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A B P-AKT total AKT P-PRAS40 P-rpS6 total rpS6 P-ERK total ERK Vehicle PF502 * Supplementary Figure S2: In vivo effects of PF502 as a single agent on MCAS xenograft tumour growth and PI3K/mTOR signalling. MCAS tumour bearing mice were treated daily with vehicle, 10 mg/kg PF502. A, Tumour volume graphed as mean + SEM, n=9-10. Unpaired t test. *, p< 0.0001. B, Immunoblot of tumours harvested at 19 days.
