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Nuclear Envelope Lamin-A Couples Actin Dynamics with Immunological Synapse Architecture and T Cell Activation
by José M. González-Granado, Carlos Silvestre-Roig, Vera Rocha-Perugini, Laia Trigueros-Motos, Danay Cibrián, Giulia Morlino, Marta Blanco-Berrocal, Fernando G.
Osorio, José M. P. Freije, Carlos López-Otín, Francisco Sánchez-Madrid, and Vicente Andrés
Sci. Signal.Volume 7(322):ra37-ra37
April 22, 2014
©2014 by American Association for the Advancement of Science
A-type lamins are increased in abundance upon T cell activation.
José M. González-Granado et al., Sci. Signal. 2014;7:ra37
©2014 by American Association for the Advancement of Science
Loss of A-type lamins impairs T cell activation in vitro and in vivo.
José M. González-Granado et al., Sci. Signal. 2014;7:ra37
©2014 by American Association for the Advancement of Science
Lamin-A enhances the activation of human J77 cells.
José M. González-Granado et al., Sci. Signal. 2014;7:ra37
©2014 by American Association for the Advancement of Science
Lamin-A modulates the dynamics of human J77 cell–Raji cell interactions.
José M. González-Granado et al., Sci. Signal. 2014;7:ra37
©2014 by American Association for the Advancement of Science
Lamin-A is required for optimal movement of TCR-CD3 complexes within the plasma membrane and TCR-dependent signaling.
José M. González-Granado et al., Sci. Signal. 2014;7:ra37
©2014 by American Association for the Advancement of Science
A-type lamins promote MTOC translocation and F-actin polymerization in activated T cells.
José M. González-Granado et al., Sci. Signal. 2014;7:ra37
©2014 by American Association for the Advancement of Science
The lamin-A–mediated increase in the extent of T cell activation requires a physical connection between the nucleus and the cytoskeleton through the LINC complex.
José M. González-Granado et al., Sci. Signal. 2014;7:ra37
©2014 by American Association for the Advancement of Science