, and Regenerative Patch Technologies, LLC, to develop a stem cell therapy for Age-related Macular Degeneration. This work is funded by the California Institute for Regenerative Medicine. The California Project to Cure Blindness is an interdisciplinary research effort involving researchers at UCSB in the Center for the Study of Macular Degeneration and the Center for Stem Cell Biology and Engineering, along with retinal surgeons in the Keck School of Medicine at the University of Southern California, materials chemists at Caltech, and experts in cellular therapy from the City of Hope and University College London. The goal is to differentiate a monolayer of RPE on a synthetic substrate that can be implanted in the macula to replace damaged RPE and therefore preserve photoreceptors.

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE (CIRM)

Dennis Clegg 10/1/09-9/30/15 $844,160UCSB Laboratory for Stem Cell Biology and Engineering

A shared laboratory was established free of federal funding to allow research on all stem cell lines. Donations from biotechnology companies and private individuals allowed acquisition of material and equipment to establish the laboratory. The renovation of this facility, funded by a $2.2 million grant from CIRM, has recently been completed. The renovated shared laboratory provides access to state-of-the-art stem cell culture facilities that will promote the expansion of stem cell research at UCSB and at neighboring institutions in California’s central coast area. Clientele will include researchers in numerous Departments and Institutes at UCSB, and researchers from The Burnham Institute for Medical Research at UCSB, Sansum Diabetes Research Institute, and Santa Barbara Cottage Hospital.

Dennis Clegg 9/1/09-8/31/15 $844,160Training Program in Stem Cell Biology & Engineering

This award from the California Institute for Regenerative Medicine (CIRM) supports a graduate and postdoctoral training program in stem cell research. This grant was first awarded in 2005 and was renewed in 2009 and 2012. CIRM graduate students and postdoctoral trainees conduct research on a wide range of innovative, interdisciplinary projects in the laboratories of 20 faculty mentors in the department of Molecular, Cellular, and Developmental Biology, the College of Engineering,


and the Neuroscience Research Institute. Projects range from studies of stem cells in model systems, pluripotent human stem cells, adult stem cells, and novel biotechnologies with applications in stem cell research. The CIRM grant has allowed the establishment of two new Stem Cell Graduate Courses: Stem Cell Biology, MCDB 246 and Bioethical Issues of Stem Cell Research, MCDB 247. In addition, Scholars present their research at a Stem Cell Round Table each month, and numerous speakers are invited for seminars.

Peter Coffey 11/1/11-10/31/17 $4,880,116Development of Cellular Therapies for Retinal disease LA1-02086

Dr. Coffey was awarded a CIRM Leadership Award to establish a new laboratory within NRI and as part of The Centre for Stem Cells and Engineering. The grant has allowed him to establish a small group of researchers who understand the potential of human embryonic stem cells and their capacity to replace the diseased eye cells of a number of retinal disease, specifically in the short term age-related macular degeneration and future work in diabetic retinopathy.

INTERNATIONAL RETINAL RESEARCH FOUNDATION, INC.

Steven Fisher 10/7/11-11/7/12 $57,100Creating Brainbow Astrocytes, A New Tool for Studying Retinal and Optic Nerve Astrocytes

The goal of this project was to create a transgenic mouse randomly expressing a set of 4 fluorescent protein genes in retinal astrocytes. Cottage Hospital’s research program has on several occasions provided funds that lead to preliminary data used to submit a larger grant to a federal agency. To date, our lab has completed the design and construction of the brainbow plasmid, a critical part of the project. Using the funds provided by the Santa Barbara Cottage Hospital Research Program, we were able to clone 4 fluorescent proteins into a vector containing the human full-length glial fibrillary acidic protein promoter (GFAP). Subsequently this promoter was sequenced to verify that our design and engineered plasmid was correctly synthesized. Additionally, we were able to test this plasmid on cultured U-87 human glioblastoma cells, immortal mouse retinal astrocytes, and 293T kidney cells for cell-type specificity as well as transfection efficacy. We shipped our completed vector to UC Irvine’s transgenic mouse facility in June for final purification and DNA microinjection on July 3rd, 2012. This mouse will allow us to view retinal astrocytes stained with a nearly 90 different fluorescent hues allowing us to study the attributes of individual cells and their reaction to injury.

Awards Administered


Awards Administered

ALCON LABORATORIES

Steven Fisher 1/3/12-1/2/14 $399,784Development of an in vivo model of proliferative vitreoretinopath (PVR)

The goal of this project funded by the surgical instrument division of Alcon (Irvine) is to establishing a reliable model for generating vitreal cellular membranes (or glial scars) in the rabbit retina. So-called proliferative retinal diseases lead to scar formation in the retina which can cause major threats to sight, including the recovery of sight after intraocular surgery. These include such diseases as proliferative vitreoretinopathy after retinal reattachment, idiopathic epiretinal membranes, diabetic retinopathy, subretinal fibrosis, age-related macular degeneration, retinitis pigmentosa among others. Although several experimental reagents have been tested in animals to determine their ability to inhibit such scar formation, none have been successful in humans to date, and the treatment remains solely in the domain of retinal surgery. Developing new surgical techniques and instruments has presented a challenge for this delicate surgery and is a major goal of Alcon’s instrument division. A major issue is that no good animal models for this category of diseases exist, models on which new surgical techniques can be tested. It is the goal of this project, with funding from Alcon Surgical Division to develop such an animal model. With the recent installation of critical instrumentation (Ocular Computerized Tomography) for high resolution, non-invasive observation in the eye of living animals this project is now just getting underway with first results expected in September, 2012.

NIH NEUROLOGICAL DISORDERS & STROKE

Scott Grafton 9/1/11-8/31/12 $1,185,955Spatial and Temporal Scales of Motor Sequence Learning

This project is a collaborative effort by a team of five motor systems laboratories seeking to probe the mechanisms that underlie the brain’s capacity for learning a new motor skill. The common thread for all groups is to focus on changes that occur within motor circuits of the brain as a new sequential skill is acquired. The work is central to the problem of understanding the mechanisms where practice leads to reorganization of the human motor system in the face of aging, neurodegeneration, stroke or brain injury. Understanding these mechanisms has an impact on the design of therapies directed at preserving function, developing compensatory movements and ultimately, developing novel motor capacity.


Awards Administered

EISAI COMPANIES (JAPAN)

Mary Ann Jordan 7/1/11-10/31/12 $9,211Comparison of Pathogenic Actions of Eribulin, Paclitaxel, lxabepilone and Vincristine on Events Associated withPeripheral Neuropathy

Eribulin is a novel anticancer drug that was recently approved for metastatic breast cancer. We have previously elucidated its mechanism of action in collaboration with Eisai Pharmaceuticals, the company that developed the drug. Eribulin works its magic by targeting microtubules in cells and inhibits their dynamics. Interestingly, it appears to cause less peripheral neuropathy (a serious side effect) than some other microtubule-targeted anticancer drugs. We are trying to discover the cellular basis of this side effect with 4 microtubule-targeted drugs, namely, Eribulin, Paclitaxel, Ixabepilone and Vincristine, comparing their effects on cultured neurons, in animals, and in the test tube with purified microtubules. Our collaboration with Eisai has been very productive over a number of years, and has allowed several undergraduate students in our laboratory to experience meaningful, challenging scientific efforts as well as providing exciting projects for graduate students and postdoctoral students. NIH NATIONAL INSTITUTE ON AGING Kenneth Kosik 7/1/11-6/30/13 $126,758Development of RNAi as Treatment for Neurodegeneration

Alzheimer’s disease, already a serious global disease afflicting large segments of the population, is about to burgeon into an even larger problem as the baby-boomer bubble approaches retirement age. The disease remains incurable; however validated therapeutic targets are known. RNA interference (RNAi) technology poses a potential therapeutic option which requires further investigation. Targeting the mRNA rather than the protein offers major advantages in the ease of designing a highly specific inhibitory agent and rapidly advancing approaches to RNAi delivery suggest that the method can be developed into a therapy. Our hypothesis is that RNAi will prove to be an effective and selective strategy to slow, and perhaps even reverse, the pathogenic processes in inherited and sporadic AD.

Kenneth Kosik 2/1/11-10/31/12 $647,272Development of Cdk5 Inhibitors

This collaborative effort with RNAi development poses several questions concerning the cause and possible treatment of neurofibrillary pathology in Alzheimer’s disease. The key question for this project is whether suppression of Cdk5, an increasingly accepted disease target, can modify neurofibrillary pathology in an animal model. Cdk5 is an enzyme that phosphorylates tau protein and in so doing is thought to


contribute to the conversion of the protein into an insoluble aggregate known as the neurofibrillary tangle. Cdk5 is targeted by RNAi delivered in a viral vector. THE LARRY L. HILLBLOM FOUNDATION

Kenneth Kosik 1/1/08-12/31/12 $183,787 The Pathobiology of Tau Inclusions

Diseases, like Alzheimer’s and frontotemporal dementia, with intracellular inclusions such as neurofibrillary tangles, represent a broad category in pathology, and yet the mechanism of their formation is poorly understood. While most research directed toward the biochemical mechanism of tangle formation focuses on a class of enzymes called kinases, the aims of this project are built on the hypothesis that the accumulation of tau protein is due to a failure of the protein degradation machinery.

UC IRVINE

Kenneth Kosik 12/1/09-11/30/12 $50,000Neuro Stem Cells as a Developmental Candidate to Treat Alzheimer’s Disease

This project focuses on generating quantitative data on microRNAs using RNA extractions, real-time multiplex PCR and data analysis. The work also includes small RNA analyses by deep sequencing using our Applied Biosystems SOLiD platform. Geoffrey Lewis 7/1/11-6/30/14 $361,670Human Retinal Progenitor as Candidate Therapy for Retinitis Pigmentosa

Retinitis pigmentosa is an inherited, degenerative eye disease that causes severe vision impairment and blindness. The goal of our CIRM funded proposal “Human retinal progenitor cells as candidate therapy for retinitis pigmentosa” was to use retinal progenitor cells, injected into the eyes of rats with a similar genetic eye disease, to “deliver” survival factors and prevent the retina from degenerating. To date we have identified the injected cells using histological markers (antibodies) to stem cells and have documented that they survive for months after injection into the eyes. In addition, we have shown that the stem cells greatly slow the degeneration of the retina without causing any adverse affects. The work is the result of an ongoing collaboration with colleagues at UC Irvine. In addition, UCSB undergraduates contributed greatly to the project by doing much of the routine histology on the rat eyes.

Awards Administered


Awards Administered

NATIONAL ALLIANCE FOR RESEARCH ON SCHIZOPHRENIA & DEPRESSION (NARSAD)

Dzwokai (Zach) Ma 1/1/09-1/1/12 $15,000 Characterization of the Role of AGS3 in the Trafficking of Receptors and Channels

Although up-regulation of AGS3 (Activator of G protein Signaling 3) is shown to be necessary for recurring cocaine- and alcohol-seeking behavior in animal models of addiction, the cellular pathways modulated by AGS3 remain little understood. Further, how the AGS3 level is regulated is unknown. Our studies have discovered a novel role of AGS3 in modulating the structure and/or function of the late Golgi compartments and suggested an inhibitory function of AGS3 in macroautophagy. Moreover, we have identified USP9x as a regulator of AGS3. Future studies will aim to understand whether and how AGS3 affects addiction via the above cellular pathways. WASHINGTON UNIVERSITY, (ST. LOUIS, MO) Stanley Parsons 6/15/11-5/31/13 $59,591PET Probes for Imaging the Vesicular Acetylcholine Transporter

Amazingly, there is today no laboratory test in living people for Alzheimer’s disease. Because there are many causes of dementia (about 40% is non-Alzheimer’s), specific treatment of Alzheimer’s disease will require an accurate laboratory test, preferably at an early stage. We are seeking to develop compounds that can image the density of “cholinergic” nerve terminals (those that release the neurotransmitter acetylcholine) in brain by use of a technique called Positron Emission Tomography (PET). Loss of cholinergic terminals is characteristic of Alzheimer’s disease. Such imaging would create a laboratory diagnostic of Alzheimer’s disease and, once treatment has been developed by other researchers, allow assessment of treatment efficacy.

AMERICAN HEALTH ASSISTANCE FOUNDATION Monte Radeke 7/1/11-6/30/13 $100,000The Epigenetics of RPE Aging

Current evidence suggests that inherent age-dependent losses in retinal pigmented epithelium (RPE) function contribute to the onset and progression of AMD. Our genome contains all of the information required to generate the various cell types in our body. During the course of development each unique cell type is determined, in large part, through a process known as epigenetic modification. The most fundamental modification results from site-specific methylation of DNA and generally results in


Awards Administered

restricted gene expression. The resulting pattern of methylation is referred to as the methylome. Although once considered permanent, recent studies have shown that changes in the methylome are associated with aging and cancer. Aging is the one universal risk factor for age-related macular degeneration (AMD). Our research efforts are directed at determining if age-associated changes in the RPE methylome could contribute to the onset and/or progression of AMD.

NIH NATIONAL CENTER RESEARCH RESOURCES

Mary Raven 5/15/12-5/14/13 $429,480 Spectral Laser Scanning Biological Microscope

The extensive research need documented by an interdisciplinary group of thirteen National Institutes of Health (NIH) funded researchers led a successful application for a new Spectral Laser Scanning Microscope from the NIH. The Spectral Confocal replaces an aging confocal microscope used for imaging fluorescent samples with a system that enhances the confocal imaging capabilities available at UC, Santa Barbara. Since the award date, an Olympus Fluoview 1000S was installed in the NRI-MCDB Microscopy Facility and researchers from the Major Users Group: Anthony De Tomaso, Kenneth Kosik, Jamey Marth, William Smith, Benjamin Reese, Joel Rothman, Erkki Ruoslahti and Minor Users Group: Patrick Daugherty, Stuart Feinstein, Tod Kippin, Jacob Israelachvili, Cyrus Safinya and Thomas Weimbs have been given access to the instrument following training for their research applications. Seventeen of the eighty active confocal users have completed initial training and additional training sessions are scheduled to meet the training demand. The instrument is directly overseen by PI/Facility Director Mary Raven. NIH NATIONAL EYE INSTITUTE

Benjamin Reese 1/1/11-12/31/12 $378,792Development of Retinal Bipolar Cells

This research program is identifying the molecular and genetic determinants controlling the natural variation in nerve cell number, examining the populations of synaptically connected photoreceptors, bipolar cells and amacrine cells in the retina. We are also determining how such variation in afferent and target cell number modulates the dendritic morphology of the post-receptoral cells. This program will, consequently, clarify the developmental events and their underlying mechanisms that produce the functional architecture and connectivity of the retina. These studies will contribute to our understanding of retinal development and degeneration, and will enlighten our approach in developing treatments for retinal disease, particularly where the latter seek to re-establish connectivity following cell replacement therapy.


NIH NATIONAL CANCER INSTITUTE

Joel Rothman 8/1/11-7/31/13 $309,057Modulation of Cell Proliferation in C. elegans

We are continuing our studies on how cell division and growth are controlled by investigating the cellular components that switch dividing cells into non-dividing cells with specialized functions. These processes are critically important in the genesis of cancer and are uncontrolled in growing tumor cells. The project is providing training for graduate students and undergraduate researchers who are learning molecular genetic and cell biological experimental methods that effectively address these problems.

NIH GENERAL MEDICAL SCIENCES

William Smith 7/1/11-7/31/12 $266,608Exploring Planar Cell Polarity in a Novel InvertebrateChordate System

The formation of organs and tissues in the developing embryo requires coordinated action of multiple cells. Cells are not uniform structures, but rather have distinct sides, a property we call polarity. For example, cells in an organ may adhere tightly to a substrate with one face, while actively secreting on another face. We use a simple model organism in which the organs are composed of only tens to hundreds of cells to investigate the cellular mechanisms by which cells sense directionality and coordinate polarity while they assemble into organs.

SANTA BARBARA COTTAGE HOSPITAL

Carol Vandenberg 9/26/11-9/25/12 $15,000 Trafficking of Potassium Channels in Periodic Paralysis

This project is aimed at understanding the cellular mechanisms that underlie electrical activity of muscle. In particular, we are studying skeletal muscle potassium channels, which are pores that regulate the flux of potassium ions across the muscle plasma membrane. Inward rectifier potassium channels play an important role in skeletal muscle in controlling electrical excitability and providing a stable resting potential. Genetic mutations of the channels are associated with muscle disease. We are investigating the trafficking of potassium channels to the muscle surface membrane and how disease-associated channel mutations may alter function of skeletal muscle.

Awards Administered


NIH CENTER FOR SCIENTIFIC REVIEW

Thomas Weimbs 7/1/11-6/30/13 $329,601Regulation of the mTOR Pathway in Polycystic Kidney Disease

Polycystic Kidney Disease (PKD) is a common, life-threatening genetic disease that affects over 600,000 people in the US alone. PKD leads to kidney failure and there is currently no available treatment to slow down the progression of this disease. Previous research in our laboratory has led to the finding that a cellular signaling pathway centered around a protein called mTOR is driving the progression of PKD and is a highly promising drug target for treatment of PKD. Our present research is aimed at better understanding the regulation of this pathway in PKD with the goal to devise effective strategies for treating this disease.

CANCER CENTER OF SANTA BARBARA

Leslie Wilson 7/1/10-8/30/12 $50,000 Sulforaphane: Its Potential for the Treatment of Breast Cancer in Combination Therapy

Sulforaphane (SFN), the major isothiocyanate found in cabbages, exerts a number of chemoprotective and anticancer activities, and most importantly for this project, the ability to inhibit breast cancer cell proliferation at mitosis leading to cancer cell death in a manner similar to, but weaker than that induced by chemotherapeutic anti-mitotic drugs. Dr. Wilson’s postdoctoral researcher Dr. Olga Azarenko discovered that SFN effectively suppresses microtubule dynamics and stabilizes microtubules both in MCF7 breast adenocarcinoma cells and with purified microtubules at low concentrations. She is investigating SFN’s efficacy as a natural adjuvant to taxol and/or vinblastine.

Awards Administered


Space

Kosik


Space


Space


Space


Publications

1) Ahmado A, Carr AJ, Vugler AA, Semo M, Gias C, Lawrence JM, Chen LL, Chen FK, Turowski P, da Cruz L, Coffey PJ (2011) Induction of differentiation by pyruvate and DMEM in the human retinal pigment epithelium cell line ARPE-19. Investigative ophthalmology & visual science 52:7148-7159.

2) Aminoff EM, Clewett D, Freeman S, Frithsen A, Tipper C, Johnson A, Grafton ST, Miller MB (2012) Individual differences in shifting decision criterion: A recognition memory study. Memory & cognition.

3) Bailey J, Ma D, Szumlinski KK (2012) Rapamycin attenuates the expression of cocaine-induced place preference and behavioral sensitization. Addiction biology 17:248-258.

4) Barnea-Ygael N, Yadid G, Yaka R, Ben-Shahar O, Zangen A (2012) Cue-induced reinstatement of cocaine seeking in the rat “conflict model”: effect of prolonged home-cage confinement. Psychopharmacology 219:875-883.

5) Ben-Shahar OM, Szumlinski KK, Lominac KD, Cohen A, Gordon E, Ploense KL, DeMartini J, Bernstein N, Rudy NM, Nabhan AN, Sacramento A, Pagano K, Carosso GA, Woodward N (2012) Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex. Addiction biology 17:746-757.

6) Bernier PM, Cieslak M, Grafton ST (2012) Effector selection precedes reach planning in the dorsal parietofrontal cortex. Journal of neurophysiology 108:57-68.Cantrup R, Dixit R, Palmesino E, Bonfield S, Shaker T, Tachibana N, Zinyk D, Dalesman S, Yamakawa K, Stell WK, Wong RO, Reese BE, Kania A, Sauve Y, Schuurmans C (2012) Cell-type specific roles for PTEN in establishing a functional retinal architecture. PloS one 7:e32795.

7) Chattopadhyay PK, Gaylord B, Palmer A, Jiang N, Raven MA, Lewis G, Reuter MA, Nur-ur Rahman AK, Price DA, Betts MR, Roederer M (2012) Brilliant violet fluorophores: a new class of ultrabright fluorescent compounds for immunofluorescence experiments. Cytometry Part A : the journal of the International Society for Analytical Cytology 81:456-466.

8) Chen L, Yao X, Young A, McNulty J, Anderson D, Liu Y, Nystrom C, Croom D, Ross S, Collins J, Rajpal D, Hamlet K, Smith C, Gedulin B (2012) Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes. American journal of physiology Endocrinology and metabolism 302:E68-76.


Publications

9) Conaco C, Bassett DS, Zhou H, Arcila ML, Degnan SM, Degnan BM, Kosik KS (2012a) Functionalization of a protosynaptic gene expression network. Proceedings of the National Academy of Sciences of the United States of America 109 Suppl 1:10612-10618.

10) Conaco C, Neveu P, Zhou H, Arcila ML, Degnan SM, Degnan BM, Kosik KS (2012b) Transcriptome profiling of the demosponge Amphimedon queenslandica reveals genome-wide events that accompany major life cycle transitions. BMC genomics 13:209.

11) Ding JD, Johnson LV, Herrmann R, Farsiu S, Smith SG, Groelle M, Mace BE, Sullivan P, Jamison JA, Kelly U, Harrabi O, Bollini SS, Dilley J, Kobayashi D, Kuang B, Li W, Pons J, Lin JC, Bowes Rickman C (2011) Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 108:E279-287.

12) Frye CA, Paris JJ, Osborne DM, Campbell JC, Kippin TE (2011) Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review. Frontiers in psychiatry / Frontiers Research Foundation 2:52.

13) Gazzaniga MS (2012) QnAs with Michael S. Gazzaniga. Interview by Prashant Nair. Proceedings of the National Academy of Sciences of the United States of America 109:5137.

14) George CX, Samuel CE (2011) Host response to polyomavirus infection is modulated by RNA adenosine deaminase ADAR1 but not by ADAR2. Journal of virology 85:8338-8347.

15) Gias C, Vugler A, Lawrence J, Carr AJ, Chen LL, Ahmado A, Semo M, Coffey PJ (2011) Degeneration of cortical function in the Royal College of Surgeons rat. Vision research 51:2176-2185.

16) Grafton ST, Tipper CM (2012) Decoding intention: a neuroergonomic perspective. NeuroImage 59:14-24.

17) Gurven M, Blackwell AD, Rodriguez DE, Stieglitz J, Kaplan H (2012a) Does blood pressure inevitably rise with age?: longitudinal evidence among forager-horticulturalists. Hypertension 60:25-33.

18) Gurven M, Stieglitz J, Hooper PL, Gomes C, Kaplan H (2012b) From the womb to the tomb: The role of transfers in shaping the evolved human life history. Experimental gerontology 47:807-813.


Publications

19) Henrich J, Boyd R, McElreath R, Gurven M, Richerson PJ, Ensminger J, Alvard M, Barr A, Barrett C, Bolyanatz A, Camerer CF, Cardenas JC, Fehr E, Gintis HM, Gil-White F, Gwako EL, Henrich N, Hill K, Lesorogol C, Patton JQ, Marlowe FW, Tracer DP, Ziker J (2012a) Culture does account for variation in game behavior. Proceedings of the National Academy of Sciences of the United States of America 109:E32-33; author reply E34.

20) Henrich J, Boyd R, McElreath R, Gurven M, Richerson PJ, Ensminger J, Alvard M, Barr A, Barrett HC, Bolyanatz A, Camerer CF, Cardenas JC, Fehr E, Gintis HM, Gil-White F, Gwako EL, Henrich N, Hill K, Lesorogol C, Patton JQ, Marlowe FW, Tracer DP, Ziker J (2012b) Reply to van Hoorn: Converging lines of evidence. Proceedings of the National Academy of Sciences of the United States of America 109:E1678.

21) Hinow P, Rezania V, Lopus M, Jordan MA, Tuszynski JA (2011) Modeling the effects of drug binding on the dynamic instability of microtubules. Physical biology 8:056004.

22) Ingham RJ (2012) Comments on recent developments in stuttering treatment maintenance research using the Camperdown Program. Journal of speech, language, and hearing research : JSLHR 55:306-309; author reply 310-302.

23) Ingham RJ, Bothe AK, Wang Y, Purkhiser K, New A (2012a) Phonation interval modification and speech performance quality during fluency-inducing conditions by adults who stutter. Journal of communication disorders 45:198-211.

24) Ingham RJ, Grafton ST, Bothe AK, Ingham JC (2012b) Brain activity in adults who stutter: similarities across speaking tasks and correlations with stuttering frequency and speaking rate. Brain and language 122:11-24.

25) Ingham RJ, Ingham JC, Bothe AK (2012c) Integrating functional measures with treatment: a tactic for enhancing personally significant change in the treatment of adults and adolescents who stutter. American journal of speech-language pathology / American Speech-Language-Hearing Association 21:264-277.

26) Jacobs GH (2012) The evolution of vertebrate color vision. Advances in experimental medicine and biology 739:156-172.

27) Johnson LV, Forest DL, Banna CD, Radeke CM, Maloney MA, Hu J, Spencer CN, Walker AM, Tsie MS, Bok D, Radeke MJ, Anderson DH (2011) Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 108:18277-18282.


Publications

28) Jun G, Nicolaou M, Morrison MA, Buros J, Morgan DJ, Radeke MJ, Yonekawa Y, Tsironi EE, Kotoula MG, Zacharaki F, Mollema N, Yuan Y, Miller JW, Haider NB, Hageman GS, Kim IK, Schaumberg DA, Farrer LA, DeAngelis MM (2011) Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology. PloS one 6:e25775.

29) Keeley PW, Sliff B, Lee SC, Fuerst PG, Burgess RW, Eglen SJ, Reese BE (2011) Neuronal clustering and fasciculation phenotype in dscam- and bax-deficient mouse retinas. The Journal of comparative neurology.

30) Keeley PW, Sliff BJ, Lee SC, Fuerst PG, Burgess RW, Eglen SJ, Reese BE (2012) Neuronal clustering and fasciculation phenotype in Dscam- and Bax-deficient mouse retinas. The Journal of comparative neurology 520:1349-1364.

31) Kerstetter KA, Kippin TE (2011) Impact of Sex and Gonadal Hormones on Cocaine and Food Reinforcement Paradigms. Journal of addiction research & therapy S4.

32) Kippin TE (2011) Does drug mis-instrumentalization lead to drug abuse? The Behavioral and brain sciences 34:316-317.

33) Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH (2012) Mechanisms of age-related cognitive change and targets for intervention: epigenetics. The journals of gerontology Series A, Biological sciences and medical sciences 67:741-746.

34) Kye MJ, Neveu P, Lee YS, Zhou M, Steen JA, Sahin M, Kosik KS, Silva AJ (2011) NMDA mediated contextual conditioning changes miRNA expression. PloS one 6:e24682.

35) Landmann C, Landi SM, Grafton ST, Della-Maggiore V (2011) FMRI supports the sensorimotor theory of motor resonance. PloS one 6:e26859.

36) Lee EJ, Banerjee S, Zhou H, Jammalamadaka A, Arcila M, Manjunath BS, Kosik KS (2011a) Identification of piRNAs in the central nervous system. RNA 17:1090-1099.

37) Lee SC, Cowgill EJ, Al-Nabulsi A, Quinn EJ, Evans SM, Reese BE (2011b) Homotypic regulation of neuronal morphology and connectivity in the mouse retina. The Journal of neuroscience : the official journal of the Society for Neuroscience 31:14126-14133.

38) Li Z, Okonski KM, Samuel CE (2012) Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the induction of interferon by measles virus. Journal of virology 86:3787-3794.


Publications

39) Lin J, Valentine MT (2012) High-force NdFeB-based magnetic tweezers device optimized for microrheology experiments. The Review of scientific instruments 83:053905.

40) Lominac KD, Sacramento AD, Szumlinski KK, Kippin TE (2012) Distinct neurochemical adaptations within the nucleus accumbens produced by a history of self-administered vs non-contingently administered intravenous methamphetamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 37:707-722.

41) Lopus M, Manatschal C, Buey RM, Bjelic S, Miller HP, Steinmetz MO, Wilson L (2012) Cooperative stabilization of microtubule dynamics by EB1 and CLIP-170 involves displacement of stably bound P(i) at microtubule ends. Biochemistry 51:3021-3030.

42) Mandal N, Lewis GP, Fisher SK, Heegaard S, Prause JU, la Cour M, Vorum H, Honore B (2011) Protein changes in the retina following experimental retinal detachment in rabbits. Molecular vision 17:2634-2648.

43) Marlowe FW, Berbesque JC, Barrett C, Bolyanatz A, Gurven M, Tracer D (2011) The ‘spiteful’ origins of human cooperation. Proceedings Biological sciences / The Royal Society 278:2159-2164.

44) Martin MA, Lassek WD, Gaulin SJ, Evans RW, Woo JG, Geraghty SR, Davidson BS, Morrow AL, Kaplan HS, Gurven MD (2012) Fatty acid composition in the mature milk of Bolivian forager-horticulturalists: controlled comparisons with a US sample. Maternal & child nutrition 8:404-418.

45) McCall C, Tipper CM, Blascovich J, Grafton ST (2011) Attitudes trigger motor behavior through conditioned associations: neural and behavioral evidence. Social cognitive and affective neuroscience.

46) McCullough K, Sharma P, Ali T, Khan I, Smith WC, MacLeod A, Black C (2012) Measuring the population burden of chronic kidney disease: a systematic literature review of the estimated prevalence of impaired kidney function. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 27:1812-1821.

47) Mishra RC, Karna P, Gundala SR, Pannu V, Stanton RA, Gupta KK, Robinson MH, Lopus M, Wilson L, Henary M, Aneja R (2011) Second generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluation. Biochemical pharmacology 82:110-121.


Publications

48) Morrison MA, Silveira AC, Huynh N, Jun G, Smith SE, Zacharaki F, Sato H, Loomis S, Andreoli MT, Adams SM, Radeke MJ, Jelcick AS, Yuan Y, Tsiloulis AN, Chatzoulis DZ, Silvestri G, Kotoula MG, Tsironi EE, Hollis BW, Chen R, Haider NB, Miller JW, Farrer LA, Hageman GS, Kim IK, Schaumberg DA, DeAngelis MM (2011) Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. Human genomics 5:538-568.

49) Newman AM, Gallo NB, Hancox LS, Miller NJ, Radeke CM, Maloney MA, Cooper JB, Hageman GS, Anderson DH, Johnson LV, Radeke MJ (2012) Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks. Genome medicine 4:16.

50) Oberstein SY, Byun J, Herrera D, Chapin EA, Fisher SK, Lewis GP (2011) Cell proliferation in human epiretinal membranes: characterization of cell types and correlation with disease condition and duration. Molecular vision 17:1794-1805.

51) Olsan EE, Mukherjee S, Wulkersdorfer B, Shillingford JM, Giovannone AJ, Todorov G, Song X, Pei Y, Weimbs T (2011) Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proceedings of the National Academy of Sciences of the United States of America 108:18067-18072.

52) Parasuraman R, Christensen J, Grafton S (2012) Neuroergonomics: the brain in action and at work. NeuroImage 59:1-3.

53) Pfaller CK, Li Z, George CX, Samuel CE (2011) Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response. Current opinion in immunology 23:573-582.

54) Pfaus JG, Kippin TE, Coria-Avila GA, Gelez H, Afonso VM, Ismail N, Parada M (2012) Who, what, where, when (and maybe even why)? How the experience of sexual reward connects sexual desire, preference, and performance. Archives of sexual behavior 41:31-62.

55) Reese BE (2012) Retinal Mosaics: Pattern Formation Driven by Local Interactions between Homotypic Neighbors. Frontiers in neural circuits 6:24.

56) Rowland TJ, Blaschke AJ, Buchholz DE, Hikita ST, Johnson LV, Clegg DO (2012a) Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins. Journal of tissue engineering and regenerative medicine.


Publications

57) Rowland TJ, Buchholz DE, Clegg DO (2012b) Pluripotent human stem cells for the treatment of retinal disease. Journal of cellular physiology 227:457-466.

58) Rucas SL, Gurven M, Winking J, Kaplan H (2012) Social aggression and resource conflict across the female life-course in the Bolivian Amazon. Aggressive behavior 38:194-207.

59) Samuel CE (2012) ADARs: viruses and innate immunity. Current topics in microbiology and immunology 353:163-195.

60) Stayner C, Shields J, Slobbe L, Shillingford JM, Weimbs T, Eccles MR (2012) Rapamycin-mediated suppression of renal cyst expansion in del34 Pkd1(-/-) mutant mouse embryos; an investigation of the feasibility of renal cyst prevention in the fetus. Nephrology (Carlton).

61) Stieglitz J, Kaplan H, Gurven M, Winking J, Tayo BV (2011) Spousal violence and paternal disinvestment among Tsimane’ forager-horticulturalists. American journal of human biology : the official journal of the Human Biology Council 23:445-457.

62) Su ZI, Kichaev G, Wenzel J, Ben-Shahar O, Ettenberg A (2012) Weakening of negative relative to positive associations with cocaine-paired cues contributes to cue-induced responding after drug removal. Pharmacology, biochemistry, and behavior 100:458-463.

63) Taghavi N, Samuel CE (2012) Protein kinase PKR catalytic activity is required for the PKR-dependent activation of mitogen-activated protein kinases and amplification of interferon beta induction following virus infection. Virology 427:208-216.

64) Trumble BC, Cummings D, von Rueden C, O’Connor KA, Smith EA, Gurven M, Kaplan H (2012) Physical competition increases testosterone among Amazonian forager-horticulturalists: a test of the ‘challenge hypothesis’. Proceedings Biological sciences / The Royal Society 279:2907-2912.

65) Tu Z, Wang W, Cui J, Zhang X, Lu X, Xu J, Parsons SM (2012) Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups. Bioorganic & medicinal chemistry 20:4422-4429.

66) Valdman D, Atzberger PJ, Yu D, Kuei S, Valentine MT (2012) Spectral analysis methods for the robust measurement of the flexural rigidity of biopolymers. Biophysical journal 102:1144-1153.


67) van Elk M, Viswanathan S, van Schie HT, Bekkering H, Grafton ST (2012) Pouring or chilling a bottle of wine: an fMRI study on the prospective planning of object-directed actions. Experimental brain research Experimentelle Hirnforschung Experimentation cerebrale 218:189-200.

68) Viswanathan S, Fritz C, Grafton ST (2012) Telling the right hand from the left hand: multisensory integration, not motor imagery, solves the problem. Psychological science 23:598-607.

69) von Rueden C, Gurven M, Kaplan H (2011) Why do men seek status? Fitness payoffs to dominance and prestige. Proceedings Biological sciences / The Royal Society 278:2223-2232.

70) von Rueden CR, Gurven M (2012) When the strong punish: why net costs of punishment are often negligible. The Behavioral and brain sciences 35:43-44.

71) Wang W, Cui J, Lu X, Padakanti PK, Xu J, Parsons SM, Luedtke RR, Rath NP, Tu Z (2011) Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for sigma1 receptors. Journal of medicinal chemistry 54:5362-5372.

72) Wenzel JM, Waldroup SA, Haber ZM, Su ZI, Ben-Shahar O, Ettenberg A (2011) Effects of lidocaine-induced inactivation of the bed nucleus of the stria terminalis, the central or the basolateral nucleus of the amygdala on the opponent-process actions of self-administered cocaine in rats. Psychopharmacology 217:221-230.

73) Winking J, Gurven M (2011) The total cost of father desertion. American journal of human biology : the official journal of the Human Biology Council 23:755-763.

74) Wymbs NF, Bassett DS, Mucha PJ, Porter MA, Grafton ST (2012) Differential recruitment of the sensorimotor putamen and frontoparietal cortex during motor chunking in humans. Neuron 74:936-946.

75) Yang Y, Lin J, Meschewski R, Watson E, Valentine MT (2011) Portable magnetic tweezers device enables visualization of the three-dimensional microscale deformation of soft biological materials. BioTechniques 51:29-34.

76) Young A, Jiang M, Wang Y, Ahmedli NB, Ramirez J, Reese BE, Birnbaumer L, Farber DB (2011) Specific interaction of Galphai3 with the Oa1 G-protein coupled receptor controls the size and density of melanosomes in retinal pigment epithelium. PloS one 6:e24376.

77) Zhou H, Arcila ML, Li Z, Lee EJ, Henzler C, Liu J, Rana TM, Kosik KS (2012a) Deep annotation of mouse iso-miR and iso-moR variation. Nucleic acids research 40:5864-5875.

Publications


Statistical Summary Academic personnel engaged in research: a. Faculty 23 b. Professional Researchers (including Visiting) 2 c. Project Scientists 9 d. Specialists 20 e Postdoctoral Scholars 18 f. Postgraduate Researchers - g. Academic Coordinator - TOTAL 722. Graduate Students: a Employed on contracts and grants 27 b. Employed on other sources of funds - c. Participating through assistantships - d. Participating through traineeships 5 e Other (specify) TOTAL 323. Undergraduate Students: a. Employed on contracts and grants 18 b. Employed on other funds - c. Number of volunteers, & unpaid interns - TOTAL 14. Participation from outside UCSB: (optional) a. Academics (without Salary Academic Visitors) 34 b. Other (specify) 5. Staff (Univ. & Non-Univ. Funds): a. Technical 26 b. Administrative/Clerical 106. Seminars, symposia, workshops sponsored 7. Proposals submitted 758. Number of different awarding agencies dealt with* 309. Number of extramural awards administered 6110. Dollar value of extramural awards $53,023,565 administered during year** 11. Number of Principal Investigators*** 2912. Dollar value of other project awards **** $2,727,689 13. Number of other projects administered 3814. Total base budget for the year (as of June 30, 2012) $310,313 15. Dollar value of intramural support $1,116,859 16. Total assigned square footage in ORU 14,66117. Dollar value of awards for year (2012 Total) $12,716,748


PERMANENT NR02 447636-19900 APPROPRIATION EXPENSEAcademic Salaries Director $12,000 $12,000

Staff Salaries $268,439 $261,448General Assistance $21,072 $0Employee Benefits $134,362 $134,362Supplies & Expense $0 $737 Travel & Equipment $0 Other: Copier Recharge ($7) Total 2011-2012 $435,873 $408,540

Adjusted total 2011-2012 $435,873 $408,540Carry forward/(overdraft) $27,333 PERMANENT NR01 447636-07427Associate Director $3,287 $237 Supplies & Expense $5,515 $0 Total 2011-2012 $8,802 $237

Adjusted total 2011-2012 $8,802 $237 Carry forward (overdraft) $8,565

TEMPORARY

Intramural Funding*-Funds allocated directly to Organized Research Unit

Person/Project-Source of funds APPROPRIATION EXPENSE 447636-07427 Carry Forward from FY2010-2011 $124,239 $22,404 447636-07427 Indirect Cost Return 2011-2012 $163,614 $33,133 447633-07427 Coffey CIRM Match-swap $70,000 $0 447636-07427 Kydland Match $12,500 $3,544 447636-07427-Raven NIH Instr. Match $24,000 $0 447636-07427 IACUC Buchholz $1,301 $1,301 447636-19900-Kydland Salary EVC $73,175 $73,175 447636-19900-Feinstein IACUC $16,800 $16,800 447636-19900 Coffey CIRM Match $280,000 $266,701 447636-19900 Gurven Buy out funds $9,263 $1,118 447636-69750 CF 2010-2011 $104,730 $1,634 447636-19933 CF 2010-2011 $22,189

Budget Summary


447636-19933 ARRA Overhead Return 2011-2012 $24,538 $16,473 447636-19941- 19900 CF 2010-2011 $119,213 $111,737 447636-19941 Benefits $46,297 $46,297 447636-19941 Gurven Demography Lab $10,000 $0 447636-19941-Weimbs ARC $15,000 $5,291 Less Budgetary Savings Assessment (BSA) 447636-07427 Total Appropriations/Expenses $1,116,859 $599,608 Carry forward/(overdraft $517,251 Recharge/Income Account 447636-62190 INCOME EXPENSE Academic Salaries $5,785 Staff SalariesGeneral AssistanceS&E $47,328 $98,096 Benefits $794 Other: Equipment & Facilities Unallocated $36,031 Total Recharge Income/Expenses ($50,782) ($74,636) Carry forward/(overdraft) $39,156 $23,460

Other Income (specify source and use) INCOME EXPENSE Donations/Gifts/EndowmentsVarious Donors $276,817 $62,306 Gifts $1,714,912 $520,449Endowments $735,960 $17,581 Total Other Income/Expenses $2,727,689 $600,336 Carry forward/(overdraft) $2,127,353 Total Funding/Expenses for FY 2011-2012 $4,328,379 $1,632,181 Total carry forward/(overdraft) $2,696,198

Budget Summary


Advisory Committee Administrative + Technical Staff

Mark Brzezinski, EEMBPeter Coffey, NRI/MCDBScott Grafton, Psychological + Brain SciencesThomas Harriman, CommunityJanice Hartoch-Taylor, Development Richard Lehman, Santa Barbara Cottage Hospital JoAnn Kuchera-Morin, Media Arts + Technology B.S. Manjunath, Electrical + Computer Engineering

Fyl Pincus, Biomolecular Science + Engineering Art Rosenblatt, Olympus Thomas Weimbs, Chair, NRI/MCDB

EX-OFFICIO

Jeanie Cornet, NRIStuart Feinstein, NRIKenneth Kosik, NRI

ADVISORY COMMITTEE

ADMINISTRATIVE STAFF TECHNICAL STAFF

Judy Cushing, Payroll/Purchasing AssistantKaren Cisneros, Administrative/PurchasingManagerJeanie Cornet, Business OfficerStuart Feinstein, Co-DirectorKenneth S. Kosik, Co-Director Max McCumber, Purchasing AssistantJen Messecar, Assistant to Kenneth Kosik Laura Susin, Contract + Grants ManagerBee Jay Yokoi, Payroll Manager

Mary Arcila, Sequencing Facility Assistant DirectorSothy Chan, Computer SupportGeoffrey Lewis, Microscopy SupportMary Raven, Microscopy Director


Principal Investigators

Don Anderson Research Scientist NRIOsnat M. Ben Shahar Researcher Psychological + Brain SciencesDennis O. Clegg Professor MCDBStuart C. Feinstein Professor MCDB

Co-Director NRISteven K. Fisher Professor MCDBMichael Gazzaniga Professor Psychological + Brain SciencesClaudia Gottstein Adjunct Assistant Professor MCDB

Director CNS Biological Nanostructures LabScott Grafton Professor Psychological + Brain SciencesMichael Gurven Professor AnthropologyRoger Ingham Professor Speech + Hearing SciencesGerald H. Jacobs Professor Psychological + Brain SciencesLincoln V. Johnson Research Scientist NRIMary Ann Jordan Research Scientist NRITod Kippin Associate Professor Psychological + Brain SciencesKenneth S. Kosik Harriman Professor MCDB

Co-Director NRI Tonya Kydland Project Scientist NRIJohn Lew Associate Professor MCDBGeoff Lewis Research Scientist NRIDzwokai “Zach” Ma Assistant Professor MCDBStanley M. Parsons Professor Chemistry + Biochemistry Monte Radeke Assistant Research Scientist NRI Benjamin E. Reese Professor Psychological + Brain SciencesJoel Rothman Professor MCDBCharles E. Samuel C.A. Storke II Professor MCDBWilliam Smith Professor MCDBKaren Szumlinski Associate Professor Psychological + Brain SciencesMegan T. Valentine Assistant Professor Mechanical EngineeringCarol Vandenberg Professor MCDBThomas Weimbs Associate Professor MCDBLeslie Wilson Professor MCDB


Students

GRADUATES

Mary ArcilaSarah BenbowTracy ClevengerRoxanne CrozeJulia PalterNicolas DoerrJulianna Erickson Erin FolchiDavid ForestIsrael HernandezMatthew Lalli Tyronne Martin Huyen NguyenBritney Pennington Jack ReifertKrista ReulandMisty Riddle Erica Sommerman Jeff TalbotLauren VucovichIrene Whitney Xu Zhoujin

UNDERGRADUATES

Shant Donoyan Joshua DorstHanna HartLyndsey LeachMegan Lim Katherine McLeanEthan McSpadden Joshua MeinertRobert MusgraveSagen Elizabeth Peterson Stephen Riffle Alex RifkindKimberly SkylesDhrov VermaAmy WalkerKelsey WalorintaKirby WelshNicole Wypychowski


Special Thanks

Special thanks to Jen Messecar for her tireless efforts in compiling the NRI 2011-2012 Annual Report, and for her dedication and creativity in designing the new NRI website, along with Brian Wolf of the Life Sciences Computing Group.

The cover image depicting a tomographic map of a neuronal synapse and the neuron seen at bottom right are courtesy of Dr. Steven Fisher. Thanks also go out to Geoff Lewis, Gabe Luna, Monte Radeke, and David Buchholz for use of their images.

Please follow us on Twitter and Facebook for current updates on NRI research news.

@UCSB_NRI UCSB NRI

mailto:jen.messecar%40lifesci.ucsb.edu?subject=

Date post:	29-Jan-2017
Category:	Documents
Upload:	dodung
View:	215 times
Download:	0 times

NRI Annual Report 2011-12

Documents