Date post: | 11-Jan-2017 |
Category: |
Science |
Upload: | prince-arora |
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Presented by : Prince
Obama’s Precision Medicine Initiative• Medical treatments have been designed for “average patients”
• Precision Medicine is an innovative approach that takes into account individual differences in people’s genes, environment, and lifestyles
•As a result of this “one-size-fits-all” approach, treatments are not successful for all
What is Obesity?Abnormal accumulation of body fat
Just measure your weight in Kilograms (kg) and your height in meters (m), and then use this formula
Are you Obese?
Pathophysiology of Obesity
Pre-opiomelanocortin
*MSH – Melanocyte Stimulating Hormone
*
Melanocortin4 Receptor
What causes Obesity? Genetics
Overeating
Physical inactivity
Medication
Diseases
Lack of sleep
Social issues
Genes associated with
obesity• Leptin
•MC4R (Melanocortin 4 receptor)
• PCK1 (Phosphoenol pyruvate carboxylase 1)
• POMC ( Pre-opiomelanocortin)
Drugs Mechanism of Action
Adverse Drug Reaction
Orlistat Inhibit pancreatic
lipase
Gastrointestinal side effects
Sibutramine Inhibit norepinephrine & Serotonin
Heart attack
Rimonabant Cannabinoid 1 receptor
antagonist___
Metformin Decrease production of glucose from
pancreas
Impaired Renal
functions
What are the complications of obesity?
High blood pressure
Heart disease
Gallbladder disease
Osteoarthritis
High cholesterol and triglycerides
Obesity Treatment Pyramid