+ All Categories
Home > Documents > Nucleotide Metabolism. nucleotide nucleoside.

Nucleotide Metabolism. nucleotide nucleoside.

Date post: 15-Jan-2016
Category:
Upload: teresa-padmore
View: 225 times
Download: 1 times
Share this document with a friend
Popular Tags:
29
Nucleotide Metabolism
Transcript
Page 1: Nucleotide Metabolism. nucleotide nucleoside.

Nucleotide Metabolism

Page 2: Nucleotide Metabolism. nucleotide nucleoside.

nucleotide

nucleoside

Page 3: Nucleotide Metabolism. nucleotide nucleoside.
Page 4: Nucleotide Metabolism. nucleotide nucleoside.
Page 5: Nucleotide Metabolism. nucleotide nucleoside.

a key molecule in purine and pyrimidine biosynthesis

Page 6: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-32

purines: where does all them darn atoms come from??

Page 7: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-33

Page 8: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-33

Page 9: Nucleotide Metabolism. nucleotide nucleoside.

ETC.

fig 22-33, sorta

Page 10: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-33, still

inosine, built“on the ribose”to make IMP

Page 11: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-34

and inosinate begat adenylate and xanthylate, and xanthylatebegat guanylate…

Page 12: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-35

regulationof the early stepsof purinesynthesis

Page 13: Nucleotide Metabolism. nucleotide nucleoside.

pyrimidinebiosynthesis

orotate, built“off the ribose”

fig 22-36

Page 14: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-36

pyrimidinebiosynthesis

OTP thenmodified toCTP, etc

Page 15: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-38

Page 16: Nucleotide Metabolism. nucleotide nucleoside.

Two ways for mammals to make and/or use purines and pyrimidines

1) de novo synthesis (see above)

2) salvage pathways

Ad + PRPP AMP + PP

Page 17: Nucleotide Metabolism. nucleotide nucleoside.

Two ways for mammals to make and/or use purines and pyrimidines

1) de novo synthesis (see above)

2) salvage pathways

hypoxanthine + PRPP IMP + PP

Lesch-Nyhan disease

Page 18: Nucleotide Metabolism. nucleotide nucleoside.

Two ways for mammals to make and/or use purines and pyrimidines

1) de novo synthesis (see above)

2) salvage pathways

pyrimidine salvage is similar but not wellunderstood in mammals…

Page 19: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-48

inhibitors of glutamineamindo-transferases

chemo-therapeutics

Page 20: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-39

rememberthe “D” inDNA???

either or

Page 21: Nucleotide Metabolism. nucleotide nucleoside.

what’s thedifference between T and U??

fig 22-44

Page 22: Nucleotide Metabolism. nucleotide nucleoside.

where theTHF getsits methy...

fig 22-44

Page 23: Nucleotide Metabolism. nucleotide nucleoside.

more chemotherapeutics

Page 24: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-49

inhibitors of dihydrofolate reductase cycle

Page 25: Nucleotide Metabolism. nucleotide nucleoside.

catabolism ofpurines…

fig 22-45

xanthineoxidase

Page 26: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-45

Page 27: Nucleotide Metabolism. nucleotide nucleoside.

out with gout!!!

1735

Page 28: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-47

out with gout!!!

xanthine oxidase too active

Page 29: Nucleotide Metabolism. nucleotide nucleoside.

fig 22-47

out with gout!!!

xanthine oxidase inhibitor


Recommended