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Surgery

University of Toronto

SummarySummarySummarySummary

Resident PresentationNir Lipsman, R4 Neurosurgery

2nd year PhD student through IMSSupervisor: Dr Andres Lozano

Surgeon Scientist ProgramClinician Investigator Program

CIHR Fellowship

Resident PresentationNir Lipsman, R4 Neurosurgery

2nd year PhD student through IMSSupervisor: Dr Andres Lozano

Surgeon Scientist ProgramClinician Investigator Program

CIHR Fellowship

Surgery

University of Toronto

Probing and modulating neural circuitry underlying reward and emotional processing

•Probing and modulating neural circuitry underlying reward and emotional processing

• Intraoperative single-unit recording (SUR)• Post-operative multi-unit recording (MUR)• Perioperative frequency analysis, interregional coherence and MUR

• Intraoperative single-unit recording (SUR)• Post-operative multi-unit recording (MUR)• Perioperative frequency analysis, interregional coherence and MUR

• Deep Brain Stimulation

Probing and modulating neural circuitry underlying reward and emotional processing

PhD Supervisor Dr. Andres M. Lozano

CollaboratorsUniversity of Toronto: Dr. Jonathan Dostrovsky (Physiology)

Dr. Bill Hutchison (Physiology)Dr. Peter Giacobbe (Psychiatry)Dr. Sidney Kennedy (Psychiatry)Dr. Blake Woodside (Psychiatry)Dr. Jeff Daskalakis (Psychiatry)Dr. Roger McIntyre (Psychiatry)

Dr. Adam Anderson (Psychology)

USC/McGill: Dr. Antoine Bechara (Neurology/Psychology)

University of Hong Kong: Dr. Savio Wong (Psychology)

University of Ottawa: Dr. Georg Northoff (Psychiatry/Psychology)Dr. Takashi Nakao (Psychology)

•Probing and modulating neural circuitry underlying reward and emotional processing

1) Acquire unique data to answer questions not previously subject to empirical testing (e.g. The nature of self and its relationship to reward)

2) Develop novel therapeutic options for patients with no treatment alternatives (e.g. Treatment resistant psychiatric disease)

Single-neuron activity during Self Task in Subgenual Cingulate Gyrus during Depression

DBS

Own Famous Neutral

Mean firing rate for Own is significantly higher in first second of stimulus presentation vs. Famous

vs. Neutral (p<0.05)

Own Famous Neutral

Mean firing rate for Own is significantly higher in first second of stimulus presentation vs. Famous vs.

Neutral (p<0.05)

Single-neuron activity during Self Task in Subgenual Cingulate Gyrus during Depression

DBS

FAMOUSNEUTRA

LOWN

Logarithmic representation of local field potential frequencies

Diminished power in

alpha band

‘Frequency of Self’

•Tasks now under development will look at decision-making under uncertainty, emotion recognition and reward anticipation

•From Neurophysiology to Clinical Research

– Depression– Bipolar Disorder– Obsessive-Compulsive Disorder– Anorexia Nervosa– Schizophrenia– Drug Addiction– Alcoholism

Disorders of self processing and primary

reward dysfunction

Implications

Depression Alzheimer’s Disease

DBS can modulate neural circuits underlying mood and memory

Mayberg et al 2005; Laxton et al 2010

Disorder Target Subjects Status

*Obsessive-Compulsive Disorder

Inferior Thalamic Peduncle 6 Operated on 1;

Now recruiting

*Bipolar Disorder type II

Subgenual cingulate gyrus (SCG) 6 REB Approved;

Now recruiting

**Anorexia nervosa, restricting subtype

SCG and Nucleus Accumbens (NAcc) 12 REB Approved;

Now recruiting

**SchizophreniaNAcc and Ventral Tegmental Area

(VTA)6 REB Approved;

Now recruiting

*Canadian First**Global First

Modulating Neural Circuitry

Surgery

University of Toronto

Saturday July 9th, 2011 149 Mossgrove TrailSaturday July 9th, 2011 149 Mossgrove Trail

Welcome Party for PGY1’s

Welcome Party for PGY1’sSaturday July 9th, 2011 149

Mossgrove TrailSaturday July 9th, 2011 149 Mossgrove Trail

Welcome Party for PGY1’s

Welcome Party for PGY1’s

Surgery

University of Toronto

Coming your way in 2011-12! Coming your way in 2011-12!

Dept WebmasterCommunications

Stephanie Neilson

Coming your way in 2011-12! Coming your way in 2011-12!

Surgery

University of Toronto

Also Coming Your Way!Also Coming Your Way!Strategic Planning Initiative 2011-12Strategic Planning Initiative 2011-12

Also Coming Your Way!Also Coming Your Way!

Surgery

University of Toronto

Also Coming Your Way!Also Coming Your Way!Strategic Planning Initiative 2011-12Strategic Planning Initiative 2011-12

• Co-Chairs Late fall, early winter• Tagline: TBD• Retreat: January 2012• Survey Monkey: Sept 2011• Stra: James Rutka and Bryce Taylor• Facilitator: Helena Axler• Timeline: tegic Foci: Education, Research, Faculty Development, Best Practices, Integration

Also Coming Your Way!Also Coming Your Way!

Surgery

University of Toronto

A New Department of Surgery Brand!A New Department of Surgery Brand!

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New Dept Surgery Logo

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Surgery

University of Toronto

Thank you!Thank you!Thank you!Thank you!