Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 78, No. 10, [Part 2: Biological Sciences] (Oct., 1981), pp. i-xPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/10983 .

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ProceedIngs OF THE

National Academy of Sciences

OF THE UNITED STATES OF AMERICA

October 1981 Volume 78, Number 10 pp. 5919-6560

Table of Contents

INFORMATION TO CONTRIBUTORS ix-xii

AUTHOR INDEX xiii-xiv

Physical Sciences 5919-5952

Biological Sciences

APPLIED BIOLOGY

Evolution of DNA sequence organization in mitochondrial genomes of Zea (cloned R. R. Sederoff, C. S. Levings III, D. H. 5953-5957 DNA fragment/chromosome rearrangement/maize/teosinte) Timothy, and W. W. L. Hu

BIOCHEMISTRY

Application of differential scanning microcalorimetry to the study of cellular John D. Loike, Samuel C. Silverstein, 5958-5962 processes: Heat production and glucose oxidation of murine macrophages and Julian M. Sturtevant (scanning calorimetry/glucose metabolism/drug effects)

Yeast tRNALU gene transcribed and spliced in a HeLa cell extract (in vitro David N. Standring, Alejandro 5963-5967 transcription/tRNA biosynthesis/DNA sequence/RNA polymerase III) Venegas, and William J. Rutter

Chicken erythrocyte nucleus contains two classes of chromatin that differ in Andrew W. Fulmer and Victor A. 5968-5972 micrococcal nuclease susceptibility and solubility at physiological ionic Bloomfield strength (nuclease digestion kinetics/chromatin superstructure)

Reinitiation of translation from the triplet next to the amber termination codon in Masaru Ryoji, Robert Berland, and 5973-5977 the absence of ribosome-releasing factor (ribosome read-through/in vitro Akira Kaji tr a n sIat i on/ ba ct er io p h age R 1 7/p ep t ide m ap pi ng )

Asparagine amide metabolism in developing cotyledons of soybean (double cross- Jacob Schaefer, T. A. Skokut, E. 0. 5978-5982 polarization/15N NMR/magic-angle spinning/stable-isotope chemical bond Stejskal, R. A. McKay, and J. E. labeling) Varner

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Contents

Molecular cloning of the genome of poliovirus type 1 (recombinant DNA/colony Sylvie Van Der Werf, Frangois 5983-5987 filter hybridization/restriction endonucleases) Bregegere, Helena Kopecka, Naomi

Kitamura, Paul G. Rothberg, Philippe Kourilsky, Eckard Wimmer, and Marc Girard

Loss of chromosomal high mobility group proteins HMG1 and HMG2 when mouse Saeid M. Seyedin, John R. Pehrson, 5988-5992 neuroblastoma and Friend erythroleukemia cells become committed to and R. David Cole differentiation (mitotic inhibition/chromatin/histone Hl0)

5'-O-Monophosphoryladenylyl(2'-->5')adenosine is an antagonist of the action of Paul F. Torrence, Jiro Imai, and 5993-5997 5'-O-triphosphoryladenylyl(2'-*5')adenylyl(2'-*5')adenosine and double- Margaret I. Johnston stranded RNA [poly(I)-poly(C)/interferon/initiation factor eIF-2/(2'->5')- oligodA)-activated ribonuclease/translational control]

Adult chicken a-globin genes, aA and aD: No anemic shock a-globin exists in Jerry B. Dodgson, Kevin C. McCune, 5998-6002 domestic chickens (nonanemic cDNA clones/chromosomal clones/DNA Drew J. Rusling, Andree Krust, and sequence) James Douglas Engel

mRNA in human cells contains sequences complementary to the Alu family of Bruno Calabretta, Donald L. 6003-6007 repeated DNA (RNA association complexes/electron microscopy/restriction Robberson, Abby L. Maizel, and enzymes/recombinant reiterated DNA/R-loop hybridization) Grady F. Saunders

RNAs involved in copy-number control and incompatibility of plasmid Rl Peter Stougaard, S0ren Molin, and 6008-6012 (inhibition or replication/unstable RNA in Escherichia coli minicells/promoter Kurt Nordstrom mutant/transcription-termination mutant)

Characterization of sites for tyrosine phosphorylation in the transforming protein J. E. Smart, H. Oppermann, A. P. 6013-6017 of Rous sarcoma virus (pp60vsn) and its normal cellular homologue (pp60c-) Czernilofsky, A. F. Purchio, R. L. (oncogene/tumor virus/protein kinase/phosphotyrosine/src gene) Erikson, and J. M. Bishop

Directionality and polarity in recA protein-promoted branch migration (recA/ Michael M. Cox and I. R. Lehman 6018-6022 recombination/D loops/strand exchange/restriction analysis)

Sequence-specific antibodies show that maturation of Moloney leukemia virus Nicola Green, Thomas M. Shinnick, 6023-6027 envelope polyprotein involves removal of a COOH-terminal peptide (synthetic Owen Witte, Alfred Ponticelli, J. peptides/membrane protein processing) Gregor Sutcliffe, and Richard A.

Lerner Mechanisms of Kirsten murine sarcoma virus transformation-induced changes in John F. Bateman and Beverly 6028-6032

the collagen phenotype and synthetic rate of BALB 3T3 cells (productive Peterkofsky infection and transformation/temperature-sensitive Kirsten sarcoma virus/ procollagen mRNA)

Cloning of the uvrC gene of Escherichia coli: Expression of a DNA repair gene Surendra Sharma, Akinori Ohta, 6033-6037 (repair of ultraviolet irradiation damage/expression of cloned genes) William Dowhan, and Robb E. Moses

Two periplasmic transport proteins which interact with a common membrane Christopher F. Higgins and Giovanna 6038-6042 receptor show extensive homology: Complete nucleotide sequences (histidine Ferro-Luzzi Ames and arginine transport/gene duplication/Salmonella/chimeric binding protein/ signal peptides)

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135- Jeffrey D. Milbrandt, Nicholas H. 6043-6047 kilobase-pair region that includes the dihydrofolate reductase gene (restriction Heintz, W. Carlton White, Steven M. fragments/drug resistance/homogeneously staining region/tetrahydrofolate Rothman, and Joyce L. Hamlin dehydrogenase)

Fluorometric assay for adenosine 3',5'-cyclic monophosphate-dependent protein David E. Wright, Emily Shacter 6048-6050 kinase and phosphoprotein phosphatase activities (peptide substrate/ Noiman, P. Boon Chock, and Vincent phosphorylation/enzyme kinetics/fluorescence) Chau

Posttranslational processing of methyl-accepting chemotaxis proteins in David Sherris and John S. Parkinson 6051-6055 Escherichia coli (sensory transduction/membrane proteins/cheR and cheB mutants)

Synthesis, intracellular transport, and processing of the precursors for Masataka Mori, Tetsuo Morita, 6056-6060 mitochondrial ornithine transcarbamylase and carbamoyl-phosphate Fumiaki Ikeda, Yoshihiro Amaya, synthetase I in isolated hepatocytes (mitochondrial enzyme precursors/ Masamiti Tatibana, and Philip P. extramitochondrial pool/import and processing) Cohen

tif-1 mutation alters polynucleotide recognition by the recA protein of Escherichia Kevin McEntee and George M. 6061-6065 coli (ATPase/oligonucleotide/A repressor cleavage/cold-sensitive revertant/SOS Weinstock induction)

Membrane potential depolarization and increased intracellular pH accompany the Robert W. Schackmann, Richard 6066-6070 acrosome reaction of sea urchin sperm (amine accumulation/ Christen, and Bennett M. Shapiro tetraphenylphosphonium accumulation/thiocyanate exclusion/fluorescent tracers/fertilization)

Membrane glycoproteins involved in cell-substratum adhesion (surface Karen A. Knudsen, Patricia E. Rao, 6071-6075 membrane/glycoprotein) Caroline H. Damsky, and Clayton A.

Buck

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Contents

Structure of the 6 chain of human embryonic hemoglobin (globin gene evolutionl J. B. Clegg and J. Gagnon 6076-6080 oxygen affinity/Bohr effect)

Use of whole-cell fixation to visualize replicating and maturing simian virus 40: V. Jackson and R. Chalkley 6081-6085 Identification of new viral gene product

The Mr 80,000 common forms of neurophysin and vasopressin from bovine Marc Lauber, Pierre Nicolas, Hamadi 6086-6090 neurohypophysis have corticotropin- and ,3-endorphin-like sequences and Boussetta, Christine Fahy, Pierre liberate by proteolysis biologically active corticotropin (prohormones/ Beguin, Maryse Camier, Hubert precursors/hypothalamus/radioimmunoassay/affinity chromatography) Vaubry, and Paul Cohen

Synthesis of stable unspliced mRNA from an intronless simian virus 40-rat Peter Gruss, Argiris Efstratiadis, 6091-6095 preproinsulin gene recombinant (intron/RNA splicing/mRNA stability) Sotiris Karathanasis, Monika Konig,

and George Khoury

Plasmid ColEl incompatibility determined by interaction of RNA I with primer Jun-ichi Tomizawa and Tateo Itoh 6096-6100 transcript (mutants/transcription/copy number/hybridization/secondary structure)

Conformational transition in the myosin hinge upon activation of muscle (rabbit Hitoshi Ueno and William F. 6101-6105 skeletal muscle/contraction/crossbridge movement/subfragment 2-light Harrington meromyosin/enzyme probe)

Isolation of the Escherichia coli leader peptidase gene and effects of leader Takayasu Date and William Wickner 6106-6110 peptidase overproduction in vivo (membrane biogenesis/phage M13 coat protein)

Escherichia coli factor Y sites of plasmid pBR322 can function as origins of DNA S. L. Zipursky and K. J. Marians 6111-6115 replication (site specificity/ATP hydrolysis/initiation of DNA synthesis)

Elongation of displacement-loop strands in human and mouse mitochondrial DNA_ Jackie N. Doda, Catharine T. Wright, 6116-6120 is arrested near specific template sequences (DNA replication/3',terminal and David A. Clayton labeling/nucleotide sequence)

Expression of early adenovirus genes requires a viral.encoded acidic polypeptide R. P. Ricciardi, R. L. Jones, C. L. 6121-6125 (host-range mutants/hybridization selection/cell-free translation/two- Cepko, P. A. Sharp, and B. E. dimensional protein gels/DNA sequence analysis) Roberts

32P-Labeling test for DNA damage (environmental carcinogens/mutagens/ Kurt Randerath, M. Vijayaraj Reddy, 6126-6129 polyethyleneimine-cellulose/thin-layer chromatography) and Ramesh C. Gupta

Low molecular weight RNAs transcribed in vitro by RNA polymerase III from Susan R. Haynes and Warren R. 6130-6134 Alu-type dispersed repeats in Chinese hamster DNA are also found -in vivo Jelinek (cloned DNA/DNA sequence determination/cell-free transcription/molecular hybridization/RNA oligonucleotide analysis)

Human somatotropin: Covalent reconstitution of two polypeptide contiguous Laszl6 GrAf and Choh Hao Li 6135-6138 fragments with thrombin (enzymatic resynthesis/growth-promoting activity/ radioreceptor assay/radioimmunoassay)

Uninfected cell polymerase efficiently transcribes early but not late herpes Raymond J. Frink, Kenneth G. Draper, 6139-6143 simplex virus type 1 mRNA (herpesvirus DNA sequence/T-A-T-A and C-A-T and Edward K. Wagner boxes/unspliced mRNA/in vitro transcription)

Carcinogen-mediated amplification of viral DNA sequences in simian virus 40- Sara Lavi 6144-6148 transformed Chinese hamster embryo cells (induction of simian virus 40 DNA/ A gene dependence/analysis of amplified DNA/general amplification of replicons/carcinogenesis)

Heteroduplex formation by recA protein: Polarity of strand exchanges (genetic Stephen C. West, Era Cassuto, and 6149-6153 recombination/homologous pairing/postreplication repair) Paul Howard-Flanders

Kallikrein-induced uterine contraction independent of kinin formation (serine Julie Chao, John Buse, Kazuaki 6154-6157 proteinases/smooth muscle/kininogen/kininogenases/kinin antibodies) Shimamoto, and Harry S. Margolius

Molecular complexes involved in the regulation of adenylate cyclase (cytoskeleton/ Naji E. Sahyoun, Harry LeVine III, 6158-6162 N-protein/guanyl nucleotides//3-adrenergic receptor) Jonathan Davis, George M. Hebdon,

and Pedro Cuatrecasas Regulation of protein synthesis: Translational control by procollagen-derived Dietrich Horlein, John McPherson, 6163-6167

fragments (cell-free translation/pactamycin/fibroblast culture) Swee Han Goh, and Paul Bornstein Amino acid sequence of the first constant region domain and the hinge region of Frank W. Putman, Nobuhiro 6168-6172

the 8 heavy chain of human IgD (antibody structure/IgM/protein evolution/ Takahashi, Daniel Tetaert, Brigitte galactosamine Qligosaccharides/lymphocyte receptor) Debuire, and Lien-Ching Lin

Preparation of tritium- or deuterium-labeled vitamin D analogs by a convenient Herbert E. Paaren, Mary A. Fivizzani, 6173-6175 general method (calcium/labeled vitamin D/calciferol/bone) Heinrich K. Schnoes, and Hector F.

DeLuca Rat basophilic leukemia cell lines defective in phospholipid methyltransferase- Anne McGivney, Fulton T. Crews, 6176-6180

enzymes, Ca2+ influx, and histamine release: Reconstitution by hybridization Fusao Hirata, Julius Axelrod, and (IgE receptor/CaY+ ionophore/phosphatidylcholine) Reuben P. Siraganian

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Classification of multiple morphine and enkephalin binding sites in the central Benjamen L. Wolozin and Gavril W. 6181-6185 nervous system (opiate receptor/naloxazone/,u receptor/6 receptor) Pasternak

Amino acid sequence of a human leukocyte interferon (micro-sequence Warren P. Levy, Menachem 6186-6190 determination/interferon diversity/automatic sequence determination/ Rubinstein, John Shively, UJrsino multigene family/protein primary structure) Del Valle, Chun-Yen Lai, John

Moschera, Larry Brink, Louise Gerber, Stanley Stein, and Sidney Pestka

Sequence-specific contacts between the RNA polymerase of vesicular stomatitis Jack D. Keene, Barbara J. Thornton, 6191-6195 virus and the leader RNA gene (nucleocapsid structure/methylation protection/ and Suzanne U. Emerson RNA polymerase promoters/protein-nucleic acid interactions)

DNA sequence analysis reveals extensive homologies of regions preceding hsp70 Roger W. Hackett and John T. Lis 6196-6200 and af heat shock genes in Drosophila melanogaster (transcription/genetic regulation/promoters/transposition/evolution)

Pathway of protein glycosylation in the trypanosomatid Crithidia fasciculata Armando J. Parodi, Luis A. Quesada 6201-6205 (dolichol/glycoprotein/protozoa/oligosaccharides) Allue, and Juan J. Cazzulo

Synthesis of parvovirus H-1 replicative form from viral DNA by DNA polymerase Regine Kollek and Mehran Goulian 6206-6210 y (in vitro DNA synthesis/eukaryotic DNA replication/parental replicative form/adenovirus)

p8-Endorphin: Characteristics of binding sites in a neuroblastoma-glioma hybrid R. Glenn Hammonds, Jr., Pascual 6560 cell (Correction) (opiate receptor/opioid peptide/morphine/naloxone) Ferrara, and Choh Hao Li

BIOPHYSICS

Effect of surface modification on aggregation of phospholipid vesicles (liposome/ Po-Shun Wu, George W. Tin, John D. 6211-6215 macrophage/phagocytosis/proton magnetic resonance/drug delivery system) Baldeschwieler, T. Y. Shen, and M.

M. Ponpipom

Configuration of the four iron atoms in dissolved human hemoglobin as studied H. B. Stuhrmann and H. Notbohm 6216-6220 by anomalous dispersion (synchrotron radiation/small-angle scattering)

Coordination environment of the active-site metal ion of liver alcohol Marvin W. Makinen and Moon B. Yim 6221-6225 dehydrogenase (electron paramagnetic resonance/high-spin cobalt/Orbach process/spin-lattice relaxation/zero-field splitting)

CELL BIOLOGY

Interactions among clonal subpopulations affect stability of the metastatic George Poste, John Doll, and Isaiah J. 6226-6230 phenotype in polyclonal populations of B16 melanoma cells (cancer/cellular Fidler interactions/phenotypic regulation/growth control)

Involvement of trypsin-like activity in binding of mouse spermatozoa to zonae Patricia M. Saling 6231-6235 pellucidae (cell-cell interaction/protease inhibitors/fertilization in vitro/gamete recognition)

Induction of plasminogen activator by UV light in normal and xeroderma Ruth Miskin and Ruth Ben-Ishai 6236-6240 pigmentosum fibroblasts (DNA repair/SOS function/xeroderma pigmentosum heterozygotes)

Tumor promoters alter gene expression and protein phosphorylation in avian cells Andrei Laszlo, Kathryn Radke, Steven 6241-6245 in culture (phorbol esters/src gene/34- to 36-kilodalton protein/ Chin, and Mina J. Bissell phosphotyrosine)

Rate of lateral diffusion of intramembrane particles: Measurement by Arthur E. Sowers and Charles R. 6246-6250 electrophoretic displacement and rerandomization (lateral diffusion coefficient/ Hackenbrock integral proteins/freeze-fracture electron microscopy)

Metabolism of benzo[a]pyrene by human mammary epithelial cells: Toxicity and Martha R. Stampfer, James C. 6251-6255 DNA adduct formation (polycyclic aromatic hydrocarbons/carcinogenesis) Bartholomew, Helene S. Smith, and

Jack C. Bartley

Lectins activate lymphocyte pyruvate dehydrogenase by a mechanism sensitive to Joanna C. Beachy, Diane Goldman, 6256-6260 protease inhibitors (mitogens/transmembrane signalling/receptor/lymphocyte and Michael P. Czech activation)

Fibronectin-like protein in Porifera: Its role in cell aggregation (phylogenesis/cell Jacqueline Labat-Robert, Ladislas 6261-6265 membrane/intercellular matrix/differentiation/ morphogenesis) Robert, Carole Auger, Claire

Lethias, and Robert Garrone

Effect of vinblastine on distribution of murine leukemia virus-derived membrane- M. Satake, P. N. McMillan, and R. B. 6266-6270 associated antigens (gag and env gene-derived membrane antigens/ Luftig cytoskeleton/cap -like phenomenon/indirect immunofluorescence)

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Contents

pH homeostasis in Escherichia coli: Measurement by 3ap nuclear magnetic Joan L. Slonczewski, Barry P. Rosen, 6271-6275 resonance of methylphosphonate and phosphate (pH regulation/intracellular Jeffry R. Alger, and Robert M. pH/protonmotive force/Fourier-transform NMR) Macnab

Mapping functional domains in the promoter region of the herpes thymidine D. Zipser, L. Lipsich, and J. Kwoh 6276-6280 kinase gene (herpes simplex virus type 1/in vitro mutagenesisiDNA -mediated transformation/gene expression)

Interferon increases the abundance of submembranous microfilaments in HeLa-S3 Eugenia Wang, Lawrence M. Pfeffer, 6281-6285 cells in suspension culture (immunofluorescence microscopy/electron and Igor Tamm microscopy/heavy meromyosin/plasma membrane/actin filament)

Reactivation of chicken erythrocyte nuclei in heterokaryons results in expression Stig Linder, Steven H. Zuckerman, and 6286-6289 of adult chicken globin genes (cell fusion/gene activation/blot hybridization Nils R. Ringertz technique/immunoprecipitation)

5-Azacytidine induction of mouse endogenous type C virus and suppression of Ohtsura Niwa and Tsutomu Sugahara 6290-6294 DNA methylation (cytidine analogue/hypomethylation/gene expression)

Most of the G1 period in hamster cells is eliminated by lengthening the S period George M. Stancel, David M. Prescott, 6295-6298 (growth cycle/chromosome cycle/hydroxyurea) and R. Michael Liskay

Membrane differentiation in human myeloid cells: Expression of unique profiles Minoru Fukuda, H. Phillip Koeffler, 6299-6303 of cell surface glycoproteins in myeloid leukemic cell lines blocked at different and Jun Minowada stages of differentiation and maturation (granulocyte-monocyte cell lineage/ stem cell/onco-differentiation antigen/lactosaminoglycan/li antigen)

Proglumide and benzotript: Members of a different class of cholecystokinin W. F. Hahne, R. T. Jensen, G. F. Lemp, 6304-6308 receptor antagonists (pancreatic secretagogues/amylase secretion/gastrin/ and J. D. Gardner caerulein)

Desensitization to gonadotropins in cultured Leydig tumor cells involves loss of Dale A. Freeman and Mario Ascoli 6309-6313 gonadotropin receptors and decreased capacity for steroidogenesis (choriogonadotropin/hormone receptors/hormone action/target cell responses/ desensitization)

DEVELOPMENTAL BIOLOGY

Successive generations of mice produced from an established culture line of Timothy A. Stewart and Betrice Mintz 6314-6318 euploid teratocarcinoma cells (microinjection into blastocysts/developmental totipotency/germ-line transmission)

EVOLUTION

Extensive polymorphism in the mitochondrial DNA of apes (cleavage map/ Stephen D. Ferris, Wesley M. Brown, 6319-6323 ribosomal gene/ape population/human evolution) William S. Davidson, and Allan C.

Wilson

Structured habitats and the evolution of anticompetitor toxins in bacteria Lin Chao and Bruce R. Levin 6324-6328 (allelopathy/interference competition/altruism/frequency-dependent selection/ colicin)

GENETICS

Estimating genetic divergence and genetic variability with restriction William R. Engels 6329-6333 endonucleases (heterozygosity/base substitutions/population genetics/ maximum likelihood)

The cycl-ll mutation in yeast reverts by recombination with a nonallelic gene: Joachim F. Ernst, John W. Stewart, 6334-6338 Composite genes determining the iso-cytochromes c (cytochrome c/ and Fred Sherman Saccharomyces cerevisiae/transposition)

Studies of the locus for androgen receptor: Localization on the human X Barbara R. Migeon, Terry R. Brown, 6339-6343 chromosome and evidence for homology with the Tfm locus in the mouse Joyce Axelman, and Claude J. (somatic cell hybrids/complementation analysis/androgen insensitivity Migeon syndrome)

Potential for selection among nearly neutral allozymes of 6-phosphogluconate Daniel L. Hartl and Daniel E. 6344-6348 dehydrogenase in Escherichia coli (natural selection/selective neutrality/ Dykhuizen allozyme/gnd gene/chemostat)

A general high-efficiency procedure for production of microcell hybrids (somatic R. E. K. lFournier 6349-6353 cell genetics/chromosome transfer/gene mapping)

Yeast transformation: A model system for the study of recombination (plasmid Terry L. Orr-Weaver, Jack W. Szostak, 6354-6358 integration/double-strand break repair/rad52-1 mutation/DNA repair and Rodney J. Rothstein synthesis)

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Genetic control of insulin receptors (mouse/gene regulation/cell differentiation/ Anne E. Goldfeld, Charles S. Rubin, 6359-6361 hormone receptors) Todd W. Siegel, Phyllis A. Shaw,

Susan G. Schiffer, and Salome Gluecksohn-Waelsch

Mouse a-globin genes and a-globin-like pseudogenes are not syntenic (somatic cell Raymond A. Popp, Peter A. Lalley, J. 6362-6366 hybrids/recombinant DNA) Barry Whitney III, and W. French

Anderson Molecular cloning of a mouse submaxillary gland renin cDNA fragment Frangois Rougeon, B6atrice 6367-6371

(androgen target organs/strain variations/kidney renin mRNA/differential Chambraud, Simon Foote, Jean- screening/hybrid-arrested translation) Jacques Panthier, Roland Nageotte,

and Pierre Corvol

Molecular basis for familial isolated growth- hormone deficiency (growth hormone John A. Phillips III, Brian L. Hjelle, 6372-6375 loci/gene deletions/DNA) Peter H. Seeburg, and Milo

Zachmann

Microinjection of a rabbit f-globin gene into zygotes and its subsequent Thomas E. Wagner, Peter C. Hoppe, 6376-6380 expression in adult mice and their offspring (gene transfer/interspecific gene Joseph D. Jollick, David R. Scholl, expression) Richard L. Hodinka, and Janice B.

Gault

Longer-than-unit-length viroid minus strands are present in RNA from infected Andrea D. Branch, Hugh D. Robertson, 6381-6385 plants (potato spindle tuber viroid/blot hybridization/denaturing gel/double- and Elizabeth Dickson stranded RNA/ribonuclease III)

Transcription of the simian virus 40 genome in DNA-transformed murine Alban Linnenbach, Kay Huebner, and 6386-6390 teratocarcinoma stem cells (cell differentiation/gene regulation/tumor antigen/ Carlo M. Croce RNA blotting/S1 nuclease duplex analysis)

IMMUNOLOGY

Herpesvirus ateles and herpesvirus saimiri transform marmoset T cells into Donald R. Johnson and Mikael Jondal 6391-6395 continuously proliferating cell lines that can mediate natural killer cell-like cytotoxicity (cellular cytotoxicity/transformed killer cells)

Selective natural killer resistance in a clone of YAC lymphoma cells (tumor John C. Roder, Timothy J. Beaumont, 6396-6400 variants/natural killer cells) Robert S. Kerbel, Tina Haliotis, and

Danuta Kozbor

Influence of H-2 antigen expression on killer T cell specificity, differentiation, Pamela J. Fink and Michael J. Bevan 6401-6405 and induction (radiation chimera/thymus/major histocompatibility complex/ helper cells)

Selective loss of antigen-specific Ir gene function in L4 mutant B6.C-H-2bml2 is an Chiu-Chuan Shirley Lin, Alan S. 6406-6410 antigen presenting cell defect (insulin/T-cell proliferation/complementation) Rosenthal, Howard C. Passmore, and

Ted H. Hansen

Characterization of T-cell surface proteins bound by heterologous antisera to Robert E. Cone, Robert W. Rosenstein, 6411-6415 antigen-specific T-cell products (T-lymphocyte/antigen receptor/membrane) James H. Murray, G. Michael

Iverson, Wlodzimierz Ptak, and Richard K. Gershon

Suppression of a "recurrent" idiotype results in profound alterations of the whole Rosa R. Bernab6, Antonio Coutinho, 6416-6420 B-cell compartment (maternal effect/B-cell ontogeny/idiotypic network) Pierre-Andr6 Cazenave, and Luciana

Forni

Single channel currents induced by complement in antibody-coated cell Meyer B. Jackson, Cathy L. Stephens, 6421-6425 membranes (humoral cytolysis/membrane damage) and Harold Lecar

Assembly of the functional membrane attack complex of human complement: Carl F. Ware and William P. Kolb 6426-6430 Formation of disulfide-linked C9 dimers (immune lysis/membrane channel heterogeneity/covalent protein-protein interactions/immunoreplication procedures)

Functional helper activity of monoclonal T cell populations: Antigen-specific and Richard J. Hodes, Masao Kimoto, 6431-6435 H-2 restricted cloned T cells provide help for in vitro antibody responses to Karen S. Hathcock, C. Garrison trinitrophenyl-poly(LTyr,Glu)-poly(DLAla)--poly(LLys) (cell interactions/major Fathman, and Alfred Singer histocompatibility complex/Ir genes)

Synthesis and processing of the a heavy chains of secreted and membrane-bound Hitoshi Kikutani, Roberto Sitia, Robert 6436-6440 IgA (murine B lymphoma/hybridoma(/two-dimensional gel electrophoresis/ax A. Good, and Janet Stavnezer chain mRNA/in vitro translation)

Suppressor factor from a T cell hybrid inhibits delayed-type hypersensitivity R. Blake Whitaker, Jerry T. Nepom, 6441-6445 responses to azobenzenearsonate (suppressor cells/T hybridomas) Man-Sun Sy, Muneo Takaoki,

Colette F. Gramm, Ira Fox, Ronald N. Germain, Mitchell J. Nelles, Mark I. Greene, and Baruj Benacerraf

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MEDICAL SCIENCES

Episomal simian virus 40 genomes in human brain tumors (papovavirus genomesl P. Krieg, E. Amtmann, D. Jonas, H. 6446-6450 cell fusion/restriction endonucleases/transformation) Fischer, K. Zang, and G. Sauer

Hypersensitivity to N-methyl-N'-nitro-N-nitrosoguanidine in fibroblasts from Dominic A. Scudiero, Sharon A. Meyer, 6451-6455 patients with Huntington disease, familial dysautonomia, and other primary Brian E. Clatterbuck, Robert E. neuronal degenerations (DNA damage and repairlneurodegeneration/ Tarone, and Jay H. Robbins spinocerebellar ataxia/infantile spinal muscular atrophy)

Expression of major histocompatibility antigens on pancreatic islet cells (major Steinunn Baekkeskov, Takahiro 6456-6460 histocompatibility complex/transplantation antigens/monoclonal antibodiesl Kanatsuna, Lars Klareskog, David pancreatic beta cells/insulin-dependent diabetes) A. Nielsen, Per A. Peterson, Arthur

H. Rubenstein, Donald F. Steiner, and Ake Lernmark

Herpes simplex type 1 DNA in human brain tissue (latent virus/Southern blotl Nigel W. Fraser, William C. Lawrence, 6461-6465 cloned DNA fragment/multiple sclerosis) Zofia Wroblewska, Donald H.

Gilden, and Hilary Koprowski

Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent George S. Drummond and Attallah 6466-6470 competitive inhibitor of heme oxidation [neonatal jaundice/heme oxidase Kappas (decyclizing)/metalloporphyrins]

Protein variations associated with Lesch-Nyhan syndrome (genetic screening/two- Carl R. Merril, David Goldman, and 6471-6475 dimensional electrophoresis/polymorphism/lymphocyte) Michael Ebert

Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to Yorio Hinuma, Kinya Nagata, Masao 6476-6480 the antigen in human sera (immunofluorescence/lymphoid cell line/specific Hanaoka, Masuyo Nakai, Tadashi antibody/type C virus) Matsumoto, Ken-Ichiro Kinoshita,

Shigeru Shirakawa, and Isao Miyoshi

Increased ascorbic acid content in chronic lymphocytic leukemia B lymphocytes (T L. Liebes, R. Krigel, S. Kuo, D. Nevrla, 6481-6484 lymphocytes/high-performance liquid chromatography) E. Pelle, and R. Silber

Monoclonal antibody against a Burkitt lymphoma-associated antigen (hybridoma/ Joelle Wiels, Marc Fellous, and 6485-6488 tumor antigen/Epstein-Barr virus) Thomas Tursz

a-Hydroxylation pathway in the in vitro metabolism of carcinogenic nitrosamines: Marilyn B. Kroeger-Koepke, Steven R. 6489-6493 N-Nitrosodimethylamine and N-nitroso-N-methylaniline (activation/ Koepke, Gary A. McClusky, Peter N. mechanism/nitrogen-15 labeling/mass spectrometry/carcinogenesis) Magee, and Christopher J. Michejda

Atherosclerosis and hypertension induction by lead and cadmium ions: An effect N. W. Revis, A. R. Zinsmeister, and R. 6494-6498 prevented by calcium ion (drinking water/elements/cardiovascular disease/ Bull pigeon)

Enhanced macrophage degradation of low density lipoprotein previously Tore Henriksen, Eileen M. Mahoney, 6499-6503 incubated with cultured endothelial cells: Recognition by receptors for and Daniel Steinberg acetylated low density lipoproteins (cell surface receptors/atherosclerosis)

Manifold expression of new cellular genes in human lymphoid neoplasia (single- Nicole Hanania, Dan Shaool, Colette 6504-6508 stranded DNA/DNA-RNA hybridization) Poncy, and Jacques Harel

Inhibition of prostate tumor growth in two rat models by chronic administration T. W. Redding and A. V. Schally 6509-6512 of D-Trp6 analogue of luteinizing hormone-releasing hormone (prostate adenocarcinoma/tumor remission)

Amygdalin (Laetrile) and prunasin fglucosidases: Distribution in germ-free rat Jonathan Newmark, Roscoe 0. Brady, 6513-6516 and in human tumor tissue [cyanogenic glucosides/neutral P'1-3f6)- and Philip M. Grimley, Andrew E. Gal, f(1-~1)-glucosidases/gentiobiose] Stephen G. Waller, and J. Richard

Thistlethwaite Primary structure of corticotropin-releasing factor from ovine hypothalamus Joachim Spiess, Jean Rivier, Catherine 6517-6521

(micro-sequence analysis/reverse-phase high-pressure liquid chromatography/ Rivier, and Wylie Vale dansylation/thermolysin/carboxypeptidase Y)

MICROBIOLOGY

Repression and activation of the genome of herpes simplex viruses in human cells Brian L. Wigdahl, Harriet C. Isom, and 6522-6526 (herpesviruses/virus-virus interaction/antiviral selectivity/virus gene Fred Rapp regulation)

Clones of the malaria parasite Plasmoudium falciparum obtained by microscopic W. Trager, M. Tershakovec, L. 6527-6530 selection: Their characterization with regard to knobs, chloroquine sensitivity, Lyandvert, H. Stanley, N. Lanners, and formation of gametocytes (cultivation in vitro) and E. Gubert

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Contents

NEUROBIOLOGY

Dopaminergic modulation of adenylate cyclase stimulation by vasoactive Pierluigi Onali, Joan P. Schwartz, and 6531-6534 intestinal peptide in anterior pituitary (prolactin-releasing factor/cyclic AMPI Erminio Costa dopamine)

Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: Pierre J. Magistretti, John H. 6535-6539 A possible regulatory mechanism for the local control of energy metabolism Morrison, William J. Shoemaker, (cerebral cortex/peptideslbrain energy metabolism/glycogen/norepinephrine) Viveca Sapin, and Floyd E. Bloom

Linear information processing in the retina: A study of horizontal cell responses Daniel Tranchina, James Gordon, 6540-6542 (vision/intracellular recording/sinusoidal gratings/spatial summation) Robert Shapley, and Jun-ichi Toyoda

Specific receptor for the opioid peptide dynorphin: Structure-activity relationships Charles Chavkin and Avram Goldstein 6543-6547 (myenteric plexus/opiate/endorphin/multiple opiate receptors/neuropeptide)

Abnormal action potentials associated with the Shaker complex locus of Mark A. Tanouye, Alberto Ferrus, and 6548-6552 Drosophila (behaviorlneurogenetics/potassium channel/membrane physiology! Shinobu C. Fujita gene complex)

Immunocytochemical localization of aspartate aminotransferase Richard A. Altschuler, Gabrielle R. 6553-6557 immunoreactivity in cochlear nucleus of the guinea pig (aspartate/glutamate/ Neises, George G. Harmison, Robert afferent synapses/auditory nerve) J. Wenthold, and Jorgen Fex

POPULATION BIOLOGY

Marginal underdominance at a stable equilibrium (two-locus model/induced Alan Hastings 6558-6559 underdominance/epistasis)

PSYCHOLOGY

Galloping induced by pontine tegmentum damage in rats: A form of J.-T. Cheng, T. Schallert, M. De Ryck, 6560 "Parkinsonian festination" not blocked by haloperidol (Correction) (akinesial and P. Teitelbaum locomotion/nucleus reticularis tegmenti pontis/y-aminobutyric acid/movement subsystems)

Corrections

BIOCHEMISTRY

,B-Endorphin: Characteristics of binding sites in a neuroblastoma-glioma hybrid R. Glenn Hammonds, Jr., Pascual 6560 cell (opiate receptor/opioid peptide/morphine/naloxone) Ferrara, and Choh Hao Li

PSYCHOLOGY

Galloping induced by pontine tegmentum damage in rats: A form of J.-T. Cheng, T. Schallert, M. De Ryck, 6560 "Parkinsonian festination" not blocked by haloperidol (akinesia/locomotionl and P. Teitelbaum nucleus reticularis tegmenti pontis/y-aminobutyric acid/movement subsystems)

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Missing pages are

Physical Sciences issues.

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