• Opportunistic pathogen
• Commensal organism
Candida albicans
superficial and systemic infections~ 10,000 deaths per year in U.S.A.
Cell Morphologies of C. albicans
Hyphae
PseudohyphaeYeast
Environmental Control of Morphogenesis
Serum, 37o CpH > 7Starvation
Yeast Pseudohyphae/hyphae
YPD or YNB medium30o C
Yeast Cell Division Cycle
Actin Cables and Actin Patches
Yeast Cell Division Cycle
Environmental Control of Morphogenesis
Serum, 37o CpH > 7Starvation
Yeast Pseudohyphae/hyphae
YPD or YNB medium30o C
Light Microscope
Hyphal Formation in Candida albicans
Light Microscopy Fluorescence Microscopy ofHWP1-GFP gene