new biotechnology

Genetic Screening based on Prevention and Personalized Management of Obesity

Discover Your Genes,Control Your Weight !

Visible Results in Weight Loss

Predictive Genomics

is the area of medi-

cine that deals with

the detection of specific

“changes” in DNA called muta-

tions. These mutations deter-

mine desirable or undesirable

traits and have been associated

with risk for common poly-

genic multifactorial dis-

eases including obesity.

Predictive Medicine is based

on early detection of the risk for

several human illnesses includ-

ing obesity. Based on the Genetic

Profile, appropriate nutritional and

dietary guidelines and lifestyle

choices are recommended.

These guidelines are individu-

alized, personalized and more

specific than the universal

recommendations applicable

to the general population.

Head Office: 70, Omirou str. - GR 171 21 Nea SmyrniTel. / Fax: +30 210 9319050 & +30 210 9370222

E-mail: genomed@genomed.gr www.genomed.gr

Obesity Management

Obesity Management

Obesity Management

Sampling process and turnaround timeDNA sampling is painless and does not require blood drawing. It involves taking cells from the inside of the cheek with a specialized and sterilized buccal swab. The procedure lasts no more than a minute. Results are usu-ally available within 15 working days. The confidential nature of personal data is strictly respected.

Genes AnalyzedGenes screened relate to the following biological processes:

Weight Loss• Sense of Hunger and Fulfillment• Energy intake vs. Energy expenditure• Lipolysis – Thermogenesis

Reward Deficiency Syndrome• Feed-back inhibition mechanisms• Adipocyte hormones controlling weight loss

NutriGenetics – NutriGenomics• Anti-oxidation and Detoxification• Lipid and Cholesterol metabolism• Inflammation – Stress response• Folic Acid -Vitamins B - Homocysteine levels

Nutritional and dietary guidance, support and supplementation as it pertains to physical needs and weight management is provided.

Personalized Weight LossObesity Management DNA Screening aids in weight control by identifying genes that relate to increased risk of obesity and de-termine the specific nutritional needs of the body. Thus, caloric restriction required for weight loss will be implemented for nu-trients other than those identified as absolutely essential and will avoid long term health harm from common diseases such as Cardiovascular disorders, Osteoporosis, Type 2 Diabetes etc. It will also aid in obesity intervention decisions such as pharma-cological treatment through the use of appetite suppressants and consideration of invasive medical procedures.

Obesity is a chronic disease with a strong genetic component. Genes, lack of exercise and high caloric food intake combined result in obesity.

Genes screened relate among others to the following biological processes:

• Regulation of lipolysis [break down of fat tissue] and thermo genesis [heat generation]

• Modulation of insulin sensitivity and glucose homeostasis

• Neuronal regulation of food consumption• Regulation of energy balance

OBESITY ACDC DRA2A ADRB1 ADRB2

ADRB3 AGRP BDNF CAPN10

FTO GNB3 MCHR1 MC4R

NPY SCG3 TUB PPAR-γ2

NEGR1 KCTD15 SH2B1 GNPDA2 MTCH2

INFLAMMATORY RESPONSE IL-6 TNF-alpha CRP

REWARD DEFICIENCY SYNDROME / FEEDBACK RESPONSE MECHANISM DRD2 5-HT2A LEPR

Obesity depends not only on the genetic factors but also on environmental influences, as well as the nutritional habits of the individual. In the era of Preventive Medicine, knowledge of our genetic profile is an absolute necessity for achieving and maintaining optimal health and appearance. In avoiding and managing obesity,the insight obtained from DNA genetic screening is vital for implementing preventive measures and performing appropriate corrective actions. Nutritional and dietary recommendations according to the genetic profile will provide a balanced and controlled Body Mass Index [BMI] managing and avoiding obesity providing improved life quality.

New Genomed biotechnology offers genetic screening analyzing genes and mutations with strong associations to the various biological systems investigated, all of which are documented in the medical and scientific bibliography.

Genes affect fat storage and distribution in the body, as well as how easily fat is converted to

energy through the process of burning calories.

NUTRIGENOMICSLIPID METABOLISM

APOA1 APOA5 APOB APOC3

APOE CETP GJA4 (CX37) HMGCR

LIPC LPL PON1

HEART HEALTH & HOMOCYSTEINE METABOLISM

CBS COMT MTHFR MTR

MTRR TCN2 HFE

ANTIOXIDATION & DETOXIFICATION

CAT EPHX1 GPX1 GSTM1

GSTP1 GSTT1 MnSOD SOD3

UCP2

HYPERTENSION

ACE ADD1 AGTR1 AGT

AGT CYP11B2

Obesity depends not only on the genetic factors but also on environmental in� uences, as well as the nutritional habits of the individual. In the era of Preventive Medicine, knowledge of our genetic pro� le is an absolute necessity for achieving and maintaining optimal health and appearance.In avoiding and managing obesity,the insight obtained from DNA genetic screening is vital for implementing preventive measures and performing appropriate corrective actions. Nutritional and dietary recommendations according to the genetic pro� le will provide a balanced and controlled Body Mass Index [BMI] managing and avoiding obesity providing improved life quality.

GENOMED in collaboration with the Central Laboratory Re-search Diagnostics, (ISO 17025 certi� ed, spin-o� company of the University of Athens, Scienti� c Director Nikolaos Dra-koulis, MD, PhD), developed Predictive Genomic Services in Greece and Internationally. This collaboration o� ers the high-est standards in methodology as well as professional counsel-ling in connection to multifactorial disease development.