ORU Annual Report Center for Circadian Biology (formerly ... · Page 1 ORU Annual Report Final...

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ORU Annual Report Final Template for FY15/16

Center for Circadian Biology (formerly Center for Chronobiology) Year of Establishment: 2009

Location: UC San Diego Report Period: FY 2015/16

ORU’s Major Activities

Progress towards previous goals:

1. Increasing diversity in CCB activities, both through invitations to future events that better represent different groups, and targeted outreach. Increased diversity of invited speakers

2. Submitting group grant proposals. Submitted MRPI, UCGHI Centers of Expertise, and partnered

with Center Launch group to develop training and outreach component

3. Hosting successful workshops and symposia. Hosted fall trainee/faculty workshop, winter symposium, public outreach workshop, all well-attended and well-received

4. Increasing corporate sponsorships to fund activities. Successful fundraising to enable planning

of subsequent year’s events 5. Continuing to encourage members to participate more and to submit grants through CCB

6. Increasing communication with members; added new members, improved website

Highlights:

Summer 2015-Present – Cooperated with VCR Frontiers project that included many CCB members.

October 2015-June 2016 – Clockwatchers journal club for faculty and trainees, held once per month during the academic year.

November 2015 – Fall faculty-trainee workshop attended by 57 UCSD faculty and trainees. The program included 8 trainee speakers and 8 faculty speakers. A new “speed networking” session was added where 6 UCSD faculty gave brief snapshots of their research programs. Also included was a talk by Susan Golden, “How to improve your R01 score.”

January 2015-Present – The BioClock Studio (integrated with CCB Symposium and fall clocks class).

January 2015-Present – UC Frontiers center grant launch ($75K) funded, which includes many CCB members. Grant helped to support networking for center development during the 7th annual symposium, and the CCB Workshop on Sleep, Health and Work Schedules. Living healthy in artificial light

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February 2016 – Submitted letter of intent for UCGHI Center of Excellence proposal “Living healthy in artificial light.” Met with collaborating partners from across the UC system in conjunction with the CCB symposium to develop full proposal plan.

February 2016 – 7th annual CCB Symposium “From Cells to Clinic”. This event is an annual highlight of CCB, known throughout the international community as an exceptional meeting. Featured 18 speakers (eight women, one URM, one Latin American), 150 attendees, from over 35 institutions and companies.

February 2016 – CCB “Workshop on Sleep, Health and Work Schedules” targeted for shiftworkers in the community. The workshop was held in concert with the symposium to leverage outside speakers. Featured 4 speakers, attracted 60 attendees, which included firefighters, police, RN’s, UCSD medical students, and faculty from UCSD and other Institutions.

February 2016 – Annual meeting of the External Advisory Board in conjunction with the CCB Symposium.

March 2016 – Submitted full proposal for UCGHI Center of Excellence “Living healthy in artificial light.”

May 2016 – Submitted Letter of Intent for UC Multicampus Research Programs and Initiatives proposal “Managing impacts of artificial light at night in California” (full proposal submitted July 2016)

May 2016 – CCB participation at the Society for Research on Biological Rhythms conference. Drs. Welsh and Golden helped to organize a roundtable session on communicating with the public; Dr. Golden presented the Pittendrigh-Aschoff Lecture.

May-July 2016 – Planning for the 8th annual CCB symposium, with goals of improving diversity among speakers, to be held February 2017. Continued diversity selections include six women, one Latin American, one UCSD trainee.

May-July 2016 – Planning for 4th annual CCB “Workshop on Sleep, Health and Work Schedules” (Formerly called “Workshop on Circadian Rhythms and Shiftwork”), to be held Feb 2017 in concert with the “From Cells to Clinic” symposium (continued no registration fee policy).

May 2016 – CCB trainee Dr. Hanne Hoffman gave a seminar at Cal State Fresno as part of a training and outreach plan for the center launch program

Summer-Fall 2016 – Vigorous fundraising (Sonia Ancoli-Israel, Susan Golden, David Welsh, Terry Peters, Pattie Magallanez).

Summer-Fall 2016 – 3 new members added, one member left UCSD.

Summer-Fall 2016 – Gorman and Golden deploy online tutorials for 250-student clocks class. Materials were created by S. Golden HHMI Professor grant project “The BioClock Studio” ORU’s Committees Executive Committee and Advisory Committee Meetings

Executive Committee Meeting Dates: Jul 21, 1015; Aug 18, 2015; Sep 15, 2015; Oct 20, 2015; Nov 17, 2015; Dec 15, 2015; Jan 19, 2016; Feb 9, 2016; Mar 15, 2016; Apr 19, 2016; May 17, 2016; Jun 21, 2016.

External Advisory Board Committee Meeting held on February 24, 2016. In attendance: Gene Block (UCLA); Steve Kay (USC); Margaret Moline (Eisai pharmaceutical Co.); Joseph Takahashi (University of Texas Southwestern Medical Center); Michael Young (The Rockefeller University); Phyllis Zee

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(Northwestern); Susan Golden (UCSD); Sonia Ancoli-Israel (UCSD); Stu Brody (UCSD); Michael Gorman (UCSD); Katja Lamia (TSRI); Michael McCarthy (UCSD); Satchin Panda (SALK/UCSD); David Welsh (UCSD); and Erica Schoeller (UCSD) Executive Committee and Advisory Committee Recommendations

Overall, the external advisory committee is impressed with the activities of CCB, and especially with our commitment to training and outreach, and efforts to expand collaboration throughout California. Specific recommendations included:

Invite David White of Harvard to the Advisory Board as an individual with connections to many companies and organizations that are potential donors/sponsors (done);

Seek help from development office for assistance with fundraising and corporate connections (Director Golden met with Iris Magid, Director, Industry Engagement & University Relations);

CCB needs to recognize the limited capacity for leadership and funding for activities, and that as new ones are added, existing ones need to be sidelined (current activities were confirmed as priorities);

CCB should draw upon additional strength within the UC community (system-wide group grant proposals were submitted, with significant input from groups outside of UCSD).

Executive Committee and Advisory Committee Documentation

Copies of CCB executive committee and external advisory board minutes are attached as a separate document. Diversity Efforts

Individual members of CCB participate in various diversity efforts that are reported through their home departments. In an effort to make specific contributions as an ORU, CCB is incorporating practices to improve diversity and inclusion in all of our activities.

The speaker invitation list for the 2016 symposium (18 total) included eight women; one postdoctoral trainee (winner of the speaking slot as top speaker at the fall workshop); one African American colleague from University of Michigan Medical School; and one Spanish-speaking colleague from Mexico. For the 2017 meeting, we’ve invited 18 speakers including six females, one African American, one trainee, and one Argentinian. Trainees were tasked to think deeply and consider diversity in preparing their list of preferred speakers, and recommended women and URM speakers as top picks.

CCB members’ contributions to diversity, presentations, and activities, July 2015 – June 2016:

Susan Golden:

Interview for The Scientist (Jan 2016)

Speaker, Winter qBio meeting, Honolulu, HI (Feb 2016)

Seminar, University of Texas Southwestern Medical Center, Dallas, TX (Apr 2016)

Seminar, University of Texas, Austin, TX (Apr 2016)

Pittendrigh-Aschoff Lecture, Society for Research on Biological Rhythms meeting, Palm Harbor, FL (May

2016)

Seminar, Arizona State University, Tempe, AZ (Oct 2015)

Alan Wilson Lectures, University of California at Berkeley, Berkeley, CA (Oct 2015)

Services:

"SRBR Directors' Young Investigator Award” selection committee S. Golden and David Welsh hosted

roundtable on science communication at SRBR meeting, (May 2016)

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Diversity:

Presentation to Summer Transfer Ahead Research Training (START) Program lab tours for transfer students (Jul 2015)

Search committee training on implicit bias (Sep 2015)

presentation to IRACDA (IRACDA, Institutional Research and Academic Career Development Award) participants on preparing applications for positions (Oct 2015)

Signed up for early calling to encourage under-represented students; made 20 calls Hosted students from Yokohama City University, Japan (Mar 2016)

Met with VP for Research at NMSU to discuss research opportunities (Jun 2016)

Hosted summer student from HHMI Exceptional Research Opportunities Program (EXROP) also nominated a UCSD student who conducted EXROP research in the Rosbash lab at Brandeis (Summer 2016)

David Welsh:

Invited webinar talk for Photonics Media, 4/16

Invited talk at Society for Research on Biological Rhythms, Palm Harbor, FL, 5/16

Advised Dept. Psychiatry Chair on recruiting faculty in the area of sleep research (2014-Present)

Organizer, Outreach Strategies Lunch, Society for Research on Biological Rhythms, 5/24/16

Andy LiWang:

I currently have three Hispanic undergraduate researchers in my lab doing clocks research. Each of them has been in my lab for several months now.

Summer 2015 & Summer 2016: My lab hosted disadvantaged high-school students for 8 weeks of hands-on research as part of the American Chemical Society’s Summer Experience for the Economically Disadvantaged (ACS SEED) Project.

Summer 2015 & Summer 2016: My lab hosted NSF REU students who worked on clocks projects.

Presentations:

"NMR of a Biological Clock", Bax Symposium, National Institutes of Health, Bethesda, MD (June 13, 2016 - June 14, 2016)

"Atomic-resolution mechanism of the cyanobacterial circadian clock", SRBR Conference, Society for Research on Biological Rhythms, Panel: Post-transcriptional/translational circadian mechanisms, Innisbrook Golf Resort, Palm Harbor2015, Air Force, FL (May 21, 2016 - May 25, 2016)

"Atomic-resolution mechanism of the cyanobacterial circadian clock", 20th Southern California Users of Magnets Meeting, Los Angeles (March 05, 2016 - March 05, 2016)

"Decoding the mysterious mechanism of a biological clock", Combined AFOSR Biophysics and Human Performance Program Review Office of Scientific Research, San Antonio, Texas (November 02, 2015 - November 06, 2015)

Dorothy Sears:

Presentation in for the Doris Howell Foundation luncheon titled “Simple Lifestyle Changes for Improving Women's Health” that was written up in the La Jolla Light newspaper and on their website (May 2016)

Presented my research on the associations between nighttime eating/length of night fasting interval and chronic disease risk and cancer recurrence

Presented for “Pedal the Cause”, the organization that raises funds to support the San Diego NCI Cancer Centers Council (C3) Collaborative Translational Cancer Research Pilot Projects (Jun 2016)

Presented “How nightly fasting is associated with poor health outcomes” (April 2016)

http://www.photonics.com/Webinar.aspx?WID=90

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Arizona State University School of Nutrition & Health Promotion’s Spring Speaker Series - “Novel Diet & Behavioral Interventions for Reducing Cardiometabolic Disease & Cancer Risk” (Spring 2016)

American Diabetes Association – Riverside Father of the Year Honorees Reception (2016)

Zone Diet Mexico Seminar – “Novel Diet & Behavioral Interventions for Reducing Chronic Disease Risk”

(2015)

Pint of Science, San Diego - “How Can You Reduce Your Risk of Type 2 Diabetes?” (2015)

UCSD Pathology Research Lecture Series – “Novel Diet & Behavioral Interventions for Reducing Insulin

Resistance & Cancer Risk” (2015)

William Joiner:

SURF summer student mentor (2015)

Panel discussion about research ethics with UCSD IRACDA members (Feb 2016)

Invited Speaker, University of Pennsylvania, CSCN 25th anniversary symposium (May 2016)

Invited Speaker, Annual meeting of the Associated Professional Sleep Societies (Jun 2016)

Davide Dulcis:

Chronobiology-related talk at the Univ. of Vienna Title: Light-induced neurotransmitter plasticity

affecting behaviour. Time and light: sensory and chronobiology symposium, University of Vienna, Austria

(May 8, 2016)

Hosted a master student from the Netherlands for 6 months who worked on a chronobiology-related

project.-Student:Esther M.C. Schrurs, Pharmacology Master Prgm, Utrecht University (Sept-2015-Feb-

2016)

Pamela Mellon:

Speaker, Diabetes Research Center, Junior Faculty Workshop, UC Los Angeles

Diabetes Research Center Retreat, UC Los Angeles, Poster presentation

Endocrine Society Annual Meeting, Symposium Chair, Presidential Poster Judge, San Diego

Speaker, Career Development Workshop, Mentorship with Women in Endocrinology, The Endocrine

Society Annual Meeting, San Diego

Katja Lamia:

Cold Spring Harbor Asia Conference on Biological Rhythms, 10/2015

University of California, San Diego, Bioengineering Department, 10/2015

San Diego Muscle Research Consortium, 9/2015

ResearcHERS presentation: a public lecture for San Diego community, 6/2016

Society for Research on Biological Rhythms Bi-Annual Meeting, 5/2016

The Scripps Research Institute cell cycle meeting, 2/2016

Barbara Parry:

Crossing the Desert of Our Lives. Insights from CS Lewis The Horse and His Boy. Adult Forum. St. Paul’s

Anglican/Episcopal Cathedral. San Diego, CA. July 12, 2015.

Early wake therapy reduces the melatonin onset-sleep onset phase-angle and improves mood in

depressed pregnant women. In symposium: Sleep and circadian rhythms as risk factors for perinatal

mental health. Perinatal Mental Health Conference. Northwestern University. Chicago, Ill. November

3-6, 2015.

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The Hormonal Basis of Mood Disorders in Women. Southern California Psychiatric Society:

Psychopharmacology Update 27. Los Angeles, CA. January 30, 2016.

Invited presentation by Thomas Kelly, MD, Department of Reproductive Medicine, to the Perinatal

Practice Group on Women’s Studies of Sleep and Light Therapy. UCSD Medical Center. March 10, 2016

The Chronobiological Basis of Women’s Mood Disorders. Reproductive Medicine Grand Rounds. UCSD

Medical Center, San Diego, CA March 30, 2016.

Treating Women’s Mood Changes with Sleep and Light Therapy. Poster presentation, Public Health

Research Day, Second Annual UCSD presentation by the Institute for Public Health. UCSD, La Jolla, CA.

April 6, 2016.

Chronobiology of Women’s Mood Disorders. Psychiatry Departmental Faculty Meeting. June 14, 2016,

La Jolla, CA.

Supervision and consultation Psychiatry junior faculty member, Jeanne Maglionne, MD, PhD re:

presentation to the VA on Women’s Mental Health, sources of grant funding support, circadian

measures for sleep, activity and melatonin and Academic Senate Award on light therapy for medically ill

patients. Fall 2015-present

Clinical Chronobiological Research Consultant: Center for Circadian Biology. Faculty Mentor and

Collaborator for ongoing interdisciplinary studies and journal clubs

Supervision as Faculty Research Mentor: Department of Psychiatry Residency Research Track, Mercedes

Szpunar, MD, PhD on neuroendocrinology of peripartum depression and response to chronobiological

interventions. July 2014-present

Supervision post-doctoral psychology fellow, Melissa Tarasenko, PhD: 20% effort on clinical assessment

of women with mood disorders related to the reproductive cycle. Jan 2016-present

Supervision and mentor of undergraduate student Emily Judd, recipient of a $5,000 research scholarship

from the Doris A. Howell Foundation Women’s Health Research for her summer research proposal on

subjective vs. objective sleep measures in women with perinatal depression vs. healthy controls. An

abstract was submitted, and accepted for presentation at the Sleep Research Society in Denver, CO,

June 2016

Hanne Hoffmann:

K99/R00 HD084759-01. K99/R00 Pathway to Independence award from NICHD (2016-2021). The Role of

the Homeoprotein Vax1 in Fertility and Circadian Rhythm 2016

The Homeodomain Protein VAX1 is Required for GnRH Neuron Maturation and Fertility. Invited seminar in the Reproductive Endocrinology Unit of the Department of Medicine, Harvard Medical School, Mass. General Hospital. Boston, MA (March 2016)

Hanne M. Hoffmann, Jason D. Meadows, Crystal Trang, Brittainy Hereford, Kapil Bharti, Michael R. Gorman, Pamela L. Mellon. Deletion of SIX3 or VAX1 in the SCN impairs circadian rhythms and fertility. ENDO 2016 (Endocrine Society), Boston, MA (March 2016).

o Recipient of the 2016 Neena Schwartz Young Investigator Award in Basic Science

o Recipient of the 2016 Early Investigators Award supported by Merck & Co., Inc.

Deletion of the transcription factor Vax1 affects neuronal development and impairs fertility. Lecturer in

the graduate biology program. California State University, Fresno, CA (May 2016)

CCB symposium: From Cells to Clinic, Center for Circadian Rhythms, San Diego (February 2016)

Mentoring minority Rotation Student in Mellon lab Erica C. Pandolfi, UCSD PhD Rotation Student (2014-

present)

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Volunteering at the UCSD outreach program “Society for Undergraduate Research and Outreach” (SURO) (2014-current)

Committee member of the Mentoring Committee at Women in Endocrinology (2015-current) Mentor in the Mentor Assistance Program (MAP) at UC San Diego (2015-current) Mentor Crystal Trang, UCSD Undergraduate Masters Student, (July 2015-June 2016) Mentor Crystal Trang, UCSD Masters Student (July 2015-June 2016)

o o Summer Research Fellowship: Excellence in Research Award from Endocrinology- project on

circadian rhythms in fertility (2016) Mentor Brittainy M. Hereford. Summer Student from University of Virginia (June-August 2015)

o Short-Term Research Experience for Underrepresented Persons (STEP-UP) program at NIH-NIDDK o Annual Biomedical Research Conference for Minority Students (ABRCMS) Travel award

Pagkapol Pongsawakul:

Lab Demo/Tour: Metabolism and Clock at March of Dimes High School Science Day. The Salk Institute for Biological Studies - San Diego high school students and teachers (awarded Best Rated Lab Tour by students and teachers) (February 2016)

Lab Demo/Tour: Metabolism and Clock at the 4th Annual Explore Salk. The Salk Institute for Biological

Studies - adults from La Jolla/San Diego areas (April 2016)

Takako Noguchi:

“Calcium Circadian Rhythmicity in the Suprachiasmatic Nucleus: Cell Autonomy and Network Reinforcement. Society for Research on Biological Rhythms (SRBR), Palm Harbor, USA (May 21-25, 2016)

“Mechanisms of fast resetting of clocks following rhythm bifurcation” Japanese Society for Chronobiology, The 22nd annual meetingTokyo, Japan (Nov 21-22, 2015)

Bartlomiej Borek:

Participated in developing and implementing guest lectures on diversity and inclusiveness in teaching for Stanley Lo's Graduate Undergraduate Instructional Apprentice courses (BENG195, BGGN500) required for all Instructional Assistants in the Division of Biology

First and corresponding author on a draft of a perspective piece for eLife (for which the Editor has expressed enthusiasm). This manuscript entitled "The Value of Postdoctoral Teaching about Diversity and Inclusion" describes the experience of participating in the BENG195/BGGN500 courses, and the value of this type of initiative for postdoctoral career development

Developed and implemented lectures, tutorials and groups projects at the Center for Systems Biology Mathematical Modeling Workshop (Feb. 2016) and the q-Bio Summer Schools in Synthetic Biology (Aug. 2015, and July 2016). These outreach activities provided support for underprivileged applicants, and the Summer Schools were made up of an international mix of students

Co-mentored the UCSD iGEM Team which was composed of undergraduates from diverse fields and backgrounds (2015).

ORU Goals for the coming year

Evaluate, prioritize, and implement recommendations from the external advisory board

Continue to Increase diversity in CCB activities

Improve media coverage of CCB events

Continue to host successful workshops and symposia

Work with the campus development office to increase corporate and private fundraising

Submit additional group grants, seeking center-level funding

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Other Income Comments on the Campus Data Report

The Campus Data report incorrectly reflects the space assigned to the Center for Circadian Biology. CCB is assigned two administrative offices and a conference room. The total is 558 square feet. STAFF & PARTICIPANTS

TYPE NAME TITLE START DATE

END

DATE

HOME DEPARTMENT

or INSTITUTION

Director Golden, Susan Professor 7/1/2009 Biological Sciences,

Molecular

Associate

Director Welsh, David

Associate

Professor 7/1/2009 Psychiatry

External

Advisory Board Block, Gene

Chancellor-

Professor 5/1/2011

UCLA Chancellor's

Office

External

Advisory Board Kay, Steve Dean-Professor 7/1/2012

University of Southern

California

External

Advisory Board Moline, Margaret PhD, Director 9/1/2012 Eisai, Inc.

External

Advisory Board Takahashi, Joseph Professor 5/1/2011 UT Southwestern

External

Advisory Board White, David P. Professor 3/15/16 Harvard Medical School

External

Advisory Board Young, Michael Professor 5/1/2011

The Rockefeller

University

External

Advisory Board Zee, Phyllis Professor 5/1/2011

Northwestern

University

Executive

Committee Ancoli-Israel , Sonia

Professor

Emeritus 7/1/2009 Psychiatry

Executive

Committee Brody, Stu

Professor

Emeritus 7/1/2009

Biological Sciences,

Molecular

Executive

Committee Gorman, Michael Professor 7/1/2009 Psychology

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Executive

Committee McCarthy, Michael

Assistant

Professor 5/1/2011 Psychiatry

Executive

Committee Panda, Satchin

Asst. Adjunct

Professor 7/1/2009 Salk, Biological Sciences

CCB Lab

Member Schoeller, Erica Postdoc Fellow 8/30/2013 Reproductive Medicine

Faculty

Member Bechtel, William Professor 7/1/2009 Philosophy

Faculty

Member Chory, Joanne Professor 7/1/2009 Salk, Biological Sciences

Faculty

Member Desplats, Paula Asst Professor 7/31/2014 Neurosciences

Faculty

Member Dulcis, Davide Assoc Res Sci 8/1/15 Psychiatry

Faculty

Member Elliott, Jeff

Project Scientist


Faculty

Member Ellisman, Mark Professor 7/5/2011 Neurosciences

Faculty

Member Evans, Ronald Professor 7/1/2009 Salk, Biological Sciences

Faculty

Member Greenspan, Ralph

Research

Scientist 7/1/2009

Kavli Institute for Brain

& Mind

Faculty

Member Hasty, Jeff Professor 7/1/2009


Bioengineering

Faculty

Member Holmes, Todd Professor 1/24/2011 UC Irvine

Faculty

Member Huberman, Andy

Assistant

Professor 1/1/2011 6/20/16 Neurobiology

Faculty

Member

Hwa, Terence

(Terry) Professor 7/1/2009 Physics

Faculty

Member Joiner, William

Assistant

Professor 7/1/2009 Pharmacology

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Faculty

Member

Kauffman,

Alexander (Sasha)

Assistant

Professor 7/1/2009 Reproductive Medicine

Faculty

Member Kelsoe, John Professor 9/21/2011 Psychiatry

Faculty

Member Kripke, Daniel

Professor


Faculty

Member Lamia, Katja

Assistant

Professor 9/1/2010

The Scripps Research

Institute

Faculty

Member LiWang, Andy

Associate

Professor 9/1/2010 UC Merced

Faculty

Member MacLeod, Don Professor 3/12/2015 Psychology

Faculty

Member Malhotra, Atul Professor, MD 8/30/2013

Medicine - Sleep,

Pulmonary and Critical

Care

Faculty

Member Mednick, Sara

Assistant

Adjunct

Professor

7/1/2009 Psychology

Faculty

Member Mellon, Pamela Professor 7/1/2009 Reproductive Medicine

Faculty

Member Montminy, Marc

Adjunct

Professor 7/1/2009 Salk, Biological Sciences

Faculty

Member

Nievergelt,

Caroline

Assistant

Adjunct

Professor

5/1/2011 Psychiatry

Faculty

Member Owens, Robert

Assistant

Professor 9/22/15 Medicine

Faculty

Member Parry, Barbara Professor 7/1/2009 Psychiatry

Faculty

Member Partch, Carrie

Assistant

Professor 9/28/2011 UC Santa Cruz

Faculty

Member Pruneda-Paz, Jose

Assistant

Professor 7/10/2009

Biological Sciences, Cell

& Developmental

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Faculty

Member Rickard, Timothy Professor 7/1/2009 Psychology

Faculty

Member Rulkov, Nikolai

Research

Scientist 11/1/2010

BioCircuits Institute

(BCI)

Faculty

Member

Sears, Dorothy

(Dody)

Associate

Professor 1/13/2015 Medicine

Faculty

Member Sejnowski, Terry Professor 9/1/2010

Salk, Computer Science

and Engineering

Faculty

Member Spitzer, Nicholas Professor 7/10/2009 Neurobiology

Faculty

Member Tsimring, Lev

Research

Scientist 7/1/2010


(BCI)

CCB Lab

Member Abrahamsen, Adele

Research

Scientist 7/10/2009

Center for Research in

Language

CCB Lab

Member Afetian, Megan Research Tech 9/1/2010


Institute

CCB Lab

Member Aimon, Sophie Postdoc 9/27/2012


& Mind

CCB Lab

Member Applebee, Kenyon Postdoc 6/30/2011


& Mind

CCB Lab

Member Asimgil, Hande Postdoc 3/14/16 UC Santa Cruiz

CCB Lab

Member Avanzino, Julie

Undergraduate

Student 1/7/2012 Psychiatry

CCB Lab

Member Bittihn, Philip Postdoc 12/13/2011


(BCI)

CCB Lab

Member Bonaldi, Katia Postdoc 7/5/2011

Biological Science, Cell

Development

CCB Lab

Member Bordowitz, Juliana Postdoc 7/10/2009


& Mind

CCB Lab

Member Borek, Bart Postdoc 10/3/2012 BioCircuits Institute

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CCB Lab

Member Boyd, Joseph Postdoc 10/11/2011

Center for Circadian

Biology (CCB)

CCB Lab

Member Buffington, Angela Clin Soc Wrk 9/12/2015 Psychiatry

CCB Lab

Member Burko, Yogev Postdoc 1/27/2016 Salk, Biological Sciences

CCB Lab

Member Chaix, Amandine Postdoc Fellow 9/20/2011 Salk, Biological Sciences

CCB Lab

Member

Chang, Yonggang

(Tyler) Postdoc 4/27/2011

UC Merced - School of

Natural Sciences

CCB Lab

Member Chavan, Archana Postdoc 8/13/2014

UC Merced - School of

Natural Sciences

CCB Lab

Member Clark, Daniel Assistant I 7/10/2009 Reproductive Medicine

CCB Lab

Member Cohen, Susan Postdoc 7/10/2009


Biology (CCB)

CCB Lab

Member Cookson, Scott Postdoc 3/10/2014


(BCI)

CCB Lab

Member Daulo, Anthony Writer Sr. 6/15/2015


Biology (CCB)

CCB Lab

Member DeYoung, Pamela

RPSGT Technical

Sleep Director 9/22/2015 Medicine

CCB Lab

Member Diamond, Spencer Postdoc 4/26/2011

Division of Biological

Sciences

CCB Lab

Member Didovyk, Andriy Postdoc 12/13/2011


(BCI)

CCB Lab

Member Diemer, Tanja

Staff Research

Associate II 7/27/2011 Psychiatry

CCB Lab

Member Duglan, Drew Postdoc 6/10/2016


Institute

CCB Lab

Member Farrow, Victoria Psychologist 9/12/2015 Psychiatry

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CCB Lab

Member

Fernandes,

Malcom

Undergrad


CCB Lab

Member Franks, Kyle Undergraduate 3/14/2016 UC Santa Cruz

CCB Lab

Member Glickman, Gena Postdoc 7/10/2009 Psychology

CCB Lab

Member Goularte, Nicolette Junior Specialist 3/14/2016 UC Santa Cruz

CCB Lab

Member Grover, Dhruv

Assistant Project

Scientist 1/27/2016


& Mind

CCB Lab

Member Gustafson, Chelsea

Graduate

Student 3/14/2016 UC Santa Cruz

CCB Lab

Member

Harrison, Elizabeth

(Liz) Postdoc 7/10/2009 Psychology

CCB Lab

Member Henriksson, Emma Postdoc 9/10/2015


Institute

CCB Lab

Member Hoffmann, Hanne Postdoc 6/30/2011 Reproductive Medicine

CCB Lab

Member Huang, Polly

Undergraduate

Rotation

Student

6/30/2011 1/1/16 Reproductive Medicine

CCB Lab

Member Huber, Anne-Laure

Research

Associate 1/7/2012


Institute

CCB Lab

Member Jaiswal, Stuti Physician, MD 9/22/2015 Medicine

CCB Lab

Member Jeong, Young Mi SR1 2/2/2015


Biology (CCB)

CCB Lab

Member Jin, Meng Postdoc 9/28/2012


(BCI)

CCB Lab

Member Johnson, Jeremy

Undergraduate

Student 2/7/2012 Psychology

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CCB Lab

Member Johnson, Sarah Lab Manager 1/27/2016


& Mind

CCB Lab

Member

Kanjanakantorn,

Pichaporn

Undergraduate

Student 2/4/2014


Biology (CCB)

CCB Lab

Member Kasrazadeh, Paul

Undergraduate

Student 9/21/2015

Biological Science,

Microbiology

CCB Lab

Member Katsuki, Takeo

Assistant Project

Scientist 7/10/2009


& Mind

CCB Lab

Member Kim, Jessica Undergraduate 9/21/2015 Neuroscience

CCB Lab

Member Kim, Minsu Postdoc 9/8/2011 Physics

CCB Lab

Member Lam, Diana

Research

Associate 3/14/2016


& Mind

CCB Lab

Member Lainscsek, Claudia

Assistant Project

Scientist 9/29/2011

Biological Science,

Neurosciences

CCB Lab

Member Le, Hiep

Research

Assistant 7/10/2009 Salk, Biological Sciences

CCB Lab

Member Lieu, Cuong

Undergraduate

Student 9/21/2015

Biological Science,

Microbiology

CCB Lab

Member Linges, Mary Sr Survey wkr 9/12/2015 Psychiatry

CCB Lab

Member Liu, Clifford Masters Student 7/1/2016 Pharmacology

CCB Lab

Member Liu, Lianqi

Associate

Project Scientist 7/10/2009 Psychiatry

CCB Lab

Member Long, Jaimie

Undergraduate


CCB Lab

Member López, Ana M.

Staff Research


CCB Lab

Member Loredo, Jose Director 2/8/2012 Psychiatry

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CCB Lab

Member Lowe, Laura

Undergraduate

student 9/21/2015

Biological Science,

Microbiology

CCB Lab

Member Luu, Jansen

Undergraduate

Student 3/14/2016 UC Santa Cruz

CCB Lab

Member Maglione, Jeanne

Resident

physician 7/10/2009 Psychiatry

CCB Lab

Member Manoogian, Emily Postdoc Fellow 3/14/2016 Salk, Biological Sciences

CCB Lab

Member

Martínez, Luis

Fernando

Staff Research


CCB Lab

Member May, Deborah

Undergraduate -

Lab Manager 9/17/2014 6/30/16 Psychology

CCB Lab

Member McCarra, Matthew

Resident

Physician, MD 9/22/2015 Medicine

CCB Lab

Member

McDevitt, Elizabeth

(Lizzie) Researcher 4/27/2011 Psychology

CCB Lab

Member McKenna, Ben

Clinical

Psychologist 7/10/2009 Psychiatry, VA

CCB Lab

Member McKnight, Briana

Undergraduate

Student 6/23/2015


Biology (CCB)

CCB Lab

Member McPherson, Adam Postdoc 1/27/2016 Psychiatry

CCB Lab

Member Meadows, Jason

Staff Research

Associate 6/30/2011 Reproductive Medicine

CCB Lab

Member Meliska, Charles J.

Associate

Project Scientist 7/10/2009 Psychiatry

CCB Lab

Member Mendez, Francisco Junior Specialist 3/14/2016 UC Santa Cruz

CCB Lab

Member Mure, Ludovic Postdoc 3/29/2011 Salk, Biological Sciences

CCB Lab

Member Nachnani, Rahul

Undergrad


Page 16

CCB Lab

Member Nagel, Dawn Postdoc-Fellow 12/1/2012


Institute

CCB Lab

Member Natarajan, Loki

Associate

Adjunct Prof. 7/10/2009 Psychiatry

CCB Lab

Member Nguyen, Leslee

Undergraduate

Research 3/14/2016 UC Santa Cruz

CCB Lab

Member Noguchi, Takako

Asst. Project

Scientist 7/10/2009 Psychiatry

CCB Lab

Member Orr, Jeremy

Assoicate

Physician, MD 9/22/2015 Medicine

CCB Lab

Member Paddock, Mark Project Scientist 11/11/2011 Physics

CCB Lab

Member Papp, Stephanie Research Tech 9/10/2015


Institute

CCB Lab

Member

Pongsawakul,

Pagkapol (Yhew) Postdoc 3/1/2014


Biology (CCB)

CCB Lab

Member Prindle, Arthur Postdoc 6/1/2014


Microbiology

CCB Lab

Member Rios, Luis Lab Technician 3/14/2016 Salk, Biological Sciences

CCB Lab

Member Romoli, Ben Postdoc 1/27/2016 Psychiatry

CCB Lab

Member Sancar, Cigdem Postdoc 5/18/2015


Biology (CCB)

CCB Lab

Member Seidner, Glen Postdoc 2/9/2011 Pharmacology

CCB Lab

Member Seluzicki, Adam Postdoc 6/4/2014 Salk, Biological Sciences

CCB Lab

Member

Sheredos,

Benjamin Postdoc 7/10/2009

HHMI-Center for

Circadian Biology (CCB)

CCB Lab

Member

Shultzaberger,

Ryan Postdoc 4/1/2012


& Mind

Page 17

CCB Lab

Member Simkovsky, Ryan Postdoc 3/1/2012


Biology (CCB)

CCB Lab

Member Smales, Erik

RPSGT Staff

research

associate

9/22/2015 Medicine

CCB Lab

Member Sonntag, Tim Postdoc 7/5/2011 Salk Biological Studies

CCB Lab

Member Sorenson, Diane

Staff SRA III

Supervisor 7/10/2009 Psychiatry

CCB Lab

Member Stephens, Shannon Postdoc Fellow 4/12/2016 Reproductive Medicine

CCB Lab

Member Sulli, Gabriele Postdoc 11/30/2012 Salk, Biological Sciences

CCB Lab

Member Taton, Arnaud Postdoc 4/26/2011

Biological Science,

Microbiology

CCB Lab

Member Trial, Blake Staff Technician 4/26/2011 4/15/16

Biological Science,

Microbiology

CCB Lab

Member Tonsfeldt, Karen Postdoc 2/2/2016 Reproductive Medicine

CCB Lab

Member Tseng, Roger Postdoc 4/27/2011


Biology (CCB)

CCB Lab

Member Uribe, Francisco Postdoc 11/30/2012

Biological Science, Cell

Development

CCB Lab

Member Wabnik, Krzysztof Postdoc 12/13/2011


(BCI)

CCB Lab

Member Wagner, Jenee

Staff Research

Assistant II 7/10/2009


& Mind

CCB Lab

Member Wang, Jingtong Postdoc 9/21/2015

Biological Science,

Microbiology

CCB Lab

Member Wang, Lexie

Staff Research

Assistant 9/28/2011 Psychiatry

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CCB Lab

Member

Wei, Heather

(Hongbing)

Staff Research

Associate II 1/7/2012

Psychiatry,

Neuroscience

CCB Lab

Member Welkie, David Postdoc 8/17/2015


Biology (CCB)

CCB Lab

Member Wiswell, Roxana BS/MS Student 9/21/2015

Department of

neuroscience

CCB Lab

Member Wu, Meilin Postdoc 7/10/2009 Pharmacology

CCB Lab

Member Xie, Huimin Postdoc 6/30/2011 Reproductive Medicine

CCB Lab

Member Zarrinpar, Amir Postdoc 4/27/2011 Salk, Biological Sciences

CCB Lab

Member Zhou, Lili Postdoc- 1/8/2016


Institute

CCB Lab

Member Zhao, Xuan Postdoc 7/11/2013 Salk, Biological Sciences

ACADEMIC AFFILIATES

NAME TITLE DEPARTMENT INSTITUTION

Bentley, George Assistant Professor Integrative Biology UC Berkeley

Bunney, Blynn Specialist

Psychiatry & Human

Behavior UC Irvine

Bunney, William

Distinguished

Professor

Psychiatry & Human

Behavior UC Irvine

Colwell, Chris Professor

Psychiatry and

Biobehavioral Sciences UCLA

Doyle, Frank Professor Chemical Engineering UC Santa Barbara

Fu, Ying-Hui Professor Department of Neurology UC San Francisco

Harmer, Stacey Professor

Department of Plant

Biology UC Davis

Page 19

Harmon, Frank

Adjunct Associate

Professor

Plant and Microbial

Biology UC Berkeley

Hoffmann, Alexander Professor

Chemistry &

Biochemistry UCLA

Kriegsfeld, Lance Professor

Psychology and

Neuroscience UC Berkeley

Petzold, Linda Professor

Mechanical &

Environmental

Engineering UC Santa Barbara

Plikus, Maksim Assistant Professor

Developmental & Cell

Biology UC Irvine

Ptáček, louis Professor Department of Neurology UC San Francisco

Sassone-Corsi, Paolo Professor

Department of

Pharmacology UC Irvine

Zhao, Qun-Yong Professor

Department of

Pharmacology UC Irvine

Zucker, Irving Professor Emeritus

Psysiology & Integrative

Biology UC Berkeley

GRADUATE STUDENTS

NAME ADVISOR START DATE END DATE HOME

DEPARTMENT

DEGREE / CONFERAL

DATE

Baik, Lisa Soyeon Holmes 3/14/16 UC Irvine

Baumgart, Leo Hasty 8/27/2013 Bioengineering

Benegiamo,

Giorgia Panda 7/2/2013

Salk, Biological

Sciences

Chan, Alanna Lamia 3/14/2016 The Scripps

Research Institute

Chionis, Antonios

Marios LiWang 3/11/2016 UC Merced

Csicsery, Nick Hasty 8/5/2013 Bioengineering

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Din, Omar Hasty 6/18/2012 Bioengineering

Dueck, Megan Hasty 10/1/2011 Bioengineering

Graham, Garrett Hasty 1/1/2015 Bioengineering

Heisler, Joel LiWang 9/10/2015 UC Merced

Hoffner, Nicole Joiner 3/14/16 Reproductive

Medicine

Kriebs, Anna Lamia 9/10/2015 The Scripps

Research Institute

Li, Zheng Pruneda-

Paz 10/10/2014

Biological Science,

Cell Development

Liu, Cindy Panda 12/12/2013 Salk, Biological

Sciences

Liu, Yu Hsin Panda 3/14/2016 Salk, Biological

Science

Lovelett, Jarrett Richard 9/22/2015 Psychology

Luke, Joyce Hasty 7/10/2009 Bioengineering

Marinac,

Catherine Sears 12/2/2015 Medicine

Michael, Alicia Partch 3/11/2016 UC Santa Cruz

Mott, Jennifer Desplats 9/21/2015 Department of

neuroscience

Nave, Ceazar Holmes 3/14/2016 UC Irvine

O’Laughlin, Ricky Hasty 7/29/2013 Bioengineering

Pan, Steven Rickard 9/22/2015 Psychology

Poling, Matthew Kauffman 7/10/2009 Reproductive

Medicine

Poling, Matthew Parry 7/10/2009 Reproductive

Medicine

Raiewski, Evan Gorman 7/10/2009 Psychology

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Roberts, Logan Holmes 3/14/2016 UC Irvine

Rubin, Ben Golden 12/12/2013 Center for Circadian

Biology (CCB)

Sandate, Colby Lamia 9/10/2015 The Scripps

Research Institute

Scott, Spencer Hasty 9/1/2015 Bioengineering

Soler, Robert Gorman 1/26/2016 Psychology

Satterfield,

Kendall Joiner 3/14/16 Pharmacology

Stasiowski,

Elizabeth Hasty 1/1/2015 Bioengineering

Sun, Ruichen Greenspan 9/27/2012 Kavli Institute for

Brain & Mind

Thouvenin, Greg Hasty 7/27/16 Bioengineering

Vaughan, Megan Lamia 3/14/2016 The Scripps

Research Institute

Walbeek, Thijs Gorman 9/17/2014 Psychology

Xiong, Liyang Tsimring 9/1/2014 Physics

VISITORS/VOLUNTEERS

NAME START DATE END DATE HOME

INSTITUTION SOURCE OF SUPPORT

Changeux, Jean-Pierre 3/11/2016 Kavli Inst. Home Institution

Chao, (Roy) Yi-Yun 9/21/2015 UC Riverside

Cordeiro, Rita 11/23/2014 2/1/2015 Germany Home Institution

Farkas, Andrew 6/10/16 UCSB

Hirayama, Masa 4/6/2016 Salk Home Institution

Jen, Rachel 9/22/2015 Canada Home Institution

Li, (Sylvia) Yanru 9/22/2015 China Home Institution

Page 22

Orsi, Enrico 4/13/2015 9/30/15 Visitor-Netherlands Home Institution

Shin, Wonchul 9/22/2015 Korea Home Institution

University-Industry and University-Government Activities

Drs. Satchin Panda and Michael Gorman – Joint Center for Biological Timing from the Indo-US Science & Technology Forum. Drs. Susan Golden and Rakefet Schwarz of Bar-Ilan - NSF- US-Israel Binational Foundation (BSF) Intercellular Communication Underlying Biofilm Development in Cyanobacteria. Drs. David Welsh and Michael McCarthy work at the VA. Seminars, Lectures, Symposia and Conference programs

Title: CCB Fall Workshop on Biological Timing Date: Friday, November 20, 2015 Presenter(s): Joseph Boyd - Postdoc in Susan Golden Lab, UCSD

Susan Cohen - Postdoc in Susan Golden Lab, UCSD

Susan Golden - Director of CCB, Professor of Molecular Biology, UCSD

Elizabeth Harrison - Postdoc/Visiting Scholar in Gorman Lab, UCSD

Alexander Kauffman - Associate Professor of Reproductive Endocrinology, UCSD

Dominic Landgraf - Postdoc in Welsh Lab, UCSD

Catherine Marinac - Graduate Student in Sears Lab, UCSD

Ludovic Mure - Postdoc in Panda Lab, SALK

Arthur Prindle - Postdoc in Suel Lab, UCSD

Erica Schoeller - Postdoc in Mellon Lab, UCSD

Andrew Steele - Assistant Professor of Biological Sciences, California State Polytechnic University,

Pomona

Location: UCSD 15th Floor, Village West

Title: 6th Annual CCB Symposium “From Cells to Clinic” Date: February 24-26, 2016 Presenter(s): Sonia Ancoli-Israel (UC San Diego)

Bogi Anderson (UC Irvine)

Joanna Chiu (UC Davis)

Mark Ellisman (UC San Diego)

Carolina Escobar (National Autonomous University of Mexico)

Jeff Hasty (UC San Diego)

Anne-Laure Huber (Scripps Research Institute)

Takato Imaizumi (University of Washington)

Rob Knight (UC San Diego)

Andy LiWang (UC Merced)

Doug McMahon (Vanderbilt University)

Gina R. Poe (University of Michigan Medical School)

Page 23

Till Roenneberg (Ludwig-Maximilians University Munich)

Norman F. Ruby (Stanford University)

Erica Schoeller (UC San Diego)

Debra J. Skene (University of Surrey, UK)

Joseph Takahashi (University of Texas Southwestern Medical Center)

Eve Van Cauter (University of Chicago Medicine)

Location: Sanford Consortium Auditorium, UCSD

Title: CCB Workshop on Circadian Rhythms & Shiftwork Date: Wednesday, February 24, 2016 Presenter(s): Phyllis Zee - Director of the Center for Sleep and Circadian Medicine, Northwestern University Feinberg School of Medicine Michael Gorman - Professor of Psychology, UC San Diego Debra Skene – University of Surrey Sonia Ancoli-Israel - Professor Emeritus of Psychiatry and Medicine, UC San Diego Location: Sanford Consortium Auditorium, UCSD

ORU Publications

The 3 Most Cited Publications of the ORU To be provided at next 5-year review.

Publications

CCB Publications – 7-1-2015 to 6-30-2016

Sonia Ancoli-Israel The SBSM Guide to Actigraphy Monitoring: Clinical and Research Applications Ancoli-Israel S; Martin JL; Blackwell, T; Buenaver, L; Liu, L; Meltzer LJ, Sadeh, A; Spira, AP; Taylor D Chronobiology International 32:10, pages 1427-1437.doi: 10.1080/15402002.2015.1046356 2015 Aug 14 Sleep-disordered Breathing and Incident Heart Failure in Older Men Sogol Javaheri1, Terri Blackwell2, Sonia Ancoli-Israel3, Kristine E. Ensrud4, Katie L. Stone2, and Susan Redline American Journal of Respiratory And Critical Care Medicine, Vol. 193, No. 5 (2016), pages 561-568. DOI: 10.1164/rccm.201503-0536OC 2016 March 1. Associations of PER3 and RORA Circadian Gene Polymorphisms and Depressive Symptoms in Older Adults Jeanne E. Maglione, Caroline M. Nievergelt, Neeta Parimi, Daniel S. Evans., Sonia Ancoli-Israel, Katie L. Stone, Kristine Yaffe, Susan Redline, Gregory J. Tranah The American Journal of Geriatric Psychiatry, Vol 23:10, pages 1075–1087. DOI:10.1016/j.jagp.2015.03.002 2015 March 13

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Association of Urinary 6-Sulfatoxymelatonin (aMT6s) Levels and Objective and Subjective Sleep Measures in Older Men: The MrOS Sleep Study Ingvild Saksvik-Lehouillier, Stephanie L. Harrison, Lynn M. Marshall, Greg J. Tranah, Kristine Ensrud, Sonia Ancoli-Israel, Aaron Clemons, Susan Redline, Katie L. Stone, Eva S. Schernhammer Gerontol A Biol Sci Med Sci, Vol 70:12, pages 1569-1577.DOI: 10.1093/gerona/glv088 2015 Aug 11. Genetic associations of periodic limb movements of sleep in the elderly for the MrOS sleep study John W. Winkelmana, Terri Blackwellb, Katie Stoneb, Sonia Ancoli-Israelc, Gregory J. Tranahb, Susan Redlined Sleep Medicine Journal, Vol 16:11, pages 1360-1365. DOI: 10.1016/j.sleep.2015.07.017. Obstructive Sleep Apnea and Cognition in Parkinson's disease. Harmell, Neikrug, Palmer, Avanzino, Liu, Maglione, Natarajan, Corey-Bloom, Loredo, Ancoli-Israel S Sleep Med. 2016 May;21:28-34. DOI: 10.1016/j.sleep.2016.01.001. Epub 2016 Feb 10. William Bechtel Using computational models to discover and understand mechanisms Bechtel, W. Stud Hist Philos Sci. 2016 Apr;56:113-21. DOI: 10.1016/j.shpsa.2015.10.004. Epub 2015 Nov 19. Investigating neural representations: the tale of place cells Betchel, W Synthese (2016) 193: 1287. DOI:10.1007/s11229-014-0480-8. 2014 May 20. Mechanists Must be Holists Too! Perspectives from Circadian Biology Bechtel, W Hist Biol. 2016 Mar 10. DOI: 10.1007/s10739-016-9439-6. PMID: 26966017 Circadian Rhythms and Mood Disorders: Are the Phenomena and Mechanisms Causally Related? Bechtel, W. Front Psychiatry. 2015 Aug 24;6:118. DOI: 10.3389/fpsyt.2015.00118. PMID: 26379559. Can mechanistic explanation be reconciled with scale-free constitution and dynamics? Bechtel, W. Stud Hist Philos Biol Biomed Sci. 2015 Oct;53:84-93. DOI: 10.1016/j.shpsc.2015.03.006. Epub 2015 May 11. PMID: 25977254. The Non-Redundant Contributions of Marr's Three Levels of Analysis for Explaining Information-Processing Mechanisms Bechtel, W. and Shagrir, O. Top Cogn Sci, 7: 312–322. DOI:10.1111/tops.12141. 2015 April 22. Generalizing Mechanistic Explanations Using Graph-Theoretic Representations Bechtel, W. Explanation in Biology, Vol 11, pages 199-225. 2015 DOI Joanne Chory Cryptochromes Interact Directly with PIFs to Control Plant Growth in Limiting Blue Light Pedmale V, Huang S, Zander M, Cole B, Hetzel J, Ljung K, Reis P, Sridevi P, Nito K, Nery J, Ecker J, Chory J Cell Journal, Vol 164:1-2, pages 233-245. DOI: 10.1016/j.cell.2015.12.018. 2016 Jan 14.

Page 25

Ubiquitin facilitates a quality-control pathway that removes damaged chloroplasts Woodson J, Joens M, Sinson A, Gilkerson J, Salomé P, Weigel D, Fitzpatrick J, Chory J Science Magazine, Vol 350:6259, pages 450-454, DOI: 10.1126/science.aac7444. 2015 Oct 23 Characterization of tub4(P287L) , a β-tubulin mutant, revealed new aspects of microtubule regulation in shade. Yu J, Qiu H, Liu X, Wang M, Gao Y, Chory J, Tao Y. Integrative Plant Biology, 2015 Sep;57(9):757-69. DOI: 10.1111/jipb.12363. Epub 2015 Jun 23. Sustained NIK-mediated antiviral signalling confers broad-spectrum tolerance to begomoviruses in cultivated plants. Brustolini OJ, Machado JP, Condori-Apfata JA, Coco D, Deguchi M, Loriato VA, Pereira WA, Alfenas-Zerbini P, Zerbini FM, Inoue-Nagata AK, Santos AA, Chory J, Silva FF, Fontes EP. Plant Biotechnology, 2015 Dec;13(9):1300-11. DOI: 10.1111/pbi.12349. Epub 2015 Feb 16. Paula Desplats Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease. Kim C, Ojo-Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E. J Neuroinflammation. 2015 Dec 18;12:236. DOI: 10.1186/s12974-015-0455-9. Neuro-peptide treatment with Cerebrolysin improves the survival of neural stem cell grafts in an APP transgenic model of Alzheimer disease Rockensteina E, Desplats P, Ubhia K, Mantea M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Masliah E. Stem Cell Research Journal Vol 15:1, pages 54-67. DOI: 10.1016/j.scr.2015.04.008, 2015 Jul. Davide Dulcis Investigating the mechanism(s) underlying switching between states in bipolar disorder Young J, Dulcis D. European Journal of Pharmacology, Vol 759, pages 151-162. DOI: 10.1016/j.ejphar.2015.03.019, 2015 Jul 15. Mark Ellisman Design and synthesis of a minimal bacterial genome. Hutchison CA, Chuang RY, Noskov VN, Assad-Garcia N, Deerinck TJ, Ellisman MH, Gill J, Kannan K, Karas BJ, Ma L, Pelletier JF, Qi ZQ, Richter RA, Strychalski EA, Sun L, Suzuki Y, Tsvetanova B, Wise KS, Smith HO, Glass JI1, Merryman C, Gibson DG, Venter JC. Science. 2016 Mar 25;351(6280):aad6253. DOI: 10.1126/science.aad6253. Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1. Rubio-Marrero EN, Vincelli G, Jeffries CM, Shaikh TR, Pakos IS, Ranaivoson FM, von Daake S, Demeler B, De Jaco A, Perkins G, Ellisman MH, Trewhella J, Comoletti D. Biol Chem. 2016 Mar 11;291(11):5788-802. DOI: 10.1074/jbc.M115.705681. Epub 2015 Dec 31. X-Ray Microscopy as an Approach to Increasing Accuracy and Efficiency of Serial Block-Face Imaging for Correlated Light and Electron Microscopy of Biological Specimens Bushong E, Johnson D, Kim K, Terada T, Hatori M, Peltier S, Panda S, Merkle A, Ellisman M. Microscopy and Microanalysis, Vol 21:1, pages 231-238. DOI: 10.1017/S1431927614013579, 2015 Feb

Page 26

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali S, McGeough M, Ellisman M, Seki E, Gustafsson A, Hoffman H, Diaz-Meco M, Moscat J, Karin M. Cell Journal, Vol 164:5, pages 869-910, DOI: 10.1016/j.cell.2015.12.057, 2016 Feb 25 RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth Solga A, Pong W, Kim K, CiminoP, Toonen J, Walker J, Wylie T, Magrini V, Griffith M, Griffith O, Ly A, Ellisman M, Mardis E, Gutmann D. Neoplasia Journal, Vol 17:10, pages 776-788, DOI: 10.1016/j.neo.2015.10.002, 2015 Oct. Pannexin2 oligomers localize in the membranes of endosomal vesicles in mammalian cells while Pannexin1 channels traffic to the plasma membrane Boassa D, Nguyen P, Hu J, Ellisman M, Sosinsky G. Front. Cell. Neurosci., DOI: 10.3389/fncel.2014.00468, 2015 Feb. Correlative Stochastic Optical Reconstruction Microscopy and Electron Microscopy Kim D, Deerinck T, Sigal Y, Babcock H, Ellisman M, Zhuang X. PLoS ONE 10(4): e0124581. DOI:10.1371/journal.pone.0124581, 2015 Apr 15. Efficient semi-automatic 3D segmentation for neuron tracing in electron microscopy images Jonesa C, Liua T, Cohand N, Ellisman M, Tasdizen T. Journal of Neuroscience Methods, Vol 246, pages 13-21, DOI: 10.1016/j.jneumeth.2015.03.005, 2015 May. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress Antonuccia L, Fagmana J, Kim J, Todoric J, Gukovsky I, Mackey M, Ellisman M, Karin M. PNAS, Vol 112:45, DOI: 10.1073/pnas.1519384112, 2015 Oct. Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions Schachtrup C, Ryu J, Mammadzada K, Khan A, Carlton P, Perez A, Christian F, Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan J, Nitschke R, Houslay M, Ellisman M, Wyss-Coray T, Palop J, Akassoglou K. Nature Neuroscience 18, 1077–1080 (2015) DOI:10.1038/nn.4054, 2015 June 29 Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy Oua H, Deerinck T, Bushong E, Ellisman M, O’Shea C. Methods Journal, Vol 90, pages 39-48, DOI: 10.1016/j.ymeth.2015.06.002, 2015 Nov 15. Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes Rajagopal V, Bass G, Walker C, Crossman D, Petzer A, Hickey A, Siekmann I, Hoshijima M, Ellisman M, Crampin E, Soeller C. PLoS Comput Biol Journal, 11(9), DOI: 10.1371/journal.pcbi.1004417, 2015 Sept 3.

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Ronald Evans High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice Wall, CE; Whyte, J; Suh, JM; Fan, WW; Collins, B; Liddle, C; Yu, RT; Atkins, AR; Naviaux, JC; Li, KF; Bright, AT; Alaynick, WA; Downes, M; Naviaux, RK; Evans, RM. Nat Aca of Sciences, Vol: 112:28, Pages: 8714-8719, DOI: 10.1073/pnas.1509930112, 2015 JUL 14. Imaging Fibrosis and Separating Collagens using Second Harmonic Generation and Phasor Approach to Fluorescence Lifetime Imaging Ranjit, S; Dvornikov, A; Stakic, M; Hong, SH; Levi, M; Evans, RM; Gratton, E., Scientific Reports, Vol:

5, DOI: 10.1038/srep13378, 2015 AUG 21

Disease tolerance mediated by microbiome E-coli involves inflammasome and IGF-1 signaling Schieber, AMP; Lee, YM; Chang, MW; Leblanc, M; Collins, B; Downes, M; Evans, RM; Ayres, JS. Science, Vol: 350:6260, Pages: 558-563, DOI: 10.1126/science.aac6468, 2015 OCT 30. Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice Jo, YS; Ryu, D; Maida, A; Wang, X; Evans, RM; Schoonjans, K; Auwerx, J. HEPATOLOGY, Vol:62:5, Pages: 1606-1618, DOI: 10.1002/hep.27907, 2015 NOV. Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer Arensman, MD; Nguyen, P; Kershaw, KM; Lay, AR; Ostertag-Hill, CA; Sherman, MH; Downes, M; Liddle, C; Evans, RM; Dawson, DW. Molecular Cancer Research, Vol: 13:11, Pages: 1509-1519, DOI: 10.1158/1541-7786.MCR-15-0204, 2015 NOV. Depletion of fat-resident T-reg cells prevents age-associated insulin resistance Bapat, SP; Suh, J; Fang, S; Liu, SH; Zhang, Y; Cheng, A; Zhou, C; Liang, YQ; LeBlanc, M; Liddle, C; Atkins, AR; Yu, RT; Downes, M; Evans, RM; Zheng, Y. Nature, Vol:528:7580, DOI: 10.1038/nature16151, 2015 DEC 3. BRD4 is a novel therapeutic target for liver fibrosis Ding, N; Hah, N; Yu, RT; Sherman, MH; Benner, C; Leblanc, M; He, MX; Liddle, C; Downes, M; Evans, RM. Nat Aca of Sciences, Vol: 112:51, pages 15713-15718, DOI: 10.1073/pnas.1522163112, 2015 DEC 22. PPAR delta preserves a high resistance to fatigue in the mouse medial gastrocnemius after spinal cord transection Kim, JA; Roy, RR; Zhong, H; Alaynick, WA; Embler, E; Jang, C; Gomez, G; Sonoda, T; Evans, RM; Edgerton, VR Muscle & Nerve, Vol: 53:2, Pages: 287-296, DOI: 10.1002/mus.24723, FEB 2016. ERR gamma Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive beta Cells Yoshihara, E; Wei, Z; Lin, CS; Fang, S; Ahmadian, M; Kida, Y; Tseng, T; Dai, Y; Yu, RT; Liddle, C; Atkins, A; Downes, M; Evans, RM. Cell Metabolism, Volume: 23: 4, Pages: 622-634, DOI: 10.1016/j.cmet.2016.03.005, 2016 APR 12. ROR-gamma drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer Wang, JJ; Zou, JX; Xue, XQ; Cai, DM] ; Zhang, Y; Duan, ZJ; Xiang, QP; Yang, JC; Louie, MC; Borowsky, AD; Gao, AC; Evans, CP; Lam, KS; Xu, JZ ; Kung, HJ; Evans, RM; Xu, Y; Chen, HW. Nature Medicine, Vol: 22: 5, Pages: 488-496, DOI: 10.1038/nm.4070, 2016 MAY.

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Alexander Kauffman Circadian Control of the Female Reproductive Axis Through Gated Responsiveness of the RFRP-3 System to VIP Signaling Russo, KA; La, JL; Stephens, SBZ; Poling, MC; Padgaonkar, NA; Jennings, KJ; Piekarski, DJ; Kauffman, AS; Kriegsfeld, LJ Endocrinology, Vol: 156: 7, pages: 2608-2618, DOI: 10.1210/en.2014-1762, 2015JUL Gonadotropin and kisspeptin gene expression, but not GnRH, are impaired in cFOS deficient mice Xie, CC; Jonak, CR; Kauffman, AS; Coss, D Molecular And Cellular Endocrinology, Vol: 411:C, pages: 223-231, DOI: 10.1016/j.mce.2015.04.033, 2015 AUG 15 A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice Kauffman, AS; Thackray, VG; Ryan, GE; Tolson, KP; Glidewell-Kenney, CA; Semaan, SJ; Poling, MC; Iwata, N; Breen, KM; Duleba, AJ; Stener-Victorin, E; Shimasaki, S; Webster, NJ; Mellon, PL Biology of Reproduction, Vol: 93:3, DOI: 10.1095/biolreprod.115.131631, 2015 SEPT 1 Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice Stephens, SBZ; Tolson, KP; Rouse, ML; Poling, MC; Hashimoto-Partyka, MK; Mellon PL; Kauffman, AS Endocrinology, Vol: 156: 9, pages: 3091-3097, DOI: 10.1210/en.2015-1300, 2015 SEP Regulation and function of RFRP-3 (GnIH) neurons during postnatal development Poling, MC; Kauffman, AS, Frontiers In Endocrinology, Vol:6, DOI: 10.3389/fendo.2015.00150, 2015 SEPT 24 Corticosterone Blocks Ovarian Cyclicity and the LH Surge via Decreased Kisspeptin Neuron Activation in Female Mice Luo, E; Stephens, SBZ; Chaing, S; Munaganuru, N; Kauffman, AS; Breen, KM, Endocrinology, Vol: 157: 3, pages: 1187-1199, DOI: 10.1210/en.2015-1711, 2016 MAR John Kelsoe CDH13 and HCRTR2 May Be Associated with Hypersomnia Symptom of Bipolar Depression: A Genome-Wide Functional Enrichment Pathway Analysis Cho, CH; Lee, HJ; Woo, HG; Choi, JH; Greenwood, TA; Kelsoe, JR Psychiatry Investigation, Vol: 12: 3, pages: 402-407, DOI: 10.4306/pi.2015.12.3.402 2015 JUL Daniel Kripke Do hypnotic drugs cause cancer, like cigarettes? Kripke, DF Sleep Medicine, Vol: 16:12, pages, 1550-1551, DOI: 10.1016/j.sleep.2015.05.011, 2015 DEC Mortality Risk of Hypnotics: Strengths and Limits of Evidence Kripke, DF Drug Safety, Vol: 39:2, pages: 93-107, DOI: 10.1007/s40264-015-0362-0, 2016 FEB Katja Lamia Adipose Clocks: Burning the Midnight Oil Henriksson, E; Lamia, KA.

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Journal of Biological Rhythms, Vol: 30:5, pages: 364-373, DOI: 10.1177/0748730415581234, 2015 OCT Andy LiWang A protein fold switch joins the circadian oscillator to clock output in cyanobacteria Chang, YG; Cohen, SE; Phong, C; Myers, WK; Kim, YI; Tseng, R; Lin, J; Zhang, L; Boyd, JS; Lee, Y; Kang, S; Lee, D; Li, S; Britt, RD; Rust, MJ; Golden, SS; LiWang, A. Science, Vol: 349:6245, pages: 324-328, DOI: DOI: 10.1126/science.1260031, 2015 JUL 17 Don MacLeod Mesopic luminance assessed with minimally distinct border perception Raphael, S (Raphael, Sabine)[ 1,2 ] ; MacLeod, DIA. Journal of Vision, Vol: 15:9:12, DOI: 10.1167/15.9.12, 2015 A Lack of Experience-Dependent Plasticity After More Than a Decade of Recovered Sight Huber, E; Webster, JM; Brewer, AA; MacLeod, DIA; Wandell, BA; Boynton, GM; Wade, AR; Fine, I. Psychological Science, Vol: 26:4, pages: 393-401, DOI: 10.1177/0956797614563957, 2015 Atul Malhotra Obstructive Sleep Apnea Effects on the Right Ventricle and Beyond Raisinghani, A; Jen, R; Wilson, J; Malhotra, A. Canadian Journal of Cardiology, Vol: 31:7, pages: 821-822, 10.1016/j.cjca.2015.02.035, 2015 JUL Future of Sleep-Disordered Breathing Therapy Using a Mechanistic Approach Jen, R; Grandner, MA; Malhotra, A. Canadian Journal of Cardiology, Vol: 31:7, pages: 880-888, DOI: 10.1016/j.cjca.2015.02.007, 2015 JUL Should All Congestive Heart Failure Patients Have a Routine Sleep Apnea Screening? Con Li, YR; Daniels, LB; Strollo, PJ; Malhotra, A. Canadian Journal of Cardiology, Vol: 31:7, pages: 940-944, DOI: 10.1016/j.cjca.2015.04.013, 2015 JUL Central sleep apnoea in congestive heart failure Malhotra, A; Patil, S; Sands, S; Ayas, N. Lancet Respiratory Medicine, Vol: 32:7, pages: 507-508, DOI: 10.1016/S2213-2600(15)00235-0, 2015 JUL The Civil Liberty of Smoking Cigarettes Alexander, Malhotra, A. Chest, Vol: 148:1, pages: 6-8, DOI: 10.1378/chest.15-0340, 2015 JUL Treatment of Central Sleep Apnea with Adaptive Servoventilation in Chronic Heart Failure Ayas, NT; Patil, SP; Stanchina, M; Malhotra, A. American Journal of Respiratory And Critical Care Medicine Vol: 192:2, pages: 132-133, 2015 JUL 15 Use of Adaptive Servo-ventilation (ASV) for People With Heart Failure and Trouble Sleeping Malhotra, A American Journal of Respiratory And Critical Care Medicine Vol: 192:2, pages: 1-2, 2015 JUL 15 The Need for More E-Cigarette Data: A Call to Action Alexander, LC; Fuster, M; Montgrain, P; Malhotra, A.

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American Journal of Respiratory And Critical Care Medicine Vol: 192:3, pages: 275-276, 2015 AUG 1 Early Improvement of Dyspnea And Neurohormonal Status Using Minute Ventilation-Targeted Adaptive Servo Ventilation in Acute Heart Failure Arbit, B; Kawahara, M; Lee, E; Gluck, T; Sarmiento, K; Malhotra, A; Maisel, A. Journal of Cardiac Failure, Vol: 21:8, pages: 90-91, 2015 AUG Minute Ventilation-Targeted Adaptive Servo Ventilation Protects Renal Function In Acute Decompensated Heart Failure Patients Kawahara, M; Gluck, T; Lee, E; Arbit, B; Sarmiento, K; Malhotra, A. Journal of Cardiac Failure, Vol: 21:8, pages: S124-S124, S25-S25, S28-S28, 2015 AUG Obstructive Sleep Apnea Is Associated with Nonalcoholic Steatohepatitis and Advanced Liver Histology Corey, KE; Misdraji, J; Gelrud, L; King, LY; Zheng, H; Malhotra, A; Chung, RT. Digestive Diseases And Sciences, Vol: 60:8, pages: 2523-2528, DOI: 10.1007/s10620-015-3650-8, 2015 AUG New developments in the use of positive airway pressure for obstructive sleep apnea Donovan, LM; Boeder, S; Malhotra, A. Journal of Thoracic Disease, Vol: 7:8, pages: 1323-1342, DOI: 10.3978/j.issn.2072-1439.2015.07.30, 2015 AUG Electronic cigarettes: the new face of nicotine delivery and addiction Alexander, LEC; Vyas, A; Schraufnagel, DE; Malhotra, A. Journal of Thoracic Disease, Vol: 7:8, pages: E248-E21, DOI: 10.3978/j.issn.2072-1439.2015.07.37, 2015 AUG The air we breathe and lung disease Rice, MB; Malhotra, A. Journal of Thoracic Disease, Vol: 7:8, pages: E245-E247, DOI: 10.3978/j.issn.2072-1439.2015.08.02, 2015 AUG Functional Capacity, Health Status, and Inflammatory Biomarker Profile in a Cohort of Patients With Chronic Obstructive Pulmonary Disease Kohli, P; Pinto-Plata, V; Divo, M; Malhotra, A; Harris, RS; Lazaar, A; Flynn, A; Tal-Singer, R; Panettieri, RA; Celli, B Journal of Cardiopulmonary Rehabilitation And Prevention Vol: 35:5, pages: 348-355, DOI: 10.1097/HCR.0000000000000123, OCT 2015 Novel Nasal Pillow Mask Designed to Meet CPAP Efficacy and Improve Comfort DeYoung, P; Smales, E; Zammit, G; Bogan, R; Henninger, D; Fleming, W; Seiden, D; Sharief, I; Sherman, B; Owens, R ; Malhotra, A. Chest, Vol: 148:4, DOI: 10.1378/chest.2268807, 2015 OCT What Is the Future of Sleep Medicine in the United States? Phillips, B; Gozal D; Malhotra, A American Journal of Respiratory And Critical Care Medicine, Vol: 192-8, pages: 915-917, 2015 OCT 15 Relationship Between Sleep Duration and Body Mass Index Depends on Age Grandner, MA; Schopfer, EA; Sands-Lincoln, M; Jackson, N; Malhotra, A Obesity, Vol: 23:12, pages: 2491-2498, DOI: 10.1002/oby.21247, 2015 DEC

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PEEP titration during prone positioning for acute respiratory distress syndrome Beitler, JR; Guerin, C; Ayzac, L; Mancebo, J; Bates, DM; Malhotra, A; Talmor, D Critical Care, Vol: 19: 436, DOI: 10.1186/s13054-015-1153-9, 2015 DEC 21 Volume Delivered During Recruitment Maneuver Predicts Lung Stress in Acute Respiratory Distress Syndrome Beitler, JR; Majumdar, R; Hubmayr, RD; Malhotra, A; Thompson, BT; Owens, RL; Loring, SH; Talmor, D Critical Care Medicine, Vol: 44:1, pages: 91-99, DOI: 10.1097/CCM.0000000000001355, 2016 JAN Lifestyle Factors and Risk of Restless Legs Syndrome: Prospective Cohort Study Batool-Anwar, S; Li, YP; De Vito, K; Malhotra, A; Winkelman, J; Gao, X Journal of Clinical Sleep Medicine, Vol: 12:2, pages: 187-194, DOI: 10.5664/jcsm.5482, 2016 Sleep in Chronic Obstructive Pulmonary Disease: Evidence Gaps and Challenges Jen, R] ; Li, YR; Owens, RL; Malhotra, A Canadian Respiratory Journal, DOI: 10.1155/2016/7947198, 2016 Treatment of Obstructive Sleep Apnea Prospects for Personalized Combined Modality Therapy Deacon, NL; Jen, R; Li, YR; Malhotra, A Annals of The American Thoracic Society, Vol: 13:1, pages: 101-108, DOI: 10.1513/AnnalsATS.201508-537FR, 2016 JAN Improved Outcomes in Critically Ill Patients With AIDS: How Does This Trend Continue? Sweeney, DA; Akrami, K; Malhotra, A Critical Care Medicine, Vol: 44: 2, pages: 446-447, DOI: 10.1097/CCM.0000000000001492 2016 FEB Different Craniofacial Characteristics Predict Upper Airway Collapsibility in Japanese-Brazilian and White Men Schorr, F; Kayamori, F; Hirata, RP; Danzi-Soares, NJ ; Gebrim, EM; Moriya, HT ; Malhotra, A; Lorenzi, G; Genta, PR Chest, Vol: 149: 3, pages: 737-746, DOI: 10.1378/chest.15-0638, 2016 MAR Personalizing mechanical ventilation for acute respiratory distress syndrome Berngard, SC; Beitler, JR; Malhotra, A Journal of Thoracic Disease Vol: 8: 3, pages: E172-E174, Published: 2016 MAR Usefulness of Low Cardiac Index to Predict Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary Hypertension Orr, JE; Auger, WR; DeYoung, PN; Kim, NH; Malhotra, A; Owens, RL American Journal of Cardiology, Vol: 117: 6, pages: 1001-1005, DOI: 10.1016/j.amjcard.2015.12.035, 2016 MAR 15 Effect of CPAP on New Endothelial Dysfunction Marker, Endocan, in People With Obstructive Sleep Apnea Altintas, N; Mutlu, LC; Akkoyun, DC; Aydin, M; Bilir, B; Yilmaz, A; Malhotra, A. Angiology, Vol: 67: 4, pages: 364-374, DOI: 10.1177/0003319715590558, 2016 APR

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BEAR Cage: Mentoring through Engagement Reiss, TF; Moss, J; Watkins, TR; Malhotra, A. American Journal of Respiratory And Critical Care Medicine Vol: 193: 7, pages: 714-716, DOI: 10.1164/rccm.201602-0297ED, 2016 APR 1 Associations between cystatin C-based eGFR, ambulatory blood pressure parameters, and in-clinic versus ambulatory blood pressure agreement in older community-living adults Woodell, TB; Hughes-Austin, JM; Tran, TV; Malhotra, A; Abdelmalek, JA; Rifkin, DE. Blood Pressure Monitoring Vol: 21: 2, pages: 87-94, DOI: 10.1097/MBP.0000000000000168, 2016 APR Looking Back at My American Thoracic Society Presidency Attracting and Retaining the Next Generation Malhotra, A American Journal of Respiratory And Critical Care Medicine Vol: 193: 9, pages: 946-948, 2016 MAY 1 Nonadherence with Employer-Mandated Sleep Apnea Treatment and Increased Risk of Serious Truck Crashes Burks, SV; Anderson, JE; Bombyk, M; Haider, R; Ganzhorn, D; Jiao, XY; Lewis, C; Lexvold, A; Liu, H; Ning, JC; Toll, A; Hickman, JS; Mabry, E; Berger, M; Malhotra, A; Czeisler, CA; Kales, SN Sleep Vol: 39: 5, pages: 967-975, Article Number: PII sp-00674-15, DOI: 10.5665/sleep.5734, 2016 MAY 1 The Face of the Next Generation in China Wang, C; Li, JH; Wu, SN; Malhotra, A American Journal of Respiratory And Critical Care Medicine Vol: 193: 10, pages: 1090-1091, 2016 MAY 15 Unmasking a Role for Noninvasive Ventilation in Early Acute Respiratory Distress Syndrome Beitler, JR; Owens, RL; Malhotra, A Jama-Journal of The American Medical Association Vol: 315: 22, pages: 2401-2403, DOI: 10.1001/jama.2016.5987, 2016 JUN 14 Comment on viewpoint: hypercapnia is more important than hypoxia in the neuro-outcomes of sleep-disordered breathing Deacon, NL; Malhotra, A Journal of Applied Physiology Vol: 120: 12, pages: 1487-1487, 2016 JUN 15 Michael McCarthy Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder Mertens, J; Wang, QW; Kim, Y, McCarthy, MJ, Yao, J, et al. Nature Volume: 527: 7576, pages: 95-99, DOI: 10.1038/nature15526, 2015 NOV 5 Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms McCarthy, MJ; Le Roux, MJ; Wei, H; Beesley, S; Kelsoe, JR; Welsh, DK Neuropharmacology Vol: 101, pages: 439-448, DOI: 10.1016/j.neuropharm.2015.10.017, 2016 FEB

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Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study Hou, LP] ; Heilbronner, U; Degenhardt, F; Adli, M; Akiyama, K; Akula, N; Ardau, R, McCarthy, MJ, et al. Lancet Vol: 387: 10023, pages: 1085-1093, DOI: 10.1016/S0140-6736(16)00143-4, 2016 MAR 12 The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample Oedegaard, KJ; Alda, M; Anand, A, McCarthy, MJ, Kelsoe, JR. et al. Bmc Psychiatry Vol: 16, Article Number: 129, DOI: 10.1186/s12888-016-0732-x, 2016 MAY 5 Sara Mednick Synaptic clustering within dendrites: An emerging theory of memory formation Kastellakis, G; Cai, DJ; Mednick, SC; Silva, AJ; Poirazi, P Progress In Neurobiology Vol: 126, pages: 19-35, DOI: 10.1016/j.pneurobio.2014.12.002, 2015 MAR Validation of an Automated Wireless System for Sleep Monitoring During Daytime Naps Cellini, N; McDevitt, EA; Ricker, AA; Rowe, KM; Mednick, SC Behavioral Sleep Medicine Vol: 13: 2, pages: 157-168, DOI: 10.1080/15402002.2013.845782, 2015 MAR 4 REM sleep rescues learning from interference McDevitt, EA; Duggan, KA; Mednick, SC Neurobiology of Learning And Memory Vol: 122, pages: 51-62, DOI: 10.1016/j.nlm.2014.11.015, 2015 JUL Sleep after practice reduces the attentional blink Cellini, N; Goodbourn, PT; McDevitt, EA; Martini, P; Holcombe, AO ; Mednick, SC Attention Perception & Psychophysics Vol: 77: 6, pages: 1945-1954, DOI: 10.3758/s13414-015-0912-7, 2015 AUG Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans Niknazar, M; Krishnan, GP; Bazhenov, M; Mednick, SC Plos One Vol: 10: 12, DOI: 10.1371/journal.pone.0144720, 2015 DEC 15 Automatic detection of rapid eye movements (REMs): A machine learning approach Yetton, BD; Niknazar, M Duggan, KA; McDevitt, EA; Whitehurst, LN; Sattari, N; Mednick, SC Journal of Neuroscience Methods Vol: 259, pages: 72-82, DOI: 10.1016/j.jneumeth.2015.11.015, 2016 FEB 1 Free-living cross-comparison of two wearable monitors for sleep and physical activity in healthy young adults Cellini, N; McDevitt, EA; Mednick, SC; Buman, MP Physiology & Behavior Vol: 157, pages: 79-86, DOI: 10.1016/j.physbeh.2016.01.034, 2016 APR 1 Heart rate variability during daytime naps in healthy adults: Autonomic profile and short-term reliability Cellini, N; Whitehurst, LN; Mcdevitt, EA; Mednick, SC Psychophysiology

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Vol: 53: 4. pages: 473-481, DOI: 10.1111/psyp.12595, 2016 APR Autonomic activity during sleep predicts memory consolidation in humans Whitehurst, LN; Cellini, N; McDevitt, EA; Duggan, KA; Mednick, SC Proceedings of The National Academy of Sciences of The United States of America Vol: 113: 26, pages: 7272-7277, DOI: 10.1073/pnas.1518202113, 2016 JUN 28 Pamela Mellon Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development Xie, HM; Hoffmann, HM; Meadows, JD; Mayo, SL ; Trang, C; Leming, SS; Maruggi, C; Davis, SW; Larder, R; Mellon, PL Molecular Endocrinology Vol: 29: 6, pages: 842-855, DOI: 10.1210/me.2014-1279, 2015 JUN A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice Kauffman, AS; Thackray, VG; Ryan, GE; Tolson, KP; Glidewell-Kenney, CA; Semaan, SJ; Poling, MC; Iwata, N; Breen, KM; Duleba, AJ; Stener-Victorin, E; Shimasaki, S ; Webster, NJ; Mellon, PL Biology of Reproduction Vol: 93: 3, Article Number: 69, DOI: 10.1095/biolreprod.115.131631, 2015 SEP 1 Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice Stephens, SBZ; Tolson, KP; Rouse, ML; Poling, MC ; Hashimoto-Partyka, MK; Mellon, PL; Kauffman, AS Endocrinology Vol: 156: 9, pages: 3091-3097, DOI: 10.1210/en.2015-1300, 2015 SEP P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma Skowronska-Krawczyk, D; Zhao, L; Zhu, J, Mellon, PL, Zhang, K, et al. Molecular Cell Vol: 59: 6, pages: 931-940, DOI: 10.1016/j.molcel.2015.07.027, 2015 SEP 17 Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility Hoffmann, HM; Trang, C; Gong, P; Kimura, I; Pandolfi, EC; Mellon, PL Journal of Neuroscience Vol: 36: 12, pages: 3506-3518, DOI: 10.1523/JNEUROSCI.2723-15.2016, 2016 MAR 23 Marc Montminy Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance Blanchet, E; Van de Velde,S; Matsumura, S; Hao, EG; Lelay, J ; Kaestner, K; Montminy, M CELL REPORTS Vol: 10: 7, pages: 1149-1157, DOI: 10.1016/j.celrep.2015.01.046, 2015 FEB 24 ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis Tsai, WW; Matsumura, S; Liu, WY; Phillips, NG; Sonntag, T; Hao, E; Lee, S; Hai, T; Montminy, M Proceedings of The National Academy of Sciences of The United States of America Vol: 112: 9, pages: 2699-2704, DOI: 10.1073/pnas.1424641112, 2015 MAR 3

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Girkin, CA; Nievergelt, CM; Kuo, JZ; Maihofer, AX; Huisingh, C; Liebmann, JM; Ayyagari, R; Weinreb, RN; Ritch, R; Zangwill, LM Investigative Ophthalmology & Visual Science Vol: 56: 3, pages: 2043-2049, DOI: 10.1167/iovs.14-15719, 2015 MAR Diagnostic Utility of the Posttraumatic Stress Disorder (PTSD) Checklist for Identifying Full and Partial PTSD in Active-Duty Military Dickstein, BD; Weathers, FW; Angkaw, AC; Nievergelt, CM; Yurgil, K; Nash, WP; Baker, DG; Litz, BT Assessment, Vol: 2: 3, pages: 289-297, DOI: 10.1177/1073191114548683, 2015 JUN Prevalence of suicidal ideation and other suicide warning signs in veterans attending an urgent care psychiatric clinic McClure, JR; Criqui, MH; Macera, CA; Ji, M; Nievergelt, CM; Zisook, S Comprehensive Psychiatry, Vol: 60, pages: 149-155, DOI: 10.1016/j.comppsych.2014.09.010, 2015 JUL Heritability of Biomarkers of Oxidized Lipoproteins Twin Pair Study Rao, F; Schork, AJ; Maihofer, AX; Nievergelt, CM; Marcovina, SM; Miller, ER; Witztum,; O'Connor, DT; Tsimikas, S Arteriosclerosis Thrombosis And Vascular Biology Vol: 35:7, pages: 1704-1711, DOI: 10.1161/ATVBAHA.115.305306, 2015 JUL Molecular Mechanism for Hypertensive Renal Disease: Differential Regulation of Chromogranin A Expression at 3 '-Untranslated Region Polymorphism C+87T by MicroRNA-107 Zhang, KX; Mir, SA; Hightower, CM; Miramontes-Gonzalez, JP; Maihofer, AX; Chen, YQ; Mahata, SK; Nievergelt, CM; Schork, NJ, et al. Journal of The American Society of Nephrology Vol: 26: 8, pages: 1816-1825, DOI: 10.1681/ASN.2014060537, 2015 AUG Comparison of the genetic variation of captive ring-tailed lemurs with a wild population in Madagascar Pastorini, J; Sauther, ML; Sussman, RW; Gould, L; Cuozzo, FP; Fernando, P; Nievergelt, CM; Mundy, NI Zoo Biology Vol: 34: 5, pages: 463-472, DOI: 10.1002/zoo.21225, 2015 SEP-OCT Associations of PER3 and RORA Circadian Gene Polymorphisms and Depressive Symptoms in Older Adults Maglione, JE; Nievergelt, CM; Parimi, N; Evans, DS; Ancoli-Israel, S; Stone, KL; Yaffe, K; Redline, S; Tranah, GJ American Journal of Geriatric Psychiatry Vol: 23: 10, pages: 1075-1087, DOI: 10.1016/j.jagp.2015.03.002, 2015 OCT Association of Predeployment Heart Rate Variability With Risk of Postdeployment Posttraumatic Stress Disorder in Active-Duty Marines Minassian, A; Maihofer, AX; Baker, DG; Nievergelt, CM; Geyer, MA; Risbrough, VB Jama Psychiatry, Vol: 72: 10, pages: 979-986, DOI: 10.1001/jamapsychiatry.2015.0922, 2015 OCT Post-traumatic stress disorder Yehuda, R; Hoge, CW; McFarlane, AC; Vermetten, E; Lanius, R; Nievergelt, CM; Hobfoll, SE; Koenen, KC; Neylan, TC; Hyman, SE Nature Reviews Disease Primers Vol: 1, DOI: 10.1038/nrdp.2015.57, 2015 OCT 8

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Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder Mertens, J; Wang, QW; Kim, Y; Yu, DX, Nievergelt, CM, et al. Nature Vol: 527: 7576, pages: 95-99, DOI: 10.1038/nature15526, 2015 NOV 5 HIGH AND LOW THRESHOLD FOR STARTLE REACTIVITY ASSOCIATED WITH PTSD SYMPTOMS BUT NOT PTSD RISK: EVIDENCE FROM A PROSPECTIVE STUDY OF ACTIVE DUTY MARINES Glenn, DE; Acheson, DT ; Geyer, MA; Nievergelt, CM; Baker, DG; Risbrough, VB Depression And Anxiety Vol: 33: 3, pages: 192-202, DOI: 10.1002/da.22475, 2016 MAR Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system Biswas, N; Maihofer, AX; Mir, SA; Rao, FW; Zhang, KX; Khandrika, S; Mahata, M; Friese, RS; Hightower, CM; Mahata, SK; Baker, DG; Nievergelt, CM; Vaingankar, SM; O'Connor, DT Bmc Medical Genetics Vol: 17, DOI: 10.1186/s12881-016-0283-5, 2016 MAR 11 Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study Hou, LP; Heilbronner, U; Degenhardt, F; Adli, M; Akiyama, K, Nievergelt, CM, et al. Lancet, Vol: 387:10023, pages: 1085-1093, DOI: 10.1016/S0140-6736(16)00143-4, 2016 MAR 12 Associations of Genetically Determined Continental Ancestry With CD4(+) Count and Plasma HIV-1 RNA Beyond Self-Reported Race and Ethnicity Brummel, SS; Singh, KK; Maihofer, AX; Farhad, M; Qin, M; Fenton, T; Nievergelt, CM (Nievergelt,; Spector, SA Jaids-Journal of Acquired Immune Deficiency Syndromes Vol: 71: 5, pages: 544-550, DOI: 10.1097/QAI.0000000000000883, 2016 APR 15 The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample Oedegaard, KJ; Alda, M; Anand, A; Andreassen, OA; Balaraman, Y, Nievergelt, CM, et al. Bmc Psychiatry, Vol: 16, DOI: 10.1186/s12888-016-0732-x, 2016 MAY 5 Robert Owens On the cutting edge of obstructive sleep apnoea: where next? Malhotra, A; Orr, JE; Owens, RL Lancet Respiratory Medicine Vol: 3: 5, pages: 397-403, DOI: 10.1016/S2213-2600(15)00051-X, 2015 MAY Congestive Heart Failure and Central Sleep Apnea Sands, SA; Owens, RL Critical Care Clinics Vol: 3: 3, DOI: 10.1016/j.ccc.2015.03.005, 2015 JUL Update in Sleep Medicine 2014 Ayas, NT; Owens, RL; Kheirandish-Gozal, L American Journal of Respiratory And Critical Care Medicine Volume: 192: 4, pages: 415-420, 2015 AUG 15

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Impact of sleep disturbance in myelodysplastic syndromes (MDS) Solis, RM; Cronin, A; Watts, CD; Steensma, DP; Stone, RM; DeAngelo, DJ; Owens, RL; Wadleigh, M; Abel, GA Journal of Clinical Oncology Vol: 33: 29, 2015 OCT 10 Volume Delivered During Recruitment Maneuver Predicts Lung Stress in Acute Respiratory Distress Syndrome Beitler, JR; Majumdar, R; Hubmayr, RD; Malhotra, A; Thompson, BT; Owens, RL; Loring, SH; Talmor, D Critical Care Medicine Vol: 44: 1, pages: 91-99, DOI: 10.1097/CCM.0000000000001355, 2016 JAN Sleep in Chronic Obstructive Pulmonary Disease: Evidence Gaps and Challenges Jen, R; Li, YR; Owens, RL; Malhotra, A Canadian Respiratory Journal, DOI: 10.1155/2016/7947198, 2016 Usefulness of Low Cardiac Index to Predict Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary Hypertension Orr, JE ; Auger, WR; DeYoung, PN; Kim, NH; Malhotra, A ; Owens, RL American Journal of Cardiology Vol: 117: 6, pages: 1001-1005, DOI: 10.1016/j.amjcard.2015.12.035, 2016 MAR 15 Unmasking a Role for Noninvasive Ventilation in Early Acute Respiratory Distress Syndrome Beitler, JR; Owens, RL; Malhotra, A Jama-Journal of The American Medical Association Vol: 315: 22, pages: 2401-2403, DOI: 10.1001/jama.2016.5987, 2016 JUN 14 Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria Beitler, JR; Sands, SA; Loring, SH; Owens, RL; Malhotra, A; Spragg, RG; Matthay, MA; Thompson, BT; Talmor, D Intensive Care Medicine Vol: 42: 9, pages: 1427-1436, DOI: 10.1007/s00134-016-4423-3, 2016 SEP Satchin, Panda Relevance of Circadian Rhythm in Cancer DiTacchio, L; DiTacchio, KA; Panda, S Murine Models, Energy Balance, And Cancer Book Series: Energy Balance and Cancer, Pages: 1-19, DOI: 10.1007/978-3-319-16733-6_1 2015 X-Ray Microscopy as an Approach to Increasing Accuracy and Efficiency of Serial Block-Face Imaging for Correlated Light and Electron Microscopy of Biological Specimens Bushong, EA; Johnson, DD; Kim, KY; Terada, M; Hatori, M; Peltier, ST; Panda, S; Merkle, A; Ellisman, MH Microscopy And Microanalysis Vol: 21: 1, pages: 231-238, DOI: 10.1017/S1431927614013579, 2015 FEB

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Identification of Arabidopsis Transcriptional Regulators by Yeast One-Hybrid Screens Using a Transcription Factor ORFeome Breton, G; Kay, SA; Pruneda-Paz, JL Environmental Responses In Plants: Methods And Protocols Book Series: Methods in Molecular Biology Vol: 1398, pages: 107-118, DOI: 10.1007/978-1-4939-3356-3_10, 2016 Timothy Rickard Deliberate Practice for Achieving and Maintaining Expertise in Anesthesiology Hastings, RH; Rickard, TC Anesthesia And Analgesia Vol: 120: 2, pages: 449-459, DOI: 10.1213/ANE.0000000000000526, 2015 FEB Sleep and Motor Learning: Is There Room for Consolidation? Pan, SC; Rickard, TC Psychological Bulletin Vol: 141: 4, pages: 812-834, DOI: 10.1037/bul0000009, 2015 JUL Testing enhances learning across a range of episodic memory abilities Pan, SC; Pashler, H; Potter, ZE; Rickard, TC Journal of Memory And Language Vol: 83, pages: 53-61, DOI: 10.1016/j.jml.2015.04.001, 2015 AUG Does Testing With Feedback Improve Adult Spelling Skills Relative to Copying and Reading? Pan, SC; Rubin, BR; Rickard, TC Journal of Experimental Psychology-Applied Vol: 21: 4, pages: 356-369, DOI: 10.1037/xap0000062, 2015 DEC Does test-enhanced learning transfer for triple associates? Pan, SC; Wong, CM; Potter, ZE; Mejia, J; Rickard, TC Memory & Cognition Vol: 44: 1, pages: 24-36, DOI: 10.3758/s13421-015-0547-x, 2016 JAN Testing With Feedback Yields Potent, but Piecewise, Learning of History and Biology Facts Pan, SC; Gopal, A; Rickard, TC Journal of Educational Psychology Vol: 108: 4, pages: 563-575, DOI: 10.1037/edu0000074, 2016 MAY Beyond the Rainbow: Retrieval Practice Leads to Better Spelling than does Rainbow Writing Jones, AC; Wardlow, L; Pan, SC; Zepeda, C; Heyman, GD; Dunlosky, J; Rickard, TC Educational Psychology Review Vol: 28: 2, pages: 385-400, DOI: 10.1007/s10648-015-9330-6, 2016 JUN Dorothy Sears Evaluation of the Synuclein-gamma (SNCG) Gene as a PPAR gamma Target in Murine Adipocytes, Dorsal Root Ganglia Somatosensory Neurons, and Human Adipose Tissue Dunn, TN; Akiyama, T; Lee, HW; Kim, JB; Knotts, TA; Smith, SR; Sears, DD; Carstens, E; Adams, SH Plos One Vol: 10: 3, DOI: 10.1371/journal.pone.0115830, 2015 MAR 10

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Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES (2009-2010) Marinac, CR; Natarajan, L; Sears, DD ; Gallo, LC; Hartman, SJ; Arredondo, E; Patterson, RE Cancer Epidemiology Biomarkers & Prevention Vol: 24: 5, pages: 783-789, DOI: 10.1158/1055-9965.EPI-14-1292, 2015 MAY Intermittent Fasting and Human Metabolic Health Patterson, RE; Laughlin, G; LaCroix, AZ; Hartman, SJ; Natarajan, L; Senger, CM; Martinez, ME; Villasenor, A; Sears, DD; Marinac, CR; Gallo, LC Journal of The Academy of Nutrition And Dietetics Vol: 115: 8, pages: 1203-1212, DOI: 10.1016/j.jand.2015.02.018, 2015 AUG Gender and Age Differences in Hourly and Daily Patterns of Sedentary Time in Older Adults Living in Retirement Communities Bellettiere, J; Carlson, JA; Rosenberg, D; Singhania, A; Natarajan, L; Berardi, V; LaCroix, AZ; Sears, DD; Moran, K; Crist, K; Kerr, J Plos One Vol: 10: 8, DOI: 10.1371/journal.pone.0136161, 2015 AUG 21 Frequency and Circadian Timing of Eating May Influence Biomarkers of Inflammation and Insulin Resistance Associated with Breast Cancer Risk Marinac, CR; Sears, DD; Natarajan, L; Gallo, LC; Breen, CI; Patterson, RE Plos One Vol: 10: 8, DOI: 10.1371/journal.pone.0136240, 2015 AUG 25 Impact of increasing physical activity on cognitive functioning in breast cancer survivors: Rationale and study design of Memory & Motion Hartman, SJ; Natarajan, L; Palmer, BW; Parker, B; Patterson, RE; Sears, DD Contemporary Clinical Trials Vol: 45, pages: 371-376, DOI: 10.1016/j.cct.2015.09.021, 2015 NOV Terry Sejnowski Motor adaptation and generalization of reaching movements using motor primitives based on spatial coordinates Tanaka, Hirokazu; Sejnowski, Terrence J. Journal of Neurophysiology, Volume: 113: 4, pages: 1217-1233, 2015 FEB 15 Feedback stabilizes propagation of synchronous spiking in cortical neural networks Moldakarimov, Samat; Bazhenov, Maxim; Sejnowski, Terrence J. Proceedings of The National Academy of Sciences of The United States of America, Vol: 112: 8, pages: 2545-2550, 2015 FEB 24 Delay Differential Analysis of Time Series Lainscsek, Claudia; Sejnowski, Terrence J. Neural Computation, Vol: 27: 3, pages: 594-614, 2015 MAR Delay Differential Analysis of Electroencephalographic Data Lainscsek, C; Hernandez, ME; Poizner, H; Sejnowski, TJ Neural Computation Vol: 27: 3, pages: 615-627, DOI: 10.1162/NECO_a_00656, 2015 MAR The BRAIN Initiative: developing technology to catalyse neuroscience discovery Jorgenson, LA; Newsome, WT; Anderson, DJ, Sejnowski, TJ, et al.

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Philosophical Transactions of The Royal Society B-Biological Sciences Volume: 370: 1668, pages: 8-19, DOI: 10.1098/rstb.2014.0164, 2015 MAY 19 Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain Mo, A; Mukamel, EA; Davis, FP, Sejnowski, TJ Neuron Vol: 86: 6, pages: 1369-1384, DOI: 10.1016/j.neuron.2015.05.018, 2015 JUN 17 Discovering independent parameters in complex dynamical systems Lainscsek, C; Weyhenmeyer, J; Sejnowski, TJ; Letellier, C Chaos Solitons & Fractals Vol: 76, pages: 182-189, DOI: 10.1016/j.chaos.2015.04.001, 2015 JUL Model reduction for stochastic CaMKII reaction kinetics in synapses by graph-constrained correlation dynamics Johnson, T; Bartol, T; Sejnowski, T; Mjolsness, E Physical Biology Vol: 12: 4, DOI: 10.1088/1478-3975/12/4/045005, 2015 JUL Human body epigenome maps reveal noncanonical DNA methylation variation Schultz, MD; He, YP; Whitaker, JW, Sejnowski, TJ, et al. Nature Vol: 523: 7559, pages: 212-U189, DOI: 10.1038/nature14465, 2015 JUL 9 Spectrum of power laws for curved hand movements Huh, D; Sejnowski, TJ. Proceedings of The National Academy of Sciences of The United States of America Vol: 112: 29, pages: E3950-E3958, 2015 JUL 21 Cooperativity between remote sites of ectopic spiking allows afterdischarge to be initiated and maintained at different locations Coggan, JS; Sejnowski, T; Prescott, SA. Journal of Computational Neuroscience, Vol: 39: 1, pages: 17-28, 2015 AUG Modeling of Age-Dependent Epileptogenesis by Differential Homeostatic Synaptic Scaling Gonzalez, OC; Krishnan, GP; Chauvette, S; Timofeev, I; Sejnowski, T; Bazhenov, M Journal of Neuroscience Vol: 35: 39, pages: 13448-13462, DOI: 10.1523/JNEUROSCI.5038-14.2015 2015 SEP 30 Characterization of spatio-temporal epidural event-related potentials for mouse models of psychiatric disorders Wang, X; Pinto-Duarte, A; Behrens, MM; Zhou, XJ; Sejnowski, TJ Scientific Reports Vol: 5, DOI: 10.1038/srep14964, 2015 OCT 13 Nanoconnectomic upper bound on the variability of synaptic plasticity Bartol, TM; Bromer, C; Kinney, J; Chirillo, MA; Bourne, JN; Harris, KM; Sejnowski, TJ Elife Vol: 4, DOI: 10.7554/eLife.10778, 2015 NOV 30

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Consciousness Daedalus Vol: 144: 1, pages: 123-132, DOI: 10.1162/DAED_a_00321, 2015 WIN Periodic Forcing of Inhibition-Stabilized Networks: Nonlinear Resonances and Phase-Amplitude Coupling Veltz, R; Sejnowski, TJ Neural Computation Volume: 27: 12, pages: 2477-2509, DOI: 10.1162/NECO_a_00786, 2015 DEC Time-coded neurotransmitter release at excitatory and inhibitory synapses Rodrigues, S; Desroches, M; Krupa, M; Cortes, JM; Sejnowski, TJ, Ali, AB Proceedings of the National Academy of Sciences of the United States of America Vol: 113: 8, pages: E1108-E1115, DOI: 10.1073/pnas.1525591113, 2016 FEB 23 Correlated Percolation, Fractal Structures, and Scale-Invariant Distribution of Clusters in Natural Images Saremi, S; Sejnowski, TJ IEEE Transactions On Pattern Analysis and Machine Intelligence Vol: 38: 5, pages: 1016-1020, DOI: 10.1109/TPAMI.2015.2481402, 2016 MAY Nicholas Spitzer Neurotransmitter Switching? No Surprise Spitzer, NC Neuron Vol: 86: 5, pages: 1131-1144, DOI: 10.1016/j.neuron.2015.05.028, 2015 JUN 3 Neurotransmitter-tailored dendritic trees Spitzer, NC Science Vol: 350: 6260, pages: 510-511, DOI: 10.1126/science.aad4876, 2015 OCT 30 Differences in Number of Midbrain Dopamine Neurons Associated with Summer and Winter Photoperiods in Humans Aumann, TD; Raabus, M; Tomas, D; Prijanto, A; Churilov, L; Spitzer, NC; Horne, MK Plos One Vol: 11: 7, DOI: 10.1371/journal.pone.0158847, 2016 JUL 18 Suel, Gurol Chromosomal Arrangement of Phosphorelay Genes Couples Sporulation and DNA Replication Narula, J; Kuchina, A; Lee, DYD; Fujita, M; Suel, GM; Igoshin, OA Cell Vol: 162: 2, pages: 328-337, DOI: 10.1016/j.cell.2015.06.012 2015 JUL 16 A Synthetic Quorum Sensing System Reveals a Potential Private Benefit for Public Good Production in a Biofilm Zhang, F; Kwan, A; Xu, A; Suel, GM Plos One Vol: 10: 7, DOI: 10.1371/journal.pone.0132948, 2015 JUL 21

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Metabolic co-dependence gives rise to collective oscillations within biofilms Liu J; Prindle A; Humphries, A; Gabalda-Sagarra, M; Asally, M; Lee, D; Ly, S; Garcia-Ojalvo, J; Süel, G Nature Vol: 523, DOI: 10.1038/nature14660, 2015 30 JUL Ion channels enable electrical communication in bacterial communities Prindle, A; Liu, JT; Asally, M; Ly, S; Garcia-Ojalvo, J; Suel, GM Nature Vol: 527: 7576, pages: 59-63, DOI: 10.1038/nature15709, 2015 NOV 5 Noise Expands the Response Range of the Bacillus subtilis Competence Circuit Mugler, A; Kittisopikul, M; Hayden, L; Liu, JT; Wiggins, CH; Suel, GM; Walczak, AM Plos Computational Biology Vol: 12: 3, DOI: 10.1371/journal.pcbi.1004793, 2016 MAR Slowdown of growth controls cellular differentiation Narula, J; Kuchina, A; Zhang, F; Fujita, M; Suel, GM; Igoshin, OA Molecular Systems Biology Vol: 12: 5, DOI: 10.15252/msb.20156691, 2016 MAY Lev Tsimring Distributed Classifier Based on Genetically Engineered Bacterial Cell Cultures Didovyk, A; Kanakov, OI; Ivanchenko, MV; Hasty, J; Huerta, R; Tsimring, L Acs Synthetic Biology Vol: 4: 1, pages: 72-82, DOI: 10.1021/sb500235p 2015 JAN Considering the kinetics of mRNA synthesis in the analysis of the genome and epigenome reveals determinants of co-transcriptional splicing Davis-Turak, JC; Allison, K; Shokhirev, MN; Ponomarenko, P; Tsimring, LS; Glass, CK; Johnson, TL; Hoffmann, A Nucleic Acids Research Vol: 43: 2, pages: 699-707, DOI: 10.1093/nar/gku1338, 2015 JAN 30 Multi-Input Distributed Classifiers for Synthetic Genetic Circuits Kanakov, O; Kotelnikov, R; Alsaedi, A; Tsimring, L; Huerta, R; Zaikin, A; Ivanchenko, M Plos One Vol: 10: 5, DOI: 10.1371/journal.pone.0125144, 2015 MAY 6 Self-reproducing catalyst drives repeated phospholipid synthesis and membrane growth Hardy, MD; Yang, J; Selimkhanov, J; Cole, CM; Tsimring, LS; Devaraj, NK Proceedings of The National Academy of Sciences of The United States of America Volume: 112: 27, pages: 8187-8192, DOI: 10.1073/pnas.1506704112 2015 JUL 7 Orthogonal Modular Gene Repression in Escherichia coli Using Engineered CRISPR/Cas9 Didovyk, A; Borek, B; Hasty, J; Tsimring, L Acs Synthetic Biology Vol: 5: 1, pages: 81-88, DOI: 10.1021/acssynbio5b00147, 2016 JAN Spatiotemporal dynamics of distributed synthetic genetic circuits Kanakov, O; Laptyeva, T; Tsimring, L; Ivanchenko, M

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Physica D-Nonlinear Phenomena Vol: 318, pages: 116-123, DOI: 10.1016/j.physd.2015.10.016 2016 APR 1 Turing Patterning Using Gene Circuits with Gas-Induced Degradation of Quorum Sensing Molecules Borek, B; Hasty, J; Tsimring, L Plos One Vol: 11: 5, DOI: 10.1371/journal.pone.0153679, 2016 MAY 5 David Welsh Light Evokes Rapid Circadian Network Oscillator Desynchrony Followed by Gradual Phase Retuning of Synchrony Roberts, L; Leise, TL; Noguchi, T; Galschiodt, AM; Houl, JH; Welsh, DK; Holmes, TC Current Biology Vol: 25: 7, pages: 858-867, DOI: 10.1016/j.cub.2015.01.056, 2015 MAR 30 Dissociation of Learned Helplessness and Fear Conditioning in Mice: A Mouse Model of Depression Landgraf, D; Long, J; Der-Avakian, A; Streets, M; Welsh, DK Plos One Vol: 10: 4, DOI: 10.1371/journal.pone.0125892, 2015 APR 30 Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders Barandas, R; Landgraf, D, McCarthy, MJ; Welsh, DK Current Psychiatry Reports Vol: 17: 12, DOI: 10.1007/s11920-015-0637-2, 2015 DEC Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms McCarthy, MJ ; Le Roux, MJ; Wei, H; Beesley, S; Kelsoe, JR; Welsh, DK Neuropharmacology Vol: 101, pages: 439-448, DOI: 10.1016/j.neuropharm.2015.10.017, 2016 FEB NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators Landgraf, D; Wang, LL; Diemer, T; Welsh, DK Plos Genetics Vol: 12: 2, DOI: 10.1371/journal.pgen.1005882, 2016 FEB BOOK CHAPTERS Terry Sejnowski Communication By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 9-36, 2015 Silicon Retinas By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 37-69, 2015 Silicon Cochleas By: Sejnowski, Terrence

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Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 71-90, 2015 Locomotion Motor Control By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 91-118, 2015 Learning in Neuromorphic Systems By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 119-151, 2015 Silicon Neurons By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 155-183, 2015 Silicon Synapses By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 185-217, 2015 Silicon Cochlea Building Blocks By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 219-235, 2015 Programmable and Configurable Analog Neuromorphic ICs By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 237-259, 2015 Bias Generator Circuits By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 261-283, 2015 On-Chip AER Communication Circuits By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 285-303, 2015 Hardware Infrastructure By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 305-348, 2015 Software Infrastructure By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 349-364, 2015

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Algorithmic Processing of Event Streams By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 365-380, 2015 Towards Large-Scale Neuromorphic Systems By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 381-391, 2015 The Brain as Potential Technology By: Sejnowski, Terrence Edited by: Liu, SC; Delbruck, T; Indiveri, G; et al. Event-Based Neuromorphic Systems, Pages: 393-405, 2015 Brain Computation By: Sejnowski, Terrence J.; Poggio, Tomaso Book Author(s): Ballard, DH Brain Computation As Hierarchical Abstraction, Book Series: Computational Neuroscience-MIT, MIT Press, Pages: 3-39, 2015, 2015 Brain Overview By: Sejnowski, Terrence J.; Poggio, Tomaso Book Author(s): Ballard, DH Brain Computation As Hierarchical Abstraction, Book Series: Computational Neuroscience-MIT, Pages: 41-80, 2015 Neurons and Circuits By: Sejnowski, Terrence J.; Poggio, Tomaso Book Author(s): Ballard, DH Brain Computation As Hierarchical Abstraction, Book Series: Computational Neuroscience-MIT, Pages: 83-126, 2015 Cortical Memory By: Sejnowski, Terrence J.; Poggio, Tomaso Book Author(s): Ballard, DH Brain Computation As Hierarchical Abstraction, Book Series: Computational Neuroscience-MIT, Pages: 127-161, 2015 Programs via Reinforcement By: Sejnowski, Terrence J.; Poggio, Tomaso Book Author(s): Ballard, DH Brain Computation As Hierarchical Abstraction, Book Series: Computational Neuroscience-MIT, Pages: 163-200, 2015 Sensory-Motor Routines By: Sejnowski, Terrence J.; Poggio, Tomaso Book Author(s): Ballard, DH Brain Computation As Hierarchical Abstraction, Book Series: Computational Neuroscience-MIT, Pages: 203-234, 2015

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Motor Routines By: Sejnowski, Terrence J.; Poggio, Tomaso Book Author(s): Ballard, DH Brain Computation As Hierarchical Abstraction, Book Series: Computational Neuroscience-MIT, Pages: 235-273, 2015 Operating System By: Sejnowski, Terrence J.; Poggio, Tomaso Book Author(s): Ballard, DH Brain Computation As Hierarchical Abstraction, Book Series: Computational Neuroscience-MIT, Pages: 275-317, 2015 Decision Making By: Sejnowski, Terrence J.; Poggio, Tomaso Book Author(s): Ballard, DH Brain Computation As Hierarchical Abstraction, Book Series: Computational Neuroscience-MIT, Pages: 321-347, 2015 Emotions By: Sejnowski, Terrence J.; Poggio, Tomaso Book Author(s): Ballard, DH Brain Computation As Hierarchical Abstraction, Book Series: Computational Neuroscience-MIT, Pages: 349-375, 2015

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