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TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009 Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14 Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA Species/Strain: RATS/F 344/N Lab: MBA F1_R2_9Wk_SSAC C Number: C20537 Lock Date: 11/19/2007 Cage Range: ALL Date Range: ALL Reasons For Removal: 25017 SSAC Removal Date Range: ALL Treatment Groups: Include 004 VEHCONTRCOHRTD Include 009 2-8ADHAQP1COHTD Include 014 8-9ADHAQP1COHTD Include 019 2-11ADHAQP1COHTD Study Gender: Male TDMSE Version: 2.1.0
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Page 1: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

F1_R2_9Wk_SSAC

C Number: C20537

Lock Date: 11/19/2007

Cage Range: ALL

Date Range: ALL

Reasons For Removal: 25017 SSAC

Removal Date Range: ALL

Treatment Groups: Include 004 VEHCONTRCOHRTD Include 009 2-8ADHAQP1COHTD Include 014 8-9ADHAQP1COHTD

Include 019 2-11ADHAQP1COHTD

Study Gender: Male

TDMSE Version: 2.1.0

Page 2: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + 5.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + 5.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + 5.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + 5.........................................................................................................................................................................................................

Liver + + + + + 5Inflammation 1 1 2 1.0

.........................................................................................................................................................................................................

Oral Mucosa + + + + + 5.........................................................................................................................................................................................................

Pancreas + + + + + 5.........................................................................................................................................................................................................

Salivary Glands + + + 3Right, Submandibular Gland, Regeneration 1 2 1 3 1.3

.........................................................................................................................................................................................................

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

VEHCONTRCOHRTD

00016

00017

00018

00019

00020 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 2

Page 3: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

Stomach, Forestomach + + + + + 5.........................................................................................................................................................................................................

Stomach, Glandular + + + + + 5.........................................................................................................................................................................................................

Tongue + + + + + 5

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Blood Vessel + + + + + 5.........................................................................................................................................................................................................

Heart + + + + + 5Cardiomyopathy 1 1 1.0

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + 5.........................................................................................................................................................................................................

Adrenal Medulla + + + + + 5.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + 5.........................................................................................................................................................................................................

Parathyroid Gland + + + + + 5.........................................................................................................................................................................................................

Pituitary Gland + + + + + 5.........................................................................................................................................................................................................

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

VEHCONTRCOHRTD

00016

00017

00018

00019

00020 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 3

Page 4: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

Thyroid Gland + + + + + 5

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + 5.........................................................................................................................................................................................................

Preputial Gland + + I + + 4.........................................................................................................................................................................................................

Prostate + + + + + 5.........................................................................................................................................................................................................

Seminal Vesicle + + + + + 5.........................................................................................................................................................................................................

Testes + + + + + 5

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + 5.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M 0.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + 5.........................................................................................................................................................................................................

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

VEHCONTRCOHRTD

00016

00017

00018

00019

00020 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 4

Page 5: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

Spleen + + + + + 5.........................................................................................................................................................................................................

Thymus + + + + + 5

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + I + M M 2.........................................................................................................................................................................................................

Skin + + + + + 5

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + 5

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + 5

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + 5.........................................................................................................................................................................................................

Nose + + + + + 5.........................................................................................................................................................................................................

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

VEHCONTRCOHRTD

00016

00017

00018

00019

00020 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 5

Page 6: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

Trachea + + + + + 5

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + 5.........................................................................................................................................................................................................

Harderian Gland + + + + + 5Degeneration 3 1 3.0Inflammation 3 1 3.0Regeneration 3 1 3.0

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + 5.........................................................................................................................................................................................................

Urinary Bladder + + + + + 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

VEHCONTRCOHRTD

00016

00017

00018

00019

00020 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 6

Page 7: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + 5.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + 5.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + 5.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + 5.........................................................................................................................................................................................................

Liver + + + + + 5Basophilic Focus X 1Inflammation 1 1 1.0

.........................................................................................................................................................................................................

Oral Mucosa + + + + + 5.........................................................................................................................................................................................................

Pancreas + + + + + 5.........................................................................................................................................................................................................

Salivary Glands + + + + + 5Right, Submandibular Gland, Regeneration 1 2 1 1 1 5 1.2

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

2-8ADHAQP1COHTD

00041

00042

00043

00044

00045 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 7

Page 8: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + 5.........................................................................................................................................................................................................

Stomach, Glandular + + + + + 5.........................................................................................................................................................................................................

Tongue + + + + + 5

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Blood Vessel + + + + + 5.........................................................................................................................................................................................................

Heart + + + + + 5Cardiomyopathy 1 1 1 3 1.0

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + 5.........................................................................................................................................................................................................

Adrenal Medulla + + + + + 5.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + 5.........................................................................................................................................................................................................

Parathyroid Gland + + + + + 5.........................................................................................................................................................................................................

Pituitary Gland + + + + + 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

2-8ADHAQP1COHTD

00041

00042

00043

00044

00045 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 8

Page 9: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

.........................................................................................................................................................................................................

Thyroid Gland + + + + + 5

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + 5.........................................................................................................................................................................................................

Preputial Gland + + + + + 5.........................................................................................................................................................................................................

Prostate + + + + + 5.........................................................................................................................................................................................................

Seminal Vesicle + + + + + 5.........................................................................................................................................................................................................

Testes + + + + + 5

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + 5.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M 0.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

2-8ADHAQP1COHTD

00041

00042

00043

00044

00045 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 9

Page 10: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

.........................................................................................................................................................................................................

Spleen + + + + + 5.........................................................................................................................................................................................................

Thymus + + + + + 5

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland M + M + + 3.........................................................................................................................................................................................................

Skin + + + + + 5

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + 5

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + 5

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + 5.........................................................................................................................................................................................................

Nose + + + + + 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

2-8ADHAQP1COHTD

00041

00042

00043

00044

00045 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 10

Page 11: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

.........................................................................................................................................................................................................

Trachea + + + + + 5

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + 5.........................................................................................................................................................................................................

Harderian Gland + + + + + 5

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + 5Nephropathy 1 1 1.0

.........................................................................................................................................................................................................

Urinary Bladder + + + + + 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

2-8ADHAQP1COHTD

00041

00042

00043

00044

00045 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 11

Page 12: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + 5.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + 5.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + 5Hemorrhage 3 4 2 3.5

.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + 5.........................................................................................................................................................................................................

Liver + + + + + 5.........................................................................................................................................................................................................

Oral Mucosa + + + + + 5.........................................................................................................................................................................................................

Pancreas + + + + + 5.........................................................................................................................................................................................................

Salivary Glands + + + + + 5Right, Submandibular Gland, Inflammation 1 1 1.0Right, Submandibular Gland, Regeneration 1 1 1 1 1 5 1.0

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

8-9ADHAQP1COHTD

00066

00067

00068

00069

00070 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 12

Page 13: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + 5.........................................................................................................................................................................................................

Stomach, Glandular + + + + + 5.........................................................................................................................................................................................................

Tongue + + + + + 5

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Blood Vessel + + + + + 5.........................................................................................................................................................................................................

Heart + + + + + 5Cardiomyopathy 1 1 1 3 1.0

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + 5.........................................................................................................................................................................................................

Adrenal Medulla + + + + + 5.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + 5.........................................................................................................................................................................................................

Parathyroid Gland + + + + + 5.........................................................................................................................................................................................................

Pituitary Gland + + + + + 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

8-9ADHAQP1COHTD

00066

00067

00068

00069

00070 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 13

Page 14: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

.........................................................................................................................................................................................................

Thyroid Gland + + + + + 5

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + 5.........................................................................................................................................................................................................

Preputial Gland + + + + + 5.........................................................................................................................................................................................................

Prostate + + + + + 5.........................................................................................................................................................................................................

Seminal Vesicle + + + + + 5.........................................................................................................................................................................................................

Testes + + + + + 5

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + 5.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M 0.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

8-9ADHAQP1COHTD

00066

00067

00068

00069

00070 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 14

Page 15: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

.........................................................................................................................................................................................................

Spleen + + + + + 5.........................................................................................................................................................................................................

Thymus + + + + + 5

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland M + + + M 3.........................................................................................................................................................................................................

Skin + + + + + 5

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + 5

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + 5

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + 5.........................................................................................................................................................................................................

Nose + + + + + 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

8-9ADHAQP1COHTD

00066

00067

00068

00069

00070 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 15

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.........................................................................................................................................................................................................

Trachea + + + + + 5

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + 5.........................................................................................................................................................................................................

Harderian Gland + + + + + 5

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + 5.........................................................................................................................................................................................................

Urinary Bladder + + + + + 5Mucosa, Hyperplasia 2 1 2.0

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

8-9ADHAQP1COHTD

00066

00067

00068

00069

00070 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 16

Page 17: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + 5.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + 5.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + 5.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + 5.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + 5.........................................................................................................................................................................................................

Liver + + + + + 5Inflammation 1 1 2 1.0

.........................................................................................................................................................................................................

Oral Mucosa + + + + + 5.........................................................................................................................................................................................................

Pancreas + + + + + 5Acinus, Atrophy 2 1 2.0

.........................................................................................................................................................................................................

Salivary Glands + + + + 4Right, Submandibular Gland, Regeneration 1 2 1 1 4 1.3

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

2-11ADHAQP1COHTD

00091

00092

00093

00094

00095 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 17

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.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + 5.........................................................................................................................................................................................................

Stomach, Glandular + + + + + 5.........................................................................................................................................................................................................

Tongue + + + + + 5

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Blood Vessel + + + + + 5.........................................................................................................................................................................................................

Heart + + + + + 5Cardiomyopathy 1 1 1 3 1.0

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + 5.........................................................................................................................................................................................................

Adrenal Medulla + + + + + 5.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + 5.........................................................................................................................................................................................................

Parathyroid Gland + + + + + 5.........................................................................................................................................................................................................

Pituitary Gland + + + + + 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

2-11ADHAQP1COHTD

00091

00092

00093

00094

00095 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 18

Page 19: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

.........................................................................................................................................................................................................

Thyroid Gland + + + + + 5

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + 5.........................................................................................................................................................................................................

Preputial Gland + + + + M 4.........................................................................................................................................................................................................

Prostate + + + + + 5.........................................................................................................................................................................................................

Seminal Vesicle + + + + + 5.........................................................................................................................................................................................................

Testes + + + + + 5

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + 5.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M 0.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

2-11ADHAQP1COHTD

00091

00092

00093

00094

00095 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 19

Page 20: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

.........................................................................................................................................................................................................

Spleen + + + + + 5.........................................................................................................................................................................................................

Thymus + + + + + 5

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland M + + + M 3.........................................................................................................................................................................................................

Skin + + + + + 5

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + 5

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + 5

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + 5.........................................................................................................................................................................................................

Nose + + + + + 5

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

2-11ADHAQP1COHTD

00091

00092

00093

00094

00095 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 20

Page 21: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5

.........................................................................................................................................................................................................

Trachea + + + + + 5

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + 5.........................................................................................................................................................................................................

Harderian Gland + + + + + 5

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + 5.........................................................................................................................................................................................................

Urinary Bladder + + + + + 5

*** END OF MALE DATA ***

*** END OF REPORT ***

TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009

Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14

Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA

Species/Strain: RATS/F 344/N Lab: MBA

DAY ON TEST0057

0057

0057

0057

0057

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

2-11ADHAQP1COHTD

00091

00092

00093

00094

00095 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 21


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