WWW.OXSTEM.CO.UK

AN INTRODUCTION TO OXSTEM

NOVEL APPROACHES TO CELL THERAPIES AND REGENERATIVE MEDICINE

MARCH 2017

WWW.OXSTEM.CO.UK

AGENDA

1.  OUR MISSION

2.  OUR GROUP

3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE

4.  THE “STEMS”

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OXSTEM

•  OXSTEM IS A DEVELOPER OF CELL PROGRAMMING THERAPIES, WORKING IN CLOSE COLLABORATION WITH THE UNIVERSITY OF OXFORD.

•  OXSTEM’S UNIQUE APPROACH TO REGENERATIVE MEDICINE WILL:

Ø  DELIVER SMALL MOLECULE THERAPEUTICS THAT ACTIVATE REPAIR MECHANISMS THAT ALREADY EXIST WITHIN THE BODY

Ø  EXPLOIT A DEEP UNDERSTANDING OF THE CHEMICAL UNDERPINNINGS OF STEM AND PROGENITOR CELL FUNCTION AND DIFFERENTIATION

Ø  GENERATE A COLLECTION OF DRUG CANDIDATES TO AWAKEN ENDOGENOUS CELLS TO REPAIR TISSUES AFFECTED BY DISEASE OR INJURY

•  TO BETTER HUMAN HEALTH BY DIRECTLY IMPACTING THE QUALITY AND DURATION OF LIFE •  OXSTEM WILL REVOLUTIONIZE THE REGENERATIVE MEDICINE FIELD BY DEVELOPING UNIQUE CELL

PROGRAMMING THERAPIES TO TREAT DEGENERATIVE DISEASES WITH HIGH UNMET NEED

WHAT WE DO

OUR PURPOSE

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WWW.OXSTEM.CO.UK

AGENDA

1.  OUR MISSION

2.  OUR GROUP

3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE

4.  THE “STEMS”

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WWW.OXSTEM.CO.UK

PROFESSOR STEVE DAVIES WAYNFLETE PROFESSOR OF CHEMISTRY

OXFORD UNIVERSITY

PROFESSOR ANGELA RUSSELL ASSOC. PROFESSOR OF CHEMISTRY & PHARMACOLOGY

OXFORD UNIVERSITY

PROFESSOR DAME KAY DAVIES DR LEE’S PROFESSOR OF ANATOMY

OXFORD UNIVERSITY

DR MICHAEL STEIN CHAIRMAN & CHIEF EXECUTIVE OFFICER

RAYMOND SPENCER, CFA CHIEF FINANCIAL OFFICER

EXECUTIVE FOUNDERS

SCIENTIFIC FOUNDERS

FOUNDING TEAM

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“SPIN-IN”

RAISED £16.9M IN MAY 2016

ACUTE MYELOID LEUKEMIA AND MYELO-DYSPLASTIC SYNDROME

ALZHEIMER’S DISEASE TRAUMATIC BRAIN INJURY

AGE RELATED MACULAR DEGENERATION

MYOCARDIAL INFARCTION / HEART FAILURE

“OxStem 4D”

3D STEM CELL SUSPENSION CULTURE

GROUP STRUCTURE

ALL >90% OWNED SUBSIDIARIES

SPIN-OUT

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INITIAL FUNDRAISE AND EARLY SUCCESS TIMELINE FOR YEAR 2016

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MAY 2016: £16.9M ($20M) RAISED, A RECORD FOR OXFORD UNIVERSITY SPIN-OUTS

MAY 2016: ESTABLISHMENT OF OXSTEM ONCOLOGY AND LAUNCH OF OXSTEM 4D

OCTOBER 2016: WINNER OF THE NATIONAL BEST BIOTECHNOLOGY START-UP AT THE OBN AWARDS, UK

DECEMBER 2016: PROOF-OF-PRINCIPLE DEMONSTRATED. FIRST EVER SMALL-MOLECULE DEMONSTRATING CELL-TO-WHOLE ANIMAL EFFICACY IN NEUROGENESIS

AUGUST 2016: ESTABLISHMENT OF OXSTEM NEURO AND OXSTEM OCULAR

NOVEMBER 2016: ESTABLISHMENT OF OXSTEM CARDIO

2016

WWW.OXSTEM.CO.UK

AGENDA

1.  OUR MISSION

2.  OUR GROUP

3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE

4.  THE “STEMS”

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WWW.OXSTEM.CO.UK

PLAGUED WITH TOLERANCE ISSUES AND REJECTION; REQUIRE SPECIALIST FACILITIES FOR THERAPEUTIC DELIVERY

INTRODUCTION TO CELL THERAPY AND REGENERATIVE MEDICINE CURRENT THERAPEUTIC PARADIGMS TISSUE ENGINEERING THERAPY

VIA IMPLANTATION CELL TRANSPLANTATION THERAPY VIA IMPLANTATION

SOURCE: CULME-SEYMOUR ET AL., REGEN. MED. 2012

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DRUG HERE TO INFLUENCE PROGRESS

DRUG HERE TO INFLUENCE PROGRESS

NATURALLY OCCURRING COMMITTED ADULT STEM CELLS

NATURALLY OCCURRING ADULT STEM CELLS

FUNCTIONAL CELLS FOR REGENERATIVE TREATMENT

NATURALLY OCCURRING ADULT STEM CELLS

OXSTEM’S APPROACH: PROGRAMMABLE CELL CHEMISTRY

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ACTIVATION OF RESIDENT CELLS IN VIVO TO ALLEVIATE DISEASE

•  SALAMANDERS, AND OTHER AMPHIBIANS, REGENERATE TISSUE AND REGROW DETACHED LIMBS

•  IN HUMANS MANY CELL TYPES ARE CONTINUOUSLY REPLACED INTO ADULTHOOD: Ø  BLOOD/BONE Ø  GUT EPITHELIUM Ø  SKIN/HAIR

•  OTHER TISSUES RETAIN A LIMITED REGENERATIVE CAPACITY (IN RESPONSE TO INJURY): Ø  CARDIAC MUSCLE Ø  NEURONS Ø  RETINA

•  IN ONCOLOGY, CANCER STEM-LIKE CELLS BECOME ABERRANT à UNLIMITED GROWTH AND/OR

ARREST OF DIFFERENTIATION

OXSTEM WILL ACTIVATE AND ENHANCE NATURAL REPAIR PROCESSES IN THE BODY, THAT ARE USUALLY VERY SLOW BY USING SMALL MOLECULE DRUGS AS WELL AS REDIRECTING CANCER STEM-LIKE CELLS TOWARDS A BENIGN (DIFFERENTIATED) PHENOTYPE

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WWW.OXSTEM.CO.UK

AGENDA

1.  OUR MISSION

2.  OUR GROUP

3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE

4.  THE “STEMS” – SEE WEBSITE: WWW.OXSTEM.CO.UK

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