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Organization of the lymphoid organs and tissues
DC mackrophage
MYELOID PRECURSOR
BONE MARROW
HSC HEMATOPOIETIC STEM CELL
mast
DC monocyte neutrophilmast
neutrophil
TISSUES
BLOOD
B-cell T-cell
T-cellNK-cell
THYMUS
B-cell
LYMPHOIDPRECURSOR
LYMPHOID TISSUES
BLOOD
Blood circulation
Macrophage
Hassal’s corpuscle
Dendritic cell
Thymocytes
Epithelial cells
CapsuleSeptum
Mature naive T- lymphocytes
STRUCTURE OF THE THYMUS
STRUCTURE OF THE THYMUS
THYMUS INVOLUTION
PERIPHERAL LYMPHOID ORGANS
Sites of lymphocyte activation and differentiation
SpleenLymph nodesEpithelial cell – associated lymphoid tissues
Skin-associated lymphoid tissue (SALT)Mucosa-associated lymphoid tissue (MALT)
Gut-associated lymphoid tissue (GALT)Bronchial tract-associated lymphoid tissue
(BALT)
Organization (levels) of immunocytes
Diffuse cells
Follicle
organ
Patch
Lymph nodes are communication centers within the immune systemLymph nodes are communication centers within the immune systemThey form a unified, interconnected system via circulation They form a unified, interconnected system via circulation
of blood and lymphof blood and lymph
Fluid from tissues is collected by venules and lymphatic capillaries
Activation of adaptive immune response I.
Activation of adaptive immune response II.
5. Medullary cords (Macrophage & plasma cell area)
Medullary sinus
6. Efferent lymphatic vessel
Artery
Vein
4. Germinal centre (site of intense B cell proliferation)
3. Secondary lymphoid follicle
Paracortical(T cell) area
2. Primary Lymphoid follicle (B cell area)
1. Afferent lymphatic vessel. Lymph, Ag, & cells with captured Ag drained from tissues enters here
Lymph node
medulla
veinarthery
Collagen capsule
Marginal sinus
Paracortex Cortex
Trabecula
High endothelial venule (HEV)
Afferent lymph
Efferent lymph
Primary follicle
B CELLS
Secondory follicle
GerminalCenter (GC)
B CELLS
B CELLST CELLS
STRUCTURE OF LYMPH NODES
mature,naiveB-sejt
FDC
Plasma cell
Memory B cell
Mature,naive B cell
Naive B lymphocytes enter lymph nodes Naive B lymphocytes enter lymph nodes via HEVvia HEV
B cells are reqruited to HEV from the B cells are reqruited to HEV from the blood by CCL21 chemokine secreted by blood by CCL21 chemokine secreted by
stromal cellsstromal cells
CCL21 and CCL19 chemokines attract B CCL21 and CCL19 chemokines attract B lymphocytes to the lymph nodelymphocytes to the lymph node
HOMING OF B LYMPHOCYTES IN HOMING OF B LYMPHOCYTES IN LYMPH NODESLYMPH NODES
Subcapsular sinusValve
Capsule
Cortex
Trabecula
Follicles Medullary cords
Medullary sinuses
Capsule
LymphaticArtery and vein
Blood & Lymphatic vessels
STRUCTURE OF THE SPLEEN
STRUCTURE OF THE SPLEEN
NO LYMPHOID CIRCULATION
Filtration of blood borne antigens
Red pulp
Marginal zone
Marginal sinus
B cell corona
Germinal centre
Periarteriolar lymphocyticsheath (PALS) – T cell area
Central arteriole
Spleen white pulpTransverse section
MMALTALT
Most pathogens attack mucosal epitheliaMost pathogens attack mucosal epithelia
Covered by mucus containing glycoproteins, proteoglycans, Covered by mucus containing glycoproteins, proteoglycans, enzymesenzymes Antimicrobial peptides protect against physical damage and Antimicrobial peptides protect against physical damage and infectioninfection
Thin dynamic layers covering large areasThin dynamic layers covering large areas
Well protected by the immune systemWell protected by the immune system
More lymphocytes are assigned to the mucosal surfaces than to More lymphocytes are assigned to the mucosal surfaces than to the rest of the bodythe rest of the body
Peyer’s patches
Dome area Villi
GC
Gut-associated lymphoid tissuesGut-associated lymphoid tissues
Peyer’s patches 5-100 follicles forming a dome structurePeyer’s patches 5-100 follicles forming a dome structureM-cells: microfold cells --- no glycocalyx – antigen uptakeM-cells: microfold cells --- no glycocalyx – antigen uptake
Transport of antigens via M cells
Dendritic cells of the lamina propria outside Peyer’s patchescapture antigens by samlpeing the gut lumen directly
Intraepithelial lymphocytes
Large number of intraepithelial lymphocytes are present in gut epthelia