Partnership for Success with Huntington’s WA€¦ · School of Medical Sciences, ... Psychiatric...

Partnership for Success with Huntingtonrsquos WA

AIMS

1 To ameliorate symptoms and improve quality of life

2 TO CHANGE POLICY and PRACTICE IN PATIENT CARE

VERY GENEROUSLY FUNDED BY LOTTERYWEST

Can rehabilitation help people with

early-mid stage Huntingtonrsquos

disease

M Ziman J A Thompson T Cruickshank A Reyes Z Khan L Penailillo R A Barker SR Davies S Andrew J

Lee A Hannan R Newton School of Medical Sciences Edith Cowan University Perth WA Cambridge Centre for Brain Repair Cambridge University UK

Neurosciences Unit Department of Health North Metropolitan Area Perth WA Howard Florey Institute University of Melbourne Melbourne VIC

Launch March 2010

Huntingtonrsquos

disease (HD)

Inherited Neurodegenerative

Disorder

Mutation in the Htt gene

50 chance of inheritance if either

parent has the mutated gene

Onset ndash 30-70 years of age

Incidence ~57 per 100000 in

Australia

HD is a fatal complex and

severely debilitating disease

for which there is no cure

There is a gradual loss of neural cells and

muscle cells

So gradual loss of cognitive physical

and emotional function

HISTORY

Paracelsus (1527) 16th century

1872 recognized as a disease for first time

Dr George Huntington (New York) published

ldquoOn Choreardquo in The Medical and Surgical

Reporter of Philadelphia

22 years - Sole publication of just a few paragraphs

was entirely anecdotal and unreferenced

1993 the huntingtin protein was inextricably linked

to the huntingtin gene (Htt or IT15) and to the

disease

HOW


Htt gene has C A G repeat in

exon 1

Normal = 9-36 repeats

Mutant gene = 40 -

250

Produces an abnormal protein

with a polyglutamine tract

Length of CAG repeat

correlates with age of onset

(can be as young as 2)

ABNORMAL PROTEIN -

NEURAL LOSS

protein-protein interactions

With normal proteins

Aggregates in cytoplasm

Inclusion bodies in nucleus

bullVesicular Transport Defective

bullGene transcription and expression

affected

NORMAL PROTEIN In nucleus cell body dendrites of many nerve cells

Transcription vesicle transport cytoskeletal anchoring and pro-survival properties

Timed loss of neurons with abnormal HD protein

RESULT

Loss of neurons in specific brain regions

In the striatum (basal ganglia) causing

loss of movement control

In the cortex and cerebellum - causing

Psychosis and Dementia

Loss of brain volume

Striatal neurons

Coordinate complicated motor and

visual and thinking tasks

- Computer games

- Driving a car

Striatal neurons linked to cortical

neurons

Striatum is also

affected in

Parkinsonrsquos disease

Muscle Movement Disorders - CHOREA hyperkinetic - dystonia and rigidity hypokinetic initiating voluntary movements

Chorea Atrophy

Summary of Symptoms Neural Cell Death

Cognitive (Neural)

Symptoms

Muscle Cell Deficits

Motor (Muscular) Symptoms

STRIATUM Loss GABAergic medium spiny neurons

Loss of Executive Function (Planning)

Decreased fibre diameter Reduce neural input

Muscle Atrophy - Gait Dysfunction

CORTEX Pyramidal neurons

Loss of Short Term Memory (Dementia)

Fibre type switching

Chorea

Decreased Creatine Kinase (energy stores)

Psychiatric disturbances (delusionsparanoiaanxiety)


Saccadic eye movements

Loss of Brain Neurotrophic factor BDNF

Depression Mitochondrial dysfunction - energy

Loss of Balance - Vestibular

Huntingtonrsquos disease is not just a disease of the CNS

Peripheral effects of HD

Weight loss

(Adapted from van der Burg (2009) Lancet Neurology 8 765-774

Need to treat all defects using multi-disciplinary intervention

No treatment is

currently available that

slows alters or

reverses the disease

progression

Treatment of Symptoms

Pharmacological Therapies

Antipsychotics

Benzodiazepines

Dopamine Antagonists

Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)

Nerve Growth Factors

Creatine

Stem Cell and

Foetal Tissue Transplants

IMPROVE

NEUROGENESIS

AS THERAPY

Replacing old or lost neurons with new

neurons

NEUROGENESIS

Upregulated by Mental and Physical

Exercise

Physical stimulation (exercise)

upregulates production of endogenous

stem cells within the brain

Cognitive stimulation increases stem cell

survival and integration of new neurons

Together increased production and

survival of neural stem cells in mouse

models of HD

Environmental enrichment - combined

use of mental and physical stimulation to

effect neurological changes

HEROs (Huntingtons Enrichment Rehabilitation Optimisation Scheme)

AIM Implement Environmental Enrichment Program (HEROS)

bullOUTCOMES Slow progression of Huntingtonrsquos disease

bullUpregulate stem cells within the brain and assist their maturation and integration into the existing brain circuitry bullImprove QOL for people with HD benefits carers and families

bullChange policy and practice for treatment of HD

bullMULTIDISCIPLINARY RESEARCH COLLABORATION neuroscientists neurologists neuroradiologists psychologists and psychiatrists occupational therapists physiotherapists exercise physiologists social workers AND the HD Association

Scientifically validate our research Myriad of assessments

Participant Baseline measures Taken June 2010

1 Psychiatric assessment ndash Clinical UHDRS motor score

2 Occupational Therapy and Physiotherapy assessment

3 MRI Brain Volume and fMRI - Functional Imaging and Mapping

4 Blood Biochemical tests ndash Insulin BDNF Creatine Kinase Salivary Cortisol

5 Physical Movement analyses i Height Weight Muscle Dimensions Composition

ii Muscle Strength ndash Isokinetic Isometric Contractions

iii Gait and Walking

iv Fine Motor and Reaction time

v Balance Prevalence of Falls QOL

MRI and fMRI to measure brain volume and function

Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan

ndash Body Composition

Neurocom Balance

Visual Somatosensory

and Vestibular Control

Isokinetic and Isometric

Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait

Walking Stride Length

and Stride Frequency

Video Analysis of Muscle

and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control

Reaction Time Testing

COGNITIVE TESTING PROCEDURES

Clinical neuropsychological tests

bullBecks Depression Inventory

bullHopkins Verbal Learning Test

bullDKEFS trail making trial

bullSymbol Digit Modalities test

bullDKEFS Stroop Test

Environmental Enrichment

TREATMENT

Mental physical and social stimulation

ldquoUse it or you lose itrdquo

ndash ldquoa passive lifestyle may contribute to the earlier onset of symptomsrdquo

Neuroscientists Neurologist

Neuropsychiatrist

Neuropsychologist

Neuroradiologist

Exercise physiologists

(biomechanics muscle force

gross and fine motor training)

Physiotherapists

Cognitive

Motor

Occupational Therapist

(cognitive stimulation) Social

Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)

Intermediate Measurements

Final Measurements

Long-term

Intervention

STUDY DESIGN ndash RANDOMISED CONTROLLED

1 Clinical gym exercises ndash 1 hour per week

2 Home-based exercises - daily

3 Occupational therapy

ndash targeted deficits detected at baseline by psychologists

ndash 1 hour per fortnight

High compliance rates were experienced

OUTCOME MEASURED at 9 Mths and 18 Mths

MOTOR FUNCTION - Clinical Unified Huntingtonrsquos Disease Rating Scale (UHDRS)

BRAIN IMAGING - MRI fMRI (executive and motor function) DTI

PHYSICALPHYSIOLOGICAL FACTORS

DEXA muscle strength Neurocom Balance

COGNITION

Symbol Digit Modalities Test Hopkins Verbal Learning Test-Revised DKEFS Colour

Word Interference Test DKEFS Trail Making Trials

DEPRESSION - Beck Depression Inventory-II

QUALITY OF LIFE OUTCOMES

Short Form 36v2 Health Survey HD Quality of Life Battery for Carers

STATISTICS

Between groups analysis - Independent t-test on difference between values (summed data)

Within groups analysis - Repeated measures ANOVAKruskall-Wallis Test (within groups)

plt005 was considered statistically significant

Highly significant rate of motor deterioration during the control period

The intervention significantly reduced the rate of motor deterioration

Maintained baseline levels after 18 months

CLINICAL MEASURE

Unified Huntingtonrsquos Disease Rating Scale ndash Motor Score

0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core

UHDRS Total Motor Score

p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000

L Arm R Arm Trunk L Leg R Leg Head Total

Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS

REDUCED loss of fat and lean mass

Significantly increased lean mass over 18 months

in contrast to significant loss in controls which is characteristic of the disease

BODY COMPOSITION

Muscle Strength

Major Muscle Groups

SIGNIFICANT GAINS IN STRENGTH

AFTER 9 AND 18 MONTHS OF

INTERVENTION

Mean Difference plusmnSEM

(plt00001)

Chest Press Lat Pull Down

Seated Row

Muscle Strength

Major Muscle Groups

Beneficial physical changes ndash impacts independent functioning

Leg Press

Leg Extension Leg Flexion



INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions

Sensory Organisation Test

Control Intervention 1 Intervention 2


NeuroCom SMART Balance Master Apparatus Apparatus consists of a support surface (forceplates) and a 3-sided visual surround moved independently

A higher score denotes better postural stability (where 100 = no sway0 = fall)


SIGNIFICANT IMPROVEMENT IN BALANCE

Cognitive Changes

Timepoint (n)

Difference in values Within Groups (p)

Control (10)

9 mths (13)

18 mths (10)

Group A Group B

C 9mths 9mths 18mths

Total Recall (n) 060 plusmn115 -125 plusmn083 186 plusmn147 0535 0992 0056 0142

Delayed Recall (n) -10 plusmn052 03 plusmn042 143 plusmn115 0032 0291 0890 0095

Retention () -1975 plusmn100 148 plusmn52 2293 plusmn102 0017 0629 0634 0035

Recognition

Discrimination

Index (score)

10 plusmn068 -095 plusmn053 071 plusmn052 0274 0137 0086 0094

Significant Trend

Hopkins Verbal Learning Test - MemoryLearning

Values = Mean plusmnSEM Within Group ndash Repeated Measures ANOVA Between Groups ndash Independent T-test on difference

Significant deterioration in controls

Maintained baseline levels after 9 MONTHS

Significant improvement after 18 MONTHS

DEPRESSION

-8

-6

-4

-2

0

2

4

6

Control Int 1 Int 2Ch

an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e

Beck Depression Inventory

M


p=00886

Brain Imaging

Performed at Neuroradiology Sir Charles Gairdner Hospital

Mike Bynevelt (Head of Dept) Neuroradiologist

MRI - Structure

Whole brain volumetric analysis ndash WM vs GM

fMRI - Function

BOLD response during performance of an executive function task

(Simon Interference task)

DTI ndash Integitry

Diffusion Tensor Imaging to assess changes to FA and MD to

assess changes to white and grey matter in response to the

intervention

RESULTS STILL TO COME

Multidisciplinary rehabilitation intervention in early-mid stage HD patients appears

to slow symptoms of disease progression

Patients with early-mid stage Huntingtonrsquos disease can participate in continuous multidisciplinary

rehabilitation as an adjunct to pharmaceutical therapy without adverse effects

Participants demonstrated high levels of compliance

Participants exhibited cognitivephysicalfunctional benefits - encouraging given the small

sample size

JA Thompson TM Cruickshank LE Penailillo JW Lee RU Newton RA Barker MR Ziman

(2013) The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage

Huntingtons disease a pilot study Eur J Neurol 2012 Dec 7 doi 101111ene12053 [Epub ahead

of print]

Acknowledgments

Thank you to the patients families and carers

for their participation in this research project

The generous assistance of the gyms is

gratefully acknowledged

ECU Vario Health amp Wellness Institute

ECU Sport amp Fitness Centre

South Lakes Leisure Centre

Lords Fitness Centre

Positive Fit

We thank the many assessors and students

who assisted with data collection

This project was supported by Lotterywest

and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]

Characteristic Group A

(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45

Age (years) 508 plusmn 25 537 plusmn 29

Age at Diagnosis

(years) 495 plusmn 28 482 plusmn 22

Disease Duration


CAG Number 441 plusmn 06 431 plusmn 11

CAG Index 4279 plusmn 222 3991 plusmn 537

Body Mass Index

(kgm2) 270 plusmn 14 264 plusmn 14

Participants were assigned to two groups equally matched for

cognitive and motor scores at baseline

Groups were assessed for differences in baseline demographics ndash no statistically significant

differences were detected

Groups were randomly assigned to either receive the intervention or not

Domain Range of Score

1 Ocular pursuit 0 - 4

2 Saccade initiation 0 - 4

3 Saccade velocity 0 - 4

4 Dysarthria 0 - 4

5 Tongue protrusion 0 - 4

6 Finger taps 0 - 4

7 PronateSupinate hands 0 - 4

8 Luria 0 - 4

9 Rigidity-Arms 0 - 4

10 Bradykinesia-Body 0 - 4

11 Maximal dystonia 0 - 4

12 Maximal chorea 0 - 4

13 Gait 0 - 4

14 Tandem walking 0 - 4

15 Retropulsion pull test 0 - 4

16 Weight actual weight

17 Diagnosis confidence

level 0 - 4

Total Sum of scores

Highly significant rate of motor deterioration during the control period (p=0003)

The intervention significantly reduced the rate of motor deterioration (p=0020) which was

maintained at lower levels after intervention 2 (p=0311)

Unified Huntingtonrsquos Disease Rating Scale ndash Total Motor Score

0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core

UHDRS Total Motor Score Difference in Mean Score

p=0311 p=0020

Timepoi

nt (n)

Difference in values Within Groups (p) Between

Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)

Group A Group B Ctl v

Int 1

Int 2

v Int 1 C I 1 I 1 I 2 18mths

UHDRS 154 plusmn29 56 plusmn16 42 plusmn41

000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass

(kg) -19 plusmn07 06 plusmn04 -01 plusmn11 0013

049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)

-10 plusmn05 03 plusmn04 08 plusmn08 006

7

039

8 0102 0230 0013 0112 0596

BMD

(gcm3) 00 plusmn00 00 plusmn00 00 plusmn00 0430 0128 0567 0686 0907 0675 0679

Lean+B

MC (kg) -10 plusmn06 03 plusmn04 08 plusmn08

005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)

-29 plusmn11 10 plusmn07 07 plusmn18 0013 099

3 0161 0600 0081 0006 0875

BMI

(kgm2) -060 plusmn03 003 plusmn03 009 plusmn06

006

4 0144 0208 0829 0178 0184 0914

Body Composition

FAT MASS Significant loss of fat mass during control period (p=0013)

Maintained fat mass during intervention period (pgt005)

Highly significant difference between control + intervention groups (p=0002)

LEAN MASS A trend towards significant loss of lean mass during control period (p=0067)

No significant loss during intervention period ndash non-significant gain

After longitudinal intervention significant overall increase detected (p=0013)

TOTAL BODY MASS Significant loss of total body mass during control period (p=0013)

After longitudinal intervention a trend towards a significant increase in

body mass detected (predominantly +lean mass 0081)


Significant Trend

Note Maintenance of body composition during second round


NeuroCom SMART Balance Master Apparatus

Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved

Maintained levels (plusmn2)

No Test

Two sample test of proportion

Timepoint Deteriorated Maintained

Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046

Intervention 1 500 500


-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2

NeuroCom Balance Test Difference in composite mean

score

Group A Group B Combined

0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re

NeuroCom Composite SOT Equilibrium Scores

Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM

No Intervention + Intervention

Timepoint (n)

Difference in values Within Group (p) Between Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (11)

Group A Group B Ctl v Int 1 Int 2 v Int 1

C I 1 I 1 I 2 18mths

D-KEFS Colour Word Interference Test ndash (number performed)

Colour naming 58 plusmn29 44 plusmn25 44 plusmn37 0133 0137 0309 0218 0039 0750 0997

Non-significant improvement after intervention 1

with a further improvement after intervention 2 and significant difference from baseline (p=0039)

Word Reading 07 plusmn17 18 plusmn16 514 plusmn187 0883 0080 0746 0011 0019 0655 0249

Maintained during control period with improvement after intervention 1

and significant improvement after intervention 2 (p=0011) and overall from baseline (p=0019)

Inhibition (eg green) -18 plusmn41 31 plusmn48 1283 plusmn68 0853 0338 1000 0150 0150 0521 0291

Maintained during control period and after intervention 1


D-KEFS Trail Making Trials ndash (time taken)

Visual Scanning 62 plusmn39 41 plusmn33 -56 plusmn76 0064 0748 0150 0535 0467 0703 0187

A trend for significant deterioration after control period Non-significant deterioration after intervention 1


Number Sequencing -07 plusmn42 117 plusmn43 -107 plusmn46 0659 0057 0035 0008 0351 0076 0008

Maintained after control period Borderlinesignificant deterioration after intervention 1

Highly significant improvement after intervention 2 (p=0008)

Letter Sequencing -141 plusmn99 99 plusmn43 -49 plusmn53 0054 0076 0587 0407 0732 0015 0066

Borderline significant improvement after control period Significant deterioration after intervention 1

A trend for significant improvement after intervention 2 (p=0066)

Number-Letter Switching

-178 plusmn170 03 plusmn81 188 plusmn73 0487 0665 0373 0012 0036 0296 0380

Non-significant improvement after control period Non-significant improvement after intervention 1

Significant deterioration after intervention 2 (p=0036)

Motor Speed -85 plusmn65 20 plusmn60 -80 plusmn72 0479 0736 0170 0156 0854 0284 0371

Cognitive Changes Significant Trend Executive Function

Can rehabilitation help people with

early-mid stage Huntingtonrsquos

disease

M Ziman J A Thompson T Cruickshank A Reyes Z Khan L Penailillo R A Barker SR Davies S Andrew J

Lee A Hannan R Newton School of Medical Sciences Edith Cowan University Perth WA Cambridge Centre for Brain Repair Cambridge University UK

Neurosciences Unit Department of Health North Metropolitan Area Perth WA Howard Florey Institute University of Melbourne Melbourne VIC

Launch March 2010

Huntingtonrsquos

disease (HD)


Disorder






Australia





muscle cells



HISTORY










disease

HOW



exon 1


Mutant gene = 40 -

250






ABNORMAL PROTEIN -

NEURAL LOSS







affected




RESULT







Striatal neurons



- Computer games

- Driving a car


neurons

Striatum is also

affected in



Chorea Atrophy


Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Launch March 2010

Huntingtonrsquos

disease (HD)


Disorder






Australia





muscle cells



HISTORY










disease

HOW



exon 1


Mutant gene = 40 -

250






ABNORMAL PROTEIN -

NEURAL LOSS







affected




RESULT







Striatal neurons



- Computer games

- Driving a car


neurons

Striatum is also

affected in



Chorea Atrophy


Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Huntingtonrsquos

disease (HD)


Disorder






Australia





muscle cells



HISTORY










disease

HOW



exon 1


Mutant gene = 40 -

250






ABNORMAL PROTEIN -

NEURAL LOSS







affected




RESULT







Striatal neurons



- Computer games

- Driving a car


neurons

Striatum is also

affected in



Chorea Atrophy


Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)

































muscle cells



HISTORY










disease

HOW



exon 1


Mutant gene = 40 -

250






ABNORMAL PROTEIN -

NEURAL LOSS







affected




RESULT







Striatal neurons



- Computer games

- Driving a car


neurons

Striatum is also

affected in



Chorea Atrophy


Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























HISTORY










disease

HOW



exon 1


Mutant gene = 40 -

250






ABNORMAL PROTEIN -

NEURAL LOSS







affected




RESULT







Striatal neurons



- Computer games

- Driving a car


neurons

Striatum is also

affected in



Chorea Atrophy


Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























HOW



exon 1


Mutant gene = 40 -

250






ABNORMAL PROTEIN -

NEURAL LOSS







affected




RESULT







Striatal neurons



- Computer games

- Driving a car


neurons

Striatum is also

affected in



Chorea Atrophy


Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























ABNORMAL PROTEIN -

NEURAL LOSS







affected




RESULT







Striatal neurons



- Computer games

- Driving a car


neurons

Striatum is also

affected in



Chorea Atrophy


Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)






























RESULT







Striatal neurons



- Computer games

- Driving a car


neurons

Striatum is also

affected in



Chorea Atrophy


Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























RESULT







Striatal neurons



- Computer games

- Driving a car


neurons

Striatum is also

affected in



Chorea Atrophy


Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Striatal neurons



- Computer games

- Driving a car


neurons

Striatum is also

affected in



Chorea Atrophy


Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)






























Chorea Atrophy


Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)






























Cognitive (Neural)

Symptoms










Chorea










Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)































Weight loss



No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























No treatment is


slows alters or


progression



Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)































Antipsychotics

Benzodiazepines


Antidepressants

Antichoreic Agents

NEWER MEDICATION

Glutamate Blockers

antioxidants (Q10)


Creatine

Stem Cell and


IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























IMPROVE

NEUROGENESIS

AS THERAPY


neurons

NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























NEUROGENESIS


Exercise








models of HD






















Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)















































Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)









































Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)






























Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Body Composition

Height Weight

Arm and Thigh

measurements

Dexa Scan ndash

Dual Energy X-Ray

Absorptiometry scan


Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Neurocom Balance




Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)






























Measurements

Muscle Force

Hand Grip Strength

Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Analysis of Gait




and Joint Movement

Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Force Plate

Measurements of

Walking Stride and

Gait

Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Fine Motor Control










TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





































TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)






























TREATMENT





Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)






























Neuropsychiatrist

Neuropsychologist

Neuroradiologist




Physiotherapists

Cognitive

Motor



Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Intervention

(Group B = 9)

Intervention

Non-Intervention

CONTROL GROUP

(Group A = 10)


Final Measurements

Long-term

Intervention













COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)








































COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)


































COGNITION






STATISTICS







CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)
































CLINICAL MEASURE


0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Fat Difference

Control

Intervention 1

Intervention 2

-5000

-4000

-3000

-2000

-1000

0

1000

2000

3000


Lean Difference

Control

Intervention 1

Intervention 2

OVERALL RESULTS




BODY COMPOSITION

Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Muscle Strength

Major Muscle Groups



INTERVENTION


(plt00001)


Seated Row

Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Muscle Strength

Major Muscle Groups


Leg Press




INTERVENTION

(plt00001)


-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























-2000

-1500

-1000

-500

000

500

1000

1500

2000

2500

1 2 3 4 5 6 Comp

Ch

an

ge

in

Me

an

Eq

uil

ibri

um

Sco

re (

)

Conditions








Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Cognitive Changes

Timepoint (n)


Control (10)

9 mths (13)

18 mths (10)

Group A Group B





Recognition

Discrimination

Index (score)


Significant Trend






DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























DEPRESSION

-8

-6

-4

-2

0

2

4

6


an

ge

in

Sco

re r

ela

tiv

e t

o b

ase

lin

e


M


p=00886

Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Brain Imaging



MRI - Structure


fMRI - Function



DTI ndash Integitry



intervention








sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)



































sample size




of print]

Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Acknowledgments









Positive Fit




and ECU

Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Characteristic

Group A

(mean z-score

[range])

Group B

(mean z-score

[range])

Cognitive

Assessment

(mean z-score)

0034 [-05 to 08] 0063 [-06 to 05]

Motor Assessment

(mean z-score) -016 [-13 to 084] -013 [-17 to 10]


(mean plusmnSEM)

Group B

(mean plusmnSEM)

Number of

participants 10 9

Gender MF 64 45


Age at Diagnosis


Disease Duration




Body Mass Index











4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)

































4 Dysarthria 0 - 4


6 Finger taps 0 - 4


8 Luria 0 - 4





13 Gait 0 - 4





level 0 - 4

Total Sum of scores





0

2

4

6

8

10

12

14

16

18

20

Control I 1 I 2

Dif

fere

nce

in

Me

an

UH

DR

S S

core


p=0311 p=0020

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (13)

Interv 2 (10)


Int 1

Int 2



000

3 0178 0038 0345 0028 0020 0311

Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Timepoi

nt (n)


Groups (p)

Control (10)

Interv 1 (20)

Interv 2 (7)


Int 1

Int 2


Fat Mass


049

6 0365 0880 0497 0002 0529

Lean

Mass

(kg)


7

039

8 0102 0230 0013 0112 0596

BMD


Lean+B


005

8

039

8 0094 0232 0012 0097 0592

Total

Mass

(kg)


3 0161 0600 0081 0006 0875

BMI


006

4 0144 0208 0829 0178 0184 0914

Body Composition











Significant Trend




Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)































Control Int 1 Int 2

-6

-7 4

-14

-11

-6

6 0

-12 7

-20

-9 9

2 -2

0 -28

-5 13

-16 -6

-10

5 5

-16 -2

0 0

-19 1

1 -16

-7 -21

6

-12 22

Deteriorated

Improved


No Test



Improved p

Control Period 700 300 (0-9) 0128 (9-18) 0163 (0-18) 0046



-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























-1000

-800

-600

-400

-200

000

200

400

600

Control Int 1 Int 2


score


0001000200030004000500060007000

0 1 2 3

Me

an

Sco

re


Group A

Group B

p=0109 (27)



p=0041 (38)

Mean Difference

plusmnSEM

Error Bars =

SEM


Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Timepoint (n)


Control (10)

Interv 1 (13)

Interv 2 (11)





























Date post:	13-Apr-2018
Category:	Documents
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