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Our Solution
Use antifouling polymer coating
Recesses
Leaflets
Patent Search• Novelty of the design • FDA requirements
Patent Search
Mechanical Valve
Polymer
Coating Mechanism
Prosthetic Heart Valve with Surface Modification
Patent No. : US6764509 Issue date Jul 20, 2004
• Owned by Medtronic • Coating with a chemical substance to prevent:
Thrombus formation
Mineralization
Does not include zwitterionic carboxy betaine or its derivatives (CB-OH)
Plasma Process Surface Modification onto Pyrolytic Carbon
Patent Number: 637228Issue Date: Apr 16, 2002
• Owned by Medtronic Inc
• Purpose: Adhesion of the polymer and/or bioactive compound on pyrolytic carbon
• Plasma deposition of a silicon and oxygen film
HridhayCoeur Patent 1. A mechanical heart valve comprising titanium body, pyrolytic carbon flaps and Dacron sewing
cuff, with modifications that make it have negligible immuno-rejection by the body.2. The heart valve of claim 1, wherein the valve is a bi-leaflet mechanical heart valve.3. The heart valve of claim 1, wherein the pyrolytic carbon component is modified by coating with
anti-fouling polymers.4. The heart valve of claim 3, wherein said modification method is done prior to implantation and
reduces the risk of hemolysis, infection and/or thrombogenesis to the implant.5. The heart valve of claim 3, wherein anti-fouling polymer is deposited via the plasma deposition
process.6. The heart valve of claim 3, wherein the polymer used is zwitterionic carboxy betaine (CB-OH).7. The polymer of claim 6, wherein CB-OH and/or any other modification or derivations of CB-OH
are used to achieve same or similar properties.8. The polymer of claim 7, wherein the polymer is added to and/or coating is done on any type of
implant.9. The polymer of claim 7, wherein the polymer is added to and/or coating is done partially on any
type of implant.10. The polymer of claim 7, wherein the polymer is added to and/or coating is done on any type of
valve.11. The polymer of claim 7, wherein the polymer is added to and/or coating is done partially on any
type of valve.
HridhayCoeur Patent
“The coating of mechanical heart valve with zwitterionic carboxy betaine (CB-OH) or its derivatives to increase antithrombotic or antimicrobial properites and hence minmize immuno-rejection by the body.”
Medtronic
• Competitive Market Need for differentiation
• Minimize non-specific protein adsorption • Improve blood compatibility
We have the answer!
Medtronic Open Pivot Mechanical Heart Valve
Benefits
To Medtronic• Novel Technology• Market leadership• Wider pool of knowledge and skills • Business contact
To HirdayCoeur• Capital• Reputation