UCLA CTSI Clinical and Translational Science Institute
K Award Workshop January 10, 2012 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
www.ctsi.ucla.edu
Christina Wang, MD Associate Director, UCLA Clinical and Translational Science Institute Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute
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Purpose of the National CTSA Program
Outpatient & community based research Inpatient
GCRC
Training in clinical and translational team science
Regional and national consortia linked for collaboration
Traditional training
Individual academic
medical centers
Past Present and Future
Providing an infrastructure for clinical and translational research
Transdisciplinary team science Individual investigators
What is translational research?
UCLA CTSI translational investigation extends from molecules to society
Translating knowledge gained from laboratory science into clinical practice to improve health. The aim of translational research is to produce new:
• therapeutics • medical devices • tools for diagnosing disease • avenues for community engagement research
Overview of Pilot Grant Programs
Catalyst Grants
Rapid Response Team
Prototype Grants
CTSI Scholars Awards
Team Science Awards
Novel Methods & Technologies Award
Pilots Team Building Proposal Development Proof-of-Concept Pilots Team Building Proposal Development Proof-of-Concept
Early Career Awards
Pilots Team Building Proposal Development Proof-of-Concept
Opportunity Funds Grant Amount Duration of Award (Years)
Award Cycle Application Due Date
KL2 Awards: to pursue interdisciplinary, mentored research with training
Up to $125,000 in salary and
research support
1 year at 75% effort
(renewable for up to 3 years)
July 1 Late February 2013
TL1 Summer Program for Professional Students: provides professional students (medical, nursing and dental) early exposure to interdisciplinary, community-partnered translational or health services research
Summer stipend plus funding for training-related
expenses
The summer between
student’s first and second year
(8 weeks)
June 1 Late March 2013
Scholar Awards: for junior faculty in any series within their first three years of appointment to support mentored training in translational research in all areas of investigation.
Up to $30,000 Up to 1 year Annual Fall 2013
KL2 Year 1 Awardees
Assistant Professor, CDU “ Effects of Varenicline on Alcohol and Nicotine Consumption and changes in Dopamine D2-like Receptor Availability in High-Alcohol Preferring Mice”
Amira Brown, MS, PhD
Assistant Professor, Pediatric Nephrology, UCLA “ Hepcidin and the Anemia of Chronic Kidney Disease”
Joshua Zaritsky, MD, PhD
Assistant Professor of Medicine, UCLA/VA “ Patterns and Predictors of Poor Outcomes Following Emergency
Department Discharge in Older Adults”
Gelareh Gabayan, MD, MSHS
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KL2 Year 2 Awardees
Assistant Professor, LA-BioMed/Harbor-UCLA “Using Research in Vancomycin-Resistant Enterococcus to Validate an Efficient System of Quantifying Antibiotic Utilization”
James McKinnell, MD
Assistant Professor, UCLA “Modeling of EMT/MET transitions in breast cancer stem cells”
Mary Sehl, MD, PhD
Assistant Professor, UCLA “Development of novel therapeutic strategies to target LKB1/STK11 deficient non-small cell lung cancer”
David Shackelford, PhD
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CTSI Scholar Awards
For junior faculty in any series within their first three years of appointment to support mentored training in translational research. In 2012 12 CTSI scholars: 2 form Cedars, 2 from LA BioMed and 8 from UCLA
Early Career Awards
Funding Opportunities for All Investigators
Pilots Team Building Proposal Development Proof-of-Concept
Opportunity Funds Grant Amount
Duration of Award (Years)
Award Cycle
Application Due Date
Vouchers: for core services at CTSI institutions
Up to $10,000
1 Biannual/ Annual
Feb 2013
Seed Grants: to support research projects encouraging translational science
$1,000 to $30,000
Up to 1 year Annual Fall 2013
Voucher Awards Vouchers of up to $10,000 to utilize core services • RFAs for Voucher Awards will be issued twice a year • Next Voucher RFA will be cross-institutional and
announced early 2013 with an award date of March 1, 2013
• Awards prioritized for innovation, translational, and samples and core ready •Junior investigators are ranked separately from established investigators
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Center for Translational Technology
Awardees
Other Collaborative Funding Opportunities
Pilots Team Building Proposal Development Proof-of-Concept Opportunity Funds Grant
Amount Duration of Award (Years)
Award Cycle
Application Due Date
Team Science Awards: multidisciplinary, cross-institutional, translational science leading to a proposal under such team-science mechanisms as P01, U54, and center grants
Up to $200,000
1-2 years Annual Rolling
Catalyst Awards: to support seminar series, team-building activities and pilot studies and other activities to encourage translational team science
$1,000 to $5,000
Up to 1 year
Quarterly RFA to be released
August 15, 2012
Catalyst Awards Support team-building activities that advance translational science and promote collaborations across disciplines and CTSI institutions ($100 - $5,000)
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Collaborative Funding Opportunities
Jonathan Kaye, PhD, for the 2nd Annual Immunology LA conference at the Skirball Center on May 24, 2012. ►The meeting provided a unique opportunity for interactions
between immunologists at all partner institutions.
Cedars Awardees
Team Science Awards
Support multidisciplinary, cross-institutional, team-based research addressing major health problems (up to $200,000). Partner with other funding organizations to leverage resources. Co-funding is required.
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Collaborative Funding Opportunities
2012 Awardee
Project: Clinical and Translational Science Institute Prospective Longitudinal Assessment of Co-infected Subjects with HIV/Hepatitis C for endothelial function study (CTSI-PLACE Study).
UCLA: Kara Chew and Debika Bhattacharya LA BioMed/Harbor-UCLA: Eric Daar Cedars-Sinai: David Hardy Charles Drew: Wilbert Jordan
Major focus: How can we improve health care without increasing costs?
Anticipated release date: January 2013
The UCLA CTSI seeks to expand translational research involving the Los Angeles Department of Health Services (LA DHS) delivery system, leading to:
(1) system solutions that improve health care, health behaviors, and/or health status of Los Angeles residents without increasing costs
(2) submission of extramural grants involving the CTSI and DHS
Award: up to $30,000 for a period of one year
• Awards are non-renewable • NIH guidelines for annual and end-of-project reporting will apply • Co-funding is required
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Upcoming Team Science Award with LA DHS
Clinical and Translational Research Centers (CTRC)
Ambulatory Clinical Research Facilities at Cedars, Drew, LA BioMed-Harbor, and UCLA-CHS
• Private rooms, infusion rooms, procedure rooms • Sleep Research Facilities at LA Biomed-Harbor • Interview and conference rooms • Investigational pharmacy and sample processing • 23 hour capacity at UCLA
Inpatient Clinical Research Centers at LA Biomed/Harbor and UCLA-Ronald Reagan Medical Center
“First in man” clinical pharmacology studies
Metabolic Balance Studies
Human Physiological Phenotyping Studies
Research Facilitation Provides across-the-board assistance:
• research project/grant proposal development
• navigating and accessing CTSI research support resources and services
• expert consultation on all aspects - from study concept through regulatory approval and oversight
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Office of Investigator Services
General Questions Telephone: (310) 794-CTSI (2874) E-mail: [email protected]
Cedars-Sinai Medical Center (310) 423-2475 Jerlyn Tolentino Charles Drew University of Medicine and Sciences (323) 357-3645 Hema Ramamurthi Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (310) 222-2503 Alla Victoroff and Terry Doherty University of California, Los Angeles (310) 794-CTSI (310) 825-0791 Marisa Briones
Contact a Facilitator
UC Biomedical Research Acceleration Integration and Development (UC-BRAID)
