Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 78, No. 5, [Part 2: Biological Sciences] (May, 1981), pp. i-viiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/10678 .

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Proceedings OF THE

National Academy of Sciences

OF THE UNITED STATES OF AMERICA

May 1981 Volume 78, Number 5 pp. 2649-3286

Table of Contents

INFORMATION TO CONTRIBUTORS

AUTHOR INDEX

Physical Sciences

Biological Sciences

BIOCHEMISTRY

Distribution of proviral sequences in chromatin of embryonic fibroblasts infected by Rous sarcoma virus (virus-infected cells/cDNA/nucleic acid hybridization)

Gene duplication and transposition linked to antigenic variation in Trypanosoma brucei (surface antigens/gene expression/parasitology)

Formation of a covalent complex between the 80,000-dalton adenovirus terminal protein and 5'-dCMP in vitro (adenoviral DNA replication/5'-terminal protein/ protein-nucleic acid complex)

Differential inhibition of multiple forms of DNA polymerase a from IMR-32 human neuroblastoma cells (DNA nucleotidyltransferase/hemin/ neuroblastomas/nonhistone chromosomal protein/ricin toxin)

Phosphorylation of McArdle phosphorylase induces activity (human skeletal muscle/protein kinase)

3C NMR study of transamination during acetate utilization by Saccharomyces cerevisiae (glyoxylate cycle/Krebs cycle/glutamic-oxalacetic transaminase/ amino oxyacetate/trehalose)

On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2- bromovinyl)-2'-deoxyuridine (antiviral activity/DNA polymerases)

Tetrahydrobiopterin increases in adrenal medulla and cortex: A factor in the regulation of tyrosine hydroxylase (catecholamine biosynthesis/pterin biosynthesis/adrenal denervation/hypophysectomy/corticosteroids)

Genetic assignment of resonances in the NMR spectrum of a protein: lac repressor (gene regulation/19F/3-fluorotyrosine/nonsense suppression)

i

ix-xii

xiii-xiv

2649-2668

Panagiotis Pantazis, Robert A. Schulz, Jack G. Chirikjian, and Takis S. Papas

E. Pays, N. Van Meirvenne, D. Le Ray, and M. Steinert

Jack H. Lichy, Marshall S. Horwitz, and Jerard Hurwitz

Prabir Bhattacharya, Ira Simet, and Subhash Basu

2669-2672

2673-2677

2678-2682

2683-2687

Cesare G. Cerri and Joseph H. Willner 2688-2692

J. S. den Hollander, K. L. Behar, and R. G. Shulman

H. S. Allaudeen, J. W. Kozarich, J. R. Bertino, and E. De Clercq

Martha M. Abou-Donia and 0. Humberto Viveros

2693-2697

2698-2702

2703-2706

Mary Ann C. Jarema, Ponzy Lu, and 2707-2711 Jeffrey H. Miller

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Relationship between glycocalicin and glycoprotein Ib of human platelets (Factor VIII-related von Willebrand factor receptor/platelet glycoproteins/peanut agglutinin affinity chromatography/radioactive peptide map)

Alcohol dehydrogenase gene of Drosophila melanogaster: Relationship of intervening sequences to functional domains in the protein (recombinant DNA/gene isolation/pBR322/evolutionary homology)

Specific binding of a prokaryotic ribosomal protein to a eukaryotic ribosomal RNA: Implications for evolution and autoregulation (protein-RNA interaction/ RNA secondary structure/molecular evolution/autogenous regulation)

Mouse cells transformed by bovine papillomavirus contain only extrachromosomal viral DNA sequences (papovavirus/viral transformation/DNA hybridization/ nonintegrated DNA/cloned DNA)

Binding of amphiphilic peptides to phospholipid/cholesterol unilamellar vesicles: A model for protein-cholesterol interaction (apolipoprotein A-I)

Monoclonal antibodies to nucleic acid-containing cellular constituents: Probes for molecular biology and autoimmune disease (lupus erythematosus/anti-Sm antibody/small nuclear ribonucleoprotein/rRNA/DNA)

Physical association of pyrimidine dimer DNA glycosylase and apurinic/ apyrimidinic DNA endonuclease essential for repair of ultraviolet-damaged DNA (bacteriophage/T4 endonuclease V/multifunctional enzyme)

Mutations in the gene coding for Escherichia coli DNA topoisomerase I affect transcription and transposition ( protein/DNA supercoiling/supX)

Epidermal growth factor stimulation of ornithine decarboxylase activity in a human hepatoma cell line (polyamines/liver epidermal growth factor receptor/ phorbol ester)

Complete amino acid sequence of a-tubulin from porcine brain (sequence microheterogeneity/homology with muscle proteins)

Heterogeneity of RNA polymerase in Bacillus subtilis: Evidence for an additional a factor in vegetative cells (promoter specificity/transcriptional regulation/ holoenzyme II/RNA nucleotidyltransferase)

In vivo and in vitro detection of the leader RNA of the histidine operon of Escherichia coli K-12 (attenuation/leader RNA/minicells)

cDNA clone coding for part of a mouse H-2d major histocompatibility antigen (hybrid selection/membrane protein)

Formation of y-glutamylcyst(e)ine in vivo is catalyzed by y-glutamyl transpeptidase (glutathione/y-glutamyl cycle/cystine transport)

Preparation of azidocalmodulin: A photoaffinity label for calmodulin-binding proteins (phosphodiesterase/myosin light chain kinase/membranes/Ca2+/ crosslinking)

Erythrosomes: Large proteoliposomes derived from crosslinked human erythrocyte cytoskeletons and exogenous lipid (liposomes/transport protein reconstitution/ encapsulation systems/cytoskeletons/erythrosomes)

Solid-phase peptide synthesis under continuous-flow conditions (polystyrene supports/high-pressure liquid chromatography/peptide analysis/model tetrapeptide/ovalbumin)

Expression of the denV gene of bacteriophage T4 cloned in Escherichia coli (recombinant DNA/T4 endonuclease V/ultraviolet light/pyrimidine dimers/ DNA repair)

Immunofluorescent staining of poly(ADP-ribose) in situ in HeLa cell chromosomes in the M phase (NAD+/DNase I/3-aminobenzamide/chromatin condensation/ cell synchronization)

Internal duplication and evolution of human ceruloplasmin (protein structure/ internal homology/gene evolution/copper oxidases/ferroxidase)

Calcium control of microfilaments: Uncoupling of the F-actin-severing and -bundling activity of villin by limited proteolysis in vitro (epithelia/microvilli/ cytoskeleton)

Kenneth J. Clemetson, Hassan Y. 2712-2716 Naim, and Ernst F. Liischer

Cheetip Benyajati, Allen R. Place, 2717-2721 Dennis A. Powers, and William Sofer

Richard L. Gourse, David L. Thurlow, 2722-2726 Susan A. Gerbi, and Robert A. Zimmermann

Ming-Fan Law, Douglas R. Lowy, 2727-2731 Israel Dvoretzky, and Peter M. Howley

Daikichi Fukushima, Shinji 2732-2736 Yokoyama, F. J. K6zdy, and E. T. Kaiser

Ethan A. Lerner, Michael R. Lerner, 2737-2741 Charles A. Janeway, Jr., and Joan A. Steitz

Yusaku Nakabeppu and Mutsuo 2742-2746 Sekiguchi

Rolf Sternglanz, Stephen DiNardo, 2747-2751 Karen A. Voelkel, Y. Nishimura, Y. Hirota, Kathleen Becherer, Louis Zumstein, and James C. Wang

Debra M. Moriarity, Dennis M. 2752-2756 DiSorbo, Gerald Litwack, and C. Richard Savage, Jr.

H. Ponstingl, E. Krauhs, M. Little, and 2757-2761 T. Kempf

Janey L. Wiggs, Michael Z. Gilman, 2762-2766 and Michael J. Chamberlin

Rodolfo Frunzio, Carmelo B. Bruni, 2767-2771 and Francesco Blasi

S. Kvist, F. Bregegere, L. Rask, B. 2772-2776 Cami, H. Garoff, F. Daniel, K. Wiman, D. Larhammar, J. P. Abastado, G. Gachelin, P. A. Peterson, B. Dobberstein, and P. Kourilsky

Owen W. Griffith, Richard J. Bridges, 2777-2781 and Alton Meister

Terrence J. Andreasen, Charles H. 2782-2785 Keller, David C. LaPorte, Arthur M. Edelman, and Daniel R. Storm

John Cuppoletti, Eric Mayhew, C. R. 2786-2790 Zobel, and Chan Y. Jung

Thomas J. Lukas, Michael B. 2791-2795 Prystowsky, and Bruce W. Erickson

R. Stephen Lloyd and Philip C. 2796-2800 Hanawalt

Yoshiyuki Kanai, Seiichi Tanuma, and 2801-2804 Takashi Sugimura

Frances E. Dwulet and Frank W. 2805-2809 Putnam

John R. Glenney, Jr., and Klaus Weber 2810-2814

ii

Contents

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Expression of human and mouse nonhistone chromosomal proteins in hybrid mouse erythroleukemia cells containing a single human chromosome (chromatin/two-dimensional gel electrophoresis)

Determination of cellular RNA concentrations by electron microscopy of R loop- containing DNA (R-loop electron microscopy/recombinant DNA/mRNA abundance)

Molecular cloning and characterization of winter flounder antifreeze cDNA (recombinant DNA/antifreeze peptides/DNA DNA hybridization/DNA sequence)

Ovine prolactin: Equilibrium characteristics of the recombinant molecule formed by noncovalent interaction of two fibrinolysin fragments by fluorescence polarization (dissociation constant/fluorescein isothiocyanate/free energy of dissociation)

Protein kinase activity of RNA polymerase I purified from a rat hepatoma: Probable function of Mr 42,000 and 24,600 polypeptides (phosphorylation/RNA polymerase I subunits/antibodies/diazobenzyloxymethyl-filter technique)

Unwinding of double-stranded DNA helix by dehydration (DNA conformation/ hydration/thermodynamics/gel electrophoresis)

Molecular cloning of two fast myosin heavy chain cDNAs from chicken embryo skeletal muscle (restriction enzyme mapping/hybrid arrested translation/DNA sequence determination/electron microscopic heteroduplex analysis/hybrid melting curves)

Target cell specificity of two species of human interferon-a produced in Escherichia coli and of hybrid molecules derived from them (active site/ receptor/genetic engineering/gene expression/antiviral activity)

Orientation of histidine residues in RNase A: Neutron diffraction study (protein structure/active site/hydrogen bonds/difference Fourier maps)

Histone genes are clustered but not tandemly repeated in the chicken genome (recombinant DNA/DNA sequence analysis/development)

Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate (AMP/ gluconeogenesis)

On the molecular basis of transition mutations: Frequencies of forming 2- aminopurine.cytosine and adenine-cytosine base mispairs in vitro (DNA fidelity/replication errors/heteroduplex formation)

Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor [N6-(4-amino-2- hydroxybutyl)-2,6-diaminohexanoic acid or N"-(4-amino-2-hydroxybutyl)lysine/ putrescine/polyamines/posttranslational modification]

Assessment of estrogen receptor.histone interactions (affinity chromatography/ DNA -cellulose/protein.protein interactions/chromosomal proteins/steroid hormone action)

Regulation of collagen synthesis by ascorbic acid (prolyl hydroxylation/lysyl hydroxylation/human skin fibroblasts)

DNA breakage and closure by rat liver type 1 topoisomerase: Separation of the half-reactions by using a single-stranded DNA substrate (DNA nicking-closing enzyme/bacteriophage XX174 single-stranded DNA/reaction intermediate/ covalent protein-DNA complex/recombination)

A RNA helix-destabilizing protein is a major component of Artemia salina nuclear ribonucleoproteins (heterogeneous nuclear ribonucleoprotein structure/glycine- rich nuclear protein/RNA-protein complexes)

Cloning and expression of the Bacillus thuringiensis crystal protein gene in Escherichia coli (plasmids/radioimmunoassay/sporulation/insect toxicity)

Anti-Rho(D) IgG binds to band 3 glycoprotein of the human erythrocyte membrane [integral proteins/alkaline extraction/Rh,(D) antigen/band 3 ensembles]

Dynamic protein structures: Infrared evidence for four discrete rapidly interconverting conformers at the carbon monoxide binding site of bovine heart myoglobin (heme protein/infrared spectroscopy)

Role of glycosylation and protein synthesis in insulin receptor metabolism by 3T3- L1 mouse adipocytes (receptor synthesis and turnover/receptor density shift)

Tandem termination sites in the tryptophan operon of Escherichia coli (DNA sequence/transcription/p factor/multiple terminators)

U. Bode, A. Deisseroth, and D. Hendrick

David B. Kaback, Michael Rosbash, and Norman Davidson

Yuan Lin and Julie K. Gross

Michael D. Jibson, Choh Hao Li, and Charles B. Glaser

Kathleen M. Rose, Dean A. Stetler, and Samson T. Jacob

Che-Hung Lee, Hiroshi Mizusawa, and Tsuyoshi Kakefuda

P. K. Umeda, A. M. Sinha, S. Jakovcic, S. Merten, H.-J. Hsu, K. N. Subramanian, R. Zak, and M. Rabinowitz

Michel Streuli, Alan Hall, Werner Boll, William E. Stewart II, Shigekazu Nagata, and Charles Weissmann

Alexander Wlodawer and Lennart Sjolin

James Douglas Engel and Jerry B. Dodgson

Emile Van Schaftingen and Henri- Gery Hers

Susan M. Watanabe and Myron F. Goodman

Myung Hee Park, Herbert L. Cooper, and J. E. Folk

John Kallos, Thomas M. Fasy, and Vincent P. Hollander

S. Murad, D. Grove, K. A. Lindberg, G. Reynolds, A. Sivarajah, and S. R. Pinnell

Michael D. Been and James J. Champoux

John O. Thomas, Raziuddin, Andrzej Sobota, Miloslav Boublik, and Wlodzimierz Szer

2815-2819

2820-2824

2825-2829

2830-2832

2833-2837

2838-2842

2843-2847

2848-2852

2853-2855

2856-2860

2861-2863

2864-2868

2869-2873

2874-2878

2879-2882

2883-2887

2888-2892

H. Ernest Schnepf and H. R. Whiteley 2893-2897

Edward J. Victoria, Lawrence C. Mahan, and S. P. Masouredis

2898-2902

Winslow S. Caughey, Hideo Shimada, 2903-2907 Miles G. Choc, and Melvin P. Tucker

Brent C. Reed, Gabriele V. Ronnett, -and Daniel Lane

Anna M. Wu, Gail E. Christie, and Terry Platt

2908-2912

2913-2917

iii

Contents

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Contents

Molecular cloning of integrated simian sarcoma.virus: Genome organization of infectious DNA clones (recombinant DNA/primate retrovirus/restriction enzyme and R-loop analysisltransformation)

The polyribosomal mRNA-protein complex is a dynamic structure [poly(A)/ photocrosslinking]

Eukaryotic translational control: Adeno-associated virus protein synthesis is affected by a mutation in the adenovirus DNA-binding protein (parvovirus/ RNA splicing/protein synthesis in vivo and in vitro/protein processing/ translational control)

p53 transformation-related protein: Detection of an associated phosphotransferase activity (protein kinase/p53 monoclonal antibody/transforming protein)

Mutations that affect lamB gene expression at aposttranscriptional level (translation initiation/bacterial outer membrane/signal sequence/protein secretion/polarity in operons)

Proton transport in photooxidation of water: A new perspective on photosynthesis (uncouplers/plastoquinone/photosystems I and II/oxygenic and anoxygenic photosystems)

Location, function, and nucleotide sequence of a promotor for bacteriophage T3 RNA polymerase (Correction) (restriction map of T3 DNA/Southern hybridization/restriction fragment transcription by T3 RNA polymerase/DNA sequencing/RNA sequencing)

BIOPHYSICS

Location of platinum binding sites on bacteriorhodopsin by electron diffraction (electron crystallography/purple membrane/isomorphous replacement/ Halobacterium halobium/glycyl-1 -methionatoplatinum)

Oscillations and control features in glycolysis: Numerical analysis of a comprehensive model (phosphofructokinase-pyruvate kinase reaction coupling/ efficiency/ATP/ADP ratio)

Monomeric chlorophyll a enol: Evidence for its possible role as the primary electron donor in photosystem I of plant photosynthesis (ESR/redox potential/ cation radical/electronic structure)

Conformational transitions in Pf3 and their implications for the structure and assembly of filamentous bacterial viruses (Raman and circular dichroism spectroscopies/protein secondary structure/thermal transitions)

Proton NMR studies of the Zn(II)-bleomycin-A2-poly(dA-dT) ternary complex (drug-nucleic acid interactions/antitumor agent/DNA degradation/peptide antibiotics/glycopeptides)

Methylmercury(II) binding to single-stranded and duplex DNA: Complexes formed are distinguishable by optical detection of magnetic resonance spectroscopy (triple state/heavy atom effect)

BOTANY

Probing the molecular structure of phytochrome with immobilized Cibacron blue 3GA and blue dextran (biospecific binding/hydrophobic forces/FMN/ mechanism of action)

Apoplastic transport of ions in the motor organ of Samanea (circadian rhythms/ leaf movements/x-ray microanalysis)

Light limitation of photosynthesis and activation of ribulose bisphosphate carboxylase in wheat seedlings (CO2 exchange/carbon reduction cycle)

CELL BIOLOGY

Adrenocorticotropin-like and a-melanotropin-like peptides in a subpopulation of human gastrin cell granules: Bioassay, immunoassay, and immunocytochemical evidence (immunosorbent-bioassay/radioimmunoassay/ electron microscopy/chromatography/isoelectric focusing)

Inducibility of spleen focus-forming virus by BrdUrd is controlled by the differentiated state of the cell (Friend cells/Friend anemia virus/Friend polycythemia virus/thymidine kinase/erythroid differentiation)

iv

Keith C. Robbins, Sushilkumar.G. Devare, and Stuart A. Aaronson

Jay R. Greenberg

Francis T. Jay, Catherine A. Laughlin, and Barrie J. Carter.

Gilbert Jay, George Khoury, Albert B. DeLeo, Wolfgang G. Dippold, and Lloyd J. Old

Maxime Schwartz, Michele Roa, and Michel D6barbouille

Daniel I. Arnon, Harry Y. Tsujimoto, and George M.-S. Tang

Samit Adhya, Shantanu Basu, Probir Sarkar, and Umadas Maitra

Mark E. Dumont, J. W. Wiggins, and S. B. Hayward

Yves Termonia and John Ross

Michael R. Wasielewski, James R. Norris, Lester L. Shipman, Chih- Ping Lin, and Walter A. Svec

George J. Thomas, Jr., and Loren A. Day

Jerry D. Glickson, Rajasekharan P. Pillai, and Ted T. Sakai

August H. Maki and Christopher M. Ott

William O. Smith, Jr.

Neil A. Campbell, Ruth L. Satter, and Robert C. Garber

John T. Perchorowicz, Deborah A. Raynes, and Richard G. Jensen

Lars-Inge Larsson

I. Greiser-Wilke, W. Ostertag, P. Goldfarb, A. Lang, M. Furusawa, and J. F. Conscience

2918-2922

2923-2926

2927-2931

2932-2936

2937-2941

2942-2946

3286

2947-2951

2952-2956

2957-2961

2962-2966

2967-2971

2972-2976

2977-2980

2981-2984i

2985-2989

2990-2994

2995-2999

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Contents

Hormonal regulation of cytodifferentiation and intercellular communication in cultured granulosa cells (gonadotropin receptors/gonadotropin-releasing hormone/gap junctions/cyclic AMP/progesterone)

Interaction of a-actinin and vinculin with actin: Opposite effects on filament network formation (actin binding proteins/microfilament bundling and crosslinking/viscometry/electron microscopy)

High molecular weight microtubule-associated proteins are preferentially associated with dendritic microtubules in brain (tubulin/ immunohistochemistry/immunoelectrophoresis/postsynaptic density)

All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus (inverted terminal repeats/ chromosome processing/gene excision/DNA replication)

Aortic smooth muscle cells contain vimentin instead of desmin (10-nm filaments/ viscera/vasculature/immunofluorescence/two-dimensional gel electrophoresis)

Quiescent human diploid cells can inhibit entry into S phase in replicative nuclei in heterodikaryons (cell cycle/cell fusion/cellular senescence/simian virus 40/ chemical transformation)

Nature of the G1 phase of the yeast Saccharomyees cerevisiae (cell cycle/ hydroxyurea)

Differential staining of actin in metaphase spindles with 7-nitrobenz-2-oxa-l,3- diazole-phallacidin and fluorescent DNase: Is actin involved in chromosomal movement? (phallacidin/phalloidin/mitosis/fluorescence)

Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin (monoclonal antibody/serum factor)

Angiotensin alters 45Ca2+ fluxes in bovine adrenal glomerulosa cells (aldosterone/ steroidogenesis/cation flux/polypeptide hormones/receptors)

Intracellular localization of DNA polymerase a (cytochalasin B/enucleation/ cytoplasmic DNA polymerase/DNA cytochemistry)

Anchorage-independent growth of normal human fibroblasts (methylcellulose/ hydrocortisone/high serum concentration)

Replication of a and 8 globin DNA sequences occurs during early S phase in murine erythroleukemia cells (DNA replication/cell cycle/globin genes/ ribosomal RNA genes)

Microtubule-disrupting agents affect two different events regulating the initiation of DNA synthesis in Swiss 3T3 cells (epidermal growth factor/Colcemid/ synergistic effect/lag phase)

Angiogenic activity from bovine retina: Partial purification and characterization (endothelial cells/growth factor/angiogenic factor/neovascularization/ retinopathy)

Posttranslational uptake and processing of in vitro synthesized ornithine transcarbamoylase precursor by isolated rat liver mitochondria (mitochondrial biogenesis/cell-free protein synthesis/precursor proteins/processing and segregation by mitochondria/ornithine carbamoyltransferase)

Specific disruption of vimentin filament organization in monkey kidney CV-1 cells by diphtheria toxin, exotoxin A, and cycloheximide (Correction) (intermediate filaments)

DEVELOPMENTAL BIOLOGY

Full-grown oocytes from Xenopus laevis resume growth when placed in culture (follicle cells/vitellogenin/nutrient availability/oocyte maturation)

Regulation of synthesis of cell-specific ribosomal proteins during differentiation of Dictyostelium discoideum (slime mold/development/ribosome heterogeneity/ ribosomal proteins/translational control)

EVOLUTION

Sexual selection in Drosophila silvestris of Hawaii (behavior/evolution/courtship/ reproduction)

GENETICS

X chromosome reactivation in oocytes of Mus caroli (glucose-6-phosphate dehydrogenase/meiosis)

Abraham Amsterdam, Michael Knecht, 3000-3004 and Kevin J. Catt

Brigitte M. Jockusch and Gerhard Isenberg

Andrew Matus, Robert Bernhardt, and Taff Hugh-Jones

Lawrence A. Klobutcher, Marshal T. Swanton, Pierluigi Donini, and David M. Prescott

Evan D. Frank and Leonard Warren

Gretchen'H. Stein and Rosalind M. Yanishevsky

R. A. Singer and G. C. Johnston

Larry S. Barak, Eugene A. Nothnagel, Eileen F. DeMarco, and W. W. Webb

3005-3009

3010-3014

3015-3019

3020-3024

3025-3029

3030-3033

3034-3038

Ian S. Trowbridge and M. Bishr Omary 3039-3043

M. E. Elliott and T. L. Goodfriend

McKay Brown, F. J. Bollum, and L. M. S. Chang

3044-3048

3049-3052

Donna M. Peehl and Eric J. Stanbridge 3053-3057

Elliot Epner, Richard A. Rifkind, and 3058-3062 Paul A. Marks

Angela M. Otto, Marie-Odile Ulrich, Albert Zumbe, and Luis Jimenez de Asua

3063-3067

Patricia A. D'Amore, Bert M. Glaser, 3068-3072 Sandra K. Brunson, and Allan H. Fenselau

John G. Conboy and Leon E. Rosenberg 3073-3077

Arlene H. Sharpe, Lan Bo Chen, John 3284-3285 R. Murphy, and Bernard N. Fields

Robin A. Wallace, Ziva Misulovin, and Laurence D. Etkin

3078-3082

Subbanaidu Ramagopal and Herbert L. 3083-3087 Ennis

Eliot B. Spiess and Hampton L. Carson 3088-3092

Paul G. Kratzer and Verne M. Chapman

3093-3097

v

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Contents

Pseudohypoparathyroidism: Inheritance of deficient receptor-cyclase coupling activity (dominant inheritance/recessive inheritance/adenylate cyclase)

Structural analysis of an electrophoretically cryptic alcohol dehydrogenase variant from an Australian population of Drosophila melanogaster (genetic polymorphism/clines/peptide mapping/secondary structure prediction)

Is there a difference among human populations in the rate with which mutation produces electrophoretic variants? (tribal mutation rates/human electrophoretic variants/human population sampling theory)

Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons (gene duplication/ chromosomal merodiploidy/transposon)

Differential activity of DNA methyltransferase in the life cycle of Chlamydomonas reinhardtii [DNA (cytosine-5)-methyltransferase/chloroplast DNA methylation/mat-1 mutant/symmetrical methylation]

Leukocyte and fibroblast interferon genes are located on human chromosome 9 (gene mapping/cell hybrids/cloned genes)

Origin of replication from Xenopus laevis mitochondrial DNA promotes high- frequency transformation of yeast (DNA replication/yeast replicon/ recombinant DNA)

Elevated spontaneous mutation rate in Bloom syndrome fibroblasts (mutator gene/carcinogenesis/somatic mutations)

Electrophoretically detected germinal mutations induced in the mouse by ethylnitrosourea

An unusual symmetric recombinant between adenovirus type 12 DNA and human cell DNA (symmetric DNA molecules/defective adenovirus DNA/ recombination/hairpin molecules/end-labeling of adenovirus DNA)

Genes in mice that affect susceptibility to cortisone-induced cleft palate are closely linked to Ir genes on chromosomes 2 and 17 (major histocompatibility complex/ H-3 locus)

Mutagen-induced resistance to mycophenolic acid in hamster cells can be associated with increased inosine 5'-phosphate dehydrogenase activity (gene regulation/Chinese hamster V79 cells/N-methyl-N'-nitro-N-nitrosoguanidine)

IMMUNOLOGY

Differential effects of glucocorticosteroids on the functions of helper and suppressor T lymphocytes (immune regulation/dexamethasone/macrophage factors/T cell growth factors/autoimmunity)

Dissection of distinct human immunoregulatory T-cell subsets by a monoclonal antibody recognizing a cell surface antigen with wide tissue distribution (T- and B-cell lines/T- and B-cell leukemias/helper and suppressor T cells)

Hybridoma-derived antibody with immunodiagnostic potential for schistosomiasis japonica (Schistosoma japonicum/immunodiagnosis)

Expression and synthesis of murine immune response-associated (Ia) antigens by brain cells (major histocompatibility complex/immunoperoxidase/ immunoprecipitation)

MEDICAL SCIENCES

Human embryonic somatomedin (human fetal growth/pregnancy)

Monoclonal antibodies to the thyrotropin receptor: Implications for receptor structure and the action of autoantibodies in Graves disease (ganglioside/ cholera toxin/hybridoma/adenylate cyclase/thyroid)

Selective growth in serum-free hormone-supplemented medium of tumor cells obtained by biopsy from patients with small cell carcinoma of the lung (primary human tumor culture/clonogenic assay/flow cytometry/nude mice)

Zvi Farfel, Virginia M. Brothers, Arnold S. Brickman, Felix Conte, Robert Neer, and Henry R. Bourne

Geoffrey K. Chambers, W. Graeme Laver, Sally Campbell, and John B. Gibson

James V. Neel and Edward Rothman

Philip Anderson and John Roth

Hiroshi Sano, Constance Grabowy, and Ruth Sager

David Owerbach, William J. Rutter, Thomas B. Shows, Patrick Gray, David V. Goeddel, and Richard M. Lawn

Virginia A. Zakian

Stephen T. Warren, Roger A. Schultz, Chia-Cheng Chang, Margaret H. Wade, and James E. Trosko

F. M. Johnson and Susan E. Lewis

Renate Deuring, Guinther Klotz, and Walter Doerfler

David L. Gasser, Lisa Mele, Diana D. Lees, and Allen S. Goldman

Eliezer Huberman, Catherine K. McKeown, and Joseph Friedman

Linda M. Bradley and Robert I. Mishell

Oscar H. Irigoyen, Philip V. Rizzolo, Yolene Thomas, Martin E. Hemler, Harry H.-L. Shen, Steven M. Friedman, Jack L. Strominger, and Leonard Chess

Graham F. Mitchell, Kathy M. Cruise, Edito G. Garcia, and Robin F. Anders

Jenny P. Y. Ting, Brian L. Shigekawa, D. Scott Linthicum, Leslie P. Weiner, and Jeffrey A. Frelinger

Vicki R. Sara, Kerstin Hall, Charles H. Rodeck, and Lennart Wetterberg

Ephraim Yavin, Ziva Yavin, Michael D. Schneider, and Leonard D. Kohn

Desmond N. Carney, Paul A. Bunn, Jr., Adi F. Gazdar, Jose A. Pagan, and John D. Minna

vi

3098-3102

3103-3107

3108-3112

3113-3117

3118-3122

3123-3127

3128-3132

3133-3137

3138-3141

3142-3146

3147-3150

3151-3154

3155-3159

3160-3164

3165-3169

3170-3174

3175-3179

3180-3184

3185-3189

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Contents

Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases (systemic lupus erythematosus/IgM/ prostaglandin/arachidonic acid/monoclonal antibody)

Contractile activities of structural analogs of leukotrienes C and D: Necessity of a hydrophobic region (slow-reacting substance of anaphylaxis/leukotriene receptor)

A spectrum of monoclonal antibodies reactive with human mammary tumor cells (breast cancer/tumor-associated antigens/radioimmunoassays/ immunoperoxidase technique/breast tumor metastases)

Parathyroid hormone stimulates bone formation and resorption in organ culture: Evidence for a coupling mechanism (endocrine/mineralization/bone metabolism/cartilage/regulation)

LDHk, an unusual oxygen-sensitive lactate dehydrogenase expressed in human cancer (lactate dehydrogenase isozymes/Kirsten sarcoma virus/GTP)

Clinical applications of the radioimmunoassay of secretory tuberculoprotein (bacterial growth/antibiotic susceptibility testing/diagnosis of tuberculosis)

Deposition of plasma fibronectin in tissues (extracellular matrix/basement membranes/plasma proteins)

Changes in serum iron levels due to infection with hepatitis B virus (iron/ hepatitis B/carrier/bacterial infection)

Analysis of a predominant immunoglobulin population in the cerebrospinal fluid of a multiple sclerosis patient by means of an anti-idiotypic hybridoma antibody (oligoclonal immunoglobulins/pathogenesis of multiple sclerosis/ Theiler's viruses)

Von Willebrand syndrome induced by a Bothrops venom factor: Bioassay for venom coagglutinin (Factor VIII complex/platelet aggregation/animal model)

Lethality of human myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA (leukemia/cytotoxicity/nucleoside analog)

MICROBIOLOGY

Biochemical stratagem for obligate parasitism of eukaryotic cells by Coxiella burnetii (intracellular parasitism/pathogenic mechanisms/phagolysosome/ compartmentation)

NEUROBIOLOGY

Simultaneous optical measurements of electrical activity from multiple sites of processes of cultured neurons (tissue culture/neurons/membrane potential/ fluorescence/growth cone)

Distinct pharmacological properties of excitatory amino acid receptors in the rat striatum: Study by Na+ efflux assay (glutamate analogs/agonists/antagonists/ putative neurotransmitters/brain slices)

Dopamine receptor binding in inbred mice: Strain differences in mesolimbic and nigrostriatal dopamine binding sites (spiroperidol/striatum/olfactory tubercle/ Scatchard analysis)

Adenosine receptors and behavioral actions of methylxanthines [caffeine/ theophylline/N6-cyclohexyladenosine/N6-(phenylisopropyl)adenosine]

A highly potent 3200-dalton adrenal opioid peptide that contains both a [Met]- and [Leu]enkephalin sequence (adrenal medulla/guinea pig ileum/hormone/ sequence microanalysis)

Polarity of axoplasmic microtubules in the olfactory nerve of the frog (axoplasm/ ultrastructure/detergent extraction/tubulin assembly/protofilament ribbons)

Fusao Hirata, Ranata del Carmine, Carol A. Nelson, Julius Axelrod, Elliott Schiffmann, Akira Warabi, Angel L. De Blas, Marshall Nirenberg, Vincent Manganiello, Martha Vaughan, Shunichi Kumagai, Ira Green, John L. Decker, and Alfred D. Steinberg

Jeffrey M. Drazen, Robert A. Lewis, K. Frank Austen, Masaaki Toda, Francis Brion, Anthony Marfat, and E. J. Corey

D. Colcher, P. Horan Hand, M. Nuti, and J. Schlom

Guy A. Howard, Brian L. Bottemiller, Russell T. Turner, Jeanne I. Rader, and David J. Baylink

Garth R. Anderson and William P. Kovacik, Jr.

Eugene Straus, Nancy Wu, M. A. H. Quraishi, and Susan Levine

Esther Oh, Michael Pierschbacher, and Erkki Ruoslahti

Baruch S. Blumberg, Edward D. Lustbader, and Pamela L. Whitford

Walter Gerhard, Alex Taylor, Zofia Wroblewska, Magnhild Sandberg- Wollheim, and Hilary Koprowski

K. M. Brinkhous, D. S. Barnes, J. Y. Potter, and M. S. Read

P. P. Major, E. M. Egan, G. P. Beardsley, M. D. Minden, and D. W. Kufe

Ted Hackstadt and Jim C. Williams

Amiram Grinvald, William N. Ross, and Ira Farber

Alberto Luini, Ora Goldberg, and Vivian I. Teichberg

Richard E. Boehme and Roland D. Ciaranello

Solomon H. Snyder, Jefferson J. Katims, Zoltan Annau, Robert F. Bruns, and John W. Daly

Daniel L. Kilpatrick, Takashi Taniguchi, Barry N. Jones, Alvin S. Stern, John E. Shively, John Hullihan, Sadao Kimura, Stanley Stein, and Sidney Udenfriend

Paul R. Burton and Jeffrey L. Paige

3190-3194

3195-3198

3199-3203

3204-3208

3209-3213

3214-3217

3218-3221

3222-3224

3225-3229

3230-3234

3235-3239

3240-3244

3245-3249

3250-3254

3255-3259

3260-3264

3265-3268

3269-3273

.7.i

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Contents

PHYSIOLOGICAL SCIENCES

Analogues of red and white muscle in squid mantle (cephalopod metabolism/ muscle enzymes/cephalopod muscle histochemistry/jet propulsion muscles)

PSYCHOLOGY

Galloping induced by pontine tegmentum damage in rats: A form of "Parkinsonian festination" not blocked by haloperidol (akinesia/locomotion/ nucleus reticularis tegmenti pontis/y-aminobutyric acid/movement subsystems)

Corrections

BIOCHEMISTRY

Location, function, and nucleotide sequence of a promotor for bacteriophage T3 RNA polymerase (restriction map of T3 DNA/Southern hybridization/ restriction fragment transcription by T3 RNA polymerase/DNA sequencing/ RNA sequencing)

CELL BIOLOGY

Specific disruption of vimentin filament organization in monkey kidney CV-1 cells by diphtheria toxin, exotoxin A, and cycloheximide (intermediate filaments)

T. P. Mommsen, J. Ballantyne, D. MacDonald, J. Gosline, and P. W. Hochachka

3274-3278

J.-T. Cheng, T. Schallert, M. De Ryck, 3279-3283 and P. Teitelbaum

Samit Adhya, Shantanu Basu, Probir Sarkar, and Umadas Maitra

3286

Arlene H. Sharpe, Lan Bo Chen, John 3284-3285 R. Murphy, and Bernard N. Fields

This content downloaded from 130.132.123.28 on Thu, 1 May 2014 20:44:27 PMAll use subject to JSTOR Terms and Conditions