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We have added CHEMICON®, LINCO® & UPSTATE® expertiseto our Life Science capabilities to bring you complete work�owsupport in:
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Drive your cancer research discoveries with Roche Applied Science’s
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Discover... Analyze... Validate.Visit www.roche-applied-science.com for more information or to
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LIGHTCYCLER and HRM are trademarks of Roche.
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Roche Diagnostics GmbH
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A Comprehensive Oncology Toolkit
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Enabling Technologies for
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Analysis of tumor suppressor gene methylation with
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In 2005, the Genome Sequencer 20 System was launched
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454 and GENOME SEQUENCER are trademarks of 454 Life Sciences Corporation,
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© 2008 Roche Diagnostics GmbH. All rights reserved.
Roche Diagnostics GmbH
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Coming Soon!
The 3rd edition of the Sigma Cell Culture Manual will be a
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Our Innovation, Your Research — Shaping the Future of Life Science
Fulfilling a global mission to advance science and serve society.In bestowing its prestigious Public Welfare Medal, the US National Academy of
Sciences recognized Norman P. Neureiter for “spurring international cooperation”
and “integrating science and technology into foreign policy” while serving as the
first S&T adviser to a US secretary of state. His three-year term began in 2000
under Madeleine Albright and continued under Colin Powell.
Whatmakes aninternationalleader?
Norman P. Neureiter
Awarded the 2008 PublicWelfareMedal
by the USNational Academy of Sciences
Director, AAAS Center for Science,
Technology, and Security Policy
We congratulate our valued colleague who, since 2004, has continued his
distinguished career in global affairs as director of the AAAS Center for Science,
Technology, and Security Policy. He epitomizes the AAAS leadership role in
advancing science and serving society internationally.
Microsoft is calling on research and academic health institutions to join us in the search for new, innovative health
applications that accelerate connections between consumers and physicians and the information they need to make
informed and personalized decisions.
Working together, we can empower physicians and patients with the solutions they need to make a difference.
Building on the Microsoft® HealthVault™ consumer health platform, you have the potential to enable fundamentally
new and innovative scenarios.
Submit your ideas to the HealthVault Be Well Fund and join our goal of identifying and developing new,
yet-to-be-imagined Web applications that will help people live longer, healthier lives.
For more information on how your institution can submit a proposal to the HealthVault Be Well Fund,
visit: www.healthvault.com/fund
Let’s do it together.
BeWell Fund
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Thank you for your support.
Yoursupportmatters!
FROM BENCH TO BEDSIDE
ATS 2008Toronto • Canada
MAY 16-21
THE AMERICAN THORACIC SOCIETY’S INTERNATIONAL CONFERENCE
IS THE WORLD’S PREMIER EDUCATIONAL PROGRAM FOR CLINICIANS AND
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Scientists from nearly 100 countries are expected to participate in the 2008 ATS International
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lung structure and function, inflammatory biology and gene therapy. In addition, more than 5,600
abstracts of original research will be presented.
Among the symposia scheduled for the 2008 International Conference are:
• Host Defense Mechanisms in Pulmonary Infections*
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• Autophagic Cell Death in Lung Diseases: An Emerging Paradigm?
• Toronto Science 2008: Mechanistic Insights into Inflammation, Signaling and Immunity
• Beyond Hemostasis: Targeting Procoagulant and Fibrinolytic Signaling Pathways in Acute and
Chronic Lung Injury
• Harnessing Airway Responsiveness: Novel Tools, Mechanisms and Strategies for Treatment
• Two Decades of Making Mouse Models of Allergic Asthma: Where Has It Gotten Us?
• The Matrix Revisited: A New Reality?
• New Perspectives on Remodeling and Physiological Consequences in COPD
• More Just So Stories: Respiration Meets Evolution
• Endothelial Progenitor Cells: Lung Vascular Repair and Angiogenesis
• Beyond Th1 and Th2: Interleukin-17 at the Interface of Innate and Acquired Immunity in the Lungs
*Postgraduate course
The Advance Program is available online. To
access the site, visit www.thoracic.org and
click on the International Conference icon. If
you would like a program mailed to you, please
send a request to [email protected].
Fashion Breakthroughof the Year
Our Science Gene SequenceT-shirt—get yours today!
By popular demand! Created to celebrate our Breakthrough
of the Year for 2007, this T-shirt is designed from an
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Since the shirt appeared on the cover of Science, we’ve been
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www.sciencemag.org/products SCIENCE VOL 319 14 MARCH 2008 1547
New Products
LIFE SCIENCE TECHNOLOGIESAAAS/Science Business Office
Biological Sample ConcentrationThe miVac Quattro is a versatile, high capacity biological sample concentrator that rapidlyremoves a wide range of solvents, from volatile organic solvents to water. It is suitable foruse in applications including oligonucleotide synthesis, RNA and DNA preparation, peptidepreparation, sequencing, molecular biology, and absorption, distribution, metabolism,excretion, toxicity (ADMET) research. A high displacement pump removes water quickly andquietly. Solvent removal can be enhanced by the addition of a miVac SpeedTrap refrigeratedcondenser. The four-swing position rotor can simultaneously accommodate up to 20
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Instrument-Free DNA DetectionThe BioHelix Express Strip Cassette is a novel, disposable DNAdetection device. It is designed for instrument-free, cross-contamination-proof detection of amplicons derived frompolymerasechain reaction, helicase-dependent amplification, and other nucleicamplification reactions. The amplicons are dual-labeled by biotinand fluorescein isothiocyanate during amplification and detected ona test strip embedded in the device. The method is 10 times moresensitive than gel-based detection methods, with results viewable ascolored lines in 10minutes.BioHelixFor information 866-800-5458www.biohelix.com
Protein-DNA Binding AssayThe Protein-DNA Binding Assay provides a safe, fast, and sensitivealternative to traditional electromobility shift assays for detection andquantitative characterization of protein-DNA interactions. This assayeliminates the need for radioactive labeling and gel electrophoresisbecause it features chemiluminescent ProLabel detection and canbe performed in a 96-well plate. A small (about 6 kDa) ProLabeltag is fused to the protein of interest to generate a fusion proteinthat is capable of producing a strong chemiluminescent signal viaan enzyme complementation assay. The ProLabel tag allows directdetection of specific binding between the protein of interest and abiotinylated double-stranded-DNAoligonucleotide. The biotinmoietyon the oligonucleotide permits the resulting protein-DNA complex tobe captured on the 96-well plate, which is coated with streptavidin.Clontech LaboratoriesFor information 800-662-2566www.clontech.com
Bioinformatics SoftwareProteinScape 2 software is a next-generation bioinformatics platformdesigned for addressing needs in biomarker profiling, quantification,and validation. A comprehensive solution for qualitative andquantitative liquid chromatography/mass spectrometry (LC/MS) protein analysis, ProteinScape 2 supports all current labelchemistries, including multiplexed labels, as well as label-freequantification. Interactive validation of protein quantification basedon raw LC/MS data is simple and straightforward. It streamlinesthe discovery process through decoy autovalidation algorithmsand the ProteinExtractor algorithm, which produces nonredundantprotein result lists across entire proteomics projects. The softwarehas a number of dedicated data viewers that permit the evaluationand validation on each level of proteomics experiments, suchas the LC/MS survey viewer, the gel viewer, and sequence MS/MS
spectra. All these views are linked and permit simple browsingthrough scientists’ proteomics data, supported by extensive queries.Bruker DaltonicsFor information 978-667-9580www.bdal.com
Orange Fluorescent LabelThe Qdot 625 nanocrystal fluorescent label can be seen as orangeand fills an important spectral gap for dense multicolor experiments.In addition, the Qdot 625 glowsmore brightly than longer wavelengthQdots. Current products using it include the Qdot 625 streptavidinconjugate, the Qdot 625 goat F(ab’)2 antimouse IgG conjugate, andthe Qdot 625 F(ab’)2 antirabbit IgG conjugate. When excited by asingle light source, Qdot nanocrystals emit in a range of brilliant,articulate colors with long-term photostability.InvitrogenFor information 800-955-6288www.invitrogen.com/qdots
Biodiesel Gas ChromatographyTheThermoScientificBiodieselGasChromatography(GC)ProductivitySolutions provide a high level of integration and productivity forthe three most common GC-based methods: EN 14103 for FattyAcid Methyl Ester characterization and linolenic acid methyl esterdetermination, EN 14105/ASTM D6584 for free and total glycerinecontent, and EN 14110 for methanol content. Delivering completeautomatic characterization of pure biodiesel, the systems offer fullcompliance with these official standards, which aim to certify thequality of pure biodiesel for any commercial trading. The interest inbiodiesel asa clean-burningalternative fuel produced fromrenewablesources has increased tremendously over the past few years becauseof its environmental advantages over conventional petrodiesel.Thermo FisherFor information 408-965-6022www.thermofisher.com
GenevacFor information +44 1473 240000
www.genevac.com
Newly offered instrumentation, apparatus, and laboratory materials ofinterest to researchers in all disciplines in academic, industrial, and gov-ernmental organizations are featured in this space. Emphasis is given topurpose, chief characteristics, and availabilty of products and materials.Endorsement by Science or AAAS of any products or materials mentionedis not implied. Additional informationmay be obtained from themanufac-turer or supplier.
New Products
Electronically submit your new product description or product literatureinformation! Go to www.sciencemag.org/products/newproducts.dtl formore information.
To find your local sales office, visitwww.bio-rad.com/contact/
In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723)Visit us on the Web at discover.bio-rad.com
Convenience Is What HappensWhen You Rethink PCRChange the way you think about PCR with Bio-Rad’s new family of thermal cyclers.
Wouldn’t you rather optimize your reactions in minutes and not days?
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■ Easily interchangeable reaction modules meet any
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When you rethink PCR, you realize how easy it should be.
For more information, visit us on the Web at www.bio-rad.com/pcr
1000-Series Thermal Cyclers
Purchase of this instrument conveys a limited non-transferable immunity from suit for the purchaser’s own internal research and development
and for use in applied fields other than Human In Vitro Diagnostics under one or more of U.S. Patents Nos. 5,656,493, 5,333,675, 5,475,610
(claims 1, 44, 158, 160–163 and 167 only), and 6,703,236 (claims 1–7 only), or corresponding claims in their non-U.S. counterparts, owned by
Applera Corporation. No right is conveyed expressly, by implication or by estoppel under any other patent claim, such as claims to apparatus,
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Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA.
WE THINK YOU
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