Pathogenic spirochetes.

Chair of Medical Biology, Microbiology, Virology, and Immunology

SpirochetesTreponemaBorreliaLeptospira

Main pathogenic bacteria of Spirochetaceae

Genus Species Subspecies Disease

Treponema T.pallidumT.pallidum T. pallidum

T.сarateum

T.vincentii

pallidum

endemicum

Pertenue

Syphilis

Bejel

Yaws

Pinta

Vincent’s angina

Borellia B.recurrentis

B.caucasica, B.duttoni, B.persica та ін

Epidemic relapcing fever

Endemic relapsing fever

B.burgdorferi Lyme disease

Leptospira Icterohaemo-rrhagiae

Leptospirosis

Spirochetes structure

Spirochetes morphology

Treponema

Leptospira

Borrelia

Spirochetes ultrastructure

Borrelia

Leptospira

Classification of Human Terponema

Non-pathogenic T.denticola T.macrodenticum T.orale

Conditionally pathogenic T.vincentii

Pathogenic T.pallidum pallidum

(syphilis) T.pallidum

endemicum (bejel) T.pallidum pertenue

(yaws) T.carateum (pinta)

Vincent’s angina

Noma (gangrenous stomatitis)

Treponema in tested material

Cell attacked by treponema

Hard chancre

Clinical findings of Syphilis

Secondary syphilis

Hetchinzone teeth

Microbiologic diagnosis of Syphilis

Microscopy (native an fixed material) Romanovsky-Giemsa

stain Phase contrast Dark field

Serologic diagnosis Wassermann’s test (CFT) Sedimentation reartions

(Каhn’s and Sachs-Witebsky’s tests)

Microreaction of Treponema pallidum immobilization

IFT, ELYSA, IHATChain polymerase reaction

Tropic treponematoses: pinta (T.carateum), bejel (T.endemicum), yaws (T.pertenue)

Yaws (tropic granuloma)

Bejel (endemic syphilis)

Yaws

Pinta

Bejel

Borrelia morphology

Borrelia in blood smear

Lyme disease

Causative agents:

Borrelia burgdorferi

Borrelia garinii

Borrelia afzelii

B. burgdorferi

Leptospira morphology

Clinical findings of leptospirosis