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CLINICO-THERAPEUTIC MANAGEMENT OF

CANINE PARVOVIRAL GASTRO-ENTERITIS

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Signalment:-

Animal Species Breed Sex Age Colour Parity Body wt.

Pup Canine Lhasa

Apso

Male 7 months White - 5.3 kg

Anamnesis:-Vomiting

Diarrhoea

LethargicInappetance

Not vaccinated

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OBSERVATIONS:-

Resp : 35/min

Pulse : 96/min

MM : Congested

Dehydration : 6-10%

Temp : 105F

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Vomitus

Haematemesis

Faeces

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F/S:- No ova of parasitic importance couldbe detected.

Ancylostoma, Coccidia- Ruled out

INVESTIGATION & LABORATORY FINDINGS:-

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RBC count :4.5 million/cu.mm (5.5-8.5)

Total WBC :12000/cu.mm(6000-17000)DLC

Neutrophils :70% (60-70)

Lymphocytes : 30%(12-30)ESR : 8mm/hr (5-25)

Hb :13.6g% (12-18)

Platelet count :2,90,000/cu.mm(2-9 lakhs)V P R C :43% (37-55)

M C V :72 fl (60-77)

M C H C :31% (32-36)

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Lateral flow technique:-

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A Test (Titres from 1/128 to 1/256)

Titre-1/128

H I T (Ti f 80 120)

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H I Test (Titres from 80 to 120)

Titre- 128

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TREATMENT GIVEN:-1 st day,1.Inj. Moxel- 500mg

Aqua dest ad 5ml Mft.Sig. 5ml I/V2.Inj.Metrogyl

Sig 10 ml I/V3.Inj.Botropase

Sig 1ml as I/V

4. Inj. RANITIDINESig 0.25 ml I/M5.INJ.EMESET

sig 0.2ml I/V6. Inj. Haemaccel

Sig 50 ml I/V6.Inj.DNS

Sig 100 ml I/V7.Inj.RL

Sig 100 ml I/V

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1.Inj. Moxel- 500mgAqua dest ad 5ml Mft.Sig. 5ml I/V

2.Inj.MetrogylSig 10 ml I/V

3.Inj.Pantocid

Sig 1.2ml I/V4.Inj.EmesetSig 0.2ml I/V

5.Inj.DNSSig 100 ml I/V

6.Inj.RLSig 100 ml I/V

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1.Inj. Moxel- 500mg

Aqua dest ad 5ml Mft.Sig. 5ml as I/V

2.Inj.Pantocid

Sig 1.2ml as I/V

3.Inj.Emeset

Sig 0.2ml as I/V

4.Inj.DNS

Sig 100 ml as I/V

5.Inj.RL

Sig 100 ml as I/V

7.Inj.Metrogyl

Sig 10 ml as I/V

8.Inj.Botropase

Sig 1ml as I/V

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4th,5th,6th,7thDays

3rd,4th & 5th - Gradual Improvement

6th - Showed thirst, Fluid therapy &Anti-emetics stopped

7th - Normal appetite

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Follow up:-

Soft & Easily digestible diet

24 hr clean water

Warmth

Vaccination of other pups

Review after 10 days

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Survived-6, Dead-1

14%

86%

survival rate

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Canine parvo virus -2Small, non enveloped, ss DNA

2a, 2b, 2c-strains

Close relation- FPV, MEVDisease of young to adolescent dogs.

Breeds: Rottweiler, Dobermann, German

shepherd, Labrador, Staffordshire terriorMyocardial or Intestinal form.

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Principally by faecal-oral route

oral, nasal or oronasal exposure

IM, IV, S/C

In utero infection

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Pathogenesis

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Pathogenesis :-Oronasal exposure

Regional lymph nodes,pharynx,tonsils

Viremia

Leukopenia Crypt necrosis Minimal pathology

Enteritis, Diarrhoea

Severe Mild

Gram negative sepsis Recovery

D.I.C

DEATH!!

Lymphoid tissue, Bone marrow Intestine Lung,Liver,Kidney

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Less than 8 weeks of age

In utero or oronasal exposure

Cardiac arrhythmia, Cardiac

myopathy, CHF, Pulmonary oedema.

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Fever

Vomiting

Diarrhoea

Depression, anorexia , lethargy

Myocarditis- CHF

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RAPID DIAGNOSIS

Antigen dependant immunochromatographic

method: Lateral flow technique

DIAGNOSIS

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-ve +ve

RAPID LATERAL FLOW TEST

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SLIDE AGGLUTINATION TEST

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ELISA

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P C R

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ELECTRON MICROSCOPY

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HA HI TEST

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DIFFERENTIAL DIAGNOSIS

Ancylostoma caninum infection

Coccidiosis

Corona virus infection

Canine distemper

Foreign body

Poisoning

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ARRIVE AT A CONFIRMED

DIAGNOSIS AT THE

EARLIEST!

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TREATMENT

Supportive and Symptomatic

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OBJECTIVE

Replacement of fluid loss

Prevention of secondary bacterial infection

Rest to the G I tract

Antibiotics

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Haemocoagulants

AntiemeticH2 blocker5HT3

blocker

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Inactivated. Live attenuated/Modified live.

VACCINATION

Sub -unitWhole agent

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6-8 week.6,9,12,15,18,22week.

Once in a fortnight.

Weekly.Annual booster.

Our Hospital- 12 weeks, 18 week, Annual.

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Puppy-DP - NobivacDHPPiL -BiocanCompanion-C3 -IntervetProgard puppy-DP

Canigen

VirbacDuramune Max Pv-

Fort DodgeMegavac-6 - IIM

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Formaline- 1%

Ethyl alcohol-50-95%

Ethylene Oxide

F10, Trigene

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Treat diseases..?

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A HEALTHY POPULATION OF ANIMALS

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Craig E. Greene, Infectious Diseases of the Dog and Cat, 5th Edition, 2006,

W.B.Saunders Company, pp1387.

Max J. Appel, Virus Infections of Carnivores, Vol.2, 1987, Elsevier Inc., pp.500.

Stephen J. Ettinger, Edward C. Feldman, Textbook of Veterinary InternalMedicine, Vol.2, 6th Edition, 2005, Elsevier Inc.,pp1992.

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