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Overview of the Harvard Catalyst Imaging program
Randy Gollub,MD,PhD; Valerie Humblet,PhD
http://catalyst.harvard.edu April 28, 2009
Institutions participating in Harvard CTSC
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Academic Healthcare Centers• Beth Israel-Deaconess Medical
Center• Brigham and Women’s Hospital• Massachusetts General Hospital• Children’s Hospital Boston
Specialty Hospitals and Institutes• Dana-Farber Cancer Institute• Forsyth Dental Institute• Joslin Diabetes Center• Massachusetts Eye and Ear
Infirmary• McLean Hospital• Schepens Eye Research Institute
Massachusetts Institutes of Technology
Harvard University• Faculty of Arts and Sciences• Harvard Business School• Harvard School of Dental Medicine• Harvard Divinity School• Graduate School of Design• Graduate School of Education• Kennedy School of Government• Harvard Law School• Harvard Medical School• Harvard School of Public Health• Harvard School of Engineering
Community Healthcare Institutions• Cambridge Health Alliance• HMS Department of Ambulatory
Care and Prevention at Harvard Pilgrim Healthcare
Yearly budget: $38 million (23 NIH + 15 matching)
Harvard Catalyst
• Programs (Selected list)
– Development of Novel C/T Methodologies– Biomedical Informatics– Research Education, Career Development– Pilot studies– Community Engagement– Design and Biostatistics– Diversity and Health Disparities Research– Ethics– Linkages across the institutions– Regulatory Knowledge and Support
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Bruce Rosen, DirectorRandy Gollub, Co-DirectorGordon J. Harris, Site Co-Director
Robert Lenkinski, Site Co-DirectorNeil Rofsky, Site Co-Director
Clare Tempany, Site Co-DirectorRon Kikinis, Site Co-DirectorGordon Williams, PI for CTSC Translational Technologies
Stephan Voss, Site Co-DirectorSimon Warfield, Site Co-Director
Annick D. Van den Abbeele, Site Co-DirectorJeff Yap, Site Co-Director
Gordon J. Harris, Site Co-DirectorAnnick D. Van den Abbeele, Site Co-DirectorWilliam Hanlon, Core Manager
Valerie Humblet, Imaging LiaisonYong Gao, XNAT Engineer
Imaging Consortium Team
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Mission of the Imaging Consortium
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• Expand imaging in clinical research– Build infrastructure (software, image analysis and
visualization tools, cross-site acquisition tools)– Provide expert consultation in the use of imaging as
part of clinical translational research– Educate and advise about available imaging and
image processing capabilities in the Harvard environment.
– Provide education at the local and national level (participation in RSNA education program)
Image Consortium Consultation Service
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Technologies and Expertise
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• Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging.
• Focused on assisting with planning and design of research proposals and/or methods for image analysis.
• Consultation is available for the preparation of a grant or IRB submission.
• We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies.
Examples of Imaging Consultation
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• Standardization of physiologic monitoring system for MRI.
– Deployed at 6 institutions (MGH, BWH.BIDMC, CHB, MIT, Harvard)
– Creation of a biomedical engineer working group
Examples of Imaging Consultation
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• Development of lingual nerve imaging (MGH-BIDMC)
– MGH maxillofacial surgeon contacted us regarding pre-op imaging of lingual nerve
– Bob Lenkinski (BIDMC) had expertise in MRI nerve imaging
– Healthy volunteer was scanned at BIDMC
– Head and neck radiologist (BIDMC) will help with reading of images
Examples of Imaging Consultation
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• Study of brain-development in premature infants (new collaboration: CHB-BWH-MGH)
Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR) Optical Imaging of Cerebral Oxygenation
in Infants (MGH)
CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center
Medical Imaging Informatics
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• Examples:
– Clinical:• Ruling out appendicitis based on CT scans. Are
there metrics that can be found by analyzing clinical data?
• Quantitative output from Freesurfer for Alzheimer disease
– Research:• Helping TIMC get easier access to PACS system
for clinical trials
Medical Imaging Informatics
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• IT Catalyst infrastructure:– i2b2: scalable computational framework to help
translation of genomic findings. – BIRN: XNAT imaging informatics platform: large
collections of images and study-specific metadata to be managed by image-driven clinical translational research groups.
– NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer.
XNATEnterprise
DataRepository
(CRC)
FileRepository
IdentityManagement
OntologyManagement
CorrelationAnalysis
De -Identification
Of dataNatural
LanguageProcessing
AnnotatingGenomicData #1
ProjectManagement
WorkflowFramework
AnnotatingGenomicData #2PACS PACS
i2b2 HIVE
Dr X Desktop Pediatric
rare disease
Dr YDesktop
Alzheimer
Dr ZDesktop
Chronic pain management Dr W
Desktop Quantitative
cancer biomarkers
Medical Imaging Informatics
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Educational Program
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• Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff
• Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc)
• Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms
• Dissemination: through national networks (CTSA, RSNA, IRAT, SNM)
Pilot funds
• Eligibility:All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation.
• First round: 62 projects funded (out of 602)• Funds:
Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected)
• Deadlines:Letter of intent: May 13, 2009
Full application: June 12, 2009• Contact:
Harvard Catalyst Research Navigators617 432-7800
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