GFS ChemicalsGFS Chemicals

Building Blocks and BeyondBuilding Blocks and Beyond

GFS ChemicalsGFS Chemicals

• Specialty chemical Specialty chemical manufacturingmanufacturing

• Volumes from Volumes from research toresearch to bulk bulk

• Focused on Core Focused on Core CompetenciesCompetencies

Core CompetenciesCore Competencies

• Acetylene Acetylene chemistrychemistry

• Propargylic aminesPropargylic amines

• Grignard chemistryGrignard chemistry

• Specialty halidesSpecialty halides

• Si blocked Si blocked compoundscompounds

• Birch reductionsBirch reductions

• Alpha/omega Alpha/omega functionalizationfunctionalization

Acetylene ChemistryAcetylene Chemistry

HC CH R1C CR2

O

O

(CH2)9CH3

Propargylic AminesPropargylic Amines

H2N

NH

N

NH

NH

Recently Manufactured Recently Manufactured GrignardsGrignards

O

MgBr

CH3(CH2)nMgX

n = 0 - 7; X = Cl, BrMgBr

MgBr

RC CMgX

R = H

Scale: 10's - 1000's LT

10's of LT

1000's of LT

10's - 1000's of LT

100's of LT

Specialty HalidesSpecialty Halides

I

Br

Si(CH3)3

X

X = Cl, Br, I

Br

Br

X

ClX = F, Cl

Si Blocked CompoundsSi Blocked Compounds

Br

Si(CH3)3X

Si(CH3)3

X = OH, Br

Si CH2MgCl (H3C)3Si Si(CH3)3

Si

(H3C)3Si Si(CH3)3

Birch ReductionsBirch Reductions

Y

Z H3COOH

O

H3CO CH3

Y,Z = H, R, OR, COOH

αα,,ωω Functionalized Functionalized MoleculesMolecules

Br

Cl NH2

OH

ICl

BrBr

New TechnologiesNew Technologies

• ThiophenesThiophenes

• Bridged orthoestersBridged orthoesters

Specialty ThiophenesSpecialty Thiophenes

• OLED/Conductive Polymer ApplicationsOLED/Conductive Polymer Applications

• Pharmaceutical and Biotechnology ApplicationsPharmaceutical and Biotechnology Applications

SS

S

Br

R

S

O

H

O

H

S

O O

Bridged OrthoestersBridged Orthoesters• Protected Carboxylic acidsProtected Carboxylic acids

OCH2OH

CH3

O

O

O

Br

O

O

O

R

R OR'

O

R = alkyl, aryl, vinyl, alkynyl

Protecting Group Reagent: