TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
F3_R2
C Number: C93025
Lock Date: 03/22/2006
Cage Range: ALL
Date Range: ALL
Reasons For Removal: ALL
Removal Date Range: ALL
Treatment Groups: Include ALL
Study Gender: Both
TDMSE Version: 2.1.0
Note: Animals arranged according to days on test.
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + A + + + + + + + + + + + + + + A A.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + A + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + A + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + A + + A + + + + + + + + + + + A + + A A.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + A + + A + + + + + + + + + + + A + + + A.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + +
Hepatocellular Adenoma.........................................................................................................................................................................................................
Mesentery + + + + +.........................................................................................................................................................................................................
Oral Mucosa.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0372
0530
0557
0563
0563
0586
0586
0591
0593
0600
0600
0605
0628
0642
0642
0647
0647
0647
0648
0649
0662
0668
0670
0678
0682
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00040
00047
00025
00039
00045
00012
00016
00009
00050
00014
00020
00021
00001
00003
00028
00008
00035
00044
00043
00018
00048
00006
00013
00031
00037
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 2
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Tongue.........................................................................................................................................................................................................
Tooth +
Adamantinoma Malignant X
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Pheochromocytoma Benign X X X X
Pheochromocytoma Malignant X
Bilateral, Pheochromocytoma Benign X
Bilateral, Pheochromocytoma Malignant
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0372
0530
0557
0563
0563
0586
0586
0591
0593
0600
0600
0605
0628
0642
0642
0647
0647
0647
0648
0649
0662
0668
0670
0678
0682
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00040
00047
00025
00039
00045
00012
00016
00009
00050
00014
00020
00021
00001
00003
00028
00008
00035
00044
00043
00018
00048
00006
00013
00031
00037
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 3
.........................................................................................................................................................................................................Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X
Carcinoma.........................................................................................................................................................................................................
Parathyroid Gland + + + + + + + + + + + + + + + + M + + + + + + + +.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X X X X X X X X X X X X X X X X X X
Carcinoma.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
C-cell, Adenoma X
C-cell, Carcinoma
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Penis +.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0372
0530
0557
0563
0563
0586
0586
0591
0593
0600
0600
0605
0628
0642
0642
0647
0647
0647
0648
0649
0662
0668
0670
0678
0682
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00040
00047
00025
00039
00045
00012
00016
00009
00050
00014
00020
00021
00001
00003
00028
00008
00035
00044
00043
00018
00048
00006
00013
00031
00037
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 4
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + +
Bilateral, Interstitial Cell, Adenoma X X X X X X
Interstitial Cell, Adenoma X X
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lymph Node + + + +.........................................................................................................................................................................................................
Lymph Node, Bronchial M M M M M M M M + M + M M M M + + M + M M M M M M.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + M M M M + + + M + + + M + + + M + M + + +
Carcinoma, Metastatic, Thyroid Gland.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0372
0530
0557
0563
0563
0586
0586
0591
0593
0600
0600
0605
0628
0642
0642
0647
0647
0647
0648
0649
0662
0668
0670
0678
0682
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00040
00047
00025
00039
00045
00012
00016
00009
00050
00014
00020
00021
00001
00003
00028
00008
00035
00044
00043
00018
00048
00006
00013
00031
00037
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 5
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Thymus + + M + + M M + + + + + + + + + + + + + + + + + +
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Fibroadenoma.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + +
Basal Cell Adenoma, Multiple
Basal Cell Carcinoma
Keratoacanthoma, Multiple
Sebaceous Gland, Adenoma
Subcutaneous Tissue, Fibroma X X
Subcutaneous Tissue, Fibrosarcoma X
Subcutaneous Tissue,Hemangiosarcoma
Subcutaneous Tissue, Osteosarcoma,Metastatic, Bone
X
Subcutaneous Tissue, SchwannomaMalignant
MUSCULOSKELETAL SYSTEM
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0372
0530
0557
0563
0563
0586
0586
0591
0593
0600
0600
0605
0628
0642
0642
0647
0647
0647
0648
0649
0662
0668
0670
0678
0682
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00040
00047
00025
00039
00045
00012
00016
00009
00050
00014
00020
00021
00001
00003
00028
00008
00035
00044
00043
00018
00048
00006
00013
00031
00037
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 6
.........................................................................................................................................................................................................Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Osteosarcoma X X
Maxilla, Osteosarcoma
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma, Metastatic, Pituitary Gland
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + +
Alveolar/Bronchiolar Carcinoma
Osteosarcoma, Metastatic, Bone X
Pheochromocytoma Malignant,Metastatic, Adrenal Medulla
X
.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Pleura
.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0372
0530
0557
0563
0563
0586
0586
0591
0593
0600
0600
0605
0628
0642
0642
0647
0647
0647
0648
0649
0662
0668
0670
0678
0682
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00040
00047
00025
00039
00045
00012
00016
00009
00050
00014
00020
00021
00001
00003
00028
00008
00035
00044
00043
00018
00048
00006
00013
00031
00037
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 7
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +
Leukemia Mononuclear X X X X X X X X X X X X X X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0372
0530
0557
0563
0563
0586
0586
0591
0593
0600
0600
0605
0628
0642
0642
0647
0647
0647
0648
0649
0662
0668
0670
0678
0682
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00040
00047
00025
00039
00045
00012
00016
00009
00050
00014
00020
00021
00001
00003
00028
00008
00035
00044
00043
00018
00048
00006
00013
00031
00037
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 8
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Cecum + A + + + + + + + + + + + + + + + + + + + + + + + 46.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Small, Ileum + A + + + + + + + + + + + + + + + + + + + + + + + 44.........................................................................................................................................................................................................
Intestine Small, Jejunum + A + + + + + + + + + + + + + + + + + + + + + + + 45.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50
Hepatocellular Adenoma X 1.........................................................................................................................................................................................................
Mesentery + + + + + + + + + + 15.........................................................................................................................................................................................................
Oral Mucosa + 1.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0684
0701
0712
0718
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00005
00022
00010
00026
00027
00004
00011
00015
00017
00023
00024
00029
00030
00032
00033
00036
00038
00041
00042
00046
00049
00002
00007
00019
00034 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 9
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Tongue + 1.........................................................................................................................................................................................................
Tooth + + 3
Adamantinoma Malignant 1
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Pheochromocytoma Benign X X X 7
Pheochromocytoma Malignant X X 3
Bilateral, Pheochromocytoma Benign X 2
Bilateral, Pheochromocytoma Malignant X 1
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0684
0701
0712
0718
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00005
00022
00010
00026
00027
00004
00011
00015
00017
00023
00024
00029
00030
00032
00033
00036
00038
00041
00042
00046
00049
00002
00007
00019
00034 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 10
.........................................................................................................................................................................................................Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X X 3
Carcinoma X 1.........................................................................................................................................................................................................
Parathyroid Gland + M + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X X X X X X X X X X X X X X X X X X 36
Carcinoma X 1.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
C-cell, Adenoma X X X X 5
C-cell, Carcinoma X X 2
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Penis 1.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0684
0701
0712
0718
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00005
00022
00010
00026
00027
00004
00011
00015
00017
00023
00024
00029
00030
00032
00033
00036
00038
00041
00042
00046
00049
00002
00007
00019
00034 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 11
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
Bilateral, Interstitial Cell, Adenoma X X X X X X X X X X X X 18
Interstitial Cell, Adenoma X X X X X X X X X 11
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lymph Node + + + + 8.........................................................................................................................................................................................................
Lymph Node, Bronchial M M M M M M M M M M M + M M M M M M M M M M M M + 7.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 0.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + M + + M + + M M + + + + + M M + + + M + + M M 33
Carcinoma, Metastatic, Thyroid Gland X 1.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0684
0701
0712
0718
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00005
00022
00010
00026
00027
00004
00011
00015
00017
00023
00024
00029
00030
00032
00033
00036
00038
00041
00042
00046
00049
00002
00007
00019
00034 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 12
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 47
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Fibroadenoma X 1.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
Basal Cell Adenoma, Multiple X 1
Basal Cell Carcinoma X X X 3
Keratoacanthoma, Multiple X 1
Sebaceous Gland, Adenoma X X 2
Subcutaneous Tissue, Fibroma X 3
Subcutaneous Tissue, Fibrosarcoma X X 3
Subcutaneous Tissue,Hemangiosarcoma
X 1
Subcutaneous Tissue, Osteosarcoma,Metastatic, Bone
1
Subcutaneous Tissue, SchwannomaMalignant
X 1
MUSCULOSKELETAL SYSTEM
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0684
0701
0712
0718
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00005
00022
00010
00026
00027
00004
00011
00015
00017
00023
00024
00029
00030
00032
00033
00036
00038
00041
00042
00046
00049
00002
00007
00019
00034 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 13
.........................................................................................................................................................................................................Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Osteosarcoma 2
Maxilla, Osteosarcoma X 1
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma, Metastatic, Pituitary Gland X 1
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50
Alveolar/Bronchiolar Carcinoma X 1
Osteosarcoma, Metastatic, Bone 1
Pheochromocytoma Malignant,Metastatic, Adrenal Medulla
X 2
.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
.........................................................................................................................................................................................................Pleura + + 2
.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0684
0701
0712
0718
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00005
00022
00010
00026
00027
00004
00011
00015
00017
00023
00024
00029
00030
00032
00033
00036
00038
00041
00042
00046
00049
00002
00007
00019
00034 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 14
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Leukemia Mononuclear X X X X X X X X X X X 25
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0684
0701
0712
0718
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
CONTROL
00005
00022
00010
00026
00027
00004
00011
00015
00017
00023
00024
00029
00030
00032
00033
00036
00038
00041
00042
00046
00049
00002
00007
00019
00034 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 15
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Cecum A + + + + + + + + + + A + + A + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Colon A + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Duodenum A + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Ileum A + + + + + + + + + + A + + A + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Jejunum A + + + + + + + + + + A + + A + + + + + + + + + +.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Mesentery + + + + + +.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0500
0513
0547
0560
0563
0563
0576
0582
0590
0633
0642
0663
0670
0674
0676
0696
0715
0715
0716
0722
0722
0729
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00239
00220
00249
00242
00226
00240
00223
00230
00217
00210
00216
00245
00224
00209
00244
00213
00201
00248
00228
00237
00243
00203
00204
00206
00207
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 16
.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Tongue
Squamous Cell Papilloma.........................................................................................................................................................................................................
Tooth
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
Alveolar/Bronchiolar Carcinoma,Metastatic, Lung
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X
.........................................................................................................................................................................................................Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Pheochromocytoma Benign X X
Pheochromocytoma Malignant X
Bilateral, Pheochromocytoma Benign.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0500
0513
0547
0560
0563
0563
0576
0582
0590
0633
0642
0663
0670
0674
0676
0696
0715
0715
0716
0722
0722
0729
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00239
00220
00249
00242
00226
00240
00223
00230
00217
00210
00216
00245
00224
00209
00244
00213
00201
00248
00228
00237
00243
00203
00204
00206
00207
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 17
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X
Carcinoma X
.........................................................................................................................................................................................................Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X X X X X X X X X X X X X X X X X X X
.........................................................................................................................................................................................................Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Bilateral, C-cell, Adenoma
C-cell, Adenoma X
C-cell, Carcinoma X
Follicular Cell, Adenoma
Follicular Cell, Carcinoma X
GENERAL BODY SYSTEM.........................................................................................................................................................................................................
Peritoneum + +
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0500
0513
0547
0560
0563
0563
0576
0582
0590
0633
0642
0663
0670
0674
0676
0696
0715
0715
0716
0722
0722
0729
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00239
00220
00249
00242
00226
00240
00223
00230
00217
00210
00216
00245
00224
00209
00244
00213
00201
00248
00228
00237
00243
00203
00204
00206
00207
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 18
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + +
Bilateral, Interstitial Cell, Adenoma X X X X X X X X
Interstitial Cell, Adenoma X X X X X X X X
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lymph Node + +.........................................................................................................................................................................................................
Lymph Node, Bronchial M M M M M M M M M M M M M M M M M M + + + M M M M.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M M M M M M M M M M M M + M M M M M M M M.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + + M M + + M + + + + + + + + M + + + + +.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0500
0513
0547
0560
0563
0563
0576
0582
0590
0633
0642
0663
0670
0674
0676
0696
0715
0715
0716
0722
0722
0729
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00239
00220
00249
00242
00226
00240
00223
00230
00217
00210
00216
00245
00224
00209
00244
00213
00201
00248
00228
00237
00243
00203
00204
00206
00207
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 19
.........................................................................................................................................................................................................Thymus + + + + + + + + + + + + + + + + + + + + + + + + M
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma
Fibroadenoma X
.........................................................................................................................................................................................................Skin + + + + + + + + + + + + + + + + + + + + + + + + +
Basal Cell Carcinoma
Keratoacanthoma
Osteosarcoma
Squamous Cell Papilloma X
Pinna, Neural Crest Tumor
Subcutaneous Tissue, Fibroma X X
Subcutaneous Tissue, Fibrosarcoma X
Subcutaneous Tissue, SchwannomaBenign
Subcutaneous Tissue, SchwannomaMalignant, Multiple
MUSCULOSKELETAL SYSTEM
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0500
0513
0547
0560
0563
0563
0576
0582
0590
0633
0642
0663
0670
0674
0676
0696
0715
0715
0716
0722
0722
0729
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00239
00220
00249
00242
00226
00240
00223
00230
00217
00210
00216
00245
00224
00209
00244
00213
00201
00248
00228
00237
00243
00203
00204
00206
00207
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 20
.........................................................................................................................................................................................................Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + +
Alveolar/Bronchiolar Carcinoma.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Pleura.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0500
0513
0547
0560
0563
0563
0576
0582
0590
0633
0642
0663
0670
0674
0676
0696
0715
0715
0716
0722
0722
0729
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00239
00220
00249
00242
00226
00240
00223
00230
00217
00210
00216
00245
00224
00209
00244
00213
00201
00248
00228
00237
00243
00203
00204
00206
00207
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 21
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Cortex, Renal Tubule, Adenoma.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +
Histiocytic Sarcoma X
Leukemia Mononuclear X X X X X X X X X
Mesothelioma Malignant X X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0500
0513
0547
0560
0563
0563
0576
0582
0590
0633
0642
0663
0670
0674
0676
0696
0715
0715
0716
0722
0722
0729
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00239
00220
00249
00242
00226
00240
00223
00230
00217
00210
00216
00245
00224
00209
00244
00213
00201
00248
00228
00237
00243
00203
00204
00206
00207
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 22
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 47.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + A + + + + + + + + + + + + + + + + 47.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + A + + + + + + + + + + + + + + + + 46.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + A + + + + + + + + + + + + + + + + 46.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Mesentery + + + + + + + 13.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00212
00214
00215
00218
00219
00227
00229
00231
00232
00233
00235
00238
00246
00247
00202
00205
00208
00211
00221
00222
00225
00234
00236
00241
00250 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 23
.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
.........................................................................................................................................................................................................Tongue + + + 3
Squamous Cell Papilloma X 1.........................................................................................................................................................................................................
Tooth + + 2
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
Alveolar/Bronchiolar Carcinoma,Metastatic, Lung
X 1
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma 1.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Pheochromocytoma Benign X X X X X X 8
Pheochromocytoma Malignant X 2
Bilateral, Pheochromocytoma Benign X X 2.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00212
00214
00215
00218
00219
00227
00229
00231
00232
00233
00235
00238
00246
00247
00202
00205
00208
00211
00221
00222
00225
00234
00236
00241
00250 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 24
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X X X 4
Carcinoma X X X 4.........................................................................................................................................................................................................
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Pituitary Gland + + + + + + M + + + + + + + + + + + + + + + + + + 49
Adenoma X X X X X X X X X X X X X X X X 35.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Bilateral, C-cell, Adenoma X 1
C-cell, Adenoma X X 3
C-cell, Carcinoma X X X 4
Follicular Cell, Adenoma X 1
Follicular Cell, Carcinoma 1
GENERAL BODY SYSTEM.........................................................................................................................................................................................................
Peritoneum 2
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00212
00214
00215
00218
00219
00227
00229
00231
00232
00233
00235
00238
00246
00247
00202
00205
00208
00211
00221
00222
00225
00234
00236
00241
00250 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 25
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
Bilateral, Interstitial Cell, Adenoma X X X X X X X X X X X X 20
Interstitial Cell, Adenoma X X X X X X X X X X X 19
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lymph Node 2.........................................................................................................................................................................................................
Lymph Node, Bronchial M M M M M M + + M M M M M M M M M M M M M M M M M 5.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 1.........................................................................................................................................................................................................
Lymph Node, Mediastinal M + + + M + M M + M + M M M + + + + + + + + + M M 36.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00212
00214
00215
00218
00219
00227
00229
00231
00232
00233
00235
00238
00246
00247
00202
00205
00208
00211
00221
00222
00225
00234
00236
00241
00250 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 26
.........................................................................................................................................................................................................Thymus + + + + + + M + + M + M M M + + + + + + + + M + + 43
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma X 1
Fibroadenoma 1.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
Basal Cell Carcinoma X 1
Keratoacanthoma X 1
Osteosarcoma X 1
Squamous Cell Papilloma 1
Pinna, Neural Crest Tumor X 1
Subcutaneous Tissue, Fibroma X X 4
Subcutaneous Tissue, Fibrosarcoma 1
Subcutaneous Tissue, SchwannomaBenign
X 1
Subcutaneous Tissue, SchwannomaMalignant, Multiple
X 1
MUSCULOSKELETAL SYSTEM
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00212
00214
00215
00218
00219
00227
00229
00231
00232
00233
00235
00238
00246
00247
00202
00205
00208
00211
00221
00222
00225
00234
00236
00241
00250 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 27
.........................................................................................................................................................................................................Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50
Alveolar/Bronchiolar Carcinoma X X 2.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Pleura + 1.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + M + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00212
00214
00215
00218
00219
00227
00229
00231
00232
00233
00235
00238
00246
00247
00202
00205
00208
00211
00221
00222
00225
00234
00236
00241
00250 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 28
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Cortex, Renal Tubule, Adenoma X 1.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1
Leukemia Mononuclear X X X X X X X 16
Mesothelioma Malignant 2
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
30 PPM
00212
00214
00215
00218
00219
00227
00229
00231
00232
00233
00235
00238
00246
00247
00202
00205
00208
00211
00221
00222
00225
00234
00236
00241
00250 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 29
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Cecum + + A + + + + + + + + A A + + + + + + + + + + + A.........................................................................................................................................................................................................
Intestine Large, Colon + + A + + + + + + + + A A + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + A A + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + A A + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Ileum + A A + + + + + + + + A A + + + + + + + + + + + A.........................................................................................................................................................................................................
Intestine Small, Jejunum + A A + + + + + + + + A A + + + + + + + + + + + +.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Mesentery + + + + + +.........................................................................................................................................................................................................
Oral Mucosa +.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0438
0480
0483
0523
0537
0547
0561
0600
0614
0619
0621
0623
0625
0640
0642
0647
0662
0662
0689
0689
0691
0698
0718
0719
0724
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00419
00444
00445
00446
00402
00403
00416
00433
00415
00412
00439
00409
00420
00423
00429
00450
00428
00434
00431
00449
00441
00442
00436
00422
00407
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 30
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Tongue.........................................................................................................................................................................................................
Tooth +
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Pheochromocytoma Benign X X X X X X X
Pheochromocytoma Complex X
Pheochromocytoma Malignant.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0438
0480
0483
0523
0537
0547
0561
0600
0614
0619
0621
0623
0625
0640
0642
0647
0662
0662
0689
0689
0691
0698
0718
0719
0724
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00419
00444
00445
00446
00402
00403
00416
00433
00415
00412
00439
00409
00420
00423
00429
00450
00428
00434
00431
00449
00441
00442
00436
00422
00407
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 31
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X X
Carcinoma X
.........................................................................................................................................................................................................Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X X X X X X X X X X X X X X X X X
Carcinoma.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Bilateral, C-cell, Adenoma
C-cell, Adenoma X X
C-cell, Carcinoma X X
Follicular Cell, Adenoma X
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0438
0480
0483
0523
0537
0547
0561
0600
0614
0619
0621
0623
0625
0640
0642
0647
0662
0662
0689
0689
0691
0698
0718
0719
0724
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00419
00444
00445
00446
00402
00403
00416
00433
00415
00412
00439
00409
00420
00423
00429
00450
00428
00434
00431
00449
00441
00442
00436
00422
00407
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 32
Adenoma
Carcinoma X
.........................................................................................................................................................................................................Prostate + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma X
.........................................................................................................................................................................................................Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Testes + + + + + + + + + + + + + + + + + + + + + + + + +
Bilateral, Interstitial Cell, Adenoma X X X X X X X
Interstitial Cell, Adenoma X X X X X
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lymph Node + + + + + +
Deep Cervical, Carcinoma, Metastatic,Thyroid Gland
X
.........................................................................................................................................................................................................Lymph Node, Bronchial M M M M M M M M M M + M + M M M M + M M M M M M M
.........................................................................................................................................................................................................Lymph Node, Mandibular + M M M M M + M M M M M M M M M M M M M M M M M M
.........................................................................................................................................................................................................Lymph Node, Mediastinal + + + + M M + + + + + M + + + + + + M + + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0438
0480
0483
0523
0537
0547
0561
0600
0614
0619
0621
0623
0625
0640
0642
0647
0662
0662
0689
0689
0691
0698
0718
0719
0724
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00419
00444
00445
00446
00402
00403
00416
00433
00415
00412
00439
00409
00420
00423
00429
00450
00428
00434
00431
00449
00441
00442
00436
00422
00407
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 33
Fibrous Histiocytoma, Metastatic, Skin.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Thymus + + + + M + + + + + + + + + + + + + M + + + + + +
Thymoma Benign
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma X
.........................................................................................................................................................................................................Skin + + + + + + + + + + + + + + + + + + + + + + + + +
Basal Cell Carcinoma X X
Keratoacanthoma
Squamous Cell Carcinoma
Squamous Cell Papilloma X
Subcutaneous Tissue, Fibroma
Subcutaneous Tissue, Fibrosarcoma X
Subcutaneous Tissue, FibrousHistiocytoma
Subcutaneous Tissue, Lipoma
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0438
0480
0483
0523
0537
0547
0561
0600
0614
0619
0621
0623
0625
0640
0642
0647
0662
0662
0689
0689
0691
0698
0718
0719
0724
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00419
00444
00445
00446
00402
00403
00416
00433
00415
00412
00439
00409
00420
00423
00429
00450
00428
00434
00431
00449
00441
00442
00436
00422
00407
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 34
Subcutaneous Tissue, Sarcoma
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Cranium, Osteosarcoma X
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma, Metastatic, Pituitary Gland
Osteosarcoma, Metastatic, Bone X
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + +
Alveolar/Bronchiolar Adenoma X
Alveolar/Bronchiolar Carcinoma
Pheochromocytoma Complex,Metastatic, Adrenal Medulla
X
.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0438
0480
0483
0523
0537
0547
0561
0600
0614
0619
0621
0623
0625
0640
0642
0647
0662
0662
0689
0689
0691
0698
0718
0719
0724
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00419
00444
00445
00446
00402
00403
00416
00433
00415
00412
00439
00409
00420
00423
00429
00450
00428
00434
00431
00449
00441
00442
00436
00422
00407
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 35
Nose + + + + + + + + + + + + A + + + + + + + + + + + +
Adenoma, Tubular.........................................................................................................................................................................................................
Pleura.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + A A + + + + + + + + + + + +.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Zymbal's Gland +
Carcinoma X
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Cortex, Renal Tubule, Adenoma.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0438
0480
0483
0523
0537
0547
0561
0600
0614
0619
0621
0623
0625
0640
0642
0647
0662
0662
0689
0689
0691
0698
0718
0719
0724
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00419
00444
00445
00446
00402
00403
00416
00433
00415
00412
00439
00409
00420
00423
00429
00450
00428
00434
00431
00449
00441
00442
00436
00422
00407
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 36
.........................................................................................................................................................................................................Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +
Leukemia Mononuclear X X X X
Mesothelioma Malignant
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0438
0480
0483
0523
0537
0547
0561
0600
0614
0619
0621
0623
0625
0640
0642
0647
0662
0662
0689
0689
0691
0698
0718
0719
0724
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00419
00444
00445
00446
00402
00403
00416
00433
00415
00412
00439
00409
00420
00423
00429
00450
00428
00434
00431
00449
00441
00442
00436
00422
00407
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 37
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 46.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 47.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 45.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 46.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Mesentery + + + + + + 12.........................................................................................................................................................................................................
Oral Mucosa + + 3.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X 1.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00405
00408
00410
00411
00414
00417
00418
00424
00425
00426
00427
00432
00435
00437
00447
00448
00401
00404
00406
00413
00421
00430
00438
00440
00443 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 38
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Tongue + + + 3.........................................................................................................................................................................................................
Tooth 1
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + M + + + + + + 49
Adenoma X X X 3.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + M + + + + + + 49
Pheochromocytoma Benign X X X X X 12
Pheochromocytoma Complex 1
Pheochromocytoma Malignant X 1.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00405
00408
00410
00411
00414
00417
00418
00424
00425
00426
00427
00432
00435
00437
00447
00448
00401
00404
00406
00413
00421
00430
00438
00440
00443 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 39
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X X 4
Carcinoma X X 3.........................................................................................................................................................................................................
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + M + + + 49
Adenoma X X X X X X X X X X X X X X X X X X X 36
Carcinoma X 1.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Bilateral, C-cell, Adenoma X 1
C-cell, Adenoma X X 4
C-cell, Carcinoma 2
Follicular Cell, Adenoma X 2
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00405
00408
00410
00411
00414
00417
00418
00424
00425
00426
00427
00432
00435
00437
00447
00448
00401
00404
00406
00413
00421
00430
00438
00440
00443 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 40
Adenoma X 1
Carcinoma 1.........................................................................................................................................................................................................
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma 1.........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
Bilateral, Interstitial Cell, Adenoma X X X X X X X X X X 17
Interstitial Cell, Adenoma X X X X X X X X X 14
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lymph Node + 7
Deep Cervical, Carcinoma, Metastatic,Thyroid Gland
1
.........................................................................................................................................................................................................Lymph Node, Bronchial + M M M M M M M M M M M M M M M M M M M M M M M M 4
.........................................................................................................................................................................................................Lymph Node, Mandibular M M M M M + M M M M M M M M M M M M M M M M M M M 3
.........................................................................................................................................................................................................Lymph Node, Mediastinal + M + + M + + M + M + + M + + + M M + M + M M + + 36
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00405
00408
00410
00411
00414
00417
00418
00424
00425
00426
00427
00432
00435
00437
00447
00448
00401
00404
00406
00413
00421
00430
00438
00440
00443 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 41
Fibrous Histiocytoma, Metastatic, Skin X 1.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Thymus + + + + + + + + + + + + M M + + + + + + + + + M M 44
Thymoma Benign X 1
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma X 2.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
Basal Cell Carcinoma 2
Keratoacanthoma X X 2
Squamous Cell Carcinoma X 1
Squamous Cell Papilloma 1
Subcutaneous Tissue, Fibroma X X X X 4
Subcutaneous Tissue, Fibrosarcoma 1
Subcutaneous Tissue, FibrousHistiocytoma
X 1
Subcutaneous Tissue, Lipoma X 1
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00405
00408
00410
00411
00414
00417
00418
00424
00425
00426
00427
00432
00435
00437
00447
00448
00401
00404
00406
00413
00421
00430
00438
00440
00443 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 42
Subcutaneous Tissue, Sarcoma X 1
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Cranium, Osteosarcoma 1
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma, Metastatic, Pituitary Gland X 1
Osteosarcoma, Metastatic, Bone 1
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50
Alveolar/Bronchiolar Adenoma 1
Alveolar/Bronchiolar Carcinoma X 1
Pheochromocytoma Complex,Metastatic, Adrenal Medulla
1
.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00405
00408
00410
00411
00414
00417
00418
00424
00425
00426
00427
00432
00435
00437
00447
00448
00401
00404
00406
00413
00421
00430
00438
00440
00443 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 43
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 49
Adenoma, Tubular X 1.........................................................................................................................................................................................................
Pleura + + + 3.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Zymbal's Gland 1
Carcinoma 1
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Cortex, Renal Tubule, Adenoma X 1.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00405
00408
00410
00411
00414
00417
00418
00424
00425
00426
00427
00432
00435
00437
00447
00448
00401
00404
00406
00413
00421
00430
00438
00440
00443 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 44
.........................................................................................................................................................................................................Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50
Leukemia Mononuclear X 5
Mesothelioma Malignant X 1
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
60 PPM
00405
00408
00410
00411
00414
00417
00418
00424
00425
00426
00427
00432
00435
00437
00447
00448
00401
00404
00406
00413
00421
00430
00438
00440
00443 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 45
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + A + + + + +.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma X
.........................................................................................................................................................................................................Intestine Small, Ileum + A + + + + + + + + + + + + + + + + + A + + + + +
.........................................................................................................................................................................................................Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + A + + + + +
.........................................................................................................................................................................................................Liver + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Mesentery + + + +
.........................................................................................................................................................................................................Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0381
0483
0484
0566
0577
0586
0614
0619
0619
0641
0647
0654
0663
0674
0687
0689
0695
0701
0703
0708
0722
0725
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00646
00642
00630
00603
00609
00629
00602
00606
00616
00648
00601
00612
00636
00634
00631
00644
00633
00627
00611
00647
00621
00619
00605
00610
00613
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 46
.........................................................................................................................................................................................................Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Tongue +
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Blood Vessel +.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Pheochromocytoma Benign X X X X X
.........................................................................................................................................................................................................Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X
Carcinoma X X
.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0381
0483
0484
0566
0577
0586
0614
0619
0619
0641
0647
0654
0663
0674
0687
0689
0695
0701
0703
0708
0722
0725
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00646
00642
00630
00603
00609
00629
00602
00606
00616
00648
00601
00612
00636
00634
00631
00644
00633
00627
00611
00647
00621
00619
00605
00610
00613
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 47
Parathyroid Gland M + + + + M + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X X X X X X X X X X X X X X X X X
.........................................................................................................................................................................................................Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
C-cell, Adenoma X X
C-cell, Carcinoma
Follicular Cell, Adenoma X
Follicular Cell, Carcinoma
GENERAL BODY SYSTEM.........................................................................................................................................................................................................
Peritoneum + +
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + + + + + + + + + I + + + + + +
Carcinoma X
.........................................................................................................................................................................................................Prostate + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0381
0483
0484
0566
0577
0586
0614
0619
0619
0641
0647
0654
0663
0674
0687
0689
0695
0701
0703
0708
0722
0725
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00646
00642
00630
00603
00609
00629
00602
00606
00616
00648
00601
00612
00636
00634
00631
00644
00633
00627
00611
00647
00621
00619
00605
00610
00613
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 48
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + +
Bilateral, Interstitial Cell, Adenoma X X X X X X X X X X X X
Interstitial Cell, Adenoma X X X X
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lymph Node.........................................................................................................................................................................................................
Lymph Node, Bronchial M M M M M M M M M M M M M M M M + M M M M M M M M.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + M + + + + + + + M + M + M M + + + M + + M +
Carcinoma, Metastatic, Zymbal'S Gland X
.........................................................................................................................................................................................................Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Thymus + + + M + + + + + + + M + + + + + + + + M + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0381
0483
0484
0566
0577
0586
0614
0619
0619
0641
0647
0654
0663
0674
0687
0689
0695
0701
0703
0708
0722
0725
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00646
00642
00630
00603
00609
00629
00602
00606
00616
00648
00601
00612
00636
00634
00631
00644
00633
00627
00611
00647
00621
00619
00605
00610
00613
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 49
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma
Fibroadenoma.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + +
Basal Cell Adenoma X
Basal Cell Carcinoma X X
Keratoacanthoma X
Squamous Cell Papilloma X
Sebaceous Gland, Adenoma
Subcutaneous Tissue, Fibroma X X X X X
Subcutaneous Tissue, Lipoma
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma, Metastatic, Zymbal'S Gland X
Cranium, Osteosarcoma X
NERVOUS SYSTEM
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0381
0483
0484
0566
0577
0586
0614
0619
0619
0641
0647
0654
0663
0674
0687
0689
0695
0701
0703
0708
0722
0725
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00646
00642
00630
00603
00609
00629
00602
00606
00616
00648
00601
00612
00636
00634
00631
00644
00633
00627
00611
00647
00621
00619
00605
00610
00613
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 50
.........................................................................................................................................................................................................Brain + + + + + + + + + + + + + + + + + + + + + + + + +
Pineal Gland, Carcinoma X
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + +
Alveolar/Bronchiolar Adenoma.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Pleura + + + +.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Zymbal's Gland +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0381
0483
0484
0566
0577
0586
0614
0619
0619
0641
0647
0654
0663
0674
0687
0689
0695
0701
0703
0708
0722
0725
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00646
00642
00630
00603
00609
00629
00602
00606
00616
00648
00601
00612
00636
00634
00631
00644
00633
00627
00611
00647
00621
00619
00605
00610
00613
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 51
Carcinoma X
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Cortex, Renal Tubule, Adenoma X X
.........................................................................................................................................................................................................Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +
Histiocytic Sarcoma X
Leukemia Mononuclear X X
Mesothelioma Malignant X X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0381
0483
0484
0566
0577
0586
0614
0619
0619
0641
0647
0654
0663
0674
0687
0689
0695
0701
0703
0708
0722
0725
0729
0729
0729
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00646
00642
00630
00603
00609
00629
00602
00606
00616
00648
00601
00612
00636
00634
00631
00644
00633
00627
00611
00647
00621
00619
00605
00610
00613
males(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 52
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma 1.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Mesentery + + + + + + + 11.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma X 1.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00614
00617
00622
00625
00638
00640
00641
00643
00649
00650
00604
00607
00608
00615
00618
00620
00623
00624
00626
00628
00632
00635
00637
00639
00645 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 53
.........................................................................................................................................................................................................Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
.........................................................................................................................................................................................................Tongue 1
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Blood Vessel 1.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Pheochromocytoma Benign X X X X 9.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma 1
Carcinoma X X 4.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00614
00617
00622
00625
00638
00640
00641
00643
00649
00650
00604
00607
00608
00615
00618
00620
00623
00624
00626
00628
00632
00635
00637
00639
00645 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 54
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + M + + + 49
Adenoma X X X X X X X X X X X X X X X X 33.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
C-cell, Adenoma X X 4
C-cell, Carcinoma X X 2
Follicular Cell, Adenoma 1
Follicular Cell, Carcinoma X 1
GENERAL BODY SYSTEM.........................................................................................................................................................................................................
Peritoneum + 3
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
Carcinoma X 2.........................................................................................................................................................................................................
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00614
00617
00622
00625
00638
00640
00641
00643
00649
00650
00604
00607
00608
00615
00618
00620
00623
00624
00626
00628
00632
00635
00637
00639
00645 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 55
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
Bilateral, Interstitial Cell, Adenoma X X X X X X X X X X X X X X X X X X 30
Interstitial Cell, Adenoma X X X X X X X 11
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lymph Node + 1.........................................................................................................................................................................................................
Lymph Node, Bronchial M M M M M M M M M + M M M M M M M + M M M M M M + 4.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 0.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + M M M + M M + + + + + M + M + M M M M + M 31
Carcinoma, Metastatic, Zymbal'S Gland 1.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Thymus + + + + + + + + M + + M + + + M + M + + + + + + + 43
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00614
00617
00622
00625
00638
00640
00641
00643
00649
00650
00604
00607
00608
00615
00618
00620
00623
00624
00626
00628
00632
00635
00637
00639
00645 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 56
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma X 1
Fibroadenoma X 1.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
Basal Cell Adenoma 1
Basal Cell Carcinoma X 3
Keratoacanthoma X 2
Squamous Cell Papilloma X X X 4
Sebaceous Gland, Adenoma X X 2
Subcutaneous Tissue, Fibroma 5
Subcutaneous Tissue, Lipoma X 1
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma, Metastatic, Zymbal'S Gland 1
Cranium, Osteosarcoma 1
NERVOUS SYSTEM
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00614
00617
00622
00625
00638
00640
00641
00643
00649
00650
00604
00607
00608
00615
00618
00620
00623
00624
00626
00628
00632
00635
00637
00639
00645 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 57
.........................................................................................................................................................................................................Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
Pineal Gland, Carcinoma 1
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50
Alveolar/Bronchiolar Adenoma X X 2.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Pleura + + + + + + 10.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Zymbal's Gland 1
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00614
00617
00622
00625
00638
00640
00641
00643
00649
00650
00604
00607
00608
00615
00618
00620
00623
00624
00626
00628
00632
00635
00637
00639
00645 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 58
Carcinoma 1
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Cortex, Renal Tubule, Adenoma 2.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1
Leukemia Mononuclear 2
Mesothelioma Malignant X 3
*** END OF MALE DATA ***
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
120 PPM
00614
00617
00622
00625
00638
00640
00641
00643
00649
00650
00604
00607
00608
00615
00618
00620
00623
00624
00626
00628
00632
00635
00637
00639
00645 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 59
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + A + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + A + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Mesentery + + + + +.........................................................................................................................................................................................................
Oral Mucosa +.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0038
0420
0522
0523
0582
0591
0624
0628
0648
0666
0675
0677
0680
0681
0682
0691
0697
0717
0717
0730
0730
0730
0730
0730
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00119
00106
00118
00105
00130
00111
00132
00112
00144
00140
00115
00117
00145
00148
00101
00103
00142
00120
00125
00113
00116
00123
00124
00139
00104
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 60
.........................................................................................................................................................................................................Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Tongue +
Squamous Cell Carcinoma X
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X X
Bilateral, Adenoma X
.........................................................................................................................................................................................................Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Pheochromocytoma Benign
Pheochromocytoma Malignant.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0038
0420
0522
0523
0582
0591
0624
0628
0648
0666
0675
0677
0680
0681
0682
0691
0697
0717
0717
0730
0730
0730
0730
0730
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00119
00106
00118
00105
00130
00111
00132
00112
00144
00140
00115
00117
00145
00148
00101
00103
00142
00120
00125
00113
00116
00123
00124
00139
00104
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 61
Parathyroid Gland + + + + + + + + + + + + + + + M + + + + + + + + +.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + M + + + + + + + + + + +
Adenoma X X X X X X X X X X X X X X X X X X X
.........................................................................................................................................................................................................Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
C-cell, Adenoma X
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma X X
.........................................................................................................................................................................................................Ovary + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Uterus + + + + + + + + + + + + + + + + + + + + + + + + +
Polyp Stromal X X X
Endometrium, Adenoma
Endometrium, Carcinoma
HEMATOPOIETIC SYSTEM
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0038
0420
0522
0523
0582
0591
0624
0628
0648
0666
0675
0677
0680
0681
0682
0691
0697
0717
0717
0730
0730
0730
0730
0730
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00119
00106
00118
00105
00130
00111
00132
00112
00144
00140
00115
00117
00145
00148
00101
00103
00142
00120
00125
00113
00116
00123
00124
00139
00104
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 62
.........................................................................................................................................................................................................Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Lymph Node + + +
.........................................................................................................................................................................................................Lymph Node, Bronchial M + M + M M M M M M + M M M M M M M M M M M M M M
.........................................................................................................................................................................................................Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M
.........................................................................................................................................................................................................Lymph Node, Mediastinal + + + + + + M + + + + + + M M + + M + + M M + + M
.........................................................................................................................................................................................................Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Thymus + + + + + + + + + M + + + + + + + + + + + + + + +
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma X X
Fibroadenoma X X X X X
Fibroadenoma, Multiple.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0038
0420
0522
0523
0582
0591
0624
0628
0648
0666
0675
0677
0680
0681
0682
0691
0697
0717
0717
0730
0730
0730
0730
0730
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00119
00106
00118
00105
00130
00111
00132
00112
00144
00140
00115
00117
00145
00148
00101
00103
00142
00120
00125
00113
00116
00123
00124
00139
00104
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 63
Lip, Squamous Cell Carcinoma X
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Squamous Cell Carcinoma, Metastatic,Skin
X
.........................................................................................................................................................................................................Skeletal Muscle +
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma, Metastatic, Zymbal'S Gland X
Squamous Cell Carcinoma, Metastatic,Tongue
X
.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0038
0420
0522
0523
0582
0591
0624
0628
0648
0666
0675
0677
0680
0681
0682
0691
0697
0717
0717
0730
0730
0730
0730
0730
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00119
00106
00118
00105
00130
00111
00132
00112
00144
00140
00115
00117
00145
00148
00101
00103
00142
00120
00125
00113
00116
00123
00124
00139
00104
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 64
.........................................................................................................................................................................................................Pleura + + + +
.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + I + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Zymbal's Gland +
Carcinoma X
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +
Histiocytic Sarcoma X X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0038
0420
0522
0523
0582
0591
0624
0628
0648
0666
0675
0677
0680
0681
0682
0691
0697
0717
0717
0730
0730
0730
0730
0730
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00119
00106
00118
00105
00130
00111
00132
00112
00144
00140
00115
00117
00145
00148
00101
00103
00142
00120
00125
00113
00116
00123
00124
00139
00104
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 65
Leukemia Mononuclear X X X X X X X X X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0038
0420
0522
0523
0582
0591
0624
0628
0648
0666
0675
0677
0680
0681
0682
0691
0697
0717
0717
0730
0730
0730
0730
0730
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00119
00106
00118
00105
00130
00111
00132
00112
00144
00140
00115
00117
00145
00148
00101
00103
00142
00120
00125
00113
00116
00123
00124
00139
00104
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 66
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Mesentery + + + + + 10.........................................................................................................................................................................................................
Oral Mucosa 1.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00107
00110
00114
00121
00126
00128
00133
00134
00135
00136
00137
00141
00143
00147
00149
00102
00108
00109
00122
00127
00129
00131
00138
00146
00150 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 67
.........................................................................................................................................................................................................Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
.........................................................................................................................................................................................................Tongue 1
Squamous Cell Carcinoma 1
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X X X X X 7
Bilateral, Adenoma 1.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Pheochromocytoma Benign X X 2
Pheochromocytoma Malignant X 1.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00107
00110
00114
00121
00126
00128
00133
00134
00135
00136
00137
00141
00143
00147
00149
00102
00108
00109
00122
00127
00129
00131
00138
00146
00150 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 68
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
Adenoma X X X X X X X X X X X X X X X X X 36.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
C-cell, Adenoma X X 3
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma X X 4.........................................................................................................................................................................................................
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Polyp Stromal X X X 6
Endometrium, Adenoma X 1
Endometrium, Carcinoma X 1
HEMATOPOIETIC SYSTEM
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00107
00110
00114
00121
00126
00128
00133
00134
00135
00136
00137
00141
00143
00147
00149
00102
00108
00109
00122
00127
00129
00131
00138
00146
00150 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 69
.........................................................................................................................................................................................................Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50
.........................................................................................................................................................................................................Lymph Node + 4
.........................................................................................................................................................................................................Lymph Node, Bronchial M M M M M M M M M M M M M M M M M M M M M M M M M 3
.........................................................................................................................................................................................................Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 0
.........................................................................................................................................................................................................Lymph Node, Mediastinal M + M + M M + + M M + + + + M + M + M M + + + + + 33
.........................................................................................................................................................................................................Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50
.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50
.........................................................................................................................................................................................................Thymus + + M + + + + + M M + + + + + + + + M + + + + M + 44
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma X 3
Fibroadenoma X X X X X X X X 13
Fibroadenoma, Multiple X 1.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00107
00110
00114
00121
00126
00128
00133
00134
00135
00136
00137
00141
00143
00147
00149
00102
00108
00109
00122
00127
00129
00131
00138
00146
00150 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 70
Lip, Squamous Cell Carcinoma 1
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Squamous Cell Carcinoma, Metastatic,Skin
1
.........................................................................................................................................................................................................Skeletal Muscle 1
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma, Metastatic, Zymbal'S Gland 1
Squamous Cell Carcinoma, Metastatic,Tongue
1
.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00107
00110
00114
00121
00126
00128
00133
00134
00135
00136
00137
00141
00143
00147
00149
00102
00108
00109
00122
00127
00129
00131
00138
00146
00150 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 71
.........................................................................................................................................................................................................Pleura + + + + + 9
.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Zymbal's Gland 1
Carcinoma 1
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 2
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00107
00110
00114
00121
00126
00128
00133
00134
00135
00136
00137
00141
00143
00147
00149
00102
00108
00109
00122
00127
00129
00131
00138
00146
00150 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 72
Leukemia Mononuclear X X X X X X X X 17
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
CONTROL
00107
00110
00114
00121
00126
00128
00133
00134
00135
00136
00137
00141
00143
00147
00149
00102
00108
00109
00122
00127
00129
00131
00138
00146
00150 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 73
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Polyp Adenomatous.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Mesentery + + + + + + + + +.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0196
0438
0474
0516
0528
0556
0644
0651
0680
0699
0703
0708
0712
0725
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00333
00307
00329
00312
00342
00302
00335
00334
00314
00350
00322
00344
00323
00301
00317
00324
00326
00337
00338
00343
00304
00305
00309
00310
00311
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 74
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Tongue
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X X
.........................................................................................................................................................................................................Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Pheochromocytoma Benign.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma
Carcinoma.........................................................................................................................................................................................................
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0196
0438
0474
0516
0528
0556
0644
0651
0680
0699
0703
0708
0712
0725
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00333
00307
00329
00312
00342
00302
00335
00334
00314
00350
00322
00344
00323
00301
00317
00324
00326
00337
00338
00343
00304
00305
00309
00310
00311
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 75
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X X X X X X X X X X X X X X
Carcinoma X
.........................................................................................................................................................................................................Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
C-cell, Adenoma X
C-cell, Carcinoma X
Follicular Cell, Adenoma
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma.........................................................................................................................................................................................................
Ovary + + + + + + + + + + + + + + + + + + + + + + + + +
Granulosa Cell Tumor Malignant.........................................................................................................................................................................................................
Oviduct.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + +
Leiomyosarcoma
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0196
0438
0474
0516
0528
0556
0644
0651
0680
0699
0703
0708
0712
0725
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00333
00307
00329
00312
00342
00302
00335
00334
00314
00350
00322
00344
00323
00301
00317
00324
00326
00337
00338
00343
00304
00305
00309
00310
00311
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 76
Polyp Stromal X X X X X
Sarcoma Stromal
Bilateral, Polyp Stromal X
Endometrium, Carcinoma
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lymph Node + +.........................................................................................................................................................................................................
Lymph Node, Bronchial M M M M M M M M M M M M + M M M M M M M M M M + M.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + M + M + M + + + + + + + + M + + + + + +.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +
Osteosarcoma.........................................................................................................................................................................................................
Thymus + + M + + + + M + + + + + + + + + + + M + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0196
0438
0474
0516
0528
0556
0644
0651
0680
0699
0703
0708
0712
0725
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00333
00307
00329
00312
00342
00302
00335
00334
00314
00350
00322
00344
00323
00301
00317
00324
00326
00337
00338
00343
00304
00305
00309
00310
00311
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 77
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma X
Fibroadenoma X X X X X X X X X
Fibroadenoma, Multiple X X X
.........................................................................................................................................................................................................Skin + + + + + + + + + + + + + + + + + + + + + + + + +
Basal Cell Carcinoma X
Keratoacanthoma X X
Subcutaneous Tissue, Fibroma X
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Skeletal Muscle +
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Peripheral Nerve +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0196
0438
0474
0516
0528
0556
0644
0651
0680
0699
0703
0708
0712
0725
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00333
00307
00329
00312
00342
00302
00335
00334
00314
00350
00322
00344
00323
00301
00317
00324
00326
00337
00338
00343
00304
00305
00309
00310
00311
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 78
.........................................................................................................................................................................................................Spinal Cord +
Oligodendroglioma Malignant X
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + +
Sarcoma, Metastatic, Uncertain PrimarySite
X
.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Respiratory Epithelium, Turbinate,Adenoma
.........................................................................................................................................................................................................Pleura + + + +
.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0196
0438
0474
0516
0528
0556
0644
0651
0680
0699
0703
0708
0712
0725
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00333
00307
00329
00312
00342
00302
00335
00334
00314
00350
00322
00344
00323
00301
00317
00324
00326
00337
00338
00343
00304
00305
00309
00310
00311
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 79
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
Transitional Epithelium, Papilloma
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +
Histiocytic Sarcoma X X
Leukemia Mononuclear X X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0196
0438
0474
0516
0528
0556
0644
0651
0680
0699
0703
0708
0712
0725
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00333
00307
00329
00312
00342
00302
00335
00334
00314
00350
00322
00344
00323
00301
00317
00324
00326
00337
00338
00343
00304
00305
00309
00310
00311
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 80
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Polyp Adenomatous X 1.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Mesentery + + + + + + + + + 18.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00313
00318
00320
00321
00325
00328
00330
00331
00336
00339
00340
00345
00346
00303
00306
00308
00315
00316
00319
00327
00332
00341
00347
00348
00349 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 81
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Tongue + 1
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X X X 5.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Pheochromocytoma Benign X 1.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X 1
Carcinoma X 1.........................................................................................................................................................................................................
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00313
00318
00320
00321
00325
00328
00330
00331
00336
00339
00340
00345
00346
00303
00306
00308
00315
00316
00319
00327
00332
00341
00347
00348
00349 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 82
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X X X X X X X X X X X X X X X 29
Carcinoma 1.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
C-cell, Adenoma X X 3
C-cell, Carcinoma X 2
Follicular Cell, Adenoma X 1
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma X X 2.........................................................................................................................................................................................................
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50
Granulosa Cell Tumor Malignant X 1.........................................................................................................................................................................................................
Oviduct + 1.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Leiomyosarcoma X 1
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00313
00318
00320
00321
00325
00328
00330
00331
00336
00339
00340
00345
00346
00303
00306
00308
00315
00316
00319
00327
00332
00341
00347
00348
00349 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 83
Polyp Stromal X X X 8
Sarcoma Stromal X 1
Bilateral, Polyp Stromal X 2
Endometrium, Carcinoma X 1
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lymph Node + 3.........................................................................................................................................................................................................
Lymph Node, Bronchial + M M M M M M M M M M M + M M M + M M M M M M M M 5.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 0.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + M M M M M M + + + + + + M + M + + + + M M 36.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50
Osteosarcoma X 1.........................................................................................................................................................................................................
Thymus + + + + + M + + + M + + + + + + + + + + + + + + + 45
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00313
00318
00320
00321
00325
00328
00330
00331
00336
00339
00340
00345
00346
00303
00306
00308
00315
00316
00319
00327
00332
00341
00347
00348
00349 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 84
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma X X 3
Fibroadenoma X X X X X 14
Fibroadenoma, Multiple X X X X X X 9.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
Basal Cell Carcinoma X 2
Keratoacanthoma 2
Subcutaneous Tissue, Fibroma 1
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Skeletal Muscle 1
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Peripheral Nerve 1
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00313
00318
00320
00321
00325
00328
00330
00331
00336
00339
00340
00345
00346
00303
00306
00308
00315
00316
00319
00327
00332
00341
00347
00348
00349 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 85
.........................................................................................................................................................................................................Spinal Cord 1
Oligodendroglioma Malignant 1
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50
Sarcoma, Metastatic, Uncertain PrimarySite
1
.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Respiratory Epithelium, Turbinate,Adenoma
X 1
.........................................................................................................................................................................................................Pleura + + + + + + + + + + + + 16
.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00313
00318
00320
00321
00325
00328
00330
00331
00336
00339
00340
00345
00346
00303
00306
00308
00315
00316
00319
00327
00332
00341
00347
00348
00349 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 86
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
Transitional Epithelium, Papilloma X 1
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 2
Leukemia Mononuclear 2
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
30 PPM
00313
00318
00320
00321
00325
00328
00330
00331
00336
00339
00340
00345
00346
00303
00306
00308
00315
00316
00319
00327
00332
00341
00347
00348
00349 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 87
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Cecum + + A + + + + + + + + + + + + + + A + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + A + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Ileum + + A + + + + + + + + + + + + + + A + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Jejunum + + A + + + + + + + + + + + + A + A + + + + + + +.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + +
Fibrous Histiocytoma X
Fibrous Histiocytoma, Metastatic, Skin X
Hepatocellular Carcinoma.........................................................................................................................................................................................................
Mesentery + + + + + +.........................................................................................................................................................................................................
Oral Mucosa.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0425
0509
0515
0528
0591
0607
0614
0627
0631
0641
0663
0685
0704
0704
0708
0715
0717
0723
0727
0730
0730
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00524
00543
00539
00515
00530
00520
00510
00536
00522
00516
00541
00547
00501
00517
00538
00550
00506
00509
00531
00518
00521
00502
00504
00505
00508
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 88
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
Epithelium, Adenoma X
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma
Fibrous Histiocytoma, Metastatic, Skin X
Bilateral, Adenoma X
.........................................................................................................................................................................................................Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Pheochromocytoma Malignant.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0425
0509
0515
0528
0591
0607
0614
0627
0631
0641
0663
0685
0704
0704
0708
0715
0717
0723
0727
0730
0730
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00524
00543
00539
00515
00530
00520
00510
00536
00522
00516
00541
00547
00501
00517
00538
00550
00506
00509
00531
00518
00521
00502
00504
00505
00508
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 89
Adenoma X
.........................................................................................................................................................................................................Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X X X X X X X X X X X X X X X X X X
Carcinoma.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
C-cell, Adenoma X X
Follicular Cell, Carcinoma
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma X X
.........................................................................................................................................................................................................Ovary + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Uterus + + + + + + + + + + + + + + + + + + + + + + + + +
Polyp Stromal X X X X X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0425
0509
0515
0528
0591
0607
0614
0627
0631
0641
0663
0685
0704
0704
0708
0715
0717
0723
0727
0730
0730
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00524
00543
00539
00515
00530
00520
00510
00536
00522
00516
00541
00547
00501
00517
00538
00550
00506
00509
00531
00518
00521
00502
00504
00505
00508
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 90
Sarcoma Stromal X
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lymph Node +
Renal, Stromal Nephroma, Metastatic,Kidney
X
.........................................................................................................................................................................................................Lymph Node, Bronchial M M M + M M M M M M M M M M M M M M M M M M M M M
.........................................................................................................................................................................................................Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M
.........................................................................................................................................................................................................Lymph Node, Mediastinal + + + + M + + + + + + + + + M + + + M + + M + + +
Fibrous Histiocytoma, Metastatic, Skin X
.........................................................................................................................................................................................................Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + +
Fibrous Histiocytoma, Metastatic, Skin X
.........................................................................................................................................................................................................Thymus + + + + M + + + + + + + + + + + + M + + + + + + +
Thymoma Benign X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0425
0509
0515
0528
0591
0607
0614
0627
0631
0641
0663
0685
0704
0704
0708
0715
0717
0723
0727
0730
0730
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00524
00543
00539
00515
00530
00520
00510
00536
00522
00516
00541
00547
00501
00517
00538
00550
00506
00509
00531
00518
00521
00502
00504
00505
00508
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 91
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma X X X
Fibroadenoma X X X X X X X X X
Fibroadenoma, Multiple X X X
.........................................................................................................................................................................................................Skin + + + + + + + + + + + + + + + + + + + + + + + + +
Fibrous Histiocytoma X
Subcutaneous Tissue, FibrousHistiocytoma
X
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Rib, Osteosarcoma X
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0425
0509
0515
0528
0591
0607
0614
0627
0631
0641
0663
0685
0704
0704
0708
0715
0717
0723
0727
0730
0730
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00524
00543
00539
00515
00530
00520
00510
00536
00522
00516
00541
00547
00501
00517
00538
00550
00506
00509
00531
00518
00521
00502
00504
00505
00508
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 92
Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + +
Fibrous Histiocytoma, Metastatic, Skin X
Osteosarcoma, Metastatic, Bone X
Stromal Nephroma, Metastatic, Kidney X
.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Pleura + + + + + +
.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + I + + + + + + + + +.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Fibrous Histiocytoma, Metastatic, Skin X
Nephroblastoma X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0425
0509
0515
0528
0591
0607
0614
0627
0631
0641
0663
0685
0704
0704
0708
0715
0717
0723
0727
0730
0730
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00524
00543
00539
00515
00530
00520
00510
00536
00522
00516
00541
00547
00501
00517
00538
00550
00506
00509
00531
00518
00521
00502
00504
00505
00508
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 93
.........................................................................................................................................................................................................Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +
Histiocytic Sarcoma X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0425
0509
0515
0528
0591
0607
0614
0627
0631
0641
0663
0685
0704
0704
0708
0715
0717
0723
0727
0730
0730
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00524
00543
00539
00515
00530
00520
00510
00536
00522
00516
00541
00547
00501
00517
00538
00550
00506
00509
00531
00518
00521
00502
00504
00505
00508
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 94
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 47.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50
Fibrous Histiocytoma 1
Fibrous Histiocytoma, Metastatic, Skin 1
Hepatocellular Carcinoma X 1.........................................................................................................................................................................................................
Mesentery + + + + + + + + + + + + 18.........................................................................................................................................................................................................
Oral Mucosa + 1.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00511
00512
00519
00525
00526
00527
00529
00546
00549
00503
00507
00513
00514
00523
00528
00532
00533
00534
00535
00537
00540
00542
00544
00545
00548 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 95
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Epithelium, Adenoma 1
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X X X X 4
Fibrous Histiocytoma, Metastatic, Skin 1
Bilateral, Adenoma 1.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Pheochromocytoma Malignant X 1.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00511
00512
00519
00525
00526
00527
00529
00546
00549
00503
00507
00513
00514
00523
00528
00532
00533
00534
00535
00537
00540
00542
00544
00545
00548 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 96
Adenoma 1.........................................................................................................................................................................................................
Parathyroid Gland + + + + + + + + + + + + + M + + + + M + + + + + + 48.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X X X X X X X X X X X X X X 32
Carcinoma X 1.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
C-cell, Adenoma X X 4
Follicular Cell, Carcinoma X 1
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma X 3.........................................................................................................................................................................................................
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Polyp Stromal X X X X 9
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00511
00512
00519
00525
00526
00527
00529
00546
00549
00503
00507
00513
00514
00523
00528
00532
00533
00534
00535
00537
00540
00542
00544
00545
00548 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 97
Sarcoma Stromal 1
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lymph Node + + 3
Renal, Stromal Nephroma, Metastatic,Kidney
1
.........................................................................................................................................................................................................Lymph Node, Bronchial M M M M M + M M M + M M M M M M M M M M M M M M M 3
.........................................................................................................................................................................................................Lymph Node, Mandibular M M + M M M M M M M M M M M M M M M M M M M M M M 1
.........................................................................................................................................................................................................Lymph Node, Mediastinal + + M + + M M + + + M + + + + + + + M + + + + + M 40
Fibrous Histiocytoma, Metastatic, Skin 1.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50
Fibrous Histiocytoma, Metastatic, Skin 1.........................................................................................................................................................................................................
Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 48
Thymoma Benign 1
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00511
00512
00519
00525
00526
00527
00529
00546
00549
00503
00507
00513
00514
00523
00528
00532
00533
00534
00535
00537
00540
00542
00544
00545
00548 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 98
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma X X 5
Fibroadenoma X X X X X X X X X X 19
Fibroadenoma, Multiple X 4.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
Fibrous Histiocytoma 1
Subcutaneous Tissue, FibrousHistiocytoma
1
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Rib, Osteosarcoma 1
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00511
00512
00519
00525
00526
00527
00529
00546
00549
00503
00507
00513
00514
00523
00528
00532
00533
00534
00535
00537
00540
00542
00544
00545
00548 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 99
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50
Fibrous Histiocytoma, Metastatic, Skin 1
Osteosarcoma, Metastatic, Bone 1
Stromal Nephroma, Metastatic, Kidney 1.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Pleura + + + + + + + + + 15.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Fibrous Histiocytoma, Metastatic, Skin 1
Nephroblastoma 1
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00511
00512
00519
00525
00526
00527
00529
00546
00549
00503
00507
00513
00514
00523
00528
00532
00533
00534
00535
00537
00540
00542
00544
00545
00548 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 100
.........................................................................................................................................................................................................Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
60 PPM
00511
00512
00519
00525
00526
00527
00529
00546
00549
00503
00507
00513
00514
00523
00528
00532
00533
00534
00535
00537
00540
00542
00544
00545
00548 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 101
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma, Metastatic, Kidney X
Hepatocellular Adenoma X X
Hepatocellular Carcinoma X
.........................................................................................................................................................................................................Mesentery + + + + + +
.........................................................................................................................................................................................................Oral Mucosa
.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0442
0488
0563
0645
0647
0648
0670
0681
0685
0694
0703
0703
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00702
00738
00731
00723
00721
00742
00729
00714
00732
00735
00703
00739
00708
00711
00713
00737
00744
00706
00707
00709
00710
00712
00715
00716
00717
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 102
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Tongue +
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Blood Vessel.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma, Metastatic, Kidney X
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X X X X X X X X
.........................................................................................................................................................................................................Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma, Metastatic, Kidney X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0442
0488
0563
0645
0647
0648
0670
0681
0685
0694
0703
0703
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00702
00738
00731
00723
00721
00742
00729
00714
00732
00735
00703
00739
00708
00711
00713
00737
00744
00706
00707
00709
00710
00712
00715
00716
00717
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 103
Pheochromocytoma Benign
Pheochromocytoma Malignant.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Parathyroid Gland + M + M + + + + + + + + + + + + + + + + + M + + +.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X X X X X X X X X X X X X X X X X X X
Carcinoma.........................................................................................................................................................................................................
Thyroid Gland + + + M + + + + + + + + + + + + + + + + + + + + +
C-cell, Adenoma X X X X
C-cell, Carcinoma X
Follicular Cell, Carcinoma X
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Adenoma X
Carcinoma X X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0442
0488
0563
0645
0647
0648
0670
0681
0685
0694
0703
0703
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00702
00738
00731
00723
00721
00742
00729
00714
00732
00735
00703
00739
00708
00711
00713
00737
00744
00706
00707
00709
00710
00712
00715
00716
00717
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 104
.........................................................................................................................................................................................................Ovary + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma, Metastatic, Kidney X
Granulosa Cell Tumor Benign
Granulosa Cell Tumor Malignant X
.........................................................................................................................................................................................................Uterus + + + + + + + + + + + + + + + + + + + + + + + + +
Polyp Stromal X X X X X X
.........................................................................................................................................................................................................Vagina
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lymph Node + +.........................................................................................................................................................................................................
Lymph Node, Bronchial + M M M M M M M M M + M M M M M M M M M M M M M M
Carcinoma, Metastatic, Kidney X
.........................................................................................................................................................................................................Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M
.........................................................................................................................................................................................................Lymph Node, Mediastinal + + + + + + + + M + + M + M M M + M + M + + + + +
.........................................................................................................................................................................................................Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0442
0488
0563
0645
0647
0648
0670
0681
0685
0694
0703
0703
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00702
00738
00731
00723
00721
00742
00729
00714
00732
00735
00703
00739
00708
00711
00713
00737
00744
00706
00707
00709
00710
00712
00715
00716
00717
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 105
.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma, Metastatic, Kidney X
.........................................................................................................................................................................................................Thymus M + + + + + + + + + + + + M + + + + + + + + + + +
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma X X X
Fibroadenoma X X X X X X X
Fibroadenoma, Multiple X
.........................................................................................................................................................................................................Skin + + + + + + + + + + + + + + + + + + + + + + + + +
Basal Cell Carcinoma
Keratoacanthoma
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0442
0488
0563
0645
0647
0648
0670
0681
0685
0694
0703
0703
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00702
00738
00731
00723
00721
00742
00729
00714
00732
00735
00703
00739
00708
00711
00713
00737
00744
00706
00707
00709
00710
00712
00715
00716
00717
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 106
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma, Metastatic, Kidney X
.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + +
.........................................................................................................................................................................................................Pleura + + + + + + + +
Carcinoma, Metastatic, Kidney X
.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +
URINARY SYSTEM.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0442
0488
0563
0645
0647
0648
0670
0681
0685
0694
0703
0703
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00702
00738
00731
00723
00721
00742
00729
00714
00732
00735
00703
00739
00708
00711
00713
00737
00744
00706
00707
00709
00710
00712
00715
00716
00717
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 107
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Carcinoma X
Cortex, Renal Tubule, Adenoma X
.........................................................................................................................................................................................................Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +
Histiocytic Sarcoma
Leukemia Mononuclear X X X
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0442
0488
0563
0645
0647
0648
0670
0681
0685
0694
0703
0703
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00702
00738
00731
00723
00721
00742
00729
00714
00732
00735
00703
00739
00708
00711
00713
00737
00744
00706
00707
00709
00710
00712
00715
00716
00717
females(cont...)
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 108
ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma, Metastatic, Kidney 1
Hepatocellular Adenoma X 3
Hepatocellular Carcinoma 1.........................................................................................................................................................................................................
Mesentery + + + + + + + + 14.........................................................................................................................................................................................................
Oral Mucosa + 1.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00724
00733
00736
00740
00741
00743
00745
00747
00749
00701
00704
00705
00718
00719
00720
00722
00725
00726
00727
00728
00730
00734
00746
00748
00750 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 109
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Tongue + + 3
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Blood Vessel + 1.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma, Metastatic, Kidney 1
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X X X X X 13.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma, Metastatic, Kidney 1
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00724
00733
00736
00740
00741
00743
00745
00747
00749
00701
00704
00705
00718
00719
00720
00722
00725
00726
00727
00728
00730
00734
00746
00748
00750 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 110
Pheochromocytoma Benign X 1
Pheochromocytoma Malignant X 1.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 47.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma X X X X X X X X X X X X X X X X X X 37
Carcinoma X 1.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
C-cell, Adenoma X 5
C-cell, Carcinoma 1
Follicular Cell, Carcinoma 1
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adenoma 1
Carcinoma X X 4
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00724
00733
00736
00740
00741
00743
00745
00747
00749
00701
00704
00705
00718
00719
00720
00722
00725
00726
00727
00728
00730
00734
00746
00748
00750 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 111
.........................................................................................................................................................................................................Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma, Metastatic, Kidney 1
Granulosa Cell Tumor Benign X 1
Granulosa Cell Tumor Malignant 1.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Polyp Stromal X X X X X X X X X X X 17.........................................................................................................................................................................................................
Vagina + 1
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lymph Node + 3.........................................................................................................................................................................................................
Lymph Node, Bronchial M M M M M M M M M M M M M M M M M M M M M M M M M 2
Carcinoma, Metastatic, Kidney 1.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 0.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + M + + + + + + + M M M M M M + M + + + M + + 34.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00724
00733
00736
00740
00741
00743
00745
00747
00749
00701
00704
00705
00718
00719
00720
00722
00725
00726
00727
00728
00730
00734
00746
00748
00750 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 112
.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma, Metastatic, Kidney 1.........................................................................................................................................................................................................
Thymus + + + + + + + + + + + + M + + + + + + + + + M + + 46
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma X 4
Fibroadenoma X X X X 11
Fibroadenoma, Multiple X X X X 5.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
Basal Cell Carcinoma X 1
Keratoacanthoma X 1
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00724
00733
00736
00740
00741
00743
00745
00747
00749
00701
00704
00705
00718
00719
00720
00722
00725
00726
00727
00728
00730
00734
00746
00748
00750 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 113
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma, Metastatic, Kidney 1.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Pleura + + + + + + + + + 17
Carcinoma, Metastatic, Kidney 1.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
URINARY SYSTEM.........................................................................................................................................................................................................
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00724
00733
00736
00740
00741
00743
00745
00747
00749
00701
00704
00705
00718
00719
00720
00722
00725
00726
00727
00728
00730
00734
00746
00748
00750 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 114
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Carcinoma 1
Cortex, Renal Tubule, Adenoma 1.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS.........................................................................................................................................................................................................
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X 1
Leukemia Mononuclear X 4
*** END OF REPORT ***
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009
Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03
Species/Strain: RATS/F 344/N Lab: BNW
DAY ON TEST0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
.................................................................................................................................................................
FISCHER 344 RATS FEMALEANIMAL ID
120 PPM
00724
00733
00736
00740
00741
00743
00745
00747
00749
00701
00704
00705
00718
00719
00720
00722
00725
00726
00727
00728
00730
00734
00746
00748
00750 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 115